staurosporine has been researched along with Hepatocellular Carcinoma in 41 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 16 (39.02) | 18.2507 |
| 2000's | 9 (21.95) | 29.6817 |
| 2010's | 12 (29.27) | 24.3611 |
| 2020's | 4 (9.76) | 2.80 |
| Authors | Studies |
|---|---|
| Cetin Atalay, R; Guven, EB; Onder, T; Tuncbilek, M | 1 |
| Fan, H; Hong, JL; Hu, JF; Xia, G; Xiong, J; Yang, GX; Ye, M; Zhao, Y; Zhu, JJ | 1 |
| Dominici, L; Fatigoni, C; Levorato, S; Moretti, M; Pagiotti, R; Vannini, S; Villarini, M | 1 |
| Cai, Y; Chen, D; Chen, X; Chen, Y; Dong, Z; Liu, Y; Liu, Z; Wu, J; Xia, Q; Zhang, L; Zhao, C; Zheng, X | 1 |
| El-Hamamsy, MH; Petreni, A; Supuran, CT; Tawfik, HO | 1 |
| Chen, Y; Liu, N; Qi, D; Tong, X; Wen, J; Ye, X | 1 |
| Dong, H; Guo, X; Han, B; Hong, X; Jiang, W; Liu, K; Lu, S; Qiu, F; Qiu, X; Qu, L; Shi, T; Tian, L; Wu, Z; Yao, K; Zhao, J; Zhao, W; Zhong, L; Zhong, M; Zhou, B | 1 |
| Chen, X; Ding, Y; Ge, J; Wang, B; Zhou, Y | 1 |
| Aschenbrenner, DS | 1 |
| Feitelson, MA; Lin, N; Liu, B; Wu, G; Xu, L | 1 |
| Cai, X; Fan, K; Li, N; Li, X; Li, Z; Liu, Y; Qi, J; Wang, L; Yao, W; Yin, P; Zha, X; Zhao, C | 1 |
| Aderca, I; Ahmed, K; Bani-Hani, AH; Bonilla-Guerrero, R; Burgart, LJ; Cazanave, SC; Cunningham, JM; Lai, JP; Mettler, TA; Montoya, DP; Moser, CD; Nagorney, DM; Roberts, LR; Shire, A; Thibodeau, SN; Veerasamy, M | 1 |
| Bai, LC; Chan, UP; Chen, GG; Fung, KY; Lai, PB; Merchant, JL; Tessier, A; To, AK | 1 |
| Hill, CE; Mishra, R; Rao, V; Shobeiri, N; Ta, R | 1 |
| Doki, Y; Hayashi, N; Hikita, H; Hosui, A; Ishida, H; Kodama, T; Miyagi, T; Mori, M; Nagano, H; Noda, T; Shimizu, S; Takehara, T; Tatsumi, T | 1 |
| Blache, C; Danan, JL; Daveau, M; Gidrol, X; Hiron, M; Saint-Auret, G; Salier, JP; Sulpice, E; Tendil, S | 1 |
| Chao, WT; Cheng, CC; Ho, CC; Hsu, YH; Lai, YS; Liu, YH; Pei, RJ | 1 |
| Choi, YH; Kwon, TK; Lee, JS; Oh, JS; Park, BS; Park, C; Song, YS; Yoo, SH; Yoo, YH; Yoon, YG | 1 |
| Fan, J; Fan, K; Li, N; Li, X; Li, Z; Mei, C; Qi, J; Qiu, S; Shi, Y; Wang, L; Yao, W; Yin, P; Zha, X; Zhao, C | 1 |
| Aderca, I; Chien, JR; Cunningham, JM; Greene, EL; Lai, JP; Matthews, TA; Montoya, DP; Moser, DR; Nagorney, DM; Roberts, LR; Shridhar, V; Smith, DI; Staub, JK | 1 |
| Izumi, T; Yamaguchi, M | 1 |
| Cuezva, JM; Fabregat, I; Martínez-Diez, M; Santamaría, G | 1 |
| Chen, L; Chu, X; De, W; Du, L; Geng, H; Guan, X; Wang, J; Zhang, Q | 1 |
| Danaher, M; Fallon, RJ; Saxena, A; Saylors, RL | 1 |
| Evans, SW; Thompson, D; Whicher, JT | 1 |
| Babish, JG; Bleckwenn, NA; Mufti, NA; Shuler, ML | 1 |
| Ko, FN; Teng, CM; Yu, SM | 1 |
| Buschmann, J; Heinrich, PC; Horn, F; Lottspeich, F; Lütticken, C; Müller-Esterl, W; Roeb, E; Schindler, C; Wegenka, UM; Yuan, J | 1 |
| Aggarwal, BB; Pandita, R | 1 |
| Hoekstra, D; Zegers, MM | 1 |
| Higashiyama, S; Ito, N; Kawata, S; Kiso, S; Matsuzawa, Y; Nakagawa, T; Tamura, S; Taniguchi, N; Tsushima, H | 1 |
| Kim, KW; Lee, KY; Lee, SK; Oh, YJ; Park, JA | 1 |
| Kim, KW; Kim, SI; Lee, SK; Park, JA | 1 |
| Friedman, SL; Fujimoto, J; Liu, X; Takahashi, H; Takehara, T | 1 |
| Inagaki, S; Yamaguchi, M | 1 |
| Corvol, P; Eckardt, KU; Fabbro, D; Kurtz, A; Pugh, C; Ratcliffe, P | 1 |
| Heinrich, PC; Müllberg, J; Rose-John, S; Schooltink, H; Stoyan, T | 1 |
| Izumi, N; Liu, J; Liu, JH; Marumo, F; Sakai, Y; Sato, C; Takano, T; Tang, L; Yauchi, T | 1 |
| Fandrey, J; Huwiler, A; Jelkmann, W; Pfeilschifter, J | 1 |
| Fallon, RJ | 1 |
| Ito, N; Kawata, S; Shirai, Y; Takaishi, K; Tamura, S; Tarui, S | 1 |
41 other study(ies) available for staurosporine and Hepatocellular Carcinoma
| Article | Year |
|---|---|
Synthesis of novel 6-(4-substituted piperazine-1-yl)-9-(β-D-ribofuranosyl)purine derivatives, which lead to senescence-induced cell death in liver cancer cells.
Topics: Adenosine; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Death; Cell Line, Tumor; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p15; Drug Screening Assays, Antitumor; Humans; Liver Neoplasms; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Purine Nucleosides; Retinoblastoma Protein; Structure-Activity Relationship | 2012 |
Leonurusoleanolides E-J, minor spirocyclic triterpenoids from Leonurus japonicus fruits.
Topics: Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Cell Survival; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Fruit; Humans; Inhibitory Concentration 50; Leonurus; Liver Neoplasms; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Spiro Compounds; Triterpenes | 2014 |
Investigation of the cytotoxic, genotoxic, and apoptosis-inducing effects of estragole isolated from fennel (Foeniculum vulgare).
Topics: Acridine Orange; Allylbenzene Derivatives; Animals; Anisoles; Apoptosis; Carcinoma, Hepatocellular; DNA Damage; DNA Fragmentation; Electrophoresis; Fluorescent Dyes; Foeniculum; Hep G2 Cells; Humans; Indoles; Liver Neoplasms; Membrane Potential, Mitochondrial; Mice; Molecular Structure; Oils, Volatile | 2014 |
Design, synthesis, and biological evaluation of indazole derivatives as selective and potent FGFR4 inhibitors for the treatment of FGF19-driven hepatocellular cancer.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Indazoles; Liver Neoplasms; Molecular Structure; Protein Kinase Inhibitors; Receptor, Fibroblast Growth Factor, Type 4; Structure-Activity Relationship | 2021 |
Discovery of new carbonic anhydrase IX inhibitors as anticancer agents by toning the hydrophobic and hydrophilic rims of the active site to encounter the dual-tail approach.
Topics: Antineoplastic Agents; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Carcinoma, Hepatocellular; Catalytic Domain; Humans; Liver Neoplasms; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship | 2022 |
[HBV-upregulated Lnc-HUR1 inhibits the apoptosis of liver cancer cells].
Topics: Animals; Annexins; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Cell Proliferation; Hep G2 Cells; Hepatitis B virus; Humans; Liver Neoplasms; Mice; Poly(ADP-ribose) Polymerase Inhibitors; Proto-Oncogene Proteins c-bcl-2; RNA, Long Noncoding; Staurosporine; Transforming Growth Factor beta; Tumor Suppressor Protein p53 | 2022 |
PLK1/NF-κB feedforward circuit antagonizes the mono-ADP-ribosyltransferase activity of PARP10 and facilitates HCC progression.
Topics: Animals; Antineoplastic Agents; Carcinogenesis; Carcinoma, Hepatocellular; Cell Cycle Proteins; Disease Progression; Feedback, Physiological; Female; HEK293 Cells; Hepatectomy; Humans; Kaplan-Meier Estimate; Liver; Liver Neoplasms; Male; Mice; Middle Aged; Mutagenesis, Site-Directed; Neoplasm Staging; Nitriles; Phosphorylation; Polo-Like Kinase 1; Poly(ADP-ribose) Polymerases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Pteridines; Signal Transduction; Staurosporine; Sulfones; Transcription Factor RelA; Xenograft Model Antitumor Assays | 2020 |
Staurosporine suppresses survival of HepG2 cancer cells through Omi/HtrA2-mediated inhibition of PI3K/Akt signaling pathway.
Topics: Apoptosis; Carcinoma, Hepatocellular; Enzyme Inhibitors; Hep G2 Cells; High-Temperature Requirement A Serine Peptidase 2; Humans; Liver Neoplasms; Mitochondrial Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Serine Endopeptidases; Signal Transduction; Staurosporine | 2017 |
New Approvals in Cancer Treatment.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Drug Approval; Humans; Leukemia, Myeloid, Acute; Liver Neoplasms; Phenylurea Compounds; Pyridines; Staurosporine; United States; United States Food and Drug Administration | 2017 |
UCN-01 induces S and G2/M cell cycle arrest through the p53/p21(waf1) or CHK2/CDC25C pathways and can suppress invasion in human hepatoma cell lines.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; cdc25 Phosphatases; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cell Proliferation; Checkpoint Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Humans; Inhibitory Concentration 50; Liver Neoplasms; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Signal Transduction; Staurosporine; Tumor Suppressor Protein p53 | 2013 |
MAGI2 enhances the sensitivity of BEL-7404 human hepatocellular carcinoma cells to staurosporine-induced apoptosis by increasing PTEN stability.
Topics: Adaptor Proteins, Signal Transducing; Apoptosis; Carcinoma, Hepatocellular; Carrier Proteins; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Activation; Enzyme Stability; Gene Expression; Gene Expression Regulation, Neoplastic; Guanylate Kinases; Humans; Liver Neoplasms; Protein Binding; Protein Transport; Proteolysis; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; PTEN Phosphohydrolase; Recombinant Fusion Proteins; RNA Interference; Staurosporine; Time Factors; Transfection | 2013 |
The JNK inhibitor SP600129 enhances apoptosis of HCC cells induced by the tumor suppressor WWOX.
Topics: Adult; Aged; Aged, 80 and over; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Chromosomes, Human, Pair 16; Enzyme Inhibitors; Female; Gene Expression Regulation; Humans; Liver Neoplasms; Loss of Heterozygosity; Male; Middle Aged; Mitogen-Activated Protein Kinase 8; Oxidoreductases; RNA, Messenger; Staurosporine; Tumor Suppressor Proteins; WW Domain-Containing Oxidoreductase | 2008 |
ZBP-89 reduces the cell death threshold in hepatocellular carcinoma cells by increasing caspase-6 and S phase cell cycle arrest.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Caspase 6; Cell Cycle; Cell Death; Cell Line, Tumor; DNA-Binding Proteins; Flow Cytometry; Fluorouracil; Humans; Liver Neoplasms; S Phase; Staurosporine; Transcription Factors | 2009 |
Mg2+- and MgATP-inhibited and Ca2+/calmodulin-sensitive TRPM7-like current in hepatoma and hepatocytes.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Benzylamines; Boron Compounds; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calmodulin; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Polarity; Cell Proliferation; Cell Survival; Dialysis; Dose-Response Relationship, Drug; Female; Hepatocytes; Humans; Liver Neoplasms; Magnesium; Membrane Potentials; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Staurosporine; Sulfonamides; Time Factors; TRPM Cation Channels | 2009 |
The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma.
Topics: Antineoplastic Agents; Apoptosis; Base Sequence; bcl-X Protein; Benzenesulfonates; Carcinoma, Hepatocellular; Cyclin G1; Down-Regulation; Drug Synergism; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; MicroRNAs; Niacinamide; Oligonucleotide Array Sequence Analysis; Phenylurea Compounds; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Sorafenib; Staurosporine; Up-Regulation | 2010 |
Characterization of the transcriptional signature of C/EBPbeta isoforms (LAP/LIP) in Hep3B cells: implication of LIP in pro-survival functions.
Topics: Carcinoma, Hepatocellular; CCAAT-Enhancer-Binding Protein-beta; Cell Death; Cell Line, Tumor; Cell Proliferation; Cell Survival; Gene Expression Profiling; Genetic Engineering; Humans; Liver Neoplasms; Models, Biological; Oligonucleotide Array Sequence Analysis; Paclitaxel; Protein Isoforms; Staurosporine; Transcription, Genetic | 2011 |
Cytokeratin 18-mediated disorganization of intermediate filaments is induced by degradation of plectin in human liver cells.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Line; Cell Line, Tumor; Down-Regulation; Hepatocytes; Humans; Intermediate Filaments; Keratin-18; Liver Neoplasms; Plectin; Staurosporine | 2011 |
Etoposide induces a mixed type of programmed cell death and overcomes the resistance conferred by Bcl-2 in Hep3B hepatoma cells.
Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Beclin-1; Carcinoma, Hepatocellular; Caspase Inhibitors; Drug Resistance, Neoplasm; Etoposide; Gene Expression Regulation, Neoplastic; Genes, bcl-2; Humans; Liver Neoplasms; Membrane Proteins; Staurosporine | 2012 |
Down-regulation of DNA methyltransferase 3B in staurosporine-induced apoptosis and its mechanism in human hepatocarcinoma cell lines.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methyltransferase 3B; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Genes, p16; Humans; Liver Neoplasms; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; RNA Stability; RNA, Small Interfering; Staurosporine | 2013 |
hSulf1 Sulfatase promotes apoptosis of hepatocellular cancer cells by decreasing heparin-binding growth factor signaling.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Division; Cell Line, Tumor; Cell Membrane; Cisplatin; DNA Methylation; Fibroblast Growth Factor 2; Heparitin Sulfate; Hepatocyte Growth Factor; Humans; Liver Neoplasms; Loss of Heterozygosity; Protein Structure, Tertiary; RNA, Messenger; Signal Transduction; Staurosporine; Sulfates; Sulfotransferases | 2004 |
Overexpression of regucalcin suppresses cell death and apoptosis in cloned rat hepatoma H4-II-E cells induced by lipopolysaccharide, PD 98059, dibucaine, or Bay K 8644.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Apoptosis; Calcium; Calcium Channel Agonists; Calcium-Binding Proteins; Calmodulin; Carboxylic Ester Hydrolases; Carcinoma, Hepatocellular; Caspase 3; Caspases; Cell Death; Clone Cells; Dibucaine; Flavonoids; Intracellular Signaling Peptides and Proteins; Lipopolysaccharides; Nitric Oxide Synthase; Protein Kinase Inhibitors; Rats; Staurosporine; Sulfotransferases; Tumor Cells, Cultured | 2004 |
Efficient execution of cell death in non-glycolytic cells requires the generation of ROS controlled by the activity of mitochondrial H+-ATP synthase.
Topics: Animals; Carcinoma, Hepatocellular; Caspase 3; Caspases; Cell Death; Cell Nucleus; Electrophoresis, Gel, Two-Dimensional; Glycolysis; Membrane Potentials; Mitochondria; Mitochondrial Proton-Translocating ATPases; Oxygen; Rats; Reactive Oxygen Species; Staurosporine | 2006 |
Mutations of phosphorylation sites Ser10 and Thr187 of p27Kip1 abolish cytoplasmic redistribution but do not abrogate G0/1 phase arrest in the HepG2 cell line.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p27; Cytoplasm; Fatty Acids, Unsaturated; G1 Phase; Humans; Mutation; Phosphoserine; Phosphothreonine; Recombinant Proteins; Resting Phase, Cell Cycle; Staurosporine | 2006 |
Defective asialoglycoprotein receptor endocytosis mediated by tyrosine kinase inhibitors. Requirement for a tyrosine in the receptor internalization signal.
Topics: Adenosine Triphosphate; Alkaloids; Asialoglycoprotein Receptor; Carcinoma, Hepatocellular; Catechols; Cell Line; Endocytosis; Genistein; Humans; Isoflavones; Kinetics; Liver Neoplasms; Nitriles; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor Protein-Tyrosine Kinases; Receptors, Cell Surface; Signal Transduction; Staurosporine; Transferrin; Tumor Cells, Cultured; Tyrosine; Tyrphostins | 1994 |
Interleukin 6 signal transduction in a human hepatoma cell line (Hep G2).
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acute-Phase Proteins; Alkaloids; Carcinoma, Hepatocellular; Genistein; Humans; Interleukin-1; Interleukin-6; Isoflavones; Isoquinolines; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Possible involvement of the Ah receptor in the induction of cytochrome P-450IA1 under conditions of hydrodynamic shear in microcarrier-attached hepatoma cell lines.
Topics: Alkaloids; Benzoflavones; Carcinoma, Hepatocellular; Cell Line; Culture Techniques; Cytochrome P-450 Enzyme System; Enzyme Induction; Humans; Kinetics; Liver Neoplasms; Microspheres; Polychlorinated Dibenzodioxins; Protein Kinase C; Receptors, Aryl Hydrocarbon; Staurosporine; Stress, Mechanical; Tumor Cells, Cultured | 1995 |
Protracted treatment with phorbol ester modulates J-7 human hepatoma-cell-induced aggregation and coagulation of human platelet-rich plasma.
Topics: Alkaloids; Blood Coagulation; Blood Platelets; Carcinoma, Hepatocellular; Cell Adhesion; Concanavalin A; Extracellular Matrix Proteins; Factor IX; Factor VII; Heparin; Hirudins; Humans; Liver Neoplasms; Phorbol 12,13-Dibutyrate; Platelet Aggregation; Staurosporine; Tumor Cells, Cultured | 1994 |
The interleukin-6-activated acute-phase response factor is antigenically and functionally related to members of the signal transducer and activator of transcription (STAT) family.
Topics: 3T3 Cells; Alkaloids; Amino Acid Sequence; Animals; Base Sequence; Carcinoma, Hepatocellular; Catechols; Cell Line; Cytokines; DNA-Binding Proteins; Genistein; Growth Inhibitors; Humans; Immune Sera; Interferon-gamma; Interleukin-11; Interleukin-6; Isoflavones; Kinetics; Leukemia Inhibitory Factor; Liver Neoplasms; Lymphokines; Mice; Molecular Sequence Data; Nerve Growth Factors; Nerve Tissue Proteins; Nitriles; Oligodeoxyribonucleotides; Oncostatin M; Peptides; Protein Kinase Inhibitors; Rats; Recombinant Proteins; Signal Transduction; Sphingosine; STAT3 Transcription Factor; Staurosporine; Trans-Activators; Transcription Factors; Tumor Cells, Cultured; Tyrphostins | 1994 |
Both type I and type II interferons down-regulate human tumor necrosis factor receptors in human hepatocellular carcinoma cell line Hep G2. Role of protein kinase C.
Topics: Alkaloids; Carcinoma, Hepatocellular; Down-Regulation; Humans; Interferon Type I; Interferon-alpha; Interferon-beta; Interferon-gamma; Liver Neoplasms; Receptors, Tumor Necrosis Factor; Staurosporine; Tumor Cells, Cultured | 1994 |
Sphingolipid transport to the apical plasma membrane domain in human hepatoma cells is controlled by PKC and PKA activity: a correlation with cell polarity in HepG2 cells.
Topics: 4-Chloro-7-nitrobenzofurazan; Actin Cytoskeleton; Actins; Bile Canaliculi; Biological Transport; Carcinoma, Hepatocellular; Carrier Proteins; Cell Membrane; Cell Polarity; Ceramides; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Fluorescent Dyes; Humans; Microfilament Proteins; Protein Kinase C; Sphingolipids; Sphingomyelins; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
Regulation of heparin-binding EGF-like growth factor expression by phorbol ester in a human hepatoma-derived cell line.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Carcinoma, Hepatocellular; Cycloheximide; Epidermal Growth Factor; Gene Expression Regulation; Heparin; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Naphthalenes; Protein Kinase C; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1996 |
Activation of caspase-3 protease via a Bcl-2-insensitive pathway during the process of ginsenoside Rh2-induced apoptosis.
Topics: Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Caspase 3; Caspases; Cell Size; Cell Survival; Cysteine Endopeptidases; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Endopeptidases; Enzyme Activation; Enzyme Precursors; Flow Cytometry; Ginsenosides; Humans; Panax; Plants, Medicinal; Protease Inhibitors; Proto-Oncogene Proteins c-bcl-2; Saponins; Staurosporine; Transfection; Tumor Cells, Cultured | 1997 |
Caspase 3 specifically cleaves p21WAF1/CIP1 in the earlier stage of apoptosis in SK-HEP-1 human hepatoma cells.
Topics: Amino Acid Sequence; Apoptosis; Base Sequence; Carcinoma, Hepatocellular; Caspase 3; Caspases; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; DNA Primers; Enzyme Activation; Enzyme Inhibitors; Ginsenosides; Humans; Hydrolysis; Liver Neoplasms; Molecular Sequence Data; Saponins; Sequence Homology, Amino Acid; Staurosporine; Tumor Cells, Cultured | 1998 |
Expression and role of Bcl-xL in human hepatocellular carcinomas.
Topics: Apoptosis; bcl-X Protein; Blotting, Western; Carcinoma, Hepatocellular; Gene Expression; Genes, p53; Humans; In Situ Nick-End Labeling; Liver Neoplasms; Oligonucleotides, Antisense; Proto-Oncogene Proteins c-bcl-2; RNA Splicing; Staurosporine; Transfection; Tumor Cells, Cultured | 2001 |
Regulatory role of endogenous regucalcin in the enhancement of nuclear deoxyribonuleic acid synthesis with proliferation of cloned rat hepatoma cells (H4-II-E).
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Antibodies, Monoclonal; Calcium; Calcium-Binding Proteins; Carboxylic Ester Hydrolases; Carcinoma, Hepatocellular; Cell Division; Cell Nucleus; Clone Cells; Culture Media; DNA; Enzyme Inhibitors; Flavonoids; Intracellular Signaling Peptides and Proteins; Male; Protein Kinase Inhibitors; Rats; Rats, Wistar; Staurosporine; Sulfotransferases; Trifluoperazine | 2001 |
Phorbol ester inhibits erythropoietin production in human hepatoma cells (Hep G2).
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Carcinoma, Hepatocellular; Erythropoietin; Humans; Isoquinolines; Liver Neoplasms; Oxygen; Piperazines; Protein Kinase C; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Tissue Distribution; Tumor Cells, Cultured | 1992 |
Protein kinase C activity is rate limiting for shedding of the interleukin-6 receptor.
Topics: Alkaloids; Animals; Binding Sites; Carcinoma, Hepatocellular; Cell Line; Cycloheximide; Humans; Interleukin-6; Kinetics; Liver Neoplasms; Macromolecular Substances; Phorbol Esters; Protein Kinase C; Receptors, Immunologic; Receptors, Interleukin-6; Recombinant Proteins; Staurosporine; Transfection; Tumor Cells, Cultured | 1992 |
Possible involvement of protein kinase C and calcium in GSH efflux from Hep G2 cells.
Topics: Adenosine Triphosphate; Alkaloids; Calcium; Carcinoma, Hepatocellular; Glutathione; Humans; Liver Neoplasms; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Verapamil | 1992 |
Inhibition of erythropoietin production by phorbol ester is associated with down-regulation of protein kinase C-alpha isoenzyme in hepatoma cells.
Topics: Alkaloids; Carcinoma, Hepatocellular; Erythropoietin; Humans; Isoenzymes; Kinetics; Liver Neoplasms; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
Staurosporine inhibits a tyrosine protein kinase in human hepatoma cell membranes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Asialoglycoprotein Receptor; Carcinoma, Hepatocellular; Cations, Divalent; Cell Membrane; Humans; Isoquinolines; Liver Neoplasms; Membrane Proteins; Phosphorylation; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Immunologic; Staurosporine; Tumor Cells, Cultured | 1990 |
Effects of phorbol ester on cell growth inhibition by transforming growth factor beta 1 in human hepatoma cell lines.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Carcinoma, Hepatocellular; Cell Division; DNA; Epithelial Cells; Growth Inhibitors; Humans; In Vitro Techniques; Isoquinolines; Liver Neoplasms; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Transforming Growth Factors; Tumor Cells, Cultured | 1990 |