staurosporine has been researched along with Glial Cell Tumors in 50 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 23 (46.00) | 18.2507 |
| 2000's | 22 (44.00) | 29.6817 |
| 2010's | 5 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chang, LC; Chen, CH; Chen, Y; Choi, J; Hilliard, TS; Kawakami, JK; Li, Y; Miklossy, G; Paladino, D; Sarkaria, JN; Sun, D; Turkson, J; Wongwiwatthananukit, S; Youn, UJ; Yue, P; Zhang, M | 1 |
| Tseng, CL; Wei, JW | 1 |
| Hua, Q; Jia, W; Nan, YN; Tan, Y; Zhang, Q; Zhu, JY | 1 |
| Dluzen, D; Li, G; Liu, DX; Moreau, M; Tacelosky, D | 1 |
| Cuddapah, VA; McFerrin, MB; Sontheimer, H; Turner, KL | 1 |
| Araki, T; Bonislawski, DP; Henshall, DC; Lan, JQ; Meller, R; Minami, M; Schindler, CK; Simon, RP; Skradski, SL | 1 |
| Garber, MM; Heiman, AS | 1 |
| Lamas, M; Naranjo, JR; Segovia, J; Vergara, P; Zamorano, A | 1 |
| Peng, FF; Wu, DC; Zhang, BF; Zhang, JZ | 2 |
| Arita, K; Hama, S; Heike, Y; Kajiwara, Y; Kurisu, K; Sugiyama, K; Yahara, K; Yamasaki, F; Yoshioka, H | 1 |
| Shaikh, SA; Shirsat, NV | 1 |
| Dawson, G; Dawson, SA; Moskal, JR | 1 |
| Aoki, H; Fujiwara, K; Kanzawa, T; Kondo, S; Kondo, Y; Mills, GB; Takeuchi, H | 1 |
| Harmalkar, MN; Shirsat, NV | 1 |
| Arita, K; Hama, S; Hidaka, T; Kajiwara, Y; Kurisu, K; Murakami, T; Saito, T; Sugiyama, K; Yamasaki, F; Yoshioka, H | 1 |
| Jane, EP; Pollack, IF; Premkumar, DR | 1 |
| Ernest, NJ; Habela, CW; Sontheimer, H | 1 |
| Furuyama, J; Ikemoto, H; Matsumoto, T; Nakano, A; Tani, E | 1 |
| Barna, BP; Barnett, GH; Estes, ML; Gupta, MK; Iwasaki, K; Toms, SA | 1 |
| Couldwell, WT; Hinton, DR; Law, RE; Weiss, MH | 1 |
| Audette, M; Bouillon, M | 1 |
| Holden, CM; Mallon, BS; Rumsby, MG; Thompson, HJ; Turner, RA | 1 |
| Litherland, GJ; Mallon, BS; Rumsby, MG; Thompson, HJ | 1 |
| Chen, TC; Couldwell, WT; He, S; Hinton, DR; Law, RE; Sebat, I; Weiss, MH | 1 |
| Baltuch, GH; Couldwell, WT; Dooley, NP; Yong, VW | 1 |
| Fukushima, D; Ishiura, S; Konishi, M; Maruyama, K; Miyamoto, T; Suzuki, K | 1 |
| Baltuch, GH; Couldwell, WT; Villemure, JG; Yong, VW | 1 |
| Nozawa, Y; Sakai, N; Yamada, H; Zhang, W | 1 |
| Asano, T; Hasegawa, K; Inaguma, Y; Ito, H; Kato, K; Kozawa, O | 1 |
| Arbuckle, J; Boddeke, HW; Boeijinga, P; Docherty, RJ; Meigel, I | 1 |
| Kawecki, S; Lazo, JS; Pollack, IF | 1 |
| Inaguma, Y; Ito, H; Kato, K; Okamoto, K; Saga, S | 1 |
| Baltuch, GH; Yong, VW | 1 |
| Byers, DM; Cook, HW; Ridgway, ND; Van Iderstine, SC | 1 |
| Beale, G; Mallon, B; Morreale, A; Rumsby, M; Watson, J | 1 |
| Beyreuther, K; Diehlmann, A; Kim, TW; Tanzi, RE; Tesco, G | 1 |
| Bredel, M; Freund, JM; Lazo, JS; Pollack, IF; Rusnak, J | 1 |
| Henderson, J; Kim, TW; Kovacs, DM; Mancini, R; Na, SJ; Schmidt, SD; Tanzi, RE | 1 |
| Chien, CS; Chiu, CT; Lin, CC; Luo, SF; Tu, MT; Wang, CC; Yang, CM | 1 |
| Giese, A; Puchner, MJ | 1 |
| Inagaki, M; Nitta, M; Saya, H; Tada, M; Tsuiki, H; Ushio, Y | 1 |
| Bonislawski, DP; Henshall, DC; Lan, JQ; Meller, R; Simon, RP; Skradski, SL | 1 |
| Inaguma, Y; Ito, H; Iwamoto, I; Kato, K; Lida, K | 1 |
| da Rocha, AB; Mans, DR; Regner, A; Schwartsmann, G | 1 |
| Costa, S; Fages, C; Monville, C; Paillaud, E; Plassat, JL; Rochette-Egly, C; Tardy, M | 1 |
| Henshall, DC; Meller, R; Simon, RP; Skradski, SL | 1 |
| Chambers, WH; Erff, ML; Okada, H; Pollack, IF; Witham, TF | 1 |
| Antel, JP; Couldwell, WT; Uhm, JH; Yong, VW | 1 |
| Aiyar, N; Gleason, MM; Griffin, EC; Nambi, P | 1 |
1 review(s) available for staurosporine and Glial Cell Tumors
| Article | Year |
|---|---|
Targeting protein kinase C: new therapeutic opportunities against high-grade malignant gliomas?
Topics: Adolescent; Adult; Antineoplastic Agents; Apoptosis; Bryostatins; Cell Division; Child; Child, Preschool; Enzyme Activation; Enzyme Inhibitors; Glioma; Humans; Infant; Lactones; Macrolides; Mutation; Naphthalenes; Neoplasm Invasiveness; Neoplasm Proteins; Phenotype; Protein Kinase C; Sphingosine; Staurosporine | 2002 |
49 other study(ies) available for staurosporine and Glial Cell Tumors
| Article | Year |
|---|---|
Hirsutinolide Series Inhibit Stat3 Activity, Alter GCN1, MAP1B, Hsp105, G6PD, Vimentin, TrxR1, and Importin α-2 Expression, and Induce Antitumor Effects against Human Glioma.
Topics: alpha Karyopherins; Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Drug Evaluation, Preclinical; Female; Glioma; Glucosephosphate Dehydrogenase; HSP110 Heat-Shock Proteins; Humans; Magnetic Resonance Spectroscopy; Mice, Nude; Microtubule-Associated Proteins; Molecular Docking Simulation; Molecular Structure; STAT3 Transcription Factor; Structure-Activity Relationship; Thioredoxin Reductase 1; Trans-Activators; Vimentin; Xenograft Model Antitumor Assays | 2015 |
Homologous desensitization of histamine-mediated signal transduction system in C6 glioma cells.
Topics: Animals; Arachidonic Acid; Brain Neoplasms; Calcium; Cell Line, Tumor; Glioma; Histamine; Inositol Phosphates; Pyrilamine; Rats; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 2013 |
Staurosporine induced apoptosis rapidly downregulates TDP- 43 in glioma cells.
Topics: Apoptosis; Caspase 3; Cell Line, Tumor; DNA-Binding Proteins; Down-Regulation; Enzyme Inhibitors; Glioma; Humans; RNA, Messenger; Staurosporine | 2014 |
BCL-2 is a downstream target of ATF5 that mediates the prosurvival function of ATF5 in a cell type-dependent manner.
Topics: Activating Transcription Factors; Animals; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Culture Media, Serum-Free; Down-Regulation; Enzyme Inhibitors; Female; Glioma; Humans; Promoter Regions, Genetic; Proto-Oncogene Proteins c-bcl-2; Rats; Staurosporine; Transcription, Genetic | 2011 |
Differential role of IK and BK potassium channels as mediators of intrinsic and extrinsic apoptotic cell death.
Topics: Apoptosis; Calcium; Cell Line, Tumor; Clotrimazole; Enzyme Inhibitors; Gene Expression Regulation; Glioma; Humans; Intermediate-Conductance Calcium-Activated Potassium Channels; Ion Channel Gating; Large-Conductance Calcium-Activated Potassium Channels; Potassium; Potassium Channel Blockers; Staurosporine; TNF-Related Apoptosis-Inducing Ligand | 2012 |
Expression and differential processing of caspases 6 and 7 in relation to specific epileptiform EEG patterns following limbic seizures.
Topics: Amygdala; Animals; Apoptosis; Caspase 6; Caspase 7; Caspases; Convulsants; Diazepam; Electroencephalography; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; GABA Agonists; Glioma; HeLa Cells; Hippocampus; Humans; Infarction, Middle Cerebral Artery; Jurkat Cells; Kainic Acid; Lamin Type A; Lamins; Male; Microinjections; Nerve Tissue Proteins; Nuclear Proteins; Rats; Rats, Sprague-Dawley; Seizures; Staurosporine; Tumor Cells, Cultured | 2002 |
The in vitro effects of Pb acetate on NO production by C6 glial cells.
Topics: Animals; Carbazoles; Cytokines; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Glioma; Indoles; Neuroglia; Nitric Oxide; Organometallic Compounds; Protein Kinase Inhibitors; Pyrroles; Rats; Signal Transduction; Staurosporine; Tumor Cells, Cultured | 2002 |
Transcriptionally mediated gene targeting of gas1 to glioma cells elicits growth arrest and apoptosis.
Topics: Animals; Apoptosis; beta-Galactosidase; Blotting, Western; Caspase 3; Caspases; Cell Cycle Proteins; Cell Division; Cell Line; Enzyme Inhibitors; Fluorescent Antibody Technique; Gene Expression; Glial Fibrillary Acidic Protein; Glioma; GPI-Linked Proteins; Hydro-Lyases; Membrane Proteins; Promoter Regions, Genetic; Rats; Staurosporine; Time Factors; Transcription, Genetic; Transfection | 2003 |
[Protective effects of tacrine and donepezil against staurosporine-induced apoptotic death].
Topics: Animals; Apoptosis; Cholinesterase Inhibitors; Donepezil; Glioma; HeLa Cells; Humans; Hybrid Cells; Indans; Mice; Neuroblastoma; Piperidines; Protective Agents; Rats; Staurosporine; Tacrine | 2002 |
Staurosporine-induced apoptosis is independent of p16 and p21 and achieved via arrest at G2/M and at G1 in U251MG human glioma cell line.
Topics: Adenoviridae; Antineoplastic Agents; Apoptosis; Brain Neoplasms; CDC2 Protein Kinase; Cell Cycle; Cell Cycle Proteins; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Dose-Response Relationship, Drug; G1 Phase; G2 Phase; Gene Expression Regulation, Neoplastic; Genetic Vectors; Glioma; Humans; Retinoblastoma Protein; Staurosporine; Transfection; Tumor Cells, Cultured | 2003 |
Staurosporine induces apoptosis in NG108-15 cells.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspases; DNA Fragmentation; Enzyme Inhibitors; Glioma; Hybrid Cells; Mice; Neuroblastoma; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Staurosporine; Tumor Cells, Cultured | 2003 |
Overexpression of the immediate early gene fra-1 inhibits proliferation, induces apoptosis, and reduces tumourigenicity of c6 glioma cells.
Topics: Acetamides; Animals; Antineoplastic Agents; Apoptosis; Astrocytoma; Brain Neoplasms; Bucladesine; Cell Differentiation; Cell Division; Cell Line, Tumor; Cell Transformation, Neoplastic; Clone Cells; Enzyme Inhibitors; Feedback, Physiological; Gene Expression Regulation, Neoplastic; Glioma; Proto-Oncogene Proteins c-fos; Rats; Staurosporine; Transcription Factor AP-1 | 2003 |
Transfection of 2,6 and 2,3-sialyltransferase genes and GlcNAc-transferase genes into human glioma cell line U-373 MG affects glycoconjugate expression and enhances cell death.
Topics: Antineoplastic Agents; beta-D-Galactoside alpha 2-6-Sialyltransferase; Caspase 3; Caspases; Cell Death; Cell Line, Tumor; Cell Membrane; Cell Survival; Chromones; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Inhibitors; Etoposide; Glioma; Glycoconjugates; Glycosylation; Humans; Morpholines; N-Acetylglucosaminyltransferases; Oligosaccharides; Sialyltransferases; Sphingosine; Staurosporine; Transfection | 2004 |
Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors.
Topics: Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Cell Line, Tumor; Chromones; Drug Synergism; Enzyme Inhibitors; Glioma; Humans; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Sirolimus; Staurosporine; TOR Serine-Threonine Kinases | 2005 |
Staurosporine-induced growth inhibition of glioma cells is accompanied by altered expression of cyclins, CDKs and CDK inhibitors.
Topics: Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinases; Cyclins; Enzyme Inhibitors; Glioma; Humans; Staurosporine | 2006 |
Retinoblastoma protein prevents staurosporine-induced cell death in a retinoblastoma-defective human glioma cell line.
Topics: Blotting, Western; Brain Neoplasms; Cell Cycle; Cell Death; Cell Line, Tumor; Cell Nucleus; Cyclin-Dependent Kinase Inhibitor p21; Enzyme Inhibitors; Genes, p16; Glioma; Humans; Retinoblastoma Protein; Staurosporine; Transfection | 2007 |
AG490 influences UCN-01-induced cytotoxicity in glioma cells in a p53-dependent fashion, correlating with effects on BAX cleavage and BAD phosphorylation.
Topics: Annexin A5; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; bcl-2-Associated X Protein; bcl-Associated Death Protein; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Synergism; Genes, p53; Glioma; Humans; Poly(ADP-ribose) Polymerases; Signal Transduction; Staurosporine; Tumor Suppressor Protein p53; Tyrphostins | 2007 |
Cytoplasmic condensation is both necessary and sufficient to induce apoptotic cell death.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Apoptosis; Caspases; Cell Death; Cell Line, Tumor; Cell Size; Chlorides; Cytoplasm; DNA Fragmentation; Glioma; Humans; Ion Transport; Models, Biological; Recombinant Proteins; Staurosporine; TNF-Related Apoptosis-Inducing Ligand | 2008 |
Apoptosis of human glioma cells in response to calphostin C, a specific protein kinase C inhibitor.
Topics: Alkaloids; Antibiotics, Antineoplastic; Apoptosis; Autoradiography; Blotting, Northern; Blotting, Western; Cell Count; Cell Line; Electrophoresis, Agar Gel; Enzyme Inhibitors; Glioma; Humans; Naphthalenes; Protein Kinase C; Staurosporine; Thymidine; Tumor Cells, Cultured | 1995 |
Inhibitory effects of tamoxifen and tumor necrosis factor alpha on human glioblastoma cells.
Topics: Alkaloids; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Division; Drug Synergism; Glioma; Humans; Receptors, Estrogen; Receptors, Progesterone; Receptors, Tumor Necrosis Factor; Staurosporine; Tamoxifen; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1995 |
Paradoxical elevation of Ki-67 labeling with protein kinase inhibition in malignant gliomas.
Topics: Alkaloids; Brain Neoplasms; Cell Cycle; Flow Cytometry; Glioma; Humans; Immunohistochemistry; Ki-67 Antigen; Neoplasm Proteins; Nuclear Proteins; Protein Kinase C; Staurosporine; Tamoxifen; Tumor Cells, Cultured | 1995 |
Transduction of retinoic acid and gamma-interferon signal for intercellular adhesion molecule-1 expression on human tumor cell lines: evidence for the late-acting involvement of protein kinase C inactivation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cell Adhesion Molecules; Enzyme Activation; Glioma; Humans; Intercellular Adhesion Molecule-1; Interferon-gamma; Isoquinolines; Neuroblastoma; Piperazines; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured | 1993 |
Protein kinase C activation of phospholipase D in C6 glioma cells.
Topics: Alkaloids; Animals; Cell Line; Enzyme Activation; Glioma; Indoles; Phorbol Esters; Phospholipase D; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Staurosporine and its derivative RO31-8220, both inhibitors of protein kinase C, have different effects on C6 glioma cell morphology.
Topics: Alkaloids; Cell Line; Glioma; Indoles; Molecular Weight; Phosphoproteins; Protein Kinase C; Staurosporine; Tumor Cells, Cultured | 1993 |
Protein kinase C inhibitors induce apoptosis in human malignant glioma cell lines.
Topics: Alkaloids; Apoptosis; DNA Damage; DNA, Neoplasm; Glioma; Humans; Protein Kinase C; Staurosporine; Tamoxifen; Tumor Cells, Cultured | 1994 |
Staurosporine differentially inhibits glioma versus non-glioma cell lines.
Topics: Alkaloids; Cell Division; Cells, Cultured; Glioma; Humans; Protein Kinase C; Staurosporine; Tumor Cells, Cultured | 1993 |
Activation of the secretory pathway leads to a decrease in the intracellular amyloidogenic fragments generated from the amyloid protein precursor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amyloid beta-Protein Precursor; Animals; Cell Line; Glioma; Humans; Isoquinolines; Kinetics; Molecular Weight; Peptide Fragments; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1993 |
Protein kinase C inhibitors suppress cell growth in established and low-passage glioma cell lines. A comparison between staurosporine and tamoxifen.
Topics: Alkaloids; Brain Neoplasms; Cell Count; Cell Division; Cell Line; Dose-Response Relationship, Drug; Glioblastoma; Glioma; Humans; Protein Kinase C; Staurosporine; Tamoxifen; Tumor Cells, Cultured | 1993 |
Sensitization of C6 glioma cells to radiation by staurosporine, a potent protein kinase C inhibitor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Dose-Response Relationship, Radiation; Glioma; Isoquinolines; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Radiation Tolerance; Radiation-Sensitizing Agents; Rats; Staurosporine; Sulfonamides; Tumor Cells, Cultured | 1993 |
Modulation of the stress-induced synthesis of stress proteins by a phorbol ester and okadaic acid.
Topics: Alkaloids; Animals; Arachidonic Acid; Arsenites; Blotting, Northern; Blotting, Western; Enzyme Activation; Ethers, Cyclic; Glioma; Heat-Shock Proteins; Okadaic Acid; Protein Kinase C; Rats; RNA, Messenger; Serine Proteinase Inhibitors; Staurosporine; Stimulation, Chemical; Stress, Physiological; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Modulation by calcineurin of 5-HT3 receptor function in NG108-15 neuroblastoma x glioma cells.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Sequence; Animals; Brain Neoplasms; Calcineurin; Calmodulin-Binding Proteins; Chelating Agents; Egtazic Acid; Enzyme Inhibitors; Glioma; Half-Life; Molecular Sequence Data; Neuroblastoma; Okadaic Acid; Phosphoprotein Phosphatases; Protein Serine-Threonine Kinases; Rats; Receptors, Serotonin; Staurosporine; Tumor Cells, Cultured | 1996 |
Blocking of glioma proliferation in vitro and in vivo and potentiating the effects of BCNU and cisplatin: UCN-01, a selective protein kinase C inhibitor.
Topics: Alkaloids; Brain Neoplasms; Carmustine; Cisplatin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glioma; Humans; Protein Kinase C; Staurosporine; Tumor Cells, Cultured | 1996 |
Synthesis and accumulation of alphaB crystallin in C6 glioma cells is induced by agents that promote the disassembly of microtubules.
Topics: Animals; Aphidicolin; Colchicine; Crystallins; Culture Media, Serum-Free; Enzyme Inhibitors; Fluorescent Antibody Technique, Indirect; Glioma; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Microtubules; Mitosis; Paclitaxel; Protein Kinase Inhibitors; Rats; Staurosporine; Tubulin; Tumor Cells, Cultured | 1996 |
Signal transduction for proliferation of glioma cells in vitro occurs predominantly through a protein kinase C-mediated pathway.
Topics: Blood Physiological Phenomena; Cell Division; Enzyme Activation; Genistein; Glioma; Humans; Isoflavones; Protein Kinase C; Protein-Tyrosine Kinases; Signal Transduction; Staurosporine; Tumor Cells, Cultured | 1996 |
Phospholipase D hydrolysis of plasmalogen and diacyl ethanolamine phosphoglycerides by protein kinase C dependent and independent mechanisms.
Topics: Animals; Enzyme Activation; Enzyme Inhibitors; Glioma; Hydrolysis; Kinetics; Phosphatidylethanolamines; Phospholipase D; Plasmalogens; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
Ro31-8220 inhibits protein kinase C to block the phorbol ester-stimulated release of choline- and ethanolamine-metabolites from C6 glioma cells: p70 S6 kinase and MAPKAP kinase-1beta do not function downstream of PKC in activating PLD.
Topics: Androstadienes; Animals; Choline; Enzyme Inhibitors; Ethanolamine; Flavonoids; Glioma; Indoles; Phosphoinositide-3 Kinase Inhibitors; Phospholipase D; Polyenes; Protein Kinase C; Protein Serine-Threonine Kinases; Rats; Ribosomal Protein S6 Kinases; Ribosomal Protein S6 Kinases, 90-kDa; Sirolimus; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Wortmannin | 1997 |
Abrogation of the presenilin 1/beta-catenin interaction and preservation of the heterodimeric presenilin 1 complex following caspase activation.
Topics: beta Catenin; Blotting, Western; Cadherins; Caspases; Cell Death; Cytoskeletal Proteins; Dimerization; Glioma; Humans; Kinetics; Membrane Proteins; Peptide Fragments; Presenilin-1; Recombinant Proteins; Staurosporine; Time Factors; Trans-Activators; Transfection; Tumor Cells, Cultured | 1998 |
Protein kinase C inhibition by UCN-01 induces apoptosis in human glioma cells in a time-dependent fashion.
Topics: Alkaloids; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Coloring Agents; Electrophoresis, Agar Gel; Enzyme Inhibitors; Glioma; Humans; In Situ Nick-End Labeling; Protein Kinase C; Staurosporine; Time Factors; Trypan Blue; Tumor Cells, Cultured | 1999 |
Staurosporine-induced activation of caspase-3 is potentiated by presenilin 1 familial Alzheimer's disease mutations in human neuroglioma cells.
Topics: Alzheimer Disease; Amino Acid Substitution; Apoptosis; Brain Neoplasms; Caspase 3; Caspases; Enzyme Activation; Enzyme Precursors; Glioma; Humans; Membrane Proteins; Point Mutation; Poly(ADP-ribose) Polymerases; Presenilin-1; Recombinant Fusion Proteins; Staurosporine; Transfection | 1999 |
P2Y(2) receptor-mediated proliferation of C(6) glioma cells via activation of Ras/Raf/MEK/MAPK pathway.
Topics: Adenosine Triphosphate; Animals; Calcium; Cell Division; DNA; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glioma; Indoles; Isoenzymes; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; ras Proteins; Receptors, Purinergic P2; Receptors, Purinergic P2Y2; Staurosporine; Tumor Cells, Cultured; Uridine Triphosphate; Virulence Factors, Bordetella | 2000 |
Tamoxifen-resistant glioma-cell sub-populations are characterized by increased migration and proliferation.
Topics: Anthracenes; Antineoplastic Agents, Hormonal; Cell Division; Cell Movement; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Glioma; Humans; Perylene; Protein Kinase C; Staurosporine; Tamoxifen; Tumor Cells, Cultured | 2000 |
Mechanism of hyperploid cell formation induced by microtubule inhibiting drug in glioma cell lines.
Topics: CDC2 Protein Kinase; Glioma; Humans; Microtubules; Mitosis; Mitotic Index; Nocodazole; Polyploidy; Staurosporine; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2001 |
Cleavage of bid may amplify caspase-8-induced neuronal death following focally evoked limbic seizures.
Topics: Adaptor Proteins, Signal Transducing; Amygdala; Animals; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Carrier Proteins; Caspase 3; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cysteine Proteinase Inhibitors; DNA Fragmentation; Electroencephalography; Enzyme Inhibitors; Epilepsy; Fas-Associated Death Domain Protein; Glioma; Immunohistochemistry; In Situ Nick-End Labeling; Male; Neurons; Oligopeptides; Protein Biosynthesis; Proteins; Rats; Rats, Sprague-Dawley; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Member 25; Staurosporine; TNF Receptor-Associated Factor 1; Tumor Cells, Cultured | 2001 |
Protein kinase inhibitors can suppress stress-induced dissociation of Hsp27.
Topics: Anisomycin; Arsenites; Butadienes; Cadmium Chloride; Carcinogens; Dithiothreitol; Enzyme Inhibitors; Flavonoids; Glioma; Heat-Shock Proteins; Humans; Hydrogen Peroxide; Imidazoles; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Nitriles; Osmotic Pressure; Oxidants; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Protein Synthesis Inhibitors; Pyridines; Sodium Compounds; Sorbitol; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2001 |
Retinoic acid increases proliferation rate of GL-15 glioma cells, involving activation of STAT-3 transcription factor.
Topics: Antineoplastic Agents; Apoptosis; Brain Neoplasms; Carcinogens; Cell Division; Cell Nucleus; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Glioma; Humans; Protein Transport; Receptors, Retinoic Acid; RNA, Messenger; STAT3 Transcription Factor; Staurosporine; Tetradecanoylphorbol Acetate; Trans-Activators; Tretinoin; Tumor Cells, Cultured | 2002 |
Expression, proteolysis and activation of caspases 6 and 7 during rat C6 glioma cell apoptosis.
Topics: Animals; Apoptosis; Brain; Brain Diseases; Caspase 3; Caspase 6; Caspase 7; Caspases; Enzyme Inhibitors; Fluorescent Antibody Technique; Gene Expression Regulation, Enzymologic; Glioma; In Situ Nick-End Labeling; Lamin Type A; Lamins; Neuroglia; Nuclear Proteins; Peptide Hydrolases; Rats; Staurosporine; Tumor Cells, Cultured | 2002 |
7-Hydroxystaurosporine-induced apoptosis in 9L glioma cells provides an effective antigen source for dendritic cells and yields a potent vaccine strategy in an intracranial glioma model.
Topics: Alkaloids; Animals; Antigens, Neoplasm; Apoptosis; Brain Neoplasms; Cancer Vaccines; Cell Communication; Dendritic Cells; Drug Administration Schedule; Enzyme Inhibitors; Glioma; Gliosarcoma; Rats; Staurosporine; Tumor Cells, Cultured; Vaccination | 2002 |
Enhanced protein kinase C activity correlates with the growth rate of malignant gliomas in vitro.
Topics: Alkaloids; Animals; Brain Neoplasms; Cell Division; DNA, Neoplasm; Glioma; Humans; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
Endothelin stimulates 86Rb efflux in rat glioma C6-Bu-1 cells.
Topics: Alkaloids; Analysis of Variance; Animals; Calcium; Diltiazem; Endothelins; Glioma; Glyburide; Nifedipine; Pertussis Toxin; Potassium; Potassium Channels; Protein Kinase C; Rats; Rubidium; Staurosporine; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1991 |