staurosporine has been researched along with Cell Transformation, Neoplastic in 28 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 15 (53.57) | 18.2507 |
| 2000's | 10 (35.71) | 29.6817 |
| 2010's | 3 (10.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| DeAngelo, DJ; Luskin, MR | 1 |
| Abdel-Wahab, O; Barbui, T; Cortes, JE; Gale, RP; Gotlib, J; Hehlmann, R; Khoury, HJ; Koschmieder, S; Mauro, M; Mesa, R; Mughal, TI; Radich, JP; Saglio, G; Saussele, S; Van Etten, RA; Verstovek, S | 1 |
| Berdel, WE; Blum, H; Bohlander, SK; Braess, J; Büchner, T; Dufour, A; Graf, A; Greif, PA; Herold, T; Hiddemann, W; Hopfner, KP; Kakadia, PM; Konstandin, NP; Krebs, S; Ksienzyk, B; Opatz, S; Polzer, H; Sauerland, MC; Schneider, S; Spiekermann, K; Vosberg, S; Woermann, BJ; Zellmeier, E | 1 |
| Damania, B; Wang, L | 1 |
| Boulton, C; Fabbro, D; Gilliland, DG; Griffin, JD; Kelly, LM; Manley, P; Meyer, T; Weisberg, E | 1 |
| Chang, I; Cho, N; Koh, JY; Lee, MS | 1 |
| Shaikh, SA; Shirsat, NV | 1 |
| Dai, Y; Dent, P; Grant, S; Han, SI; Khanna, P; Mitchell, C; Pei, XY; Rahmani, M | 1 |
| Chignell, CF; Diwan, BA; He, YY; Huang, JL; Pi, J; Waalkes, MP | 1 |
| Ayusawa, D; Fujii, M; Ide, T; Kaul, SC; Mitsui, Y; Ogata, T; Oishi, M; Tahara, H; Wadhwa, R | 1 |
| Bennett, SA; Birnboim, HC | 1 |
| Hamada, J; Hosokawa, M; Kobayashi, M; Nagayasu, H; Takeichi, N | 1 |
| Bradbury, EM; Kraemer, PM | 1 |
| Akin, D; Feldherr, C | 1 |
| Dhanaraj, SN; Iwata, K; Korah, RM; Marcus, AM; Small, MB | 1 |
| Baserga, R; Schiller, JT; Steller, MA; Zou, Z | 1 |
| Gschwendt, M; Kittstein, W; Krammer, PH; Möller, P; Sträter, J; von Reyher, U | 1 |
| Bradbury, EM; Nishi, K; Schnier, JB | 1 |
| Bradford, BU; Cattley, RC; Graves, LM; Rivera, CA; Rose, ML; Schoonhoven, R; Swenberg, JA; Thurman, RG | 1 |
| Gounarides, JS; Nalin, CM; Papas, KK; Roos, ES; Shapiro, M; Sun, L | 1 |
| Amé, P; Cahn, JY; Clark, H; Dang, CV; Fest, T; Haughey, C; Kuttler, F; Mougin, C; Raffeld, M | 1 |
| Bodis, S; Fabbro, D; Glanzmann, C; Hemmings, B; Pruschy, M; Rocha, S; Schubiger, PA; Tenzer, A; Zingg, D | 1 |
| Clark, SS; Elegbede, JA; Jenkins, GJ; Perman, SM; Sahin, MB | 1 |
| Brandt-Rauf, PW; Chie, L; Chung, DL; Kanovsky, M; Michl, J; Pincus, MR; Sivendran, S; Smith, S; Way, D | 1 |
| Bradbury, EM; Crissman, HA; Gadbois, DM; Tobey, RA | 2 |
| Augereau, JM; Gleye, J; Herbert, JM; Maffrand, JP | 1 |
| Inui, N; Semba, M | 1 |
2 review(s) available for staurosporine and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Midostaurin/PKC412 for the treatment of newly diagnosed FLT3 mutation-positive acute myeloid leukemia.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Transformation, Neoplastic; Drug Approval; Drug Resistance, Neoplasm; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid, Acute; Molecular Targeted Therapy; Mutation; Prognosis; Protein Kinase Inhibitors; Staurosporine; Treatment Outcome | 2017 |
Recent advances in the genomics and therapy of BCR/ABL1-positive and -negative chronic myeloproliferative neoplasms.
Topics: Antineoplastic Agents; Calreticulin; Cardiovascular Diseases; Cell Transformation, Neoplastic; Chronic Disease; Congresses as Topic; Epigenesis, Genetic; Fusion Proteins, bcr-abl; Humans; Janus Kinase 2; Mastocytosis, Systemic; Mutation; Myeloproliferative Disorders; Protein Kinase Inhibitors; Remission Induction; Staurosporine; Translational Research, Biomedical | 2018 |
1 trial(s) available for staurosporine and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Exome sequencing identifies recurring FLT3 N676K mutations in core-binding factor leukemia.
Topics: Adolescent; Adult; Amino Acid Substitution; Apoptosis; Base Sequence; Benzothiazoles; Cell Proliferation; Cell Transformation, Neoplastic; Core Binding Factor beta Subunit; Cytokines; DNA Mutational Analysis; Exome; Female; fms-Like Tyrosine Kinase 3; Gene Expression Regulation, Leukemic; Gene Rearrangement; Humans; Leukemia; Male; Middle Aged; Models, Molecular; Molecular Sequence Data; Mutation; Oncogene Proteins, Fusion; Phenylurea Compounds; Protein Kinase Inhibitors; Staurosporine | 2013 |
25 other study(ies) available for staurosporine and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Kaposi's sarcoma-associated herpesvirus confers a survival advantage to endothelial cells.
Topics: AMP-Activated Protein Kinases; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Caspase 3; Cell Survival; Cell Transformation, Neoplastic; Culture Media, Serum-Free; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Etoposide; Fibroblast Growth Factor 2; Herpesvirus 8, Human; Humans; Multienzyme Complexes; Phosphatidylinositol 3-Kinases; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Sarcoma, Kaposi; Signal Transduction; Staurosporine; Survival Rate; TOR Serine-Threonine Kinases; Umbilical Veins; Vascular Endothelial Growth Factor A; Virus Replication | 2008 |
Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzamides; Bone Marrow Cells; Bone Marrow Transplantation; Cell Cycle; Cell Division; Cell Transformation, Neoplastic; Drug Resistance, Neoplasm; Enzyme Inhibitors; Flow Cytometry; fms-Like Tyrosine Kinase 3; Humans; Imatinib Mesylate; Immunoblotting; Interleukin-3; Leukemia, Myeloid, Acute; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Mutation; Phosphorylation; Piperazines; Protein Kinase C; Proto-Oncogene Proteins; Pyrimidines; Receptor Protein-Tyrosine Kinases; Staurosporine; Transfection; Tumor Cells, Cultured | 2002 |
Pyruvate inhibits zinc-mediated pancreatic islet cell death and diabetes.
Topics: Adenosine Triphosphate; Animals; Antigens, Polyomavirus Transforming; Antioxidants; Cell Death; Cell Line, Tumor; Cell Transformation, Neoplastic; Diabetes Mellitus, Experimental; Etoposide; Insulinoma; Interferon-gamma; Islets of Langerhans; NAD; Necrosis; Pancreatic Neoplasms; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Staurosporine; Tumor Necrosis Factor-alpha; Zinc | 2003 |
Overexpression of the immediate early gene fra-1 inhibits proliferation, induces apoptosis, and reduces tumourigenicity of c6 glioma cells.
Topics: Acetamides; Animals; Antineoplastic Agents; Apoptosis; Astrocytoma; Brain Neoplasms; Bucladesine; Cell Differentiation; Cell Division; Cell Line, Tumor; Cell Transformation, Neoplastic; Clone Cells; Enzyme Inhibitors; Feedback, Physiological; Gene Expression Regulation, Neoplastic; Glioma; Proto-Oncogene Proteins c-fos; Rats; Staurosporine; Transcription Factor AP-1 | 2003 |
Farnesyltransferase inhibitors interact synergistically with the Chk1 inhibitor UCN-01 to induce apoptosis in human leukemia cells through interruption of both Akt and MEK/ERK pathways and activation of SEK1/JNK.
Topics: Acute Disease; Alkyl and Aryl Transferases; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Caspases; Cell Transformation, Neoplastic; Checkpoint Kinase 1; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Farnesyltranstransferase; HL-60 Cells; Humans; JNK Mitogen-Activated Protein Kinases; Jurkat Cells; Leukemia, Myeloid; MAP Kinase Kinase 4; MAP Kinase Signaling System; Membrane Potentials; Methionine; Mitochondria; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Staurosporine; U937 Cells | 2005 |
Chronic UVA irradiation of human HaCaT keratinocytes induces malignant transformation associated with acquired apoptotic resistance.
Topics: Animals; Apoptosis; Arsenites; Carcinogenicity Tests; Cell Transformation, Neoplastic; Cells, Cultured; Doxorubicin; Etoposide; Humans; Keratin-13; Keratinocytes; Keratins; Mice; Mice, Nude; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Signal Transduction; Staurosporine; Ultraviolet Rays | 2006 |
Inhibitors of cGMP-dependent protein kinase block senescence induced by inactivation of T antigen in SV40-transformed immortal human fibroblasts.
Topics: Alkaloids; Antigens, Polyomavirus Transforming; Biomarkers; Carbazoles; Cell Line, Transformed; Cell Nucleus; Cell Transformation, Neoplastic; Cellular Senescence; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP-Dependent Protein Kinases; Cycloheximide; Fibroblasts; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Humans; Immunohistochemistry; Indoles; Isoquinolines; Mitochondrial Proteins; Myosin-Light-Chain Kinase; Protein Kinase C; Signal Transduction; Simian virus 40; Staurosporine; Sulfonamides | 1995 |
Platelet activating factor induces transformation of human fibroblasts.
Topics: Alkaloids; Analysis of Variance; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Fibroblasts; Genistein; Growth Inhibitors; Humans; Indomethacin; Infant, Newborn; Isoflavones; Phospholipid Ethers; Platelet Activating Factor; Protein Kinase C; Skin; Staurosporine | 1995 |
ONO-4007, a new synthetic lipid A derivative, induces differentiation of rat myelomonocytic leukemia cells in vitro and in vivo.
Topics: Alkaloids; Animals; Base Sequence; Benzoquinones; Calmodulin; Cell Division; Cell Transformation, Neoplastic; In Vitro Techniques; Interleukin-1; Interleukin-6; Lactams, Macrocyclic; Leukemia, Myeloid; Lipid A; Molecular Sequence Data; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Rats; Rifabutin; RNA, Messenger; Staurosporine; Sulfonamides; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1994 |
Abrogation of a kinase-mediated G1 cell cycle arrest point is a late event in the neoplastic progression of human fibroblasts transfected with the SV40 large T antigen gene.
Topics: Alkaloids; Antigens, Viral, Tumor; Cell Adhesion; Cell Line, Transformed; Cell Transformation, Neoplastic; Fibroblasts; G1 Phase; Humans; Phosphotransferases; Staurosporine; Transfection; Tumor Stem Cell Assay | 1993 |
Stimulation of nuclear import by simian virus 40-transformed cell extracts is dependent on protein kinase activity.
Topics: 3T3 Cells; Alkaloids; Animals; Carbazoles; Cattle; Cell Line, Transformed; Cell Nucleus; Cell Transformation, Neoplastic; Enzyme Inhibitors; Gold Colloid; Indole Alkaloids; Kinetics; Mice; Mice, Inbred BALB C; Nuclear Proteins; Nucleoplasmins; Phosphoproteins; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Serum Albumin, Bovine; Simian virus 40; Staurosporine | 1995 |
Characterization of c-myc-transformed rat fibroblasts resistant to apoptosis induced ny growth factor deprivation.
Topics: Alkaloids; Animals; Apoptosis; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Culture Media, Serum-Free; Enzyme Inhibitors; Fibroblasts; Genes, myc; Growth Substances; Humans; Phenotype; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-myc; Rats; Staurosporine; Tumor Suppressor Protein p53 | 1996 |
Transformation by human papillomavirus 16 E6 and E7: role of the insulin-like growth factor 1 receptor.
Topics: Animals; Apoptosis; Cell Transformation, Neoplastic; Cells, Cultured; DNA, Viral; Humans; Mice; Oncogene Proteins, Viral; Papillomavirus E7 Proteins; Receptor, IGF Type 1; Repressor Proteins; Staurosporine; Transfection | 1996 |
Colon carcinoma cells use different mechanisms to escape CD95-mediated apoptosis.
Topics: Antigens, Neoplasm; Apoptosis; Brefeldin A; Carcinoma; Cell Transformation, Neoplastic; Colonic Neoplasms; Cycloheximide; Cyclopentanes; Dactinomycin; Enzyme Inhibitors; Fas Ligand Protein; fas Receptor; Humans; Immunologic Capping; Interferon-gamma; Intestinal Mucosa; Membrane Glycoproteins; Nucleic Acid Synthesis Inhibitors; Phorbol Esters; Protein Kinase C; Protein Synthesis Inhibitors; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1998 |
The accumulation of cyclin-dependent kinase inhibitor p27kip1 is a primary response to staurosporine and independent of G1 cell cycle arrest.
Topics: 3T3 Cells; Animals; CDC2-CDC28 Kinases; Cell Cycle Proteins; Cell Line; Cell Transformation, Neoplastic; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Enzyme Inhibitors; G1 Phase; HeLa Cells; Humans; Mice; Microtubule-Associated Proteins; Oncogenes; Phosphorylation; Protein Serine-Threonine Kinases; Retinoblastoma Protein; Staurosporine; Tumor Cells, Cultured; Tumor Suppressor Proteins | 1998 |
Kupffer cell oxidant production is central to the mechanism of peroxisome proliferators.
Topics: Animals; Calcium Signaling; Cell Division; Cell Transformation, Neoplastic; Diet; Diethylhexyl Phthalate; Dose-Response Relationship, Drug; Endotoxins; Enzyme Activation; Enzyme Inhibitors; Glycine; Intestines; Kupffer Cells; Liver Neoplasms, Experimental; Male; Oxidants; Oxidative Stress; Peroxisome Proliferators; Protein Kinase C; Pyrimidines; Rats; Rats, Sprague-Dawley; Staurosporine; Superoxides | 1999 |
Change in lactate production in Myc-transformed cells precedes apoptosis and can be inhibited by Bcl-2 overexpression.
Topics: Animals; Apoptosis; Cell Line; Cell Transformation, Neoplastic; Culture Media, Serum-Free; Lactates; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Rats; Staurosporine; Transfection | 1999 |
c-myc box II mutations in Burkitt's lymphoma-derived alleles reduce cell-transformation activity and lower response to broad apoptotic stimuli.
Topics: Alleles; Animals; Apoptosis; Burkitt Lymphoma; Cell Line; Cell Transformation, Neoplastic; Conserved Sequence; Phenotype; Point Mutation; Proto-Oncogene Proteins c-myc; Rats; Receptors, Estrogen; Recombinant Fusion Proteins; Staurosporine; Tamoxifen; Trans-Activators; Transfection; Tumor Necrosis Factor-alpha | 2001 |
The phosphatidylinositide 3'-kinase/Akt survival pathway is a target for the anticancer and radiosensitizing agent PKC412, an inhibitor of protein kinase C.
Topics: Animals; Cell Line, Transformed; Cell Transformation, Neoplastic; Chromones; Down-Regulation; Enzyme Inhibitors; Genes, ras; Humans; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Staurosporine; Tumor Cells, Cultured | 2001 |
Antileukemia activity of perillyl alcohol (POH): uncoupling apoptosis from G0/G1 arrest suggests that the primary effect of POH on Bcr/Abl-transformed cells is to induce growth arrest.
Topics: Amiloride; Animals; Apoptosis; Cell Line, Transformed; Cell Transformation, Neoplastic; Cytoplasm; DNA Fragmentation; Enzyme Inhibitors; Fusion Proteins, bcr-abl; G1 Phase; Hematopoietic Stem Cells; Hydrogen-Ion Concentration; Interleukin-3; Lovastatin; Membrane Lipids; Mice; Monoterpenes; Naphthalenes; Neoplastic Stem Cells; Phosphatidylserines; Phosphorylation; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Resting Phase, Cell Cycle; Signal Transduction; Sodium-Hydrogen Exchangers; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate | 2002 |
A protein kinase C inhibitor induces phenotypic reversion of ras-transformed pancreatic cancer cells and cooperatively blocks tumor cell proliferation with an anti- ras peptide.
Topics: Antineoplastic Agents; Carcinoma, Acinar Cell; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Enzyme Inhibitors; Humans; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Oncogene Protein p21(ras); Pancreatic Neoplasms; Peptide Fragments; Phenotype; Protein Binding; Protein Kinase C; Signal Transduction; Staurosporine | 2002 |
Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells are absent in transformed cells.
Topics: Alkaloids; Carbazoles; Cell Cycle; Cell Transformation, Neoplastic; Cells, Cultured; Humans; In Vitro Techniques; Indole Alkaloids; Indoles; Interphase; Protein Kinase Inhibitors; Protein Kinases; Pyrroles; Staurosporine | 1992 |
Transformed mammalian cells are deficient in kinase-mediated control of progression through the G1 phase of the cell cycle.
Topics: Alkaloids; Animals; Antigens, Polyomavirus Transforming; Bromodeoxyuridine; Cell Cycle; Cell Line; Cell Transformation, Neoplastic; Clone Cells; DNA Replication; Fibroblasts; G1 Phase; Humans; Kinetics; Protein Kinase C; Simian virus 40; Skin; Staurosporine; Transfection | 1991 |
Chelerythrine is a potent and specific inhibitor of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Antibiotics, Antineoplastic; Benzophenanthridines; Binding, Competitive; Brain; Cell Transformation, Neoplastic; Isoquinolines; Kinetics; Leukemia L1210; Lymphoma; Phenanthridines; Piperazines; Protein Kinase C; Rats; Staurosporine; Tumor Cells, Cultured | 1990 |
Effects of activators and inhibitors of protein kinase C on two-stage transformation in BALB/3T3 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Line; Cell Transformation, Neoplastic; Cocarcinogenesis; Diglycerides; Drug Antagonism; Enzyme Activation; Glycerides; Isoquinolines; Methylcholanthrene; Mice; Palmitoylcarnitine; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |