Page last updated: 2024-08-23

staurosporine and Carcinoma, Squamous Cell

staurosporine has been researched along with Carcinoma, Squamous Cell in 28 studies

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's14 (50.00)18.2507
2000's11 (39.29)29.6817
2010's3 (10.71)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hahlbrock, A; Maushagen, R; Pfannerstill, AC; Pries, R; Rades, D; Rahmanzadeh, R; Reers, S; Stauber, R; Wollenberg, B1
Ames-Draycott, A; Benaich, N; Cai, W; Goldie, SJ; Hayes, TF; Sipilä, K; Watt, FM; Yin, G1
Clynes, M; Henry, M; Keenan, J; Meleady, P; Murphy, L1
Chang, YC; Ho, YC; Lee, SS; Tsai, CH; Yang, SF1
Ensley, JF; Gutkind, JS; Igishi, T; Kremer, M; Lahusen, T; Leethanakul, C; Patel, V; Quintanilla-Martinez, L; Sausville, EA; Senderowicz, AM1
Hui, ZG; Li, YX; Wu, JX; Yang, WZ; Yu, ZH1
Chang, YC; Chou, MY; Hsieh, YS; Tsai, CH; Yang, SF1
Amornphimoltham, P; Benavides, F; Conti, CJ; Gutkind, JS; Molinolo, AA; Patel, V; Sauk, J; Sausville, EA; Sriuranpong, V1
Li, JR; Ou-Yang, JP; Wang, M; Xia, D; Yu, SB; Zhang, YX1
Atarashi, Y; Sato, TA; Stanson, J; Whiteside, TL; Wieckowski, E1
Bhawal, UK; Kuniyasu, H; Mitani, Y; Nomura, Y; Otsubo, A; Ozawa, K; Sugiyama, M1
Chang, YC; Ho, YC; Lee, SS; Tsai, CH1
Akinaga, S; Gomi, K; Nomura, K; Okabe, M1
Asaoka, Y; Chang, WC; Liu, YW; Suzuki, H; Yamamoto, S; Yoshimoto, T1
Geng, Y; Gross, V; Lotz, M; Villiger, PM; Zhang, B1
Hosoi, K; Kurihara, K; Ueha, T1
Dlugosz, AA; Hennings, H; Strickland, JE; Yuspa, SH1
Ikegami, Y; Nakao, K; Yano, S1
Akinaga, S; Akiyama, T; Mizukami, T; Okabe, M; Shimizu, M; Tsujita, T; Yoshida, T1
Atsumi, T; Hosoi, K; Kurihara, K; Shioda, Y; Sugita, K; Ueha, T1
Abiko, Y; Arai, J; Kaku, T; Mitamura, J1
Devoe, G; Gear, R; Heffelfinger, SC; Miller, MA1
Alfieri, AA; Sommers, GM1
Akinaga, S; Akiyama, T; Okabe, M; Shimizu, M; Tamaoki, T1
Hatori, M; Kamijo, R; Nagumo, M; Sumitani, K; Takizawa, K; Toyoshima, T1
Bock, JM; Harari, PM; Pickart, MA; Pink, JJ1
Akinaga, S; Akiyama, T; Eastman, A; Shimizu, M; Sugiyama, K; Takahashi, R; Tamaoki, T; Yamaguchi, K1
Danenberg, KD; Danenberg, PV; Grem, JL; Kao, V; Nguyen, D1

Other Studies

28 other study(ies) available for staurosporine and Carcinoma, Squamous Cell

ArticleYear
Effects of paclitaxel on permanent head and neck squamous cell carcinoma cell lines and identification of anti-apoptotic caspase 9b.
    Journal of cancer research and clinical oncology, 2016, Volume: 142, Issue:6

    Topics: Alternative Splicing; Antineoplastic Agents, Phytogenic; Apoptotic Protease-Activating Factor 1; Carcinoma, Squamous Cell; Caspase 9; Cell Cycle; Cell Death; Cell Line, Tumor; DNA Methylation; Enzyme Activation; Head and Neck Neoplasms; Humans; Membrane Potential, Mitochondrial; Paclitaxel; Promoter Regions, Genetic; Squamous Cell Carcinoma of Head and Neck; Staurosporine

2016
Integrative genomic and functional analysis of human oral squamous cell carcinoma cell lines reveals synergistic effects of FAT1 and CASP8 inactivation.
    Cancer letters, 2016, 12-01, Volume: 383, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Cadherins; Carcinoma, Squamous Cell; Caspase 8; Cell Adhesion; Cell Differentiation; Cell Line, Tumor; Cell Movement; Cell Proliferation; Databases, Genetic; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Genome-Wide Association Study; Genomics; Head and Neck Neoplasms; Humans; Mouth Neoplasms; Mutation; Neoplasm Invasiveness; Phenotype; RNA Interference; Signal Transduction; Squamous Cell Carcinoma of Head and Neck; Staurosporine; Transfection

2016
Proteomic analysis of multidrug-resistance mechanisms in adriamycin-resistant variants of DLKP, a squamous lung cancer cell line.
    Proteomics, 2009, Volume: 9, Issue:6

    Topics: Apoptosis; Blotting, Western; Carcinoma, Squamous Cell; Cell Line, Tumor; Doxorubicin; Drug Resistance, Neoplasm; Electrophoresis, Gel, Two-Dimensional; Humans; Lung Neoplasms; Neoplasm Invasiveness; Neoplasm Proteins; Prohibitins; Proteomics; Reactive Oxygen Species; Reproducibility of Results; Staurosporine

2009
Hypoxia inducible factor-1α expression in areca quid chewing-associated oral squamous cell carcinomas.
    Oral diseases, 2010, Volume: 16, Issue:7

    Topics: Acetylcysteine; Areca; Arecoline; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Squamous Cell; Cell Line; Cholinergic Agonists; Curcumin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Free Radical Scavengers; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Mouth Mucosa; Mouth Neoplasms; Protein Kinase C; Staurosporine; Time Factors; Transcription Factor AP-1

2010
Antitumor activity of UCN-01 in carcinomas of the head and neck is associated with altered expression of cyclin D3 and p27(KIP1).
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2002, Volume: 8, Issue:11

    Topics: 3T3 Cells; Alkaloids; Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; CDC2-CDC28 Kinases; Cell Cycle; Cell Cycle Proteins; Cyclin D3; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cyclins; Dose-Response Relationship, Drug; Flow Cytometry; G1 Phase; Head and Neck Neoplasms; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Inhibitory Concentration 50; Kinetics; Mice; Mice, Nude; Neoplasm Transplantation; Prognosis; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; S Phase; Staurosporine; Time Factors; Tumor Cells, Cultured; Tumor Suppressor Proteins

2002
[Abrogation of radiation-induced G2 arrest and radiosensitization by 7-hydroxystaurosporine (UCN-01) in human nasopharyngeal carcinoma cell line].
    Ai zheng = Aizheng = Chinese journal of cancer, 2003, Volume: 22, Issue:1

    Topics: Carcinoma, Squamous Cell; Cell Cycle; Cell Line, Tumor; Cell Survival; G2 Phase; Genes, p53; Humans; Mutation; Nasopharyngeal Neoplasms; Protein Kinase C; Radiation-Sensitizing Agents; Staurosporine

2003
Matrix metalloproteinase 2 and matrix metalloproteinase 9 expression in human oral squamous cell carcinoma and the effect of protein kinase C inhibitors: preliminary observations.
    Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 2003, Volume: 95, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Carcinoma, Squamous Cell; Cell Culture Techniques; Down-Regulation; Enzyme Inhibitors; Humans; Keratinocytes; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mouth Mucosa; Mouth Neoplasms; Protein Kinase C; Staurosporine; Tumor Cells, Cultured

2003
Persistent activation of the Akt pathway in head and neck squamous cell carcinoma: a potential target for UCN-01.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Jun-15, Volume: 10, Issue:12 Pt 1

    Topics: Animals; Antineoplastic Agents; Blotting, Western; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Disease Progression; Enzyme Activation; Head and Neck Neoplasms; Humans; Immunohistochemistry; Mice; Mouth Mucosa; Neoplasm Transplantation; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Skin; Staurosporine; Time Factors

2004
Effect of protein kinase C alpha, caspase-3, and survivin on apoptosis of oral cancer cells induced by staurosporine.
    Acta pharmacologica Sinica, 2005, Volume: 26, Issue:11

    Topics: Apoptosis; Carcinoma, Squamous Cell; Caspase 3; Cell Line, Tumor; Cell Membrane; Cell Survival; Cytosol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Inhibitor of Apoptosis Proteins; Microtubule-Associated Proteins; Neoplasm Proteins; Protein Kinase C-alpha; Staurosporine; Survivin; Tongue Neoplasms

2005
FAP-1-mediated activation of NF-kappaB induces resistance of head and neck cancer to Fas-induced apoptosis.
    Journal of cellular biochemistry, 2007, Jan-01, Volume: 100, Issue:1

    Topics: Antibodies; Apoptosis; Carcinoma, Squamous Cell; CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Line, Tumor; Cell Survival; Cyclohexylamines; Etoposide; fas Receptor; Head and Neck Neoplasms; Humans; NF-kappa B; Protein Phosphatase 1; Protein Synthesis Inhibitors; Protein Tyrosine Phosphatase, Non-Receptor Type 13; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-bcl-2; RNA, Small Interfering; Signal Transduction; Staurosporine; Up-Regulation; Vanadates

2007
UCN-01 (7-hydroxystaurosporine) induces apoptosis and G1 arrest of both primary and metastatic oral cancer cell lines in vitro.
    Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 2007, Volume: 103, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Flow Cytometry; G1 Phase; Humans; Mouth Neoplasms; Protein Kinase C; Protein Kinase Inhibitors; Staurosporine

2007
The upregulation of heat shock protein 70 expression in areca quid chewing-associated oral squamous cell carcinomas.
    Oral oncology, 2008, Volume: 44, Issue:9

    Topics: Adult; Aged; Antineoplastic Agents; Areca; Arecoline; Blotting, Western; Carcinoma, Squamous Cell; Curcumin; Epithelium; Female; Flavonoids; HSP70 Heat-Shock Proteins; Humans; Lymphatic Metastasis; Male; Mastication; Middle Aged; Mouth Mucosa; Mouth Neoplasms; Staurosporine; Up-Regulation

2008
Effect of UCN-01, a selective inhibitor of protein kinase C, on the cell-cycle distribution of human epidermoid carcinoma, A431 cells.
    Cancer chemotherapy and pharmacology, 1994, Volume: 33, Issue:4

    Topics: Alkaloids; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Cycle; DNA, Neoplasm; Humans; Protein Kinase C; Staining and Labeling; Staurosporine; Time Factors; Tumor Cells, Cultured

1994
Induction of 12-lipoxygenase expression by epidermal growth factor is mediated by protein kinase C in A431 cells.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 271, Issue:1

    Topics: Alkaloids; Arachidonate 12-Lipoxygenase; Carcinoma, Squamous Cell; Diglycerides; Enzyme Induction; Epidermal Growth Factor; Humans; Naphthalenes; Phosphatidylinositol Phosphates; Polycyclic Compounds; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

1994
Regulation of interleukin-6 (IL-6) expression: evidence for a tissue-specific role of protein kinase C.
    Journal of clinical immunology, 1993, Volume: 13, Issue:5

    Topics: Alkaloids; Base Sequence; Calcimycin; Carcinoma, Squamous Cell; DNA-Binding Proteins; Gene Expression Regulation; Interleukin-1; Interleukin-6; Laryngeal Neoplasms; Lipopolysaccharides; Molecular Sequence Data; Monocytes; NF-kappa B; Organ Specificity; Polymerase Chain Reaction; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Cells, Cultured

1993
Bradykinin-stimulated transient modulation of epidermal growth factor receptors in A-431 human epidermoid carcinoma cells.
    Journal of cellular physiology, 1993, Volume: 157, Issue:1

    Topics: Alkaloids; Binding, Competitive; Bradykinin; Carcinoma, Squamous Cell; ErbB Receptors; Humans; Marine Toxins; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Staurosporine; Tumor Cells, Cultured

1993
Inhibition of tumor formation from grafted murine papilloma cells by treatment of grafts with staurosporine, an inducer of squamous differentiation.
    Carcinogenesis, 1993, Volume: 14, Issue:2

    Topics: Alkaloids; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Differentiation; Disease Models, Animal; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Papilloma; Protein Kinase C; Skin Neoplasms; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured

1993
Antitumor effect of CGP41251, a new selective protein kinase C inhibitor, on human non-small cell lung cancer cells.
    Japanese journal of pharmacology, 1996, Volume: 70, Issue:1

    Topics: Adenocarcinoma; Analysis of Variance; Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cell Cycle; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Lung Neoplasms; Male; Mice; Mice, Nude; Neoplasm Transplantation; Protein Kinase C; Staurosporine; Tumor Cells, Cultured

1996
G1 phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitor p21/Cip1/WAF1/Sdi1 in p53-mutated human epidermoid carcinoma A431 cells.
    Cancer research, 1997, Apr-15, Volume: 57, Issue:8

    Topics: Alkaloids; Antineoplastic Agents; Carcinoma, Squamous Cell; CDC2-CDC28 Kinases; Cell Cycle Proteins; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cyclins; G1 Phase; Humans; Microtubule-Associated Proteins; Phosphorylation; Protein Serine-Threonine Kinases; Retinoblastoma Protein; RNA, Messenger; Staurosporine; Tumor Cells, Cultured; Tumor Suppressor Proteins

1997
ATP- and EGF-stimulated phosphatidulinositol synthesis by two different pathways, phospholipase D and diacylglycerol kinase, in A-431 epidermoid carcinoma cells.
    Biochemistry and cell biology = Biochimie et biologie cellulaire, 1996, Volume: 74, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Bradykinin; Calcimycin; Calcium; Carcinoma, Squamous Cell; Chelating Agents; Choline; Diacylglycerol Kinase; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Ionophores; Neoplasm Proteins; Pertussis Toxin; Phosphatidic Acids; Phosphatidylinositol Diacylglycerol-Lyase; Phosphatidylinositols; Phospholipase D; Phosphotransferases (Alcohol Group Acceptor); Pyrimidinones; Receptors, Purinergic P2; Signal Transduction; Staurosporine; Sulfonamides; Thiazoles; Tumor Cells, Cultured; Type C Phospholipases; Virulence Factors, Bordetella

1996
Alteration of proto-oncogenes during apoptosis in the oral squamous cell carcinoma cell line, SAS, induced by staurosporine.
    Cancer letters, 1997, Sep-16, Volume: 118, Issue:1

    Topics: Apoptosis; Carcinoma, Squamous Cell; Cell Adhesion; Cell Nucleus; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA Fragmentation; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Microscopy, Electron; Mouth Neoplasms; Polymerase Chain Reaction; Proto-Oncogene Mas; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Proto-Oncogenes; RNA, Messenger; Staurosporine; Transcription, Genetic; Tumor Cells, Cultured

1997
Staurosporine-induced versus spontaneous squamous metaplasia in pre- and postmenopausal breast tissue.
    Journal of cellular physiology, 1998, Volume: 176, Issue:2

    Topics: Adult; Aged; Anticarcinogenic Agents; Breast; Breast Neoplasms; Carcinogens; Carcinoma, Squamous Cell; Cell Differentiation; Cell Division; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; Immunophenotyping; Keratin-10; Keratinocytes; Keratins; Middle Aged; Naphthalenes; Postmenopause; Premenopause; Protein Kinase C; Staurosporine; Tamoxifen; Tetradecanoylphorbol Acetate; Thrombomodulin; Tumor Cells, Cultured; Up-Regulation

1998
Multimodality therapy: radiation and continuous concomitant cis-platinum and PKC inhibition in a cervical carcinoma model.
    Cancer investigation, 1998, Volume: 16, Issue:7

    Topics: Alkaloids; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Combined Modality Therapy; Enzyme Inhibitors; Female; HeLa Cells; Humans; Protein Kinase C; Radiotherapy Dosage; Spheroids, Cellular; Staurosporine; Tumor Stem Cell Assay; Uterine Cervical Neoplasms

1998
Differential effects of UCN-01, staurosporine and CGP 41 251 on cell cycle progression and CDC2/cyclin B1 regulation in A431 cells synchronized at M phase by nocodazole.
    Anti-cancer drugs, 1999, Volume: 10, Issue:1

    Topics: Alkaloids; Antineoplastic Agents; Carcinoma, Squamous Cell; CDC2 Protein Kinase; cdc25 Phosphatases; Cell Cycle; Cell Cycle Proteins; Cell-Free System; Cyclin B; Cyclin B1; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Mitosis; Nocodazole; Phosphoprotein Phosphatases; Phosphorylation; Proteins; Skin Neoplasms; Staurosporine; Tumor Cells, Cultured; Tyrosine

1999
Nitric oxide up-regulates the expression of intercellular adhesion molecule-1 on cancer cells.
    Biochemical and biophysical research communications, 1999, Apr-13, Volume: 257, Issue:2

    Topics: Benzoates; Carcinoma, Squamous Cell; Cell Adhesion Molecules; Free Radical Scavengers; Genistein; Humans; Imidazoles; Intercellular Adhesion Molecule-1; Molsidomine; NF-kappa B; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Penicillamine; Phosphorylation; Promoter Regions, Genetic; Protein Kinase C; RNA, Messenger; S-Nitroso-N-Acetylpenicillamine; Staurosporine; Tongue Neoplasms; Transcription Factor AP-1; Tumor Cells, Cultured; Up-Regulation

1999
Modulation of tumor cell proliferation and apoptosis by polyamine depletion in cells of head and neck squamous cell carcinomas.
    Radiation research, 1999, Volume: 152, Issue:6

    Topics: Apoptosis; Carcinoma, Squamous Cell; Cell Division; Cell Survival; Dose-Response Relationship, Drug; Eflornithine; Head and Neck Neoplasms; Humans; Kinetics; Poly(ADP-ribose) Polymerases; Polyamines; Staurosporine; Time Factors; Tumor Cells, Cultured; Tumor Stem Cell Assay

1999
UCN-01 selectively enhances mitomycin C cytotoxicity in p53 defective cells which is mediated through S and/or G(2) checkpoint abrogation.
    International journal of cancer, 2000, Mar-01, Volume: 85, Issue:5

    Topics: Alkaloids; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Squamous Cell; Cell Cycle; Cell Survival; Cyclin B; Cyclin B1; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; DNA Damage; Drug Synergism; Female; G2 Phase; Genes, p53; Humans; In Situ Nick-End Labeling; Mitomycin; Protein Kinases; S Phase; Staurosporine; Tumor Cells, Cultured

2000
Biochemical and molecular effects of UCN-01 in combination with 5-fluorodeoxyuridine in A431 human epidermoid cancer cells.
    Anti-cancer drugs, 2002, Volume: 13, Issue:3

    Topics: Alkaloids; Antimetabolites, Antineoplastic; Carcinoma, Squamous Cell; Cell Cycle; Cell Survival; Deoxyribonucleotides; DNA Damage; DNA Fragmentation; DNA, Neoplasm; Drug Combinations; Enzyme Inhibitors; Floxuridine; Genes, p53; Humans; Lung Neoplasms; Polymerase Chain Reaction; RNA, Messenger; Staurosporine; Thymidylate Synthase; Tumor Cells, Cultured

2002