staurosporine and Carcinoma, Non-Small Cell Lung

Topics: Alkaloids; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carbazoles; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Docetaxel; Glucosides; Humans; Irinotecan; Japan; Lung Neoplasms; Mitomycin; Mitomycins; Neoplasms, Experimental; Paclitaxel; Purine Nucleosides; Staurosporine; Taxoids; Treatment Outcome; Vinblastine; Vinorelbine

Topics: Administration, Oral; Adult; Aged; Angiogenesis Inhibitors; Antineoplastic Combined Chemotherapy Protocols; Asthenia; Carcinoma, Non-Small-Cell Lung; Cisplatin; Deoxycytidine; Diarrhea; Enzyme Inhibitors; Female; Gemcitabine; Humans; Infusions, Intravenous; Lung Neoplasms; Male; Maximum Tolerated Dose; Middle Aged; Protein Kinase C; Staurosporine

Topics: Carcinoma, Non-Small-Cell Lung; Cell Line; Cell Line, Tumor; DNA Nucleotidyltransferases; Drug Discovery; Drug Resistance, Neoplasm; ErbB Receptors; Genes, Reporter; High-Throughput Screening Assays; Humans; Luciferases; Lung Neoplasms; Mutation; Phosphorylation; Protein Kinase Inhibitors; Reproducibility of Results; Small Molecule Libraries; Staurosporine

Topics: Aurora Kinase A; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Drug Discovery; Drug Synergism; Humans; Lung Neoplasms; Polo-Like Kinase 1; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proteomics; Proto-Oncogene Proteins; RNA Interference; Signal Transduction; Staurosporine

Topics: A549 Cells; Bromodeoxyuridine; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Cell Size; Giant Cells; Humans; Lung Neoplasms; Polyploidy; Staurosporine

Topics: Amino Acid Sequence; Carcinoma, Non-Small-Cell Lung; Computer Simulation; Drug Resistance, Neoplasm; ErbB Receptors; Humans; Lung Neoplasms; Models, Molecular; Molecular Sequence Data; Mutation; Protein Kinase Inhibitors; Small Molecule Libraries; Staurosporine; Structure-Activity Relationship

Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Benzimidazoles; Carbocyanines; Carcinoma, Non-Small-Cell Lung; Caspases; Cell Line, Tumor; Cell Membrane Permeability; Cell Survival; Connexins; Drug Synergism; Flow Cytometry; Fluorescent Dyes; High-Throughput Screening Assays; Humans; Indoles; Lung Neoplasms; Membrane Potential, Mitochondrial; Microscopy, Fluorescence; Nerve Tissue Proteins; Organoplatinum Compounds; Oxaliplatin; Robotics; Staining and Labeling; Staurosporine; Workflow

Topics: Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Clinical Trials, Phase III as Topic; DNA-Binding Proteins; Endonucleases; Enzyme Activation; ErbB Receptors; Erlotinib Hydrochloride; fms-Like Tyrosine Kinase 3; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glutamates; Guanine; Humans; Leukemia, Myeloid, Acute; Lung Neoplasms; Mutation; Pemetrexed; Protein Kinase Inhibitors; Quinazolines; Randomized Controlled Trials as Topic; Research Design; Staurosporine

Topics: Antimetabolites, Antineoplastic; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Deoxycytidine; Deoxycytidine Kinase; Drug Synergism; Enzyme Inhibitors; Gemcitabine; Humans; Lung Neoplasms; Protein Kinase C; Ribonucleotide Reductases; Staurosporine

Topics: Adaptor Proteins, Signal Transducing; Apoptosis; Apoptotic Protease-Activating Factor 1; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cytochromes c; Dactinomycin; GTP Phosphohydrolases; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Humans; Lung Neoplasms; Membrane Potential, Mitochondrial; Membrane Proteins; Mitochondria; Molecular Chaperones; RNA Interference; Signal Transduction; Staurosporine; Thiolester Hydrolases; Time Factors; Transfection

Topics: Antineoplastic Agents; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; bcl-X Protein; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Dactinomycin; Dose-Response Relationship, Drug; Doxorubicin; Drug Antagonism; Drug Synergism; Etoposide; Humans; Immunoblotting; Lung Neoplasms; Paclitaxel; Protein Kinase C; Signal Transduction; Staurosporine; Time Factors

Topics: Adenocarcinoma; Adenocarcinoma of Lung; Antineoplastic Agents; Apoptosis; Biosensing Techniques; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Delivery Systems; Gefitinib; Humans; Ions; Lung Neoplasms; Propylamines; Quinazolines; Silanes; Silicon; Single-Cell Analysis; Staurosporine

Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Combined Modality Therapy; Cyclin-Dependent Kinase Inhibitor p27; Ephrin-B3; Extracellular Signal-Regulated MAP Kinases; G2 Phase Cell Cycle Checkpoints; Humans; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Radiation, Ionizing; RNA Interference; RNA, Small Interfering; Signal Transduction; Staurosporine; Up-Regulation

Topics: Alkaloids; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Cycle Proteins; Cisplatin; Drug Synergism; Humans; Lung Neoplasms; Phosphorylation; Staurosporine; Tumor Cells, Cultured

Topics: Antineoplastic Agents; Apoptosis; bcl-X Protein; Butadienes; Carcinoma, Non-Small-Cell Lung; Caspases; Doxorubicin; Drug Synergism; Drug Therapy, Combination; Enzyme Activation; Enzyme Inhibitors; Humans; JNK Mitogen-Activated Protein Kinases; Lung Neoplasms; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nitriles; Paclitaxel; Phosphorylation; Poly(ADP-ribose) Polymerases; Protein Kinase C; Proteins; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Staurosporine; Tumor Cells, Cultured; X-Linked Inhibitor of Apoptosis Protein

Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Cyclin D1; Down-Regulation; G1 Phase; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Lung Neoplasms; Neoplasm Proteins; Neuroblastoma; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; Staurosporine; Transfection; Tumor Cells, Cultured; Tumor Suppressor Proteins

Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; G2 Phase; Humans; Lung Neoplasms; Protein Kinase Inhibitors; Staurosporine; Tumor Suppressor Protein p53

Topics: Amphiregulin; Androstadienes; Apoptosis; bcl-2-Associated X Protein; bcl-Associated Death Protein; Carcinoma, Non-Small-Cell Lung; Carrier Proteins; Cell Line, Tumor; Culture Media, Serum-Free; EGF Family of Proteins; Enzyme Inhibitors; Flavonoids; Glycoproteins; Humans; Insulin-Like Growth Factor I; Intercellular Signaling Peptides and Proteins; Isoenzymes; Lung Neoplasms; MAP Kinase Signaling System; Models, Biological; Naphthalenes; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Staurosporine; Wortmannin

Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; DNA Damage; DNA, Neoplasm; Enzyme Inhibitors; Humans; Intracellular Membranes; Kinetics; Lung Neoplasms; Membrane Potentials; Mitochondria; Protein Kinase Inhibitors; Staurosporine

Topics: Androstadienes; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Survival; Chromones; Enzyme Inhibitors; Etoposide; Flavonoids; Flow Cytometry; Humans; Indoles; Lung Neoplasms; MAP Kinase Kinase Kinases; Mitosis; Morpholines; Nocodazole; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; Staurosporine; Wortmannin

Topics: Antineoplastic Agents; Binding Sites; Carcinoma, Non-Small-Cell Lung; Crystallography, X-Ray; Enzyme Activation; ErbB Receptors; Gefitinib; Humans; Lapatinib; Lung Neoplasms; Models, Molecular; Mutation; Protein Conformation; Protein Structure, Tertiary; Purines; Quinazolines; Staurosporine

Topics: Adenocarcinoma; Analysis of Variance; Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cell Cycle; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Lung Neoplasms; Male; Mice; Mice, Nude; Neoplasm Transplantation; Protein Kinase C; Staurosporine; Tumor Cells, Cultured

Topics: Alkaloids; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Cycle; DNA Repair; DNA Replication; DNA-Binding Proteins; Endonucleases; Gene Expression Regulation, Neoplastic; Humans; Kinetics; Lung Neoplasms; Proteins; Staurosporine; Tumor Cells, Cultured; Xeroderma Pigmentosum; Xeroderma Pigmentosum Group A Protein

Topics: Alkaloids; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cyclin-Dependent Kinase Inhibitor p16; Enzyme Inhibitors; G1 Phase; Genes, p53; Genes, Retinoblastoma; Growth Inhibitors; Humans; Lung Neoplasms; Phosphorylation; Retinoblastoma Protein; Staurosporine; Tumor Cells, Cultured; Tumor Suppressor Protein p53

Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Apoptosis Inducing Factor; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Caspase 3; Caspase 7; Caspases; Cell Cycle; Cell Nucleus; Cysteine Proteinase Inhibitors; Cytochrome c Group; Drug Resistance, Neoplasm; Enzyme Activation; Enzyme Inhibitors; Enzyme Precursors; Flavoproteins; Gamma Rays; Humans; Jurkat Cells; Lung Neoplasms; Membrane Potentials; Membrane Proteins; Mitochondria; Poly(ADP-ribose) Polymerases; Protein Transport; Radiation Tolerance; Reactive Oxygen Species; Recombinant Fusion Proteins; Staurosporine; Superoxides; Tumor Cells, Cultured