staurosporine has been researched along with Cancer of Pancreas in 22 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (36.36) | 18.2507 |
| 2000's | 9 (40.91) | 29.6817 |
| 2010's | 5 (22.73) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Billadeau, DD; Blond, SY; Gaisina, IN; Gallier, F; Guo, S; Holzle, D; Kim, KH; Kozikowski, AP; Kurome, T; Luchini, DN; Ougolkov, AV | 1 |
| Abbe, P; Benhida, R; Cavazza, E; Cerezo, M; Jaune, E; Millet, A; Plaisant, M; Rocchi, S; Ronco, C | 1 |
| Bitzinger, D; Bundscherer, A; Graf, B; Malsy, M | 1 |
| Asoh, S; Miyato, Y; Mizutani, S; Ohta, S; Shidara, Y; Tajiri, T; Tokunaga, A | 1 |
| Du, ZX; Gao, YY; Liu, BQ; Meng, X; Niu, XF; Wang, HQ; Zhang, HY | 1 |
| Burke, SJ; Campagna, SR; Collier, JJ; Eisenhauer, ME; Frydman, CJ; Lu, D; Sapp, RC | 1 |
| Cai, X; Chen, T; Cheng, H; Fang, Z; Hoth, M; Ji, S; Liu, C; Long, J; Ni, Q; Qin, Y; Qu, B; Wu, C; Xu, J; Xu, W; Yao, W; Yu, X; Zha, X | 1 |
| Bearss, DJ; Mahadevan, D; Muñoz, RM; Rojanala, S; Saldanha, JW; Vankayalapati, H; Von Hoff, DD | 1 |
| Chang, I; Cho, N; Koh, JY; Lee, MS | 1 |
| Cao, P; Gronda, M; Hedley, DW; Jacobberger, JW; Pham, NA; Schimmer, AD | 1 |
| Büchler, MW; Büchler, P; El Fitori, J; Friess, H; Giese, NA; Herr, I; Hines, OJ; Ludwig, R; Quentmeier, H; Su, Y | 1 |
| Pradayrol, L; Sarfati, PD; Scemama, JL; Seva, C; Vaysse, N | 1 |
| Bode, HP; Göke, B | 1 |
| Habener, JF; Leech, CA | 1 |
| Sharp, GW; Tang, SH | 1 |
| Fujimoto, Y; Hirata, M; Inoue, H; Iwao, T; Kajiyama, G; Kariya, K; Kawasaki, Y; Matsubara, K; Morinaka, K; Sasaki, T; Tsuchida, A; Yamamoto, S | 1 |
| Akinaga, S; Akiyama, T; Fuse, E; Kobayashi, H; Kobayashi, S; Kurata, N; Kuwabara, T; Tanii, H; Yamaguchi, K | 1 |
| Abe, S; Kitajima, M; Kubota, T; Kumai, K; Otani, Y; Watanabe, A | 1 |
| Abe, S; Furukawa, T; Kitajima, M; Kubota, T; Kumai, K; Otani, Y; Watanabe, M | 1 |
| Abe, S; Akinaga, S; Akiyama, T; Furukawa, T; Kitajima, M; Kubota, T; Kumai, K; Otani, Y; Watanabe, M | 1 |
| Brandt-Rauf, PW; Chie, L; Chung, DL; Kanovsky, M; Michl, J; Pincus, MR; Sivendran, S; Smith, S; Way, D | 1 |
| Greten, H; Humburg, I; Kalthoff, H; Roeder, C; Schmiegel, W; Thiele, HG | 1 |
22 other study(ies) available for staurosporine and Cancer of Pancreas
| Article | Year |
|---|---|
From a natural product lead to the identification of potent and selective benzofuran-3-yl-(indol-3-yl)maleimides as glycogen synthase kinase 3beta inhibitors that suppress proliferation and survival of pancreatic cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Benzofurans; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin-Dependent Kinase 2; Drug Screening Assays, Antitumor; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Indoles; Maleimides; Models, Molecular; Pancreatic Neoplasms; Structure-Activity Relationship; X-Linked Inhibitor of Apoptosis Protein | 2009 |
Discovery and Optimization of N-(4-(3-Aminophenyl)thiazol-2-yl)acetamide as a Novel Scaffold Active against Sensitive and Resistant Cancer Cells.
Topics: Acetamides; Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Melanoma; Mice; Pancreatic Neoplasms; Structure-Activity Relationship; Thiazoles | 2016 |
Staurosporine induces apoptosis in pancreatic carcinoma cells PaTu 8988t and Panc-1 via the intrinsic signaling pathway.
Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Enzyme Inhibitors; Humans; Pancreatic Neoplasms; Signal Transduction; Staurosporine | 2019 |
Mutations in the mitochondrial genome confer resistance of cancer cells to anticancer drugs.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Cell Cycle; Cell Nucleus; Cisplatin; Drug Resistance, Neoplasm; Enzyme Inhibitors; Fluorouracil; Genome, Mitochondrial; Hybrid Cells; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred BALB C; Mice, Nude; Mitochondria; Mutation; Oxygen Consumption; Pancreatic Neoplasms; Staurosporine | 2009 |
Characterization of BAG3 cleavage during apoptosis of pancreatic cancer cells.
Topics: Adaptor Proteins, Signal Transducing; Apoptosis; Apoptosis Regulatory Proteins; Aspartic Acid; Caspase Inhibitors; Caspases; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Etoposide; Humans; Leupeptins; Mutation; Pancreatic Neoplasms; Peptide Fragments; Protein Processing, Post-Translational; Protein Structure, Tertiary; Recombinant Proteins; Staurosporine; Time Factors; Transfection; Tumor Necrosis Factor-alpha; Ultraviolet Rays | 2010 |
Pancreatic β-cell death in response to pro-inflammatory cytokines is distinct from genuine apoptosis.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Caspases; Cell Death; Cells, Cultured; Cytokines; Enzyme Inhibitors; Inflammation; Insulin; Insulin-Secreting Cells; Insulinoma; Interferon-gamma; Interleukin-1beta; Metabolomics; NF-kappa B; Pancreatic Neoplasms; Rats; Signal Transduction; Staurosporine; Tandem Mass Spectrometry | 2011 |
Profilin 1 potentiates apoptosis induced by staurosporine in cancer cells.
Topics: Apoptosis; Breast Neoplasms; Caspase 3; Cell Line, Tumor; Cell Survival; DNA-Binding Proteins; Enzyme Inhibitors; Female; Humans; Mitochondria; Pancreatic Neoplasms; Phosphorylation; Profilins; RNA Interference; RNA, Small Interfering; Staurosporine; Tumor Suppressor Protein p53 | 2013 |
Targeting aurora2 kinase in oncogenesis: a structural bioinformatics approach to target validation and rational drug design.
Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; Aurora Kinase A; Aurora Kinase B; Aurora Kinases; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Calmodulin-Binding Proteins; Cattle; Computational Biology; Cyclic AMP-Dependent Protein Kinases; Drug Design; Humans; Mice; Models, Molecular; Molecular Sequence Data; Molecular Structure; Muscle Proteins; Pancreatic Neoplasms; Protein Conformation; Protein Serine-Threonine Kinases; Sequence Homology, Amino Acid; Staurosporine; Structure-Activity Relationship | 2003 |
Pyruvate inhibits zinc-mediated pancreatic islet cell death and diabetes.
Topics: Adenosine Triphosphate; Animals; Antigens, Polyomavirus Transforming; Antioxidants; Cell Death; Cell Line, Tumor; Cell Transformation, Neoplastic; Diabetes Mellitus, Experimental; Etoposide; Insulinoma; Interferon-gamma; Islets of Langerhans; NAD; Necrosis; Pancreatic Neoplasms; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Staurosporine; Tumor Necrosis Factor-alpha; Zinc | 2003 |
The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice.
Topics: Animals; Anticarcinogenic Agents; Antigens; Apoptosis; Blotting, Western; Caspase 3; Caspase 8; Caspases; Cell Cycle; Cell Line, Tumor; Cell Membrane; Cell Nucleus; DNA; Dose-Response Relationship, Drug; Enzyme Activation; Flow Cytometry; Glutathione; Humans; Isothiocyanates; Male; Membrane Potentials; Mice; Mice, SCID; Microscopy, Fluorescence; Mitochondria; Mitosis; Neoplasm Transplantation; Neoplasms; Oxidative Stress; Pancreatic Neoplasms; Reactive Oxygen Species; Staurosporine; Sulfoxides; Thiocyanates; Time Factors; Tyrosine | 2004 |
PKC 412 small-molecule tyrosine kinase inhibitor: single-compound therapy for pancreatic cancer.
Topics: Adenocarcinoma; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Flow Cytometry; fms-Like Tyrosine Kinase 3; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Male; Mice; Mice, Inbred BALB C; Microcirculation; Pancreatic Neoplasms; Point Mutation; Polymerase Chain Reaction; Protein Kinase C; Receptors, Vascular Endothelial Growth Factor; Sequence Analysis, DNA; Signal Transduction; Staurosporine; Tandem Repeat Sequences; Tumor Cells, Cultured | 2007 |
Coupling of pancreatic gastrin/cholecystokinin-B (G/CCKB) receptors to phospholipase C and protein kinase C in AR4-2J tumoral cells.
Topics: Alkaloids; Animals; Binding Sites; Cholecystokinin; Diglycerides; Dose-Response Relationship, Drug; Enzyme Activation; Gastrins; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Ornithine Decarboxylase; Pancreas; Pancreatic Neoplasms; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Protein Kinase C; Rats; Receptors, Cholecystokinin; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Type C Phospholipases | 1994 |
Protein kinase C activates capacitative calcium entry in the insulin secreting cell line RINm5F.
Topics: Alkaloids; Animals; Biological Transport; Calcium; Cytosol; Insulin; Insulin Secretion; Insulinoma; Manganese; Pancreatic Neoplasms; Protein Kinase C; Rats; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Tumor Cells, Cultured | 1994 |
Insulinotropic glucagon-like peptide-1-mediated activation of non-selective cation currents in insulinoma cells is mimicked by maitotoxin.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cricetinae; Egtazic Acid; Glucagon-Like Peptide 1; Imidazoles; Insulinoma; Islets of Langerhans; Marine Toxins; Membrane Potentials; Oxocins; Pancreatic Neoplasms; Peptides; Staurosporine; Tumor Cells, Cultured | 1997 |
Atypical protein kinase C isozyme zeta mediates carbachol-stimulated insulin secretion in RINm5F cells.
Topics: Animals; Carbachol; Cell Membrane; Cytosol; Enzyme Activation; Enzyme Inhibitors; Insulin; Insulin Secretion; Insulinoma; Isoenzymes; Pancreatic Neoplasms; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1998 |
Cholecystokinin regulates the invasiveness of human pancreatic cancer cell lines via protein kinase C pathway.
Topics: Blotting, Western; Cholecystokinin; Collagenases; Cyclooxygenase Inhibitors; Dinoprostone; Dopamine Agents; Enzyme Induction; Enzyme Inhibitors; Humans; Immunoenzyme Techniques; Indomethacin; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Pancreatic Neoplasms; Protein Kinase C; Signal Transduction; Sincalide; Staurosporine; Tumor Cells, Cultured | 1999 |
Pharmacokinetics and pharmacodynamics of a novel protein kinase inhibitor, UCN-01.
Topics: Alkaloids; Animals; Antineoplastic Agents; Dogs; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Pancreatic Neoplasms; Rats; Rats, Sprague-Dawley; Staurosporine; Tissue Distribution; Transplantation, Heterologous | 1999 |
[Antineoplastic effect of novel agents, UCN-01 on human tumor cells transplanted in nude mice].
Topics: Alkaloids; Animals; Antineoplastic Agents; Cell Cycle; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Pancreatic Neoplasms; Staurosporine; Stomach Neoplasms | 1999 |
UCN-01 (7-hydroxystaurosporine) enhances 5-fluorouracil cytotoxicity through down-regulation of thymidylate synthetase messenger RNA.
Topics: Alkaloids; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Dose-Response Relationship, Drug; Down-Regulation; Drug Synergism; Enzyme Inhibitors; Fluorouracil; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Pancreatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Staurosporine; Thymidylate Synthase; Tumor Cells, Cultured | 2000 |
UCN-01 (7-hydoxystaurosporine) inhibits in vivo growth of human cancer cells through selective perturbation of G1 phase checkpoint machinery.
Topics: Alkaloids; Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Breast Neoplasms; CDC2-CDC28 Kinases; Cell Division; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; DNA, Neoplasm; Drug Resistance, Neoplasm; G1 Phase; Humans; Immunohistochemistry; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Pancreatic Neoplasms; Phosphorylation; Protein Serine-Threonine Kinases; Retinoblastoma Protein; Staurosporine; Transplantation, Heterologous | 2001 |
A protein kinase C inhibitor induces phenotypic reversion of ras-transformed pancreatic cancer cells and cooperatively blocks tumor cell proliferation with an anti- ras peptide.
Topics: Antineoplastic Agents; Carcinoma, Acinar Cell; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Enzyme Inhibitors; Humans; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Oncogene Protein p21(ras); Pancreatic Neoplasms; Peptide Fragments; Phenotype; Protein Binding; Protein Kinase C; Signal Transduction; Staurosporine | 2002 |
Modulation of platelet-derived growth factor A- and B-chain/c-sis mRNA by tumor necrosis factor and other agents in adenocarcinoma cells.
Topics: Adenocarcinoma; Alkaloids; Blotting, Northern; Cell Line; Cycloheximide; Dose-Response Relationship, Drug; Humans; Interferon-gamma; Pancreatic Neoplasms; Platelet-Derived Growth Factor; Protein Kinase C; Protein Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-sis; RNA, Messenger; Signal Transduction; Staurosporine; Time Factors; Tumor Necrosis Factor-alpha | 1991 |