staurosporine has been researched along with Cancer of Lung in 78 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.28) | 18.7374 |
| 1990's | 22 (28.21) | 18.2507 |
| 2000's | 29 (37.18) | 29.6817 |
| 2010's | 23 (29.49) | 24.3611 |
| 2020's | 3 (3.85) | 2.80 |
| Authors | Studies |
|---|---|
| Acero, N; Añorbe, L; Braña, MF; Domínguez, G; Mitjans, F; Muñoz-Mingarro, D; Piulats, J | 1 |
| Liu, L; Liu, Y; Qin, L; Qin, S; Wang, X; Wang, Z; Zhan, X; Zhang, C | 1 |
| Aboualizadeh, F; Akhmanova, A; Al-Awar, R; Aman, A; Datti, A; Drecun, L; Jakopović, M; Joseph, B; Kalaidzidis, Y; Leighl, N; Lyakisheva, A; Marcellus, R; Moran, MF; Park, JH; Pathmanathan, S; Pham, NA; Poda, G; Prakesch, M; Radulovich, N; Rai, A; Sacher, A; Samaržija, M; Saraon, P; Shepherd, FA; Snider, J; Stagljar, I; Thériault, B; Tsao, MS; Uehling, D; Vučetić, A; Vučković, N; Wang, J; Wang, Y; Weiss, K; Wong, V; Wybenga-Groot, LE; Yao, Z; Zerial, M | 1 |
| Ercetin, E; Hamacher, J; Janciauskiene, S; Schwarz, N; Tumpara, S; Welte, T; Wrenger, S | 1 |
| Hu, S; Jin, Y; Li, S; Ma, W; Ren, D; Wu, N; Xiao, S | 1 |
| Ctortecka, C; Fang, B; Haura, EB; Izumi, V; Kinose, F; Koomen, JM; Kuenzi, BM; Novakova, S; Palve, V; Remsing Rix, LL; Rix, U; Sumi, NJ | 1 |
| Carrillo Garcia, C; Glassmann, A; Janzen, V; Kraus, D; Probstmeier, R; Veit, N; Winter, J | 1 |
| Ai, X; Lu, S; Sun, Y; Wang, H | 1 |
| Chang, CY; Chang, LW; Chen, RJ; Hsu, CH; Lin, P; Siao, SH; Wang, YJ; Wu, CH | 1 |
| Bornancin, F; Fabbro, D; Huwiler, A; Japtok, L; Kleuser, B; Pastukhov, O; Pfeilschifter, J; Schwalm, S; Zangemeister-Wittke, U | 1 |
| Galluzzi, L; Kepp, O; Kroemer, G; Müller, K; Sauvat, A; Segura, F; Spaggiari, S; Wang, Y; Zhou, H | 1 |
| Liu, S; Molina, JR; Pang, J; Shen, N; Yan, F; Yang, P | 1 |
| Gayatri, S; Ghoshal-Gupta, S; Jiwani, S; Kutiyanawalla, A; Lee, BR; Nalluri, S; Rojiani, AM; Rojiani, MV | 1 |
| Li, JS; Wang, XW; Wang, YW; Zhang, HY | 1 |
| Ding, X; Liu, X; Song, X | 1 |
| Clynes, M; Henry, M; Keenan, J; Meleady, P; Murphy, L | 1 |
| Huang, J; Liu, H; Song, X; Wang, Y; Yang, H | 1 |
| Freidlin, B; Korn, EL; McShane, LM | 1 |
| Xing, D; Zhang, L; Zhang, Y | 1 |
| He, W; Hou, S; Hu, B; Li, H; Liu, J; Min, X; Wang, J | 1 |
| Shimizu, T | 1 |
| Bergman, AM; Hoebe, EK; Leon, LG; Loves, WJ; Peters, GJ; Sigmond, J | 1 |
| Gardner, PD; Improgo, MR; Johnson, CW; Tapper, AR | 1 |
| Beck, GR; Chang, SH; Cho, MH; Hwang, SK; Kim, JE; Lee, KH; Minai-Tehrani, A; Park, J; Yu, KN | 1 |
| Breitenbuecher, F; Guyot, M; Hoffarth, S; Höhn, Y; Meiler, J; Schuler, M; Wesarg, E | 1 |
| Hsu, CP; Hsu, PY; Lin, JJ; Wu, YL | 1 |
| Motadi, LR; Sayed, Y; Thafeni, MA | 1 |
| Chan, E; Heffron, TP; La, H; Lee, HJ; Malek, S; Merchant, M; Pirazzoli, V; Politi, K; Schaefer, G; Settleman, J; Shao, L; Sideris, S; Ubhayakar, S; Yauch, RL; Ye, X | 1 |
| Bradbury, ME; Nishi, K; Schnier, JB | 1 |
| Kagota, S; Kunitomo, M; Nakamura, K; Shinozuka, K; Yamaguchi, Y; Yoshikawa, N | 1 |
| Edelman, MJ; Gandara, DR; Gumerlock, PH; Lara, PN; Lau, AH; Mack, PC | 1 |
| Gupta, A; Hoffman, RM; Miki, K; Moossa, AR; Tomita, K; Tsuchiya, H; Tsujimoto, Y; Xu, M; Yamamoto, N | 1 |
| Chada, S; Hunt, KK; Pataer, A; Roth, JA; Swisher, SG | 1 |
| Bally, M; Dragowska, WH; Hu, Y; Mayer, L | 1 |
| Agathanggelou, A; Ahmed-Choudhury, J; Baksh, S; Bièche, I; Dammann, R; Downward, J; Gao, B; Latif, F; Maher, ER; Minna, JD; Nicke, B | 1 |
| Senderowicz, AM | 1 |
| Berthaud, P; Faivre, S; Henriksson, R; Le Chevalier, T; Monnerat, C; Novello, S; Raymond, E | 1 |
| Deng, X; Flagg, T; Gao, F; Jin, Z | 1 |
| Alley, MC; Dasmahapatra, GP; Didolkar, P; Ghosh, S; Roy, KK; Sausville, EA | 1 |
| Gandara, DR; Goldberg, Z; Gumerlock, PH; Gustafsson, MH; Jones, AA; Mack, PC | 1 |
| Hui, ZG; Li, YX; Yang, WZ; Yu, ZH | 1 |
| Auberger, P; Brambilla, C; Coll, JL; Dubrez-Daloz, L; Favrot, MC; Hurbin, A; Mari, B | 1 |
| Hemström, TH; Joseph, B; Lewensohn, R; Schulte, G; Zhivotovsky, B | 1 |
| Bandobashi, K; Kobayashi, M; Kubota, T; Nakata, H; Saito, T; Taguchi, H; Uemura, Y | 1 |
| Hemström, TH; Sandström, M; Zhivotovsky, B | 1 |
| Boggon, TJ; Eck, MJ; Greulich, H; Li, Y; Meyerson, M; Woo, MS; Yun, CH | 1 |
| Chen, GG; Lee, TW; Li, M; Mok, TS; Xu, H; Yim, AP; Yip, JH | 1 |
| Hakomori, S | 1 |
| Budworth, J; Courage, C; Gescher, A | 1 |
| Broxterman, HJ; Eekman, CA; Kuiper, CM; Lankelma, J; Pinedo, HM; Schuurhuis, GJ; Versantvoort, CH | 1 |
| Frankel, A; Viallet, J | 1 |
| Giaccia, AJ; Hahn, GM; Koong, AC; Saad, AH | 1 |
| Clark, OH; Duh, QY; Herfarth, C; Hoelting, T | 1 |
| Futami, H; Kawakami, K; Takahara, J; Yamaguchi, K | 1 |
| Ikegami, Y; Nakao, K; Yano, S | 2 |
| Courage, C; Gescher, A; Snowden, R | 1 |
| Grégoire, M; Harb, J; Meflah, K; Menanteau, J; Segain, JP | 1 |
| Bradder, SM; Courage, C; Gescher, A; Jones, T; Schultze-Mosgau, MH | 1 |
| Saijo, N | 1 |
| Kamp, DW; Panos, RJ; Pollack, N; Sporn, PH; Wu, KI | 1 |
| Andersen, RJ; Anderson, HJ; Berlinck, RG; Britton, R; Curman, D; Davies, P; Friend, SH; Haggarty, SJ; Kelly, MT; Lim, LY; Piers, E; Roberge, M; Stringer, CM; Vincent, I; Xu, L | 1 |
| Akinaga, S; Akiyama, T; Courage, C; Gescher, A; Shimizu, M; Sugiyama, K; Tamaoki, T | 1 |
| Jiang, H; Yang, LY | 1 |
| Bowen, C; Edelman, MJ; Gandara, DR; Gelmann, EP; Gumerlock, PH; Mack, PC; Paglieroni, T; Schnier, JB | 1 |
| Fukumoto, H; Fukuoka, K; Kato, H; Koh, Y; Koizumi, F; Kuh, HJ; Nakamura, T; Nishio, K; Saijo, N; Suzuki, T; Tamura, T; Usuda, J | 1 |
| Kuh, HJ; Nakagawa, S; Nishio, K; Saijo, N; Usuda, J; Yamaoka, K | 1 |
| SiTu, R; Xu, T | 1 |
| Carter, CA | 1 |
| Chai, MQ; Chen, JS; Song, JG; Zhao, S | 1 |
| Formstecher, P; Joseph, B; Kroemer, G; Lewensohn, R; Marchetti, P; Zhivotovsky, B | 1 |
| Danenberg, KD; Danenberg, PV; Grem, JL; Kao, V; Nguyen, D | 1 |
| Chrest, J; Gabrielson, E; Lin, Y; Wersto, R; Zhou, W | 1 |
| Butler, J; Franklin, WA; Makeyev, Y; Vikram, B; Xiao, HH | 1 |
| Brown, JM; Giaccia, AJ; Kim, CY; Strulovici, B | 1 |
| Bradshaw, TD; Gescher, A; Pettit, GR | 1 |
| Bitonti, AJ; Dumont, JA; Jones, WD | 1 |
| Blood, CH; Zetter, BR | 1 |
3 review(s) available for staurosporine and Cancer of Lung
| Article | Year |
|---|---|
Cell cycle modulators for the treatment of lung malignancies.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cyclin-Dependent Kinases; Enzyme Inhibitors; Genes, Retinoblastoma; Humans; Lung Neoplasms; Phosphorylation; Protein Kinase C; Staurosporine; Tumor Cells, Cultured | 2003 |
New chemotherapeutic agents for the treatment of non-small cell lung cancer: the Japanese experience.
Topics: Alkaloids; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carbazoles; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Docetaxel; Glucosides; Humans; Irinotecan; Japan; Lung Neoplasms; Mitomycin; Mitomycins; Neoplasms, Experimental; Paclitaxel; Purine Nucleosides; Staurosporine; Taxoids; Treatment Outcome; Vinblastine; Vinorelbine | 1998 |
Protein kinase C as a drug target: implications for drug or diet prevention and treatment of cancer.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Drug Delivery Systems; Enzyme Inhibitors; Gastrointestinal Neoplasms; Humans; Isoenzymes; Lung Neoplasms; Neoplasm Proteins; Neoplasms; Oligonucleotides, Antisense; Protein Kinase C; Retinoids; Staurosporine; Tretinoin | 2000 |
1 trial(s) available for staurosporine and Cancer of Lung
| Article | Year |
|---|---|
Phase I study of PKC412 (N-benzoyl-staurosporine), a novel oral protein kinase C inhibitor, combined with gemcitabine and cisplatin in patients with non-small-cell lung cancer.
Topics: Administration, Oral; Adult; Aged; Angiogenesis Inhibitors; Antineoplastic Combined Chemotherapy Protocols; Asthenia; Carcinoma, Non-Small-Cell Lung; Cisplatin; Deoxycytidine; Diarrhea; Enzyme Inhibitors; Female; Gemcitabine; Humans; Infusions, Intravenous; Lung Neoplasms; Male; Maximum Tolerated Dose; Middle Aged; Protein Kinase C; Staurosporine | 2004 |
74 other study(ies) available for staurosporine and Cancer of Lung
| Article | Year |
|---|---|
Synthesis and biological evaluation of novel indolocarbazoles with anti-angiogenic activity.
Topics: Angiogenesis Inhibitors; Animals; Capillaries; Cell Line, Tumor; Cell Proliferation; Collagen; Drug Combinations; Humans; Laminin; Lung Neoplasms; Magnetic Resonance Spectroscopy; Mice; Molecular Structure; Neovascularization, Pathologic; Proteoglycans; Spectrophotometry, Infrared; Staurosporine | 2012 |
A novel prognostic signature of metastasis-associated genes and personalized therapeutic strategy for lung adenocarcinoma patients.
Topics: Adenocarcinoma of Lung; Humans; Lung Neoplasms; Multivariate Analysis; Prognosis; Reproducibility of Results; Staurosporine | 2022 |
A drug discovery platform to identify compounds that inhibit EGFR triple mutants.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Line; Cell Line, Tumor; DNA Nucleotidyltransferases; Drug Discovery; Drug Resistance, Neoplasm; ErbB Receptors; Genes, Reporter; High-Throughput Screening Assays; Humans; Luciferases; Lung Neoplasms; Mutation; Phosphorylation; Protein Kinase Inhibitors; Reproducibility of Results; Small Molecule Libraries; Staurosporine | 2020 |
Alpha1-antitrypsin protects lung cancer cells from staurosporine-induced apoptosis: the role of bacterial lipopolysaccharide.
Topics: alpha 1-Antitrypsin; Apoptosis; Autophagy; Cell Movement; Cell Proliferation; Cytokines; Drug Resistance, Neoplasm; Enzyme Inhibitors; Humans; Lipopolysaccharides; Lung Neoplasms; Protective Agents; Serine Proteinase Inhibitors; Staurosporine; Tumor Cells, Cultured | 2020 |
RCC2 over-expression in tumor cells alters apoptosis and drug sensitivity by regulating Rac1 activation.
Topics: Apoptosis; Biomarkers, Pharmacological; Chromosomal Proteins, Non-Histone; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Guanine Nucleotide Exchange Factors; HeLa Cells; Humans; Lung Neoplasms; Ovarian Neoplasms; rac1 GTP-Binding Protein; Staurosporine | 2018 |
Functional Proteomics and Deep Network Interrogation Reveal a Complex Mechanism of Action of Midostaurin in Lung Cancer Cells.
Topics: Aurora Kinase A; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Drug Discovery; Drug Synergism; Humans; Lung Neoplasms; Polo-Like Kinase 1; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proteomics; Proto-Oncogene Proteins; RNA Interference; Signal Transduction; Staurosporine | 2018 |
Staurosporine Induces the Generation of Polyploid Giant Cancer Cells in Non-Small-Cell Lung Carcinoma A549 Cells.
Topics: A549 Cells; Bromodeoxyuridine; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Cell Size; Giant Cells; Humans; Lung Neoplasms; Polyploidy; Staurosporine | 2018 |
A systematic profile of clinical inhibitors responsive to EGFR somatic amino acid mutations in lung cancer: implication for the molecular mechanism of drug resistance and sensitivity.
Topics: Amino Acid Sequence; Carcinoma, Non-Small-Cell Lung; Computer Simulation; Drug Resistance, Neoplasm; ErbB Receptors; Humans; Lung Neoplasms; Models, Molecular; Molecular Sequence Data; Mutation; Protein Kinase Inhibitors; Small Molecule Libraries; Staurosporine; Structure-Activity Relationship | 2014 |
TCDD promotes lung tumors via attenuation of apoptosis through activation of the Akt and ERK1/2 signaling pathways.
Topics: Animals; Apoptosis; Carcinogens, Environmental; Cell Line; Cell Proliferation; Cocarcinogenesis; Drug Synergism; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; MAP Kinase Signaling System; Mice; Nitrosamines; Polychlorinated Dibenzodioxins; Staurosporine | 2014 |
The ceramide kinase inhibitor NVP-231 inhibits breast and lung cancer cell proliferation by inducing M phase arrest and subsequent cell death.
Topics: Adenocarcinoma; Apoptosis; Benzothiazoles; Blotting, Western; Breast Neoplasms; Bridged-Ring Compounds; Cell Proliferation; Cell Survival; DNA; Enzyme Inhibitors; Flow Cytometry; Humans; Lung Neoplasms; M Phase Cell Cycle Checkpoints; MCF-7 Cells; Phosphotransferases (Alcohol Group Acceptor); Staurosporine; Tumor Stem Cell Assay | 2014 |
Quantification of cellular viability by automated microscopy and flow cytometry.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Benzimidazoles; Carbocyanines; Carcinoma, Non-Small-Cell Lung; Caspases; Cell Line, Tumor; Cell Membrane Permeability; Cell Survival; Connexins; Drug Synergism; Flow Cytometry; Fluorescent Dyes; High-Throughput Screening Assays; Humans; Indoles; Lung Neoplasms; Membrane Potential, Mitochondrial; Microscopy, Fluorescence; Nerve Tissue Proteins; Organoplatinum Compounds; Oxaliplatin; Robotics; Staining and Labeling; Staurosporine; Workflow | 2015 |
The DNA Methyltransferase DNMT1 and Tyrosine-Protein Kinase KIT Cooperatively Promote Resistance to 5-Aza-2'-deoxycytidine (Decitabine) and Midostaurin (PKC412) in Lung Cancer Cells.
Topics: Animals; Antigens, CD; Azacitidine; Cadherins; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Proto-Oncogene Proteins c-kit; Staurosporine | 2015 |
TIMP-1 Inhibits Apoptosis in Lung Adenocarcinoma Cells via Interaction with Bcl-2.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Apoptosis; bcl-2-Associated X Protein; Biomarkers, Tumor; Cell Line, Tumor; Down-Regulation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Intracellular Membranes; Lung Neoplasms; Mitochondria; Permeability; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Tissue Inhibitor of Metalloproteinase-1 | 2015 |
Integrated Exploitation of the Structural Diversity Space of Chemotherapy Drugs to Selectively Inhibit HER2 T798M Mutant in Lung Cancer.
Topics: Binding Sites; Carbazoles; Catalytic Domain; Furans; Humans; Kinetics; Ligands; Lung Neoplasms; Molecular Docking Simulation; Mutation; Protein Binding; Protein Kinase Inhibitors; Receptor, ErbB-2; Staurosporine; Thermodynamics | 2017 |
Staurosporine scaffold-based rational discovery of the wild-type sparing reversible inhibitors of EGFR T790M gatekeeper mutant in lung cancer with analog-sensitive kinase technology.
Topics: Computer Simulation; Drug Design; ErbB Receptors; Humans; Hydrophobic and Hydrophilic Interactions; Lung Neoplasms; Models, Molecular; Mutation; Protein Kinase Inhibitors; Staurosporine; Structure-Activity Relationship | 2017 |
Proteomic analysis of multidrug-resistance mechanisms in adriamycin-resistant variants of DLKP, a squamous lung cancer cell line.
Topics: Apoptosis; Blotting, Western; Carcinoma, Squamous Cell; Cell Line, Tumor; Doxorubicin; Drug Resistance, Neoplasm; Electrophoresis, Gel, Two-Dimensional; Humans; Lung Neoplasms; Neoplasm Invasiveness; Neoplasm Proteins; Prohibitins; Proteomics; Reactive Oxygen Species; Reproducibility of Results; Staurosporine | 2009 |
Effect of staurosporine on the mobility and invasiveness of lung adenocarcinoma A549 cells: an in vitro study.
Topics: Adenocarcinoma; Apoptosis; Cadherins; Cell Adhesion; Cell Growth Processes; Cell Line, Tumor; Cell Movement; Humans; Integrin beta1; Lung Neoplasms; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Protein Kinase C-alpha; Staurosporine; Urokinase-Type Plasminogen Activator | 2009 |
Randomized clinical trials with biomarkers: design issues.
Topics: Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Clinical Trials, Phase III as Topic; DNA-Binding Proteins; Endonucleases; Enzyme Activation; ErbB Receptors; Erlotinib Hydrochloride; fms-Like Tyrosine Kinase 3; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glutamates; Guanine; Humans; Leukemia, Myeloid, Acute; Lung Neoplasms; Mutation; Pemetrexed; Protein Kinase Inhibitors; Quinazolines; Randomized Controlled Trials as Topic; Research Design; Staurosporine | 2010 |
LPLI inhibits apoptosis upstream of Bax translocation via a GSK-3beta-inactivation mechanism.
Topics: Adenocarcinoma; Androstadienes; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Line, Tumor; Dose-Response Relationship, Radiation; Enzyme Activation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Lasers, Gas; Low-Level Light Therapy; Lung Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Binding; Protein Kinase Inhibitors; Protein Transport; Proto-Oncogene Proteins c-akt; RNA Interference; Signal Transduction; Staurosporine; Time Factors; Transfection; Wortmannin | 2010 |
Activation of volume-sensitive Cl(-) channel is involved in carboplatin-induced apoptosis in human lung adenocarcinoma cells.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenocarcinoma; Angiogenesis Inhibitors; Antineoplastic Agents; Apoptosis; Carboplatin; Cell Line, Tumor; Chloride Channels; Humans; Hypotonic Solutions; Lung Neoplasms; Membrane Potentials; Nitrobenzoates; Patch-Clamp Techniques; Staurosporine | 2010 |
A new player in apoptosis triggered with anticancer drugs: the volume-sensitive outwardly-rectifying Cl(-) channel.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenocarcinoma; Antineoplastic Agents; Apoptosis; Carboplatin; Cell Line, Tumor; Chloride Channels; Humans; Lung Neoplasms; Membrane Potentials; Models, Biological; Staurosporine | 2010 |
Staurosporine increases toxicity of gemcitabine in non-small cell lung cancer cells: role of protein kinase C, deoxycytidine kinase and ribonucleotide reductase.
Topics: Antimetabolites, Antineoplastic; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Deoxycytidine; Deoxycytidine Kinase; Drug Synergism; Enzyme Inhibitors; Gemcitabine; Humans; Lung Neoplasms; Protein Kinase C; Ribonucleotide Reductases; Staurosporine | 2010 |
Bioluminescence-based high-throughput screen identifies pharmacological agents that target neurotransmitter signaling in small cell lung carcinoma.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Cisplatin; Dopamine Agents; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating); HEK293 Cells; Humans; Luciferases; Luminescent Measurements; Lung Neoplasms; Mice; Neurotransmitter Agents; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Serotonin Agents; Signal Transduction; Small Cell Lung Carcinoma; Staurosporine; Time Factors | 2011 |
Carboxyl-terminal modulator protein induces apoptosis by regulating mitochondrial function in lung cancer cells.
Topics: Adaptor Proteins, Signal Transducing; Apoptosis; Apoptotic Protease-Activating Factor 1; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cytochromes c; Dactinomycin; GTP Phosphohydrolases; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Humans; Lung Neoplasms; Membrane Potential, Mitochondrial; Membrane Proteins; Mitochondria; Molecular Chaperones; RNA Interference; Signal Transduction; Staurosporine; Thiolester Hydrolases; Time Factors; Transfection | 2012 |
Individual dose and scheduling determine the efficacy of combining cytotoxic anticancer agents with a kinase inhibitor in non-small-cell lung cancer.
Topics: Antineoplastic Agents; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; bcl-X Protein; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Dactinomycin; Dose-Response Relationship, Drug; Doxorubicin; Drug Antagonism; Drug Synergism; Etoposide; Humans; Immunoblotting; Lung Neoplasms; Paclitaxel; Protein Kinase C; Signal Transduction; Staurosporine; Time Factors | 2012 |
Detecting the effect of targeted anti-cancer medicines on single cancer cells using a poly-silicon wire ion sensor integrated with a confined sensitive window.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Antineoplastic Agents; Apoptosis; Biosensing Techniques; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Delivery Systems; Gefitinib; Humans; Ions; Lung Neoplasms; Propylamines; Quinazolines; Silanes; Silicon; Single-Cell Analysis; Staurosporine | 2012 |
Euphorbia mauritanica and Kedrostis hirtella extracts can induce anti-proliferative activities in lung cancer cells.
Topics: Apoptosis; Carrier Proteins; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chromatography, Thin Layer; Chrysobalanaceae; Cyclin D1; DNA Fragmentation; DNA-Binding Proteins; Drug Screening Assays, Antitumor; Euphorbia; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Necrosis; Neoplasms, Squamous Cell; Plant Extracts; Staurosporine; Tumor Suppressor Protein p53; Ubiquitin-Protein Ligases | 2012 |
Noncovalent wild-type-sparing inhibitors of EGFR T790M.
Topics: Acrylamides; Amino Acid Substitution; Animals; Area Under Curve; Base Sequence; Carbazoles; Cell Line, Tumor; Drug Resistance, Neoplasm; ErbB Receptors; Erlotinib Hydrochloride; Humans; Immunoblotting; Lung; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Mice, Transgenic; Mutation; Protein Kinase Inhibitors; Pyrimidines; Quinazolines; RNA Interference; Staurosporine; Xenograft Model Antitumor Assays | 2013 |
Cell shape change precedes staurosporine-induced stabilization and accumulation of p27kip1.
Topics: Cell Cycle; Cell Cycle Proteins; Cell Size; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cycloheximide; Cysteine Endopeptidases; Cytochalasin D; Cytoskeleton; Diacetyl; Enzyme Inhibitors; Female; Flow Cytometry; Humans; Lung Neoplasms; Microscopy, Confocal; Multienzyme Complexes; Nucleic Acid Synthesis Inhibitors; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Staurosporine; Tumor Cells, Cultured; Tumor Suppressor Proteins; Uterine Cervical Neoplasms | 2002 |
Effect of PKC412, a selective inhibitor of protein kinase C, on lung metastasis in mice injected with B16 melanoma cells.
Topics: Animals; Cell Division; Enzyme Inhibitors; Female; Lung Neoplasms; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neoplasm Invasiveness; Neoplasm Transplantation; Platelet Aggregation; Protein Kinase C; Rabbits; Staurosporine; Tumor Cells, Cultured | 2003 |
Cell cycle-dependent potentiation of cisplatin by UCN-01 in non-small-cell lung carcinoma.
Topics: Alkaloids; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Cycle Proteins; Cisplatin; Drug Synergism; Humans; Lung Neoplasms; Phosphorylation; Staurosporine; Tumor Cells, Cultured | 2003 |
Methioninase gene therapy with selenomethionine induces apoptosis in bcl-2-overproducing lung cancer cells.
Topics: Apoptosis; Bisbenzimidazole; Blotting, Western; Carbon-Sulfur Lyases; Cell Line, Tumor; Cell Nucleus; Cell Survival; Coloring Agents; Cytochromes c; Cytosol; DNA Fragmentation; Enzyme-Linked Immunosorbent Assay; Genetic Therapy; Humans; Lung Neoplasms; Mitochondria; Models, Biological; Oxidants; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Pseudomonas putida; Selenomethionine; Staurosporine; Tetrazolium Salts; Thiazoles; Transfection | 2003 |
Adenoviral melanoma differentiation-associated gene 7 induces apoptosis in lung cancer cells through mitochondrial permeability transition-independent cytochrome c release.
Topics: Adenoviridae; Apoptosis; Caspases; Cyclosporine; Cytochrome c Group; Enzyme Activation; Gene Transfer Techniques; Genes, p53; Genes, Tumor Suppressor; Humans; Interleukins; Lung Neoplasms; Membrane Potentials; Mitochondria; Staurosporine; Transduction, Genetic; Tumor Cells, Cultured | 2003 |
Inhibition of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase enhances chemotherapeutic effects on H460 human non-small cell lung cancer cells through activation of apoptosis.
Topics: Antineoplastic Agents; Apoptosis; bcl-X Protein; Butadienes; Carcinoma, Non-Small-Cell Lung; Caspases; Doxorubicin; Drug Synergism; Drug Therapy, Combination; Enzyme Activation; Enzyme Inhibitors; Humans; JNK Mitogen-Activated Protein Kinases; Lung Neoplasms; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nitriles; Paclitaxel; Phosphorylation; Poly(ADP-ribose) Polymerases; Protein Kinase C; Proteins; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Staurosporine; Tumor Cells, Cultured; X-Linked Inhibitor of Apoptosis Protein | 2003 |
Identification of novel gene expression targets for the Ras association domain family 1 (RASSF1A) tumor suppressor gene in non-small cell lung cancer and neuroblastoma.
Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Cyclin D1; Down-Regulation; G1 Phase; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Lung Neoplasms; Neoplasm Proteins; Neuroblastoma; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; Staurosporine; Transfection; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2003 |
Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone promotes functional cooperation of Bcl2 and c-Myc through phosphorylation in regulating cell survival and proliferation.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Antineoplastic Agents; Apoptosis; Bungarotoxins; Carcinogens; Carcinoma, Small Cell; Cell Division; Cell Line, Tumor; Cell Nucleus; Cell Survival; Cisplatin; Enzyme Inhibitors; Flavonoids; Humans; Lung Neoplasms; Mitochondria; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitrosamines; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Receptors, Nicotinic; RNA, Small Interfering; Signal Transduction; Staurosporine | 2004 |
In vitro combination treatment with perifosine and UCN-01 demonstrates synergism against prostate (PC-3) and lung (A549) epithelial adenocarcinoma cell lines.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Bromodeoxyuridine; Cell Cycle; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Female; Humans; Immunoblotting; Lung Neoplasms; Male; Phosphorylcholine; Prostatic Neoplasms; Signal Transduction; Staurosporine; Time Factors | 2004 |
Enhancement of radiation cytotoxicity by UCN-01 in non-small cell lung carcinoma cells.
Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; G2 Phase; Humans; Lung Neoplasms; Protein Kinase Inhibitors; Staurosporine; Tumor Suppressor Protein p53 | 2004 |
[Abrogation effect of UCN-01 on radiation-induced G2 phase arrest of tumor cells and its mechanism].
Topics: Adenocarcinoma; Antineoplastic Agents; CDC2 Protein Kinase; Cell Line, Tumor; G2 Phase; Genes, p53; Humans; Lung Neoplasms; Mutation; Nasopharyngeal Neoplasms; Particle Accelerators; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Staurosporine | 2005 |
Cooperation of amphiregulin and insulin-like growth factor-1 inhibits Bax- and Bad-mediated apoptosis via a protein kinase C-dependent pathway in non-small cell lung cancer cells.
Topics: Amphiregulin; Androstadienes; Apoptosis; bcl-2-Associated X Protein; bcl-Associated Death Protein; Carcinoma, Non-Small-Cell Lung; Carrier Proteins; Cell Line, Tumor; Culture Media, Serum-Free; EGF Family of Proteins; Enzyme Inhibitors; Flavonoids; Glycoproteins; Humans; Insulin-Like Growth Factor I; Intercellular Signaling Peptides and Proteins; Isoenzymes; Lung Neoplasms; MAP Kinase Signaling System; Models, Biological; Naphthalenes; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Staurosporine; Wortmannin | 2005 |
PKC 412 sensitizes U1810 non-small cell lung cancer cells to DNA damage.
Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; DNA Damage; DNA, Neoplasm; Enzyme Inhibitors; Humans; Intracellular Membranes; Kinetics; Lung Neoplasms; Membrane Potentials; Mitochondria; Protein Kinase Inhibitors; Staurosporine | 2005 |
Role of protein kinase C in expression of granulocyte-colony stimulating factor and granulocyte macrophage-colony stimulating factor in lung cancer cells.
Topics: Apoptosis; Enzyme Activation; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Isoenzymes; Lung Neoplasms; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NF-kappa B; Protein Kinase C; Protein Kinase Inhibitors; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2005 |
Inhibitors of the PI3-kinase/Akt pathway induce mitotic catastrophe in non-small cell lung cancer cells.
Topics: Androstadienes; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Survival; Chromones; Enzyme Inhibitors; Etoposide; Flavonoids; Flow Cytometry; Humans; Indoles; Lung Neoplasms; MAP Kinase Kinase Kinases; Mitosis; Morpholines; Nocodazole; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; Staurosporine; Wortmannin | 2006 |
Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity.
Topics: Antineoplastic Agents; Binding Sites; Carcinoma, Non-Small-Cell Lung; Crystallography, X-Ray; Enzyme Activation; ErbB Receptors; Gefitinib; Humans; Lapatinib; Lung Neoplasms; Models, Molecular; Mutation; Protein Conformation; Protein Structure, Tertiary; Purines; Quinazolines; Staurosporine | 2007 |
Increased inducible nitric oxide synthase in lung carcinoma of smokers.
Topics: Adult; Aged; Aged, 80 and over; Caspase 3; Female; Humans; Lung Neoplasms; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrosamines; S-Nitroso-N-Acetylpenicillamine; Smoking; Staurosporine | 2008 |
Novel endothelial cell activation factor(s) released from activated platelets which induce E-selectin expression and tumor cell adhesion to endothelial cells: a preliminary note.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Biological Factors; Cell Adhesion; Cell Adhesion Molecules; Cell Communication; Cells, Cultured; Colonic Neoplasms; E-Selectin; Endothelium, Vascular; Humans; Intercellular Adhesion Molecule-1; Isoquinolines; Kinetics; Lung Neoplasms; Melanoma, Experimental; Mice; Models, Biological; Naphthalenes; Neoplasms; Piperazines; Platelet Activation; Platelet Aggregation; Polycyclic Compounds; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Stomach Neoplasms; Tumor Cells, Cultured; Umbilical Veins | 1994 |
Comparison of ability of protein kinase C inhibitors to arrest cell growth and to alter cellular protein kinase C localisation.
Topics: Alkaloids; Antineoplastic Agents; Breast Neoplasms; Cell Division; Cell Line; Dose-Response Relationship, Drug; Humans; Isoenzymes; Lung Neoplasms; Protein Kinase C; Staurosporine; Structure-Activity Relationship; Tumor Cells, Cultured | 1995 |
Genistein modulates the decreased drug accumulation in non-P-glycoprotein mediated multidrug resistant tumour cells.
Topics: Alkaloids; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Carrier Proteins; Daunorubicin; Doxorubicin; Drug Resistance; Etoposide; Genistein; Humans; Hydrogen-Ion Concentration; Isoflavones; Lung Neoplasms; Membrane Glycoproteins; Neoplasms; Protein-Tyrosine Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Protein kinase C is not involved in the homologous desensitization of bombesin responses in small cell lung cancer cells.
Topics: Alkaloids; Bombesin; Calcium; Carcinoma, Small Cell; Down-Regulation; Enzyme Activation; Humans; In Vitro Techniques; Lung Neoplasms; Protein Kinase C; Staurosporine; Tumor Cells, Cultured | 1993 |
Activation of potassium channels by hypoxia and reoxygenation in the human lung adenocarcinoma cell line A549.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcysteine; Adenocarcinoma; Alkaloids; Free Radical Scavengers; Humans; Hypoxia; Isoquinolines; Lung Neoplasms; Oxidation-Reduction; Oxygen; Piperazines; Potassium Channels; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Tetraethylammonium; Tetraethylammonium Compounds; Time Factors; Tumor Cells, Cultured | 1993 |
Tamoxifen antagonizes proliferation and invasion of estrogen receptor-negative metastatic follicular thyroid cancer cells via protein kinase C.
Topics: Alkaloids; Antineoplastic Agents, Hormonal; Cell Division; Drug Interactions; Enzyme Inhibitors; Estrogen Antagonists; Humans; Lung Neoplasms; Neoplasm Invasiveness; Protein Kinase C; Receptors, Estrogen; Staurosporine; Tamoxifen; Tetradecanoylphorbol Acetate; Thyroid Neoplasms; Tumor Cells, Cultured | 1996 |
UCN-01, 7-hydroxyl-staurosporine, inhibits kinase activity of cyclin-dependent kinases and reduces the phosphorylation of the retinoblastoma susceptibility gene product in A549 human lung cancer cell line.
Topics: Alkaloids; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle; Cell Line; Cyclin-Dependent Kinases; DNA, Neoplasm; Enzyme Inhibitors; Histones; Humans; Lung Neoplasms; Phosphorylation; Protein Kinase C; Retinoblastoma Protein; Staurosporine; Tumor Cells, Cultured | 1996 |
Effects of the new selective protein kinase C inhibitor 4'-N-benzoyl staurosporine on cell cycle distribution and growth inhibition in human small cell lung cancer cells.
Topics: Animals; Apoptosis; Carcinoma, Small Cell; Cell Cycle; Cell Division; DNA, Neoplasm; Enzyme Inhibitors; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Protein Kinase C; Rats; Staurosporine; Transplantation, Heterologous | 1996 |
Antitumor effect of CGP41251, a new selective protein kinase C inhibitor, on human non-small cell lung cancer cells.
Topics: Adenocarcinoma; Analysis of Variance; Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cell Cycle; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Lung Neoplasms; Male; Mice; Mice, Nude; Neoplasm Transplantation; Protein Kinase C; Staurosporine; Tumor Cells, Cultured | 1996 |
Differential effects of staurosporine analogues on cell cycle, growth and viability in A549 cells.
Topics: Adenocarcinoma; Antineoplastic Agents; Cell Cycle; Cell Division; Cell Survival; DNA, Neoplasm; Enzyme Inhibitors; Humans; Lung Neoplasms; Staurosporine; Time Factors; Tumor Cells, Cultured | 1996 |
Induction of fibroblast gelatinase B expression by direct contact with cell lines derived from primary tumor but not from metastases.
Topics: Animals; Antibodies, Monoclonal; Carcinoma; Cell Communication; Cells, Cultured; Coculture Techniques; Collagenases; Colonic Neoplasms; Connective Tissue; Connective Tissue Cells; Cytochalasin D; Cytoskeleton; Dexamethasone; Enzyme Induction; Enzyme Inhibitors; Extracellular Matrix Proteins; Fibroblasts; Genistein; Humans; Integrin beta1; Isoflavones; Keratinocytes; Liver Neoplasms; Lung Neoplasms; Matrix Metalloproteinase 9; Mice; Mice, Nude; Neoplasm Metastasis; Protein Kinase C; Staurosporine; Transcription Factor AP-1; Tumor Cells, Cultured | 1996 |
Characterisation of novel human lung carcinoma cell lines selected for resistance to anti-neoplastic analogues of staurosporine.
Topics: Adenocarcinoma; Alkaloids; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Cell Division; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Inhibitors; Humans; Indoles; Lung Neoplasms; Multidrug Resistance-Associated Proteins; Protein Kinase C; Staurosporine; Tumor Cells, Cultured | 1997 |
Keratinocyte growth factor promotes alveolar epithelial cell DNA repair after H2O2 exposure.
Topics: Animals; Aphidicolin; Cell Death; Cycloheximide; Dactinomycin; DNA Damage; DNA Repair; Enzyme Inhibitors; Fibroblast Growth Factor 10; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Genistein; Growth Substances; Humans; Hydrogen Peroxide; Kinetics; Lung Neoplasms; Naphthalenes; Protein Kinase C; Protein-Tyrosine Kinases; Pulmonary Alveoli; Rats; Staurosporine; Tumor Cells, Cultured | 1998 |
High-throughput assay for G2 checkpoint inhibitors and identification of the structurally novel compound isogranulatimide.
Topics: Adenocarcinoma; Animals; Breast Neoplasms; DNA Repair; G2 Phase; Genes, p53; Humans; Imidazoles; Indoles; Lung Neoplasms; Radiation-Sensitizing Agents; Staurosporine; Succinimides; Tumor Cells, Cultured | 1998 |
Decrease in susceptibility toward induction of apoptosis and alteration in G1 checkpoint function as determinants of resistance of human lung cancer cells against the antisignaling drug UCN-01 (7-Hydroxystaurosporine).
Topics: Alkaloids; Antineoplastic Agents; Apoptosis; CDC2-CDC28 Kinases; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Drug Resistance, Neoplasm; G1 Phase; Humans; Lung Neoplasms; Paclitaxel; Protein Serine-Threonine Kinases; Staurosporine; Tumor Cells, Cultured | 1999 |
Cell cycle checkpoint abrogator UCN-01 inhibits DNA repair: association with attenuation of the interaction of XPA and ERCC1 nucleotide excision repair proteins.
Topics: Alkaloids; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Cycle; DNA Repair; DNA Replication; DNA-Binding Proteins; Endonucleases; Gene Expression Regulation, Neoplastic; Humans; Kinetics; Lung Neoplasms; Proteins; Staurosporine; Tumor Cells, Cultured; Xeroderma Pigmentosum; Xeroderma Pigmentosum Group A Protein | 1999 |
RB status as a determinant of response to UCN-01 in non-small cell lung carcinoma.
Topics: Alkaloids; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cyclin-Dependent Kinase Inhibitor p16; Enzyme Inhibitors; G1 Phase; Genes, p53; Genes, Retinoblastoma; Growth Inhibitors; Humans; Lung Neoplasms; Phosphorylation; Retinoblastoma Protein; Staurosporine; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1999 |
Molecular determinants of UCN-01-induced growth inhibition in human lung cancer cells.
Topics: Alkaloids; Antineoplastic Agents; CDC2-CDC28 Kinases; Cell Cycle; Cell Division; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Lung Neoplasms; Protein Serine-Threonine Kinases; Retinoblastoma Protein; Staurosporine; Tumor Cells, Cultured | 2000 |
A computational model for quantitative analysis of cell cycle arrest and its contribution to overall growth inhibition by anticancer agents.
Topics: Alkaloids; Antineoplastic Agents; Cell Cycle; Cell Division; Computer Simulation; HL-60 Cells; Humans; Jurkat Cells; Kinetics; Lung Neoplasms; Models, Biological; Probability; Reproducibility of Results; Software; Staurosporine | 2000 |
[An experimental study on the capability of laminin receptor antibody and protein kinase C inhibitor to inhibit tumor metastasis in vivo].
Topics: Animals; Female; Fibrosarcoma; Laminin; Lung Neoplasms; Male; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Protein Kinase C; Random Allocation; Receptors, Laminin; Staurosporine; Tumor Cells, Cultured | 1998 |
Propranolol increases phosphatidic acid level via activation of phospholipase D.
Topics: Enzyme Activation; Humans; Lung Neoplasms; Phosphatidic Acids; Phospholipase D; Propranolol; Protein Kinase C; Staurosporine; Tumor Cells, Cultured | 2001 |
Mitochondrial dysfunction is an essential step for killing of non-small cell lung carcinomas resistant to conventional treatment.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Apoptosis Inducing Factor; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Caspase 3; Caspase 7; Caspases; Cell Cycle; Cell Nucleus; Cysteine Proteinase Inhibitors; Cytochrome c Group; Drug Resistance, Neoplasm; Enzyme Activation; Enzyme Inhibitors; Enzyme Precursors; Flavoproteins; Gamma Rays; Humans; Jurkat Cells; Lung Neoplasms; Membrane Potentials; Membrane Proteins; Mitochondria; Poly(ADP-ribose) Polymerases; Protein Transport; Radiation Tolerance; Reactive Oxygen Species; Recombinant Fusion Proteins; Staurosporine; Superoxides; Tumor Cells, Cultured | 2002 |
Biochemical and molecular effects of UCN-01 in combination with 5-fluorodeoxyuridine in A431 human epidermoid cancer cells.
Topics: Alkaloids; Antimetabolites, Antineoplastic; Carcinoma, Squamous Cell; Cell Cycle; Cell Survival; Deoxyribonucleotides; DNA Damage; DNA Fragmentation; DNA, Neoplasm; Drug Combinations; Enzyme Inhibitors; Floxuridine; Genes, p53; Humans; Lung Neoplasms; Polymerase Chain Reaction; RNA, Messenger; Staurosporine; Thymidylate Synthase; Tumor Cells, Cultured | 2002 |
Staurosporine-induced G(1) arrest in cancer cells depends on an intact pRB but is independent of p16 status.
Topics: Adenocarcinoma; Breast Neoplasms; Cell Line; Cyclin-Dependent Kinase Inhibitor p16; DNA Replication; Enzyme Inhibitors; Female; G1 Phase; Humans; Kinetics; Lung Neoplasms; Retinoblastoma Protein; Staurosporine; Tumor Cells, Cultured | 2002 |
7-Hydroxystaurosporine (UCN-01) preferentially sensitizes cells with a disrupted TP53 to gamma radiation in lung cancer cell lines.
Topics: Adenocarcinoma; Alkaloids; Flow Cytometry; G2 Phase; Gamma Rays; Humans; Lung Neoplasms; Mutation; Radiation-Sensitizing Agents; Staurosporine; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2002 |
Differential expression of protein kinase C epsilon protein in lung cancer cell lines by ionising radiation.
Topics: Adenocarcinoma; Alkaloids; Animals; Carcinoma, Small Cell; Cell Survival; Cricetinae; DNA Damage; DNA Repair; DNA, Neoplasm; Enzyme Induction; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Isoenzymes; Kinetics; Lung Neoplasms; Mesocricetus; Neoplasm Proteins; Protein Biosynthesis; Protein Kinase C; RNA, Neoplasm; Staurosporine; Transcription, Genetic; Transcriptional Activation; Tumor Cells, Cultured | 1992 |
Modulation by staurosporine of phorbol-ester-induced effects on growth and protein kinase C localization in A549 human lung-carcinoma cells.
Topics: Alkaloids; Bryostatins; Cell Division; DNA; Down-Regulation; Enzyme Activation; Humans; Lactones; Lung Neoplasms; Macrolides; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Inhibition of experimental metastasis and cell adhesion of B16F1 melanoma cells by inhibitors of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Adhesion; Isoquinolines; Lung Neoplasms; Melanoma, Experimental; Membrane Proteins; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Oxazoles; Oxazolone; Phosphorylation; Piperazines; Protein Kinase C; Pyridines; Staurosporine; Time Factors | 1992 |
Membrane-bound protein kinase C modulates receptor affinity and chemotactic responsiveness of Lewis lung carcinoma sublines to an elastin-derived peptide.
Topics: Alkaloids; Amino Acid Sequence; Animals; Cell Line; Cell Membrane; Chemotaxis; Kinetics; Lung Neoplasms; Mice; Mice, Inbred C57BL; Oligopeptides; Protein Kinase C; Receptors, Cell Surface; Staurosporine; Tetradecanoylphorbol Acetate | 1989 |