staurosporine has been researched along with Cancer of Colon in 51 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 16 (31.37) | 18.2507 |
| 2000's | 22 (43.14) | 29.6817 |
| 2010's | 13 (25.49) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aravena, Mde L; Bruno, AM; Cabrera, M; Cascante, M; Cerecetto, H; González, M; Lavaggi, ML; López de Ceráin, A; Monge, A; Olea-Azar, C; Pachón, G; Pietrasanta, LI | 1 |
| Ahmad, I; Chhikara, BS; Kumar, A; Mandal, D; Parang, K; Tiwari, R | 1 |
| Alsamman, K; El-Masry, OS | 1 |
| Balasse, L; Franceschini, E; Guillermin, R; Guillet, B; Muleki-Seya, P; Payan, C; Roffino, S | 1 |
| Jain, A; Jain, R; Jain, S; Khatik, R; Veer Kohli, D | 1 |
| Gremida, A; McCarthy, D; Mir, F | 1 |
| Sturla, SJ; van Midwoud, PM | 1 |
| Atilla-Gokcumen, GE; Brais, CJ; del Solar, V; Hurst, JJ; Li, N; Lizardo, DY | 1 |
| Bianchi, G; Bongioanni, F; Bottoni, G; Bruzzi, P; Buschiazzo, A; Capitanio, S; Emionite, L; Fabbi, M; Garaboldi, L; Inglese, E; Marini, C; Martella, R; Monteverde, E; Orengo, AM; Petretto, A; Raffaghello, L; Ravera, S; Sambuceti, G | 1 |
| Bradford, CS; Dashwood, RH; Dashwood, WM; Fischer, KA; Ho, E; Johnson, G; Kang, Y; Löhr, CV; Wang, R; Williams, DE | 1 |
| Cartwright, CA; Mamidipudi, V | 1 |
| Bartek, J; Hasvold, G; Lukas, J; Petersen, L; Syljuåsen, RG | 1 |
| Aquino, A; Balduzzi, A; Bonmassar, E; Bonmassar, L; Caporaso, P; Cappelletti, D; Cardillo, A; Concolino, F; D'Atri, S; De Vecchis, L; Formica, V; Fossile, E; Graziani, G; Greiner, JW; Prete, SP; Roselli, M; Scoppola, A; Torino, F | 1 |
| Cuezva, JM; Formentini, L; Sánchez-Aragó, M; Sánchez-Cenizo, L | 1 |
| Aquino, A; Balduzzi, A; Bonmassar, E; Bonmassar, L; Concolino, F; Formica, V; Fossile, E; Graziani, G; Prete, SP | 1 |
| Bozko, P; Larsen, AK; Raymond, E; Skladanowski, A | 1 |
| Ho, YS; Lee, WS; Liang, YC; Lin, SY; Pan, S; Tsai, SH | 1 |
| Kohn, KW; La Rose, J; Pommier, Y; Takemura, H; Yu, Q; Zhang, H | 1 |
| Gallick, GE; Kraker, AJ; McConkey, DJ; Parikh, NU; Siwak, DR; Summy, JM; Windham, TC | 1 |
| Chan, UP; Chen, GG; Lee, JF; Leung, KL; Wang, SH | 1 |
| Casares, N; Droin, N; Fromentin, A; Garrido, C; Ghiringhelli, F; Gurbuxani, S; Hamai, A; Hammann, A; Kroemer, G; Moutet, M; Parcellier, A; Pequignot, M; Schmitt, E; Solary, E | 1 |
| Schwartz, GK; Tse, AN | 1 |
| Bhonde, MR; Daniel, PT; Hanski, C; Hanski, ML; Kohno, K; Magrini, R; Moorthy, D; Müller, A; Sausville, EA; Wiegand, P; Zeitz, M | 1 |
| Aquino, A; Baier, S; Bonmassar, E; Correale, PP; De Vecchis, L; Prete, SP; Rossi, L; Tamburrelli, G; Turriziani, M | 1 |
| Mello-Aires, M; Musa-Aziz, R; Oliveira-Souza, M | 1 |
| Brown, S; Chen, EX; Dancey, JE; Hirte, HW; Hotte, SJ; Moore, M; Oza, A; Pond, GR; Winquist, EW | 1 |
| Aladjem, MI; Aune, GJ; Bonner, WM; Furuta, T; Hayward, RL; Kohn, KW; Meng, LH; Pommier, Y; Takemura, H | 1 |
| Braun, T; Carvalho, G; Castedo, M; Coquelle, A; Kroemer, G; Métivier, D; Mouhamad, S; Pequignot, MO; Vivet, S | 1 |
| Gajkowska, B; Orzechowski, A; Pajak, B; Turowska, A | 1 |
| Hakomori, S | 1 |
| Comstock, L; Ding, X; Donelli, G; Fasano, A; Fiorentini, C; Goldblum, SE; Guandalini, S; Kaper, JB; Margaretten, K; Uzzau, S | 1 |
| Erdos, G; Lee, YJ | 1 |
| Brandsch, M; Ganapathy, V; Leibach, FH; Miyamoto, Y | 1 |
| Easom, RA; Riehl, TE; Stenson, WF; Turk, J | 1 |
| Forstner, G; Forstner, J; McCool, D; Zhang, Y | 1 |
| Erdos, G; Kim, JH; Kim, SH; Lee, YJ | 1 |
| Eastman, A; Fan, S; O'Connor, PM; Sausville, EA; Wang, Q; Worland, PJ | 1 |
| Guzman, J; Koutsos, M; Kozoni, V; Qiao, L; Rigas, B; Shiff, SJ; Tsai, LL | 1 |
| Grégoire, M; Harb, J; Meflah, K; Menanteau, J; Segain, JP | 1 |
| Pommier, Y; Shao, RG; Shimizu, T | 1 |
| Gschwendt, M; Kittstein, W; Krammer, PH; Möller, P; Sträter, J; von Reyher, U | 1 |
| André, F; Dagorn, JC; Farnarier, C; Iovanna, JL; Lissitzky, JC; Mallo, GV; Marvaldi, J; Soubeyran, P | 1 |
| Chiang, HS; Huang, TF; Lin, SW; Yang, RS | 1 |
| Antinore, MJ; Carrier, F; Fornace, AJ; Harris, CC; Smith, ML; Wang, XW; Zhan, Q | 1 |
| Aquino, A; Baier, S; Bonmassar, E; Cappelletti, D; De Vecchis, L; Graziani, G; Greiner, JW; Prete, SP | 1 |
| Chambers, TC; Drake, RR; Jones, KE; McMasters, RA; Moyer, MP; Pitlyk, K; Saylors, RL; Wilbert, TN | 1 |
| Augenlicht, LH; Heerdt, BG; Houston, MA; Mariadason, JM | 1 |
| Beauchemin, N; Fournès, B; Létourneau, S; Sadekova, S; Turbide, C | 1 |
| Birg, F; Devilard, E; Jarry, A; Palmerini, F; Xerri, L | 1 |
| Chinnadurai, G; Lomonosova, E; Theodorakis, P | 1 |
| Chadee, K; Keller, K; Olivier, M | 1 |
1 trial(s) available for staurosporine and Cancer of Colon
| Article | Year |
|---|---|
Phase I trial of UCN-01 in combination with topotecan in patients with advanced solid cancers: a Princess Margaret Hospital Phase II Consortium study.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Dose-Response Relationship, Drug; Female; Humans; Infusions, Intravenous; Leukopenia; Male; Middle Aged; Neutropenia; Ovarian Neoplasms; Salivary Gland Neoplasms; Staurosporine; Survival Analysis; Topotecan | 2006 |
50 other study(ies) available for staurosporine and Cancer of Colon
| Article | Year |
|---|---|
Study of benzo[a]phenazine 7,12-dioxide as selective hypoxic cytotoxin-scaffold. Identification of aerobic-antitumoral activity through DNA fragmentation.
Topics: Animals; Antineoplastic Agents; Caco-2 Cells; Cell Hypoxia; Cell Line; Colonic Neoplasms; Cricetinae; DNA Damage; DNA Fragmentation; Humans; Phenazines | 2010 |
Synthesis of 3-phenylpyrazolopyrimidine-1,2,3-triazole conjugates and evaluation of their Src kinase inhibitory and anticancer activities.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Female; Humans; Inhibitory Concentration 50; Models, Molecular; Molecular Structure; Ovarian Neoplasms; Pyrans; Pyrimidines; src-Family Kinases; Triazoles | 2011 |
Staurosporine alleviates cisplatin chemoresistance in human cancer cell models by suppressing the induction of SQSTM1/p62.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Biomarkers, Tumor; Breast Neoplasms; Cell Proliferation; Cisplatin; Colonic Neoplasms; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; Ovarian Neoplasms; Sequestosome-1 Protein; Staurosporine; Tumor Cells, Cultured | 2018 |
Nonlinear ultrasound parameter to monitor cell death in cancer cell samples.
Topics: Adenocarcinoma; Algorithms; Apoptosis; Colonic Neoplasms; Enzyme Inhibitors; Flow Cytometry; HT29 Cells; Humans; Monitoring, Physiologic; Nonlinear Dynamics; Staurosporine; Ultrasonography | 2018 |
Minicapsules encapsulating nanoparticles for targeting, apoptosis induction and treatment of colon cancer.
Topics: Animals; Apoptosis; Capsules; Caspase 3; Cell Line, Tumor; Cell Survival; Chitosan; Colonic Neoplasms; DNA Fragmentation; Folic Acid; Mice; Mice, Inbred C57BL; Nanoparticles; Staurosporine; Xenograft Model Antitumor Assays | 2019 |
A Granular Approach to a Patient with Diarrhea and Flushing.
Topics: Antineoplastic Agents; Cell Degranulation; Colonic Neoplasms; Diarrhea; Flushing; Histamine H1 Antagonists; Histamine H2 Antagonists; Humans; Mast Cells; Mastocytosis, Systemic; Middle Aged; Protein Kinase Inhibitors; Staurosporine; Treatment Outcome | 2019 |
Improved efficacy of acylfulvene in colon cancer cells when combined with a nuclear excision repair inhibitor.
Topics: Antineoplastic Agents, Alkylating; Cell Survival; Chromatography, High Pressure Liquid; Colonic Neoplasms; DNA Adducts; DNA Repair; DNA Repair Enzymes; Drug Synergism; HT29 Cells; Humans; Sesquiterpenes; Spectrometry, Mass, Electrospray Ionization; Spiro Compounds; Staurosporine | 2013 |
Differential Regulation of Specific Sphingolipids in Colon Cancer Cells during Staurosporine-Induced Apoptosis.
Topics: Apoptosis; Cell Survival; Colonic Neoplasms; HCT116 Cells; Humans; Mass Spectrometry; Molecular Structure; Polymerase Chain Reaction; Sphingolipids; Staurosporine | 2015 |
Divergent targets of glycolysis and oxidative phosphorylation result in additive effects of metformin and starvation in colon and breast cancer.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Energy Metabolism; Female; Fluorescent Antibody Technique; Glucose; Glycolysis; Humans; Metformin; Mice, Inbred BALB C; Models, Biological; Oxidative Phosphorylation; Reactive Oxygen Species; Staurosporine | 2016 |
Reciprocal regulation of BMF and BIRC5 (Survivin) linked to Eomes overexpression in colorectal cancer.
Topics: Adaptor Proteins, Signal Transducing; Adenocarcinoma; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; G2 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; Inhibitor of Apoptosis Proteins; Kaplan-Meier Estimate; Male; Microtubule-Associated Proteins; Neoplasm Staging; Rats, Inbred F344; RNA Interference; Signal Transduction; Staurosporine; Survival Analysis; Survivin; T-Box Domain Proteins; Time Factors; Transfection; Up-Regulation | 2016 |
A novel pro-apoptotic function of RACK1: suppression of Src activity in the intrinsic and Akt pathways.
Topics: Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Bcl-2-Like Protein 11; bcl-X Protein; Caspases; Cell Survival; Colonic Neoplasms; Cytochromes c; G1 Phase; GTP-Binding Proteins; HT29 Cells; Humans; Membrane Proteins; Mitochondria; Neoplasm Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Receptors for Activated C Kinase; Receptors, Cell Surface; Signal Transduction; src-Family Kinases; Staurosporine | 2009 |
p53-dependent G(1) arrest in 1st or 2nd cell cycle may protect human cancer cells from cell death after treatment with ionizing radiation and Chk1 inhibitors.
Topics: Cell Cycle; Cell Death; Cell Survival; Checkpoint Kinase 1; Colonic Neoplasms; Genes, p53; HCT116 Cells; Humans; Neoplasms; Nervous System Neoplasms; Protein Kinases; Radiation, Ionizing; Staurosporine; Tumor Suppressor Protein p53 | 2010 |
Detection of circulating tumor cells is improved by drug-induced antigen up-regulation: preclinical and clinical studies.
Topics: Aged; Aged, 80 and over; Animals; Antibodies, Monoclonal; Antimetabolites, Antineoplastic; Biomarkers, Tumor; Carcinoembryonic Antigen; Cell Line, Tumor; Colonic Neoplasms; Enzyme Inhibitors; Female; Fluorouracil; Humans; Immunoblotting; Immunomagnetic Separation; Keratin-19; Male; Mice; Middle Aged; Neoplasm Metastasis; Neoplastic Cells, Circulating; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Staurosporine; Up-Regulation | 2010 |
The mitochondrial ATPase inhibitory factor 1 triggers a ROS-mediated retrograde prosurvival and proliferative response.
Topics: ATPase Inhibitory Protein; bcl-X Protein; Cell Death; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colonic Neoplasms; Energy Metabolism; Fluorouracil; HeLa Cells; Humans; I-kappa B Proteins; Mitochondria; NF-kappa B; NF-KappaB Inhibitor alpha; Proteins; Reactive Oxygen Species; Signal Transduction; Staurosporine | 2012 |
Treatment of peripheral blood with staurosporine increases detection of circulating carcinoembryonic antigen positive tumor cells.
Topics: Antibodies, Monoclonal; Blood; Carcinoembryonic Antigen; Colonic Neoplasms; Enzyme Inhibitors; Humans; Immunomagnetic Separation; Protein Kinase C; Reverse Transcriptase Polymerase Chain Reaction; Sensitivity and Specificity; Staurosporine; Tumor Cells, Cultured | 2002 |
Influence of G2 arrest on the cytotoxicity of DNA topoisomerase inhibitors toward human carcinoma cells with different p53 status.
Topics: Alkaloids; Antineoplastic Agents; Apoptosis; Camptothecin; Carcinoma; Cell Cycle; Colonic Neoplasms; Etoposide; Humans; Staurosporine; Topoisomerase Inhibitors; Tumor Suppressor Protein p53 | 2002 |
Involvement of both extracellular signal-regulated kinase and c-jun N-terminal kinase pathways in the 12-O-tetradecanoylphorbol-13-acetate-induced upregulation of p21(Cip1) in colon cancer cells.
Topics: Adenocarcinoma; CDC2-CDC28 Kinases; Cell Cycle; Cell Division; Chromosome Mapping; Colonic Neoplasms; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Disease Progression; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Protein Kinase C; Protein Serine-Threonine Kinases; Protein Transport; Pyridines; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Up-Regulation | 2002 |
UCN-01 inhibits p53 up-regulation and abrogates gamma-radiation-induced G(2)-M checkpoint independently of p53 by targeting both of the checkpoint kinases, Chk2 and Chk1.
Topics: Alkaloids; Antineoplastic Agents; Apoptosis; Checkpoint Kinase 1; Checkpoint Kinase 2; Colonic Neoplasms; Enzyme Activation; Enzyme Inhibitors; G2 Phase; Gamma Rays; Humans; Mitosis; Phosphorylation; Precipitin Tests; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Staurosporine; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Up-Regulation | 2002 |
Src activation regulates anoikis in human colon tumor cell lines.
Topics: Adenocarcinoma; Amino Acid Substitution; Anoikis; Apoptosis; bcl-X Protein; Caspase 3; Caspases; Cell Adhesion; Cell Cycle; Chromones; Colonic Neoplasms; Disease Progression; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Genes, src; Humans; Morpholines; Mutation, Missense; Neoplasm Metastasis; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins pp60(c-src); Pyridones; Pyrimidines; Recombinant Fusion Proteins; Signal Transduction; Staurosporine; Transfection; Tumor Cells, Cultured | 2002 |
Induction of colon cancer cell death by 7-hydroxystaurosporine (UCN-01) is associated with increased p38 MAPK and decreased Bcl-xL.
Topics: Apoptosis; bcl-X Protein; Caspase 3; Caspases; Colonic Neoplasms; Dose-Response Relationship, Drug; HT29 Cells; Humans; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Proto-Oncogene Proteins c-bcl-2; Receptors, Cytoplasmic and Nuclear; Staurosporine; Transcription Factors | 2003 |
Increased immunogenicity of colon cancer cells by selective depletion of cytochrome C.
Topics: Animals; Apoptosis; Cisplatin; Colonic Neoplasms; Cytochromes c; DNA, Antisense; Down-Regulation; Doxorubicin; Etoposide; HCT116 Cells; HT29 Cells; Humans; Macrophages; Mice; Rats; Staurosporine; Transfection | 2004 |
Potentiation of cytotoxicity of topoisomerase i poison by concurrent and sequential treatment with the checkpoint inhibitor UCN-01 involves disparate mechanisms resulting in either p53-independent clonogenic suppression or p53-dependent mitotic catastroph
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Camptothecin; Colonic Neoplasms; DNA Damage; DNA Replication; Drug Administration Schedule; Drug Synergism; Enzyme Inhibitors; G2 Phase; HCT116 Cells; Humans; Irinotecan; Microscopy, Fluorescence; Mitosis; S Phase; Staurosporine; Topoisomerase I Inhibitors; Transfection; Tumor Suppressor Protein p53 | 2004 |
The broad-range cyclin-dependent kinase inhibitor UCN-01 induces apoptosis in colon carcinoma cells through transcriptional suppression of the Bcl-x(L) protein.
Topics: Antineoplastic Agents; Apoptosis; bcl-X Protein; Carcinoma; Colonic Neoplasms; Cyclin-Dependent Kinases; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Humans; NF-kappa B; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; STAT3 Transcription Factor; Staurosporine; Trans-Activators; Tumor Cells, Cultured | 2005 |
Combined effects of protein kinase inhibitors and 5-fluorouracil on CEA expression in human colon cancer cells.
Topics: Carcinoembryonic Antigen; Cell Line, Tumor; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Synergism; Fluorouracil; Humans; Immunosuppressive Agents; Protein Kinase Inhibitors; Staurosporine | 2005 |
Signaling pathways in the biphasic effect of ANG II on Na+/H+ exchanger in T84 cells.
Topics: Amiloride; Angiotensin II; Calcium; Cell Line, Tumor; Cell Size; Colon; Colonic Neoplasms; Dose-Response Relationship, Drug; Epithelial Cells; Humans; Hydrogen-Ion Concentration; Isoquinolines; Losartan; Signal Transduction; Sodium-Hydrogen Exchangers; Staurosporine; Sulfonamides | 2005 |
p21CDKN1A allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine.
Topics: Aphidicolin; Apoptosis; Chromosome Breakage; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; DNA; DNA Damage; DNA Repair; DNA Replication; DNA Topoisomerases, Type I; HCT116 Cells; Histones; Humans; In Situ Nick-End Labeling; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; S Phase; Staurosporine; Tumor Suppressor Protein p53 | 2006 |
Enrichment of non-synchronized cells in the G1, S and G2 phases of the cell cycle for the study of apoptosis.
Topics: Apoptosis; Bromodeoxyuridine; Camptothecin; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flow Cytometry; Fluorescent Antibody Technique; Humans; Interphase; Nitriles; Ploidies; Staurosporine; Sulfones | 2006 |
Bisindolylmaleimide IX facilitates extrinsic and initiates intrinsic apoptosis in TNF-alpha-resistant human colon adenocarcinoma COLO 205 cells.
Topics: Adenocarcinoma; Apoptosis; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspase 9; Cell Line, Tumor; Colonic Neoplasms; Drug Resistance, Neoplasm; Drug Synergism; Fas-Associated Death Domain Protein; Humans; Indoles; Maleimides; Protein Kinase C; Staurosporine; TNF Receptor-Associated Death Domain Protein; Tumor Necrosis Factor-alpha; Up-Regulation | 2008 |
Novel endothelial cell activation factor(s) released from activated platelets which induce E-selectin expression and tumor cell adhesion to endothelial cells: a preliminary note.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Biological Factors; Cell Adhesion; Cell Adhesion Molecules; Cell Communication; Cells, Cultured; Colonic Neoplasms; E-Selectin; Endothelium, Vascular; Humans; Intercellular Adhesion Molecule-1; Isoquinolines; Kinetics; Lung Neoplasms; Melanoma, Experimental; Mice; Models, Biological; Naphthalenes; Neoplasms; Piperazines; Platelet Activation; Platelet Aggregation; Polycyclic Compounds; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Stomach Neoplasms; Tumor Cells, Cultured; Umbilical Veins | 1994 |
Zonula occludens toxin modulates tight junctions through protein kinase C-dependent actin reorganization, in vitro.
Topics: Actins; Adenosine Triphosphatases; Alkaloids; Animals; Carcinoma; Cattle; Cell Line; Cholera Toxin; Colonic Neoplasms; Cytoskeleton; Endothelium, Vascular; Endotoxins; Humans; Ileum; Intercellular Junctions; Intestinal Mucosa; Isoenzymes; Kidney Cortex; Male; Organ Specificity; Permeability; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoric Diester Hydrolases; Protein Kinase C; Pulmonary Artery; Rabbits; Rats; Signal Transduction; Species Specificity; Staurosporine; Swine; Tumor Cells, Cultured; Vibrio cholerae | 1995 |
Effect of staurosporine on the transcription of HSP70 heat shock gene in HT-29 cells.
Topics: Actins; Alkaloids; Blotting, Northern; Cell Line; Cell Nucleus; Colonic Neoplasms; DNA Probes; Gene Expression; Heat-Shock Proteins; Humans; Kinetics; Protein Kinase C; RNA, Messenger; Staurosporine; Time Factors; Transcription, Genetic; Tumor Cells, Cultured | 1994 |
Expression and protein kinase C-dependent regulation of peptide/H+ co-transport system in the Caco-2 human colon carcinoma cell line.
Topics: Alkaloids; Biological Transport; Carrier Proteins; Cell Division; Colonic Neoplasms; Dipeptides; Diterpenes; Humans; Hydrogen; Kinetics; Protein Kinase C; Sodium; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Regulation of paracellular permeability in Caco-2 cell monolayers by protein kinase C.
Topics: Adenocarcinoma; Alkaloids; Carbachol; Cell Line; Cell Membrane; Cell Membrane Permeability; Colonic Neoplasms; Enzyme Activation; Glycerides; Humans; Kinetics; Mannitol; Membrane Potentials; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1993 |
Mucin secretion by T84 cells: stimulation by PKC, Ca2+, and a protein kinase activated by Ca2+ ionophore.
Topics: Adenocarcinoma; Alkaloids; Calcimycin; Calcium; Colonic Neoplasms; Culture Media; Down-Regulation; Egtazic Acid; Humans; Mucins; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Effect of staurosporine on suppression of heat shock gene expression and thermotolerance development in HT-29 cells.
Topics: Alkaloids; Colonic Neoplasms; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Gene Expression; Gene Expression Regulation, Neoplastic; Heat-Shock Proteins; Hot Temperature; Humans; Kinetics; Neoplasm Proteins; Protein Kinase C; RNA, Messenger; Staurosporine; Tumor Cells, Cultured | 1993 |
UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.
Topics: Alkaloids; Antineoplastic Agents; Burkitt Lymphoma; CDC2 Protein Kinase; Cell Division; Cell Survival; Cisplatin; Colonic Neoplasms; Cyclin B; Cyclin B1; Cyclins; Drug Synergism; Flow Cytometry; G2 Phase; Gamma Rays; Genes, p53; Humans; Immunoblotting; Mitotic Index; Mutation; Precipitin Tests; Radiation Dosage; Staurosporine; Tumor Cells, Cultured | 1996 |
Staurosporine inhibits the proliferation, alters the cell cycle distribution and induces apoptosis in HT-29 human colon adenocarcinoma cells.
Topics: Adenocarcinoma; Apoptosis; Cell Cycle; Cell Division; Colonic Neoplasms; Humans; Staurosporine; Tumor Cells, Cultured | 1996 |
Induction of fibroblast gelatinase B expression by direct contact with cell lines derived from primary tumor but not from metastases.
Topics: Animals; Antibodies, Monoclonal; Carcinoma; Cell Communication; Cells, Cultured; Coculture Techniques; Collagenases; Colonic Neoplasms; Connective Tissue; Connective Tissue Cells; Cytochalasin D; Cytoskeleton; Dexamethasone; Enzyme Induction; Enzyme Inhibitors; Extracellular Matrix Proteins; Fibroblasts; Genistein; Humans; Integrin beta1; Isoflavones; Keratinocytes; Liver Neoplasms; Lung Neoplasms; Matrix Metalloproteinase 9; Mice; Mice, Nude; Neoplasm Metastasis; Protein Kinase C; Staurosporine; Transcription Factor AP-1; Tumor Cells, Cultured | 1996 |
7-Hydroxystaurosporine (UCN-01) induces apoptosis in human colon carcinoma and leukemia cells independently of p53.
Topics: Adenocarcinoma; Alkaloids; Apoptosis; Caspase 3; Caspases; CDC2 Protein Kinase; Colonic Neoplasms; Cyclin B; Cyclin B1; Cyclins; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA Fragmentation; Enzyme Inhibitors; HL-60 Cells; HT29 Cells; Humans; Lamin Type B; Lamins; Leukemia, Myeloid, Acute; Nuclear Proteins; Poly(ADP-ribose) Polymerases; Protein Kinase C; Protein Synthesis Inhibitors; Serine Proteinase Inhibitors; Staurosporine; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1997 |
Colon carcinoma cells use different mechanisms to escape CD95-mediated apoptosis.
Topics: Antigens, Neoplasm; Apoptosis; Brefeldin A; Carcinoma; Cell Transformation, Neoplastic; Colonic Neoplasms; Cycloheximide; Cyclopentanes; Dactinomycin; Enzyme Inhibitors; Fas Ligand Protein; fas Receptor; Humans; Immunologic Capping; Interferon-gamma; Intestinal Mucosa; Membrane Glycoproteins; Nucleic Acid Synthesis Inhibitors; Phorbol Esters; Protein Kinase C; Protein Synthesis Inhibitors; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1998 |
Expression of the Cdx1 and Cdx2 homeotic genes leads to reduced malignancy in colon cancer-derived cells.
Topics: Apoptosis; Avian Proteins; Base Sequence; CDX2 Transcription Factor; Cell Division; Cell Movement; Ceramides; Colonic Neoplasms; Culture Media, Serum-Free; DNA Primers; Down-Regulation; Genes, bcl-2; Genes, Homeobox; Homeodomain Proteins; HT29 Cells; Humans; Staurosporine; Tetradecanoylphorbol Acetate; Trans-Activators; Transfection | 1998 |
Tissue factor activity of SW-480 human colon adenocarcinoma cells is modulated by thrombin and protein kinase C activation.
Topics: Adenocarcinoma; Coagulants; Colonic Neoplasms; Enzyme Activation; Enzyme Inhibitors; Hemostatics; Humans; Neoplasm Proteins; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin; Thromboplastin; Tumor Cells, Cultured | 1998 |
Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45.
Topics: Antibodies, Monoclonal; Carcinoma; CDC2 Protein Kinase; Cell Cycle Proteins; Colonic Neoplasms; Cyclin B; Cyclin B1; Cyclin E; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Epitopes; GADD45 Proteins; Genes, myc; Histones; Humans; Intracellular Signaling Peptides and Proteins; Nuclear Proteins; Nucleosome Assembly Protein 1; Precipitin Tests; Proteins; Recombinant Proteins; RNA, Antisense; Staurosporine; Transfection; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Ultraviolet Rays | 1999 |
Staurosporine increases carcinoembryonic antigen expression in a human colon cancer cell line.
Topics: Apoptosis; Carcinoembryonic Antigen; Cell Cycle; Colonic Neoplasms; Enzyme Inhibitors; Flow Cytometry; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; Protein Kinase C; Staurosporine | 2000 |
Two-drug combinations that increase apoptosis and modulate bak and bcl-X(L) expression in human colon tumor cell lines transduced with herpes simplex virus thymidine kinase.
Topics: Alkaloids; Antineoplastic Agents; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-X Protein; Butyrates; Camptothecin; Caspase 3; Caspases; Cell Survival; Colonic Neoplasms; Drug Interactions; Ganciclovir; Humans; Membrane Proteins; Paclitaxel; Peptide Hydrolases; Proto-Oncogene Proteins c-bcl-2; Recombinant Proteins; Simplexvirus; Staurosporine; Thymidine Kinase; Transfection; Tumor Cells, Cultured | 2000 |
Dissociation of staurosporine-induced apoptosis from G2-M arrest in SW620 human colonic carcinoma cells: initiation of the apoptotic cascade is associated with elevation of the mitochondrial membrane potential (deltapsim).
Topics: Apoptosis; Caspase 3; Caspases; Cell Division; Colonic Neoplasms; Cytochrome c Group; Cytosol; DNA Fragmentation; Enzyme Activation; Enzyme Inhibitors; G2 Phase; Humans; Intracellular Membranes; Ionophores; Membrane Potentials; Mitochondria; Mitosis; Neoplasm Proteins; Nigericin; RNA; Staurosporine; Tumor Cells, Cultured | 2000 |
The CEACAM1-L Ser503 residue is crucial for inhibition of colon cancer cell tumorigenicity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Antigens, CD; Antigens, Differentiation; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoembryonic Antigen; Carcinogenicity Tests; Carcinoma; Cell Adhesion Molecules; Colonic Neoplasms; Cyclic AMP; Enzyme Inhibitors; Epithelial Cells; Female; Humans; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Naphthalenes; Point Mutation; Protein Kinase C; Serine; Staurosporine; Tetradecanoylphorbol Acetate; Thionucleotides; Tumor Cells, Cultured | 2001 |
Caspase 7 downregulation as an immunohistochemical marker of colonic carcinoma.
Topics: Apoptosis; Biomarkers, Tumor; Blotting, Western; Caspase 7; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Colonic Neoplasms; Dimethyl Sulfoxide; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Humans; Immunohistochemistry; Intestinal Mucosa; Staurosporine; Tumor Cells, Cultured | 2001 |
Critical requirement of BAX for manifestation of apoptosis induced by multiple stimuli in human epithelial cancer cells.
Topics: Antibodies; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Carcinoma; Colonic Neoplasms; Epithelial Cells; fas Receptor; Humans; Membrane Glycoproteins; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Thapsigargin; TNF-Related Apoptosis-Inducing Ligand; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2002 |
The fast release of mucin secretion from human colonic cells induced by Entamoeba histolytica is dependent on contact and protein kinase C activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenocarcinoma; Alkaloids; Animals; Calcium; Carbohydrate Sequence; Cell Adhesion; Colon; Colonic Neoplasms; Entamoeba histolytica; Enzyme Activation; Humans; Intestinal Mucosa; Isoquinolines; Lectins; Membrane Glycoproteins; Mice; Mice, Nude; Molecular Sequence Data; Mucins; Neoplasm Proteins; Piperazines; Protein Kinase C; Protozoan Proteins; Secretory Rate; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |