staurosporine has been researched along with Breast Neoplasms in 107 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (1.87) | 18.7374 |
| 1990's | 24 (22.43) | 18.2507 |
| 2000's | 45 (42.06) | 29.6817 |
| 2010's | 27 (25.23) | 24.3611 |
| 2020's | 9 (8.41) | 2.80 |
| Authors | Studies |
|---|---|
| Budworth, J; Davies, R; Ferry, DR; Gant, TW; Gescher, A; Malkhandi, J | 1 |
| Ahmad, I; Chhikara, BS; Kumar, A; Mandal, D; Parang, K; Tiwari, R | 1 |
| Alam, R; Becker, A; Betzi, S; Chakrasali, R; Cubitt, CL; Francis, R; Gebhard, AW; Georg, GI; Han, H; Hazlehurst, LA; Jakkaraj, S; Kazi, A; Martin, MP; Schonbrunn, E; Sebti, SM; Tash, JS | 1 |
| Akl, MR; El Sayed, KA; Foudah, AI; Sallam, AA | 1 |
| Brueggemeier, RW; Chettiar, S; Darby, MV; Fisk, HA; Li, C; Li, PK; Mao, L; Sawant, DB; Sugimoto, Y | 1 |
| Aparicio, SA; Araki, S; Endo, S; Imaeda, Y; Ito, M; Kawamoto, T; Klein, MG; Kokubo, H; Kondo, M; Maezaki, H; Morin, GB; Morishita, N; Murakami, M; Nakanishi, A; Sameshima, T; Tanaka, T; Toita, A; Uchiyama, N; Zou, H | 1 |
| Han, X; Li, HY; Li, J; Liao, J; Peng, B; Shi, R; Wang, FC; Wang, H; Wang, WZ; Xiao, BB; Xu, X; Yang, CR; Yuan, XL | 1 |
| Abdel Latif, NA; Abdelhafez, OM; Ahmed, EY; El-Mansy, MF; Elserwy, WS | 1 |
| Afratis, K; Gavras, H; Karamanos, NK; Koutsakis, C; Leonardi, S; Papaioannou, D; Piperigkou, Z; Rassias, G; Rigopoulou, D; Vachlioti, E | 1 |
| Amer, AM; Mohamed, AK; Nafie, MS; Tantawy, ES | 1 |
| Arya, GC; Jaitak, V; Kaur, K | 1 |
| Glassmann, A; Kraus, D; Meyer, FAH; Probstmeier, R; Veit, N; Winter, J | 1 |
| Abdelhamid, D; Abourehab, MAS; Abuo-Rahma, GEA; Badr, M; Hassan, A; Hassan, HA | 1 |
| Bui, T; Hunt, KK; Keyomarsi, K; Livingston, JA; Mull, BB; Patel, N | 1 |
| Andrews, C; Maze, D; Murphy, T; Sibai, H | 1 |
| Ahmed, NS; Al-Ashmawy, AAK; Amr, AEE; Elsayed, EA; Haiba, ME; Sarhan, AE | 1 |
| Alsamman, K; El-Masry, OS | 1 |
| Galanzha, EI; Nedosekin, DA; Nolan, J; Zharov, VP | 1 |
| Jonasch, E; Jope, RS; Sun, M; Zhou, T | 1 |
| Choene, MM; Moela, P; Motadi, LR | 1 |
| Huang, D; Ji, Z; Liu, C; Su, J; Wang, H; Zhou, X | 1 |
| Bornancin, F; Fabbro, D; Huwiler, A; Japtok, L; Kleuser, B; Pastukhov, O; Pfeilschifter, J; Schwalm, S; Zangemeister-Wittke, U | 1 |
| Cambay, F; Egles, C; Follet, J; Nowacki, L; Rossi, C; Rotellini, L; Vayssade, M; Vigneron, P | 1 |
| Ding, X; Li, Y; Mao, W; Meng, X; Tang, H; Wang, X; Xie, S; Yang, H | 1 |
| Abdulkareem, ZA; Cox, CD; Gee, JM; Wann, KT | 1 |
| Bianchi, G; Bongioanni, F; Bottoni, G; Bruzzi, P; Buschiazzo, A; Capitanio, S; Emionite, L; Fabbi, M; Garaboldi, L; Inglese, E; Marini, C; Martella, R; Monteverde, E; Orengo, AM; Petretto, A; Raffaghello, L; Ravera, S; Sambuceti, G | 1 |
| Andersson, H; Franke, HR; Komen, J; van den Berg, A; Vermes, I; Wolbers, F | 1 |
| Cai, X; Li, Z; Sun, L; Wang, C; Wang, L; Wu, G; Yang, Y; Yao, W; Zha, X; Zhou, F | 1 |
| Cai, M; Chen, L; Chowdhury, D; Gao, M; Lee, DH; Li, J; Liao, J; Pfeifer, GP; Wang, H; Xu, X; Yang, YG; Yen, Y; Zhao, A; Zhong, X | 1 |
| Cance, WG; Fu, AD; Garces, CA; Golubovskaya, VM; He, D; Hunt, DL; Kurenova, EV; Massoll, NA | 1 |
| Blick, T; Hugo, HJ; Newgreen, DF; Thompson, EW; Wafai, R | 1 |
| Niu, R; Shi, Y; Wei, X; Yang, Y; Yu, M; Zang, F | 1 |
| Dluzen, D; Li, G; Liu, DX; Moreau, M; Tacelosky, D | 1 |
| Fang, Z; Li, N; Li, Z; Wang, L; Yao, W; Yin, P; Yu, X; Zha, X; Zhao, C | 1 |
| Cho, SH; Hwang, SY; Lee, BH; Lee, EK; Song, YJ | 1 |
| Jo, C; Koh, YH; Yoo, CB; Yun, SM | 1 |
| Brown, EJ; Schoppy, DW | 1 |
| Aft, RL; Cai, S; Ellis, MJ; Goiffon, RJ; Guo, Z; Hoog, J; Li, S; Lin, L; Ma, CX; Piwnica-Worms, H; Prat, A; Ryan, CE; Schaiff, WT | 1 |
| Chang, J; Di, X; Fan, W; Shen, Y; Sui, M; Zhang, H | 1 |
| Guo, H; Jiang, L; Liu, H; Ma, J; Xu, Y; Yang, H; Yu, G; Yuan, C; Zhang, Y | 1 |
| Bernard, PS; Brenin, CM; Cai, SR; Craig Lockhart, A; Creekmore, AN; Dancey, J; Doyle, LA; Ebbert, M; Ellis, MJ; Fracasso, PM; Guo, Z; Ma, CX; Mwandoro, T; Naughton, MJ; Petroni, GR; Picus, J; Piwnica-Worms, H; Pluard, TJ; Reed, J; Ryan, CE; Watson, M; Yarde, ER | 1 |
| Cai, X; Chen, T; Cheng, H; Fang, Z; Hoth, M; Ji, S; Liu, C; Long, J; Ni, Q; Qin, Y; Qu, B; Wu, C; Xu, J; Xu, W; Yao, W; Yu, X; Zha, X | 1 |
| Bender, C; Keklikoglou, I; Körner, C; Münstermann, E; Wiemann, S; Wörner, A | 1 |
| Collecchi, P; Mariani, L; Piras, A; Poliseno, L; Rainaldi, G; Zaccaro, L | 1 |
| Abe, S; Hashimoto, M; Hosoda, Y; Kitajima, M; Koh, J; Kubota, T; Migita, T | 1 |
| Al-Sakkaf, KA; Brown, BL; Dobson, PR; Mooney, LM | 1 |
| Blank, DH; Brown, MK; Eastman, A; Gribble, GW; Kohn, EA; Livingstone, M; Rathman, J | 1 |
| McKeague, AL; Nelson, J; Wilson, DJ | 1 |
| Shao, RG; Sun, XC; Wang, JJ; Zhen, YS | 1 |
| Chiu, SM; Oleinick, NL; Xue, LY | 1 |
| Hashimoto, M; Hosoda, Y; Kitajima, M; Koh, J; Koyama, T; Kubota, T; Migita, T | 1 |
| Aloj, L; Caracó, C; Del Vecchio, S; Salvatore, M; Zannetti, A | 1 |
| Bianchi, L; Bini, L; Citti, L; Evangelista, M; Liberatori, S; Mariani, L; Pallini, V; Poliseno, L; Rainaldi, G; Salvetti, A | 1 |
| Bates, SE; Blayney, M; Mistry, P; Morisaki, K; Polgar, O; Robey, RW; Steadman, K | 1 |
| Baldwin, AS; Cance, WG; Craven, RJ; Hanks, SK; Kurenova, E; Liu, ZG; Xu, LH; Yang, X | 1 |
| Andreeff, M; Chen, JS; Konopleva, M; Mehta, K; Multani, AS; Pathak, S | 1 |
| Boninsegna, A; Bonsignore, A; Cittadini, A; Faraglia, B; Mancuso, C; Scaldaferri, F; Sgambato, A | 1 |
| Daoud, SS; Mixter, P; Redkar, A | 1 |
| Albonici, L; Birarelli, P; Coppotelli, G; Giuffrida, A; Malacrino, C; Modesti, A; Modesti, M; Sallusti, E; Scarpa, S; Simonelli, L; Vasaturo, F | 1 |
| Shi, HY; Zhang, M; Zhang, W | 1 |
| Kallajoki, M; Kivinen, K; Taimen, P | 1 |
| Dai, Y; Dawson, K; Dent, P; Gilfor, D; Grant, S; Hawkins, W; McKinstry, R; Mitchell, C; Ramakrishnan, V; Roberts, JD; Starkey, J; Yacoub, A | 1 |
| Franklin, RA; Libra, M; McCubrey, JA; Stivala, F | 1 |
| Goldson, TM; Hagedorn, CH; Miller, S; Shim, H; Staub, E; Vielhauer, G | 1 |
| Krebs, CE; Liu, DS; Liu, SJ | 1 |
| Chen, CT; Ding, Q; He, X; Hsu, JM; Hung, MC; Lee, DF; Li, LY; Liu, JC; Xia, W; Xie, X; Yang, JY | 1 |
| Chen, J; Li, F; Qi, B; Wu, P; Zheng, Y; Zhu, H | 1 |
| Bansal, S; Das, GM; Konduri, SD; Li, F; Liu, W; Sayeed, A | 1 |
| Eastman, A; Fanous, AA; Poh, A; Zhang, WH | 1 |
| Budworth, J; Gescher, A | 1 |
| Meikrantz, W; Sager, R; Schlegel, R; Xu, C | 1 |
| Jeoung, DI; Sonenberg, M; Tang, B | 1 |
| Kaur, G; Sausville, EA; Sebers, S; Seynaeve, CM; Stetler-Stevenson, M; Worland, PJ | 1 |
| Abraham, I; McCroskey, MC; Sampson, KE | 1 |
| Budworth, J; Courage, C; Gescher, A | 1 |
| Chin, KV; Hait, WN; Yang, JM | 1 |
| Anzano, M; Byers, S; Crockett, C; Lechleider, R; Peer, C; Pishvaian, M; Sporn, M; Tozeren, A | 1 |
| Bar-Shalom, I; Beery, R; Geier, A; Haimsohn, M; Hemi, R; Karasik, A; Lunenfeld, B; Malik, Z | 1 |
| Buchholz, MA; Chrest, FJ; Kwon, TK; Nordin, AA | 1 |
| Lock, RB; Stribinskiene, L; Sullivan, DM; Thompson, BS | 1 |
| Jänicke, RU; Porter, AG; Sprengart, ML; Wati, MR | 1 |
| Devoe, G; Gear, R; Heffelfinger, SC; Miller, MA | 1 |
| Chen, J; Chen, L; Fodera, B; Levine, EA; Pochampally, R; Shao, W | 1 |
| Andersen, RJ; Anderson, HJ; Berlinck, RG; Britton, R; Curman, D; Davies, P; Friend, SH; Haggarty, SJ; Kelly, MT; Lim, LY; Piers, E; Roberge, M; Stringer, CM; Vincent, I; Xu, L | 1 |
| Gingras, S; Groner, B; Moriggl, R; Simard, J | 1 |
| Baker, JR; Giordano, TJ; Koenig, RJ; Myc, A; Thompson, NW; Wang, SH | 1 |
| Anderson, HJ; James, WM; Ray, JM; Roberge, M; Sauvé, DM | 1 |
| Nieves-Neira, W; Pommier, Y | 1 |
| Brown, MK; Eastman, A; Lee, SI | 1 |
| Chen, X; Keyomarsi, K; Lowe, M | 1 |
| Clements, MK; Daoud, SS; Jones, CB; Wasi, S | 1 |
| Akinaga, S; Akiyama, T; Eastman, A; Shimizu, M; Sugiyama, K; Takahashi, R; Tamaoki, T; Yamaguchi, K | 1 |
| Kidd, VJ; Lahti, JM; Tang, D | 1 |
| Tsuchida, E; Tsuchida, M; Urano, M | 1 |
| Flygare, J; Hellgren, D; Wennborg, A | 1 |
| Clements, MK; Daoud, SS; Jones, CB; Redkar, A | 1 |
| Chen, X; Danes, C; Hall, MJ; Herliczek, T; Keyomarsi, K; Lawrence, DA; Lowe, M | 1 |
| Abe, S; Akinaga, S; Akiyama, T; Furukawa, T; Kitajima, M; Kubota, T; Kumai, K; Otani, Y; Watanabe, M | 1 |
| Carter, CA | 1 |
| Aoki, C; Irie, S; Nadano, D; Sato, TA; Yoshinaka, T | 1 |
| Dragowska, WH; Duronio, V; Hu, Y; Mayer, L; Wallis, A | 1 |
| Finley, RL; Kim, HR; Raz, A; Yu, F | 1 |
| Chen, J; Devarajan, E; Mehta, K; Multani, AS; Pathak, S; Sahin, AA | 1 |
| Chrest, J; Gabrielson, E; Lin, Y; Wersto, R; Zhou, W | 1 |
| Cardinale, I; Sehgal, PB; Tamm, I | 1 |
| Eppenberger, U; Fabbro, D; Küng, W; Matter, A; Meyer, T; Novak-Hofer, I | 1 |
| Eppenberger, U; Fabbro, D; Küng, W; Matter, A; Novak-Hofer, I | 1 |
3 review(s) available for staurosporine and Breast Neoplasms
| Article | Year |
|---|---|
Isoxazole derivatives as anticancer agent: A review on synthetic strategies, mechanism of action and SAR studies.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Proliferation; Drug Screening Assays, Antitumor; Female; Humans; Isoxazoles | 2021 |
Combination treatment with CPX-351 and midostaurin in patients with secondary acute myeloid leukaemia that are FLT3 mutated: three cases and review of literature.
Topics: Aged; Allografts; Anemia, Refractory, with Excess of Blasts; Aniline Compounds; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Breast Neoplasms; Bridged Bicyclo Compounds, Heterocyclic; Clinical Trials, Phase III as Topic; Cytarabine; Daunorubicin; Fatal Outcome; Female; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid, Acute; Liposomes; Male; Middle Aged; Myelodysplastic Syndromes; Neoplasm, Residual; Neoplasms, Radiation-Induced; Oncogene Proteins, Fusion; Peripheral Blood Stem Cell Transplantation; Point Mutation; Protein Kinase Inhibitors; Pyrazines; Remission Induction; Salvage Therapy; Staurosporine; Sulfonamides | 2020 |
Protein kinase C as a drug target: implications for drug or diet prevention and treatment of cancer.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Drug Delivery Systems; Enzyme Inhibitors; Gastrointestinal Neoplasms; Humans; Isoenzymes; Lung Neoplasms; Neoplasm Proteins; Neoplasms; Oligonucleotides, Antisense; Protein Kinase C; Retinoids; Staurosporine; Tretinoin | 2000 |
1 trial(s) available for staurosporine and Breast Neoplasms
| Article | Year |
|---|---|
A phase II study of UCN-01 in combination with irinotecan in patients with metastatic triple negative breast cancer.
Topics: Adult; Aged; Anemia; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Camptothecin; Female; Genes, p53; Humans; Irinotecan; Leukocytes, Mononuclear; Middle Aged; Mutation; Ribosomal Protein S6; Staurosporine; Treatment Outcome | 2013 |
103 other study(ies) available for staurosporine and Breast Neoplasms
| Article | Year |
|---|---|
Comparison of staurosporine and four analogues: their effects on growth, rhodamine 123 retention and binding to P-glycoprotein in multidrug-resistant MCF-7/Adr cells.
Topics: Alkaloids; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Division; Cell Line; Doxorubicin; Drug Resistance, Multiple; Female; Flow Cytometry; Fluorescent Dyes; Humans; Indoles; Maleimides; Protein Kinase C; Rhodamine 123; Rhodamines; Staurosporine; Structure-Activity Relationship; Tumor Cells, Cultured; Vinblastine | 1996 |
Synthesis of 3-phenylpyrazolopyrimidine-1,2,3-triazole conjugates and evaluation of their Src kinase inhibitory and anticancer activities.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Female; Humans; Inhibitory Concentration 50; Models, Molecular; Molecular Structure; Ovarian Neoplasms; Pyrans; Pyrimidines; src-Family Kinases; Triazoles | 2011 |
Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases.
Topics: Apoptosis; Blotting, Western; Breast Neoplasms; Caspases; Cell Cycle; Cell Line, Tumor; Cell Survival; Coloring Agents; Computer Simulation; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Drug Screening Assays, Antitumor; Female; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; High-Throughput Screening Assays; Humans; Indicators and Reagents; Male; Models, Molecular; Phosphorylation; Structure-Activity Relationship; Testicular Neoplasms; Tetrazolium Salts; Thiazoles | 2013 |
Optimization, pharmacophore modeling and 3D-QSAR studies of sipholanes as breast cancer migration and proliferation inhibitors.
Topics: Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Drug Design; Epithelial Cells; Female; Humans; Models, Molecular; Molecular Structure; Neoplasm Proteins; Phosphorylation; Protein-Tyrosine Kinases; Quantitative Structure-Activity Relationship; Triterpenes | 2014 |
Novel pyrrolopyrimidines as Mps1/TTK kinase inhibitors for breast cancer.
Topics: Animals; Breast Neoplasms; Cell Cycle Proteins; Female; Humans; Mice; Mice, Nude; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyrimidines | 2017 |
Discovery of 3-Benzyl-1-( trans-4-((5-cyanopyridin-2-yl)amino)cyclohexyl)-1-arylurea Derivatives as Novel and Selective Cyclin-Dependent Kinase 12 (CDK12) Inhibitors.
Topics: Breast Neoplasms; Cell Survival; Cyclin-Dependent Kinases; Drug Discovery; Enzyme Inhibitors; Female; Humans; Phosphorylation; RNA Polymerase II; Structure-Activity Relationship; Tumor Cells, Cultured | 2018 |
Synthesis and evaluation of chalcone analogues containing a 4-oxoquinazolin-2-yl group as potential anti-tumor agents.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Chalcones; Colorectal Neoplasms; Drug Screening Assays, Antitumor; Humans; MCF-7 Cells; Mitochondria; Quinazolines; Structure-Activity Relationship | 2019 |
VEGFR-2 inhibiting effect and molecular modeling of newly synthesized coumarin derivatives as anti-breast cancer agents.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Cycle; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; Humans; MCF-7 Cells; Models, Molecular; Molecular Structure; PC-3 Cells; Protein Kinase Inhibitors; Structure-Activity Relationship; Vascular Endothelial Growth Factor Receptor-2 | 2020 |
Potent antiproliferative activity of bradykinin B2 receptor selective agonist FR-190997 and analogue structures thereof: A paradox resolved?
Topics: Anti-Bacterial Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Humans; MCF-7 Cells; Quinolines; Receptor, Bradykinin B2 | 2021 |
Discovery of novel pyrazolo[3,4-b]pyridine scaffold-based derivatives as potential PIM-1 kinase inhibitors in breast cancer MCF-7 cells.
Topics: Binding Sites; Breast Neoplasms; Caspase 3; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Drug Design; Drug Evaluation, Preclinical; Female; G2 Phase Cell Cycle Checkpoints; Half-Life; Humans; MCF-7 Cells; Molecular Docking Simulation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-pim-1; Pyrazoles; Pyridines; Structure-Activity Relationship; Tumor Suppressor Protein p53 | 2020 |
The Presence of Yin-Yang Effects in the Migration Pattern of Staurosporine-Treated Single versus Collective Breast Carcinoma Cells.
Topics: Apoptosis; Breast Neoplasms; Cell Movement; Cell Proliferation; Enzyme Inhibitors; Female; Humans; Signal Transduction; Staurosporine; Tumor Cells, Cultured; Yin-Yang | 2021 |
Design, synthesis, in vitro antiproliferative evaluation and in silico studies of new VEGFR-2 inhibitors based on 4-piperazinylquinolin-2(1H)-one scaffold.
Topics: Adenocarcinoma; Amines; Antineoplastic Agents; Breast Neoplasms; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Female; Humans; Molecular Docking Simulation; Molecular Structure; Protein Kinase Inhibitors; Sorafenib; Staurosporine; Structure-Activity Relationship; Vascular Endothelial Growth Factor Receptor-2 | 2022 |
Specific, reversible G1 arrest by UCN-01 in vivo provides cytostatic protection of normal cells against cytotoxic chemotherapy in breast cancer.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cytostatic Agents; Female; G1 Phase; Humans; Mice; Mice, Nude; Staurosporine | 2020 |
Synthesis and Characterization of New Dihydronaphthalene Candidates as Potent Cytotoxic Agents against MCF-7 Human Cancer Cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Chemistry Techniques, Synthetic; Chemistry, Pharmaceutical; Cytotoxins; Drug Design; Drug Screening Assays, Antitumor; Female; Humans; Inhibitory Concentration 50; MCF-7 Cells; Molecular Structure; Naphthalenes; Solvents; Spectroscopy, Fourier Transform Infrared; Staurosporine; Structure-Activity Relationship | 2020 |
Staurosporine alleviates cisplatin chemoresistance in human cancer cell models by suppressing the induction of SQSTM1/p62.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Biomarkers, Tumor; Breast Neoplasms; Cell Proliferation; Cisplatin; Colonic Neoplasms; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; Ovarian Neoplasms; Sequestosome-1 Protein; Staurosporine; Tumor Cells, Cultured | 2018 |
Detection of Apoptotic Circulating Tumor Cells Using in vivo Fluorescence Flow Cytometry.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Blood Vessels; Breast Neoplasms; Cell Count; Cell Line, Tumor; Cell Survival; Female; Flow Cytometry; Fluorescence; Green Fluorescent Proteins; Humans; Mice; Mice, Nude; Neoplastic Cells, Circulating; Staurosporine | 2019 |
DDX3 regulates DNA damage-induced apoptosis and p53 stabilization.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Camptothecin; Caspases; DEAD-box RNA Helicases; DNA Damage; Enzyme Inhibitors; Female; Humans; Immunoblotting; Immunoprecipitation; Signal Transduction; Staurosporine; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2013 |
Silencing RBBP6 (Retinoblastoma Binding Protein 6) sensitises breast cancer cells MCF7 to staurosporine and camptothecin-induced cell death.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Camptothecin; Carrier Proteins; Cell Growth Processes; Combined Modality Therapy; DNA-Binding Proteins; Down-Regulation; Female; Gene Silencing; Humans; MCF-7 Cells; RNA, Small Interfering; Staurosporine; Tumor Suppressor Protein p53; Ubiquitin-Protein Ligases | 2014 |
Integrating genomics and proteomics data to predict drug effects using binary linear programming.
Topics: Antineoplastic Agents; Benzamides; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Digoxigenin; Female; Gene Expression; Gene Regulatory Networks; Genomics; Histone Deacetylase Inhibitors; HL-60 Cells; Humans; Hydroxamic Acids; MCF-7 Cells; Phosphorylation; Programming, Linear; Proteome; Proteomics; Pyridines; Signal Transduction; Staurosporine; Tumor Suppressor Protein p53 | 2014 |
The ceramide kinase inhibitor NVP-231 inhibits breast and lung cancer cell proliferation by inducing M phase arrest and subsequent cell death.
Topics: Adenocarcinoma; Apoptosis; Benzothiazoles; Blotting, Western; Breast Neoplasms; Bridged-Ring Compounds; Cell Proliferation; Cell Survival; DNA; Enzyme Inhibitors; Flow Cytometry; Humans; Lung Neoplasms; M Phase Cell Cycle Checkpoints; MCF-7 Cells; Phosphotransferases (Alcohol Group Acceptor); Staurosporine; Tumor Stem Cell Assay | 2014 |
Real-time QCM-D monitoring of cancer cell death early events in a dynamic context.
Topics: Antineoplastic Agents; Apoptosis; Biosensing Techniques; Breast Neoplasms; Computer Systems; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Equipment Design; Equipment Failure Analysis; Humans; MCF-7 Cells; Micro-Electrical-Mechanical Systems; Staurosporine; Transducers | 2015 |
Drug response to HER2 gatekeeper T798M mutation in HER2-positive breast cancer.
Topics: Antineoplastic Agents; Breast Neoplasms; Bridged Bicyclo Compounds, Heterocyclic; Drug Resistance, Neoplasm; ErbB Receptors; Erlotinib Hydrochloride; Female; Gefitinib; Humans; Hydroxybutyrates; Lapatinib; Molecular Dynamics Simulation; Mutation; Protein Kinase Inhibitors; Purines; Quinazolines; Receptor, ErbB-2; Staurosporine | 2016 |
Knockdown of the small conductance Ca(2+) -activated K(+) channels is potently cytotoxic in breast cancer cell lines.
Topics: Alkanes; Apoptosis; Apoptosis Regulatory Proteins; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Gene Knockdown Techniques; Humans; Lethal Dose 50; Protein Isoforms; Pyrazoles; Pyrimidines; Quinolinium Compounds; RNA, Small Interfering; Small-Conductance Calcium-Activated Potassium Channels; Staurosporine | 2016 |
Divergent targets of glycolysis and oxidative phosphorylation result in additive effects of metformin and starvation in colon and breast cancer.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Energy Metabolism; Female; Fluorescent Antibody Technique; Glucose; Glycolysis; Humans; Metformin; Mice, Inbred BALB C; Models, Biological; Oxidative Phosphorylation; Reactive Oxygen Species; Staurosporine | 2016 |
Viability analysis and apoptosis induction of breast cancer cells in a microfluidic device: effect of cytostatic drugs.
Topics: Antineoplastic Agents; Apoptosis; Biological Assay; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Dimethylpolysiloxanes; Drug Evaluation, Preclinical; Female; Fluoresceins; Fluorescent Dyes; Humans; Microfluidic Analytical Techniques; Polymers; Reproducibility of Results; Sensitivity and Specificity; Staurosporine; Time Factors | 2008 |
E-cadherin decreased human breast cancer cells sensitivity to staurosporine by up-regulating Bcl-2 expression.
Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Breast Neoplasms; Cadherins; Cell Adhesion; Cell Line, Tumor; Humans; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Up-Regulation | 2009 |
Human RIF1 encodes an anti-apoptotic factor required for DNA repair.
Topics: Apoptosis; Blotting, Western; Breast Neoplasms; Camptothecin; Carcinoma, Ductal, Breast; Cell Differentiation; Cell Proliferation; DNA Breaks, Double-Stranded; DNA Repair; Enzyme Inhibitors; Female; Humans; Immunoenzyme Techniques; Immunoprecipitation; Nuclear Proteins; Nuclear Receptor Co-Repressor 1; Repressor Proteins; RNA, Small Interfering; Signal Transduction; Staurosporine; Tumor Cells, Cultured | 2009 |
Vascular endothelial growth factor receptor-3 promotes breast cancer cell proliferation, motility and survival in vitro and tumor formation in vivo.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Enzyme Inhibitors; Estrogens; Female; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Nude; RNA Interference; RNA, Small Interfering; Staurosporine; Transplantation, Heterologous; Vascular Endothelial Growth Factor Receptor-3 | 2009 |
Staurosporine augments EGF-mediated EMT in PMC42-LA cells through actin depolymerisation, focal contact size reduction and Snail1 induction - a model for cross-modulation.
Topics: Actins; Breast Neoplasms; Cadherins; Cell Line, Tumor; Cytoskeleton; Enzyme Inhibitors; Epidermal Growth Factor; Epithelium; Humans; Mesoderm; Microscopy, Confocal; Microscopy, Fluorescence; Snail Family Transcription Factors; Staurosporine; Transcription Factors; Tumor Cells, Cultured | 2009 |
Mitochondrial DNA depletion promotes impaired oxidative status and adaptive resistance to apoptosis in T47D breast cancer cells.
Topics: Adenosine Triphosphate; Antibiotics, Antineoplastic; Antibodies, Monoclonal; Antineoplastic Agents, Phytogenic; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Breast Neoplasms; Catalase; DNA, Mitochondrial; Doxorubicin; Enzyme Inhibitors; fas Receptor; Female; Glutathione Peroxidase; Humans; L-Lactate Dehydrogenase; Lactic Acid; Mitochondria; Oxidative Stress; Oxygen Consumption; Paclitaxel; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Staurosporine; Superoxide Dismutase; Tumor Cells, Cultured; Vincristine | 2009 |
BCL-2 is a downstream target of ATF5 that mediates the prosurvival function of ATF5 in a cell type-dependent manner.
Topics: Activating Transcription Factors; Animals; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Culture Media, Serum-Free; Down-Regulation; Enzyme Inhibitors; Female; Glioma; Humans; Promoter Regions, Genetic; Proto-Oncogene Proteins c-bcl-2; Rats; Staurosporine; Transcription, Genetic | 2011 |
Profilin1 facilitates staurosporine-triggered apoptosis by stabilizing the integrin β1-actin complex in breast cancer cells.
Topics: Actins; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Enzyme Inhibitors; Female; Flow Cytometry; Humans; Integrin beta1; Microscopy, Confocal; Profilins; Real-Time Polymerase Chain Reaction; Staurosporine | 2012 |
Cellular imaging assay for early evaluation of an apoptosis inducer.
Topics: Annexin A5; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cytological Techniques; Female; Flow Cytometry; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Humans; Microscopy, Confocal; Phosphatidylserines; Staurosporine; Surface Plasmon Resonance; Tetrazolium Salts; Thiazoles | 2011 |
γ-Secretase-dependent cleavage of E-cadherin by staurosporine in breast cancer cells.
Topics: Amino Acid Chloromethyl Ketones; Amyloid Precursor Protein Secretases; Apoptosis; Breast Neoplasms; Cadherins; Caspase 2; Caspase 8; Caspase Inhibitors; Cell Line, Tumor; Enzyme Inhibitors; Female; Humans; Microscopy, Fluorescence; Staurosporine | 2012 |
Chk'ing p53-deficient breast cancers.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Checkpoint Kinase 1; Female; Humans; Molecular Targeted Therapy; Neoplasm Proteins; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Thiophenes; Tumor Suppressor Protein p53; Urea | 2012 |
Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Breast Neoplasms; Camptothecin; Cell Cycle; Cell Line, Tumor; Checkpoint Kinase 1; DNA Damage; DNA, Neoplasm; Female; Genes, cdc; Genes, erbB-2; Genes, p53; Humans; Irinotecan; Mice; Mice, Inbred NOD; Mice, SCID; Molecular Targeted Therapy; Neoplasm Proteins; Protein Kinase Inhibitors; Protein Kinases; Receptors, Estrogen; Receptors, Progesterone; Staurosporine; Thiophenes; Tumor Suppressor Protein p53; Urea; Xenograft Model Antitumor Assays | 2012 |
G2 checkpoint abrogator abates the antagonistic interaction between antimicrotubule drugs and radiation therapy.
Topics: Analysis of Variance; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Breast Neoplasms; Cell Death; Cell Division; Cell Line, Tumor; Chemoradiotherapy; DNA Fragmentation; Female; Flow Cytometry; G2 Phase Cell Cycle Checkpoints; Humans; Microtubules; Paclitaxel; Prohibitins; Radiation, Ionizing; Staurosporine; Tumor Cells, Cultured; Vincristine | 2012 |
Silencing prion protein in MDA-MB-435 breast cancer cells leads to pleiotropic cellular responses to cytotoxic stimuli.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Doxorubicin; Drug Resistance, Neoplasm; Extracellular Signal-Regulated MAP Kinases; Gene Silencing; Genes, p53; Humans; Paclitaxel; Plasmids; Prions; Retroviridae; RNA, Small Interfering; Signal Transduction; Staurosporine; Trypan Blue | 2012 |
Profilin 1 potentiates apoptosis induced by staurosporine in cancer cells.
Topics: Apoptosis; Breast Neoplasms; Caspase 3; Cell Line, Tumor; Cell Survival; DNA-Binding Proteins; Enzyme Inhibitors; Female; Humans; Mitochondria; Pancreatic Neoplasms; Phosphorylation; Profilins; RNA Interference; RNA, Small Interfering; Staurosporine; Tumor Suppressor Protein p53 | 2013 |
MicroRNA-31 sensitizes human breast cells to apoptosis by direct targeting of protein kinase C epsilon (PKCepsilon).
Topics: 3' Untranslated Regions; Apoptosis; Base Sequence; Breast Neoplasms; Cell Survival; Drug Resistance, Neoplasm; Female; Genes, Reporter; Humans; Luciferases; MCF-7 Cells; MicroRNAs; NF-kappa B; NF-kappaB-Inducing Kinase; Protein Kinase C-epsilon; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-bcl-2; Radiation Tolerance; rhoA GTP-Binding Protein; RNA Interference; Staurosporine | 2013 |
Bcl2-negative MCF7 cells overexpress p53: implications for the cell cycle and sensitivity to cytotoxic drugs.
Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Cycle; Cisplatin; DNA Damage; Drug Resistance, Neoplasm; Female; Gene Deletion; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, bcl-2; Genes, p53; Humans; Mitochondria; Staurosporine; Tumor Stem Cell Assay; Tumor Suppressor Protein p53 | 2002 |
UCN-01 (7-hydroxystaurosporine) inhibits the growth of human breast cancer xenografts through disruption of signal transduction.
Topics: Alkaloids; Animals; Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Cyclophosphamide; Dose-Response Relationship, Drug; Doxorubicin; Drug Synergism; Estrogens; Female; Fluorouracil; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms, Hormone-Dependent; Protein Kinase C; Signal Transduction; Staurosporine; Time Factors; Transplantation, Heterologous; Tumor Cells, Cultured | 2002 |
Apoptotic mechanisms in T47D and MCF-7 human breast cancer cells.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; bcl-X Protein; Breast Neoplasms; Caspase Inhibitors; Caspases; Cytochrome c Group; Enzyme Activation; Enzyme Inhibitors; Humans; In Situ Nick-End Labeling; Membrane Potentials; Membrane Proteins; Mitochondria; Poly(ADP-ribose) Polymerases; Protein Transport; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2002 |
A novel indolocarbazole, ICP-1, abrogates DNA damage-induced cell cycle arrest and enhances cytotoxicity: similarities and differences to the cell cycle checkpoint abrogator UCN-01.
Topics: Alkaloids; Antineoplastic Agents; Breast Neoplasms; Carbazoles; Cell Cycle; Cell Division; Cisplatin; DNA; DNA Damage; Dose-Response Relationship, Drug; Female; Flow Cytometry; G2 Phase; Genes, p53; Humans; Immunoblotting; Indoles; Models, Chemical; Mutation; Protein Binding; S Phase; Staurosporine; Time Factors; Tumor Cells, Cultured | 2002 |
Staurosporine-induced apoptosis and hydrogen peroxide-induced necrosis in two human breast cell lines.
Topics: Apoptosis; Breast Neoplasms; Cell Line; Enzyme Inhibitors; Humans; Hydrogen Peroxide; Necrosis; Staurosporine; Tumor Cells, Cultured | 2003 |
[Potentiation of radiosensitivity by staurosporine associated with abrogation of G2 phase arrest].
Topics: Breast Neoplasms; Cyclin B; Cyclin B1; Enzyme Inhibitors; Female; G2 Phase; HT29 Cells; Humans; Mitotic Index; Particle Accelerators; Radiation Tolerance; Radiation-Sensitizing Agents; Staurosporine; Tumor Cells, Cultured | 2002 |
Staurosporine-induced death of MCF-7 human breast cancer cells: a distinction between caspase-3-dependent steps of apoptosis and the critical lethal lesions.
Topics: Apoptosis; Breast Neoplasms; Caspase 3; Caspases; Cell Death; Cell Survival; Clone Cells; Enzyme Inhibitors; Etoposide; Female; Humans; Mitochondria; Nucleic Acid Synthesis Inhibitors; Staurosporine; Tumor Cells, Cultured | 2003 |
Combined antitumor activity of 7-hydroxystaurosporine (UCN-01) and tamoxifen against human breast carcinoma in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Female; Humans; Mice; Mice, Inbred BALB C; Staurosporine; Tamoxifen | 2003 |
Bcl-2 overexpression prevents 99mTc-MIBI uptake in breast cancer cell lines.
Topics: Breast Neoplasms; Cell Line, Tumor; Cloning, Molecular; Humans; Metabolic Clearance Rate; Proto-Oncogene Proteins c-bcl-2; Radionuclide Imaging; Radiopharmaceuticals; Recombinant Proteins; Staurosporine; Technetium Tc 99m Sestamibi; Transfection | 2004 |
Bcl2-low-expressing MCF7 cells undergo necrosis rather than apoptosis upon staurosporine treatment.
Topics: Amino Acid Sequence; Apoptosis; Base Sequence; Breast Neoplasms; Cell Line, Tumor; Chromatin; Clone Cells; Flow Cytometry; HMGB1 Protein; Humans; Molecular Sequence Data; Necrosis; Peptide Mapping; Proteome; Proto-Oncogene Proteins c-bcl-2; RNA, Catalytic; RNA, Messenger; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Staurosporine; Transfection | 2004 |
Pheophorbide a is a specific probe for ABCG2 function and inhibition.
Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Breast Neoplasms; Camptothecin; Chlorophyll; Drug Resistance, Neoplasm; Humans; Irinotecan; Neoplasm Proteins; Quinolines; Staurosporine; Topotecan | 2004 |
Focal adhesion kinase suppresses apoptosis by binding to the death domain of receptor-interacting protein.
Topics: Animals; Antigens, CD; Apoptosis; Base Sequence; Breast Neoplasms; Cell Line; Cell Line, Tumor; Female; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Mice; Mice, Knockout; Protein Binding; Protein-Tyrosine Kinases; Proteins; Receptor-Interacting Protein Serine-Threonine Kinases; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; RNA, Small Interfering; Signal Transduction; Staurosporine | 2004 |
Drug-resistant breast carcinoma (MCF-7) cells are paradoxically sensitive to apoptosis.
Topics: Antibiotics, Antineoplastic; Apoptosis; Blotting, Western; Breast Neoplasms; Calcimycin; Carcinoma; Caspase 3; Caspase 8; Caspases; Cell Line, Tumor; Cytochromes c; Doxorubicin; Drug Resistance, Neoplasm; Enzyme Activation; Enzyme Inhibitors; Female; Humans; Ionophores; Membrane Potentials; Mitochondria; Staurosporine | 2004 |
Caspase-3 inhibits the growth of breast cancer cells independent of protease activity.
Topics: Animals; Apoptosis; Breast Neoplasms; Caspase 3; Caspases; Cell Cycle Proteins; Cell Division; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Enzyme Inhibitors; Female; Humans; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Staurosporine; Transfection; Tumor Suppressor Proteins | 2005 |
Implications of p53 in growth arrest and apoptosis on combined treatment of human Mammary epithelial cells with topotecan and UCN-01.
Topics: Antineoplastic Agents; Apoptosis; Breast; Breast Neoplasms; Carcinoma; Cell Cycle; Cell Proliferation; Epithelial Cells; Female; Genes, p53; Humans; Staurosporine; Topotecan; Tumor Cells, Cultured | 2004 |
Role of extracellular matrix in regulation of staurosporine-induced apoptosis in breast cancer cells.
Topics: Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Breast Neoplasms; Cell Death; Cell Line, Tumor; Cell Separation; Collagen; Drug Combinations; Enzyme Inhibitors; Extracellular Matrix; Fibronectins; Flow Cytometry; Humans; Immunoprecipitation; Laminin; Poly(ADP-ribose) Polymerases; Polylysine; Proteoglycans; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Transfection; Tumor Suppressor Protein p53 | 2005 |
Maspin overexpression modulates tumor cell apoptosis through the regulation of Bcl-2 family proteins.
Topics: Animals; Apoptosis; Blotting, Western; Breast Neoplasms; Caspase 8; Caspase 9; Caspase Inhibitors; Cell Line; Cell Line, Tumor; Culture Media, Serum-Free; Cytochromes c; Cytosol; Disease Progression; DNA, Complementary; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Immunoblotting; Immunoprecipitation; In Situ Nick-End Labeling; Mice; Microscopy, Fluorescence; Models, Statistical; Neoplasms; Proto-Oncogene Proteins c-bcl-2; Ribonucleases; Serpins; Staurosporine; Transcription, Genetic; Tumor Necrosis Factor-alpha | 2005 |
Caspase-3 is required in the apoptotic disintegration of the nuclear matrix.
Topics: Amino Acid Chloromethyl Ketones; Antigens, Nuclear; Apoptosis; Breast Neoplasms; Caspase 3; Caspase Inhibitors; Caspases; Cell Cycle Proteins; Cell Nucleus; Chromatin; Cysteine Proteinase Inhibitors; Cytoplasm; Enzyme Activation; Enzyme Inhibitors; Female; Fluorescent Antibody Technique; Humans; Lamin Type A; Lamin Type B; Nuclear Matrix-Associated Proteins; Nuclear Proteins; Oligopeptides; Staurosporine; Tumor Cells, Cultured | 2005 |
Transient exposure of mammary tumors to PD184352 and UCN-01 causes tumor cell death in vivo and prolonged suppression of tumor regrowth.
Topics: Apoptosis; Benzamides; Breast Neoplasms; Cell Death; Cell Line, Tumor; Drug Synergism; Enzyme Inhibitors; Female; Humans; Mitogen-Activated Protein Kinase Kinases; Protein Kinase Inhibitors; Staurosporine | 2005 |
Two targets are better than one. Promising combination therapy to treat breast cancer.
Topics: Antineoplastic Agents; Benzamides; Breast Neoplasms; Cell Line, Tumor; Drug Therapy, Combination; Enzyme Inhibitors; ErbB Receptors; Female; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mutation; Protein Kinase Inhibitors; Receptor, ErbB-2; Signal Transduction; Staurosporine | 2005 |
Eukaryotic initiation factor 4E variants alter the morphology, proliferation, and colony-formation properties of MDA-MB-435 cancer cells.
Topics: 5' Untranslated Regions; Apoptosis; Breast Neoplasms; Cell Cycle; Cell Proliferation; Drug Resistance, Neoplasm; Enzyme Inhibitors; Eukaryotic Initiation Factor-4E; Genetic Variation; Humans; Immunoblotting; Peptide Chain Initiation, Translational; Polyribosomes; Protein Biosynthesis; RNA Caps; Staurosporine; Transcription, Genetic; Tumor Cells, Cultured; Tumor Stem Cell Assay; Vascular Endothelial Growth Factor A | 2007 |
Proliferation of human breast cancer cells and anti-cancer action of doxorubicin and vinblastine are independent of PKC-alpha.
Topics: Antineoplastic Agents; Breast Neoplasms; Carcinogens; Cell Line, Tumor; Cell Proliferation; Cell Shape; Doxorubicin; Enzyme Activation; Enzyme Inhibitors; Female; Humans; Phorbol 12,13-Dibutyrate; Protein Kinase C-alpha; Staurosporine; Vinblastine | 2007 |
Myeloid cell leukemia-1 inversely correlates with glycogen synthase kinase-3beta activity and associates with poor prognosis in human breast cancer.
Topics: Breast Neoplasms; Cell Line, Tumor; Down-Regulation; Enzyme Activation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Insulin-Like Growth Factor I; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Phosphorylation; Prognosis; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Ultraviolet Rays | 2007 |
Suppression of staurosporine-mediated apoptosis in Hs578T breast cells through inhibition of neutral-sphingomyelinase by caveolin-1.
Topics: Apoptosis; Blotting, Western; Breast Neoplasms; Caveolin 1; Ceramides; Humans; Proto-Oncogene Proteins c-akt; Signal Transduction; Sphingomyelin Phosphodiesterase; Staurosporine; Tumor Cells, Cultured | 2007 |
Estrogen receptor alpha inhibits p53-mediated transcriptional repression: implications for the regulation of apoptosis.
Topics: Apoptosis; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Bone Neoplasms; Breast Neoplasms; Cell Line, Tumor; Down-Regulation; E2F1 Transcription Factor; Estrogen Receptor alpha; Estrogen Receptor Modulators; Gene Expression Regulation, Neoplastic; Histone Deacetylases; Humans; Inhibitor of Apoptosis Proteins; Microtubule-Associated Proteins; Neoplasm Proteins; Osteosarcoma; Promoter Regions, Genetic; Protein Binding; RNA, Neoplasm; Staurosporine; Survivin; Transcriptional Activation; Tumor Suppressor Protein p53 | 2007 |
DNA damage-induced S phase arrest in human breast cancer depends on Chk1, but G2 arrest can occur independently of Chk1, Chk2 or MAPKAPK2.
Topics: Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Checkpoint Kinase 1; Checkpoint Kinase 2; DNA Damage; DNA Primers; Flow Cytometry; Humans; Intracellular Signaling Peptides and Proteins; Protein Kinases; Protein Serine-Threonine Kinases; S Phase; Staurosporine | 2008 |
Differential inhibition of cytosolic and membrane-derived protein kinase C activity by staurosporine and other kinase inhibitors.
Topics: Alkaloids; Breast Neoplasms; Cell Membrane; Cytosol; Humans; Immunoblotting; Indoles; Naphthalenes; Phorbol 12,13-Dibutyrate; Polycyclic Compounds; Protein Kinase C; Staurosporine; Tumor Cells, Cultured | 1995 |
The human papilloma virus 16E6 gene sensitizes human mammary epithelial cells to apoptosis induced by DNA damage.
Topics: Alkaloids; Apoptosis; Breast; Breast Neoplasms; Cell Line, Transformed; DNA Damage; Epithelial Cells; Epithelium; Female; Flow Cytometry; Genes, Viral; Humans; Kinetics; Mitomycin; Oncogene Proteins, Viral; Papillomaviridae; Protein Kinase C; Repressor Proteins; Staurosporine; Transfection; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1995 |
Induction of tumor suppressor p21 protein by kinase inhibitors in MCF-7 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Breast Neoplasms; Bucladesine; Cell Cycle; Cell Division; Cell Line; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Enzyme Inhibitors; Flow Cytometry; Humans; Isoquinolines; Kinetics; Piperazines; Protein Kinase C; Protein Serine-Threonine Kinases; Staurosporine; Tumor Cells, Cultured | 1995 |
Cell cycle arrest and growth inhibition by the protein kinase antagonist UCN-01 in human breast carcinoma cells.
Topics: Alkaloids; Breast Neoplasms; Carcinoma; Cell Cycle; Cell Division; DNA, Neoplasm; Dose-Response Relationship, Drug; Female; Flow Cytometry; Growth Inhibitors; Humans; In Vitro Techniques; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase Inhibitors; Staurosporine; Time Factors; Tumor Cells, Cultured; Tyrosine | 1993 |
Identification of a 170 kDa membrane kinase with increased activity in KB-V1 multidrug resistant cells.
Topics: Alkaloids; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Calcium; Carbazoles; Carrier Proteins; Clone Cells; Cyclic AMP; Drug Resistance; Electrophoresis, Polyacrylamide Gel; Humans; Indole Alkaloids; Indoles; KB Cells; Melanoma, Experimental; Membrane Glycoproteins; Mice; Neoplasm Proteins; Phosphatidylserines; Phosphorylation; Phosphothreonine; Phosphotyrosine; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Pyrroles; Staurosporine; Transfection; Tumor Cells, Cultured; Tyrosine | 1993 |
Comparison of ability of protein kinase C inhibitors to arrest cell growth and to alter cellular protein kinase C localisation.
Topics: Alkaloids; Antineoplastic Agents; Breast Neoplasms; Cell Division; Cell Line; Dose-Response Relationship, Drug; Humans; Isoenzymes; Lung Neoplasms; Protein Kinase C; Staurosporine; Structure-Activity Relationship; Tumor Cells, Cultured | 1995 |
Involvement of phospholipase C in heat-shock-induced phosphorylation of P-glycoprotein in multidrug resistant human breast cancer cells.
Topics: Alkaloids; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cycloheximide; Diglycerides; Drug Resistance, Multiple; Estrenes; Hot Temperature; Humans; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Phosphorylation; Protein Kinase C; Pyrrolidinones; Staurosporine; Tumor Cells, Cultured; Type C Phospholipases | 1995 |
Retinoids increase cell-cell adhesion strength, beta-catenin protein stability, and localization to the cell membrane in a breast cancer cell line: a role for serine kinase activity.
Topics: beta Catenin; Breast Neoplasms; Cadherins; Calcium; Cell Adhesion; Cell Differentiation; Cell Membrane; Culture Media; Cytoskeletal Proteins; Drug Stability; Epithelium; Female; Humans; Indoles; Maleimides; Protein Serine-Threonine Kinases; RNA, Messenger; Staurosporine; Tissue Distribution; Trans-Activators; Tretinoin; Tumor Cells, Cultured | 1996 |
Induction of apoptosis in MDA-231 cells by protein synthesis inhibitors is suppressed by multiple agents.
Topics: Alkaloids; Apoptosis; Breast Neoplasms; Cycloheximide; DNA; Epidermal Growth Factor; Female; Humans; Protein Biosynthesis; Protein Synthesis Inhibitors; Ricin; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Staurosporine-induced G1 arrest is associated with the induction and accumulation of cyclin-dependent kinase inhibitors.
Topics: Breast Neoplasms; Cell Division; Cyclin-Dependent Kinases; Cyclins; Enzyme Inhibitors; Female; G1 Phase; Gene Expression Regulation, Neoplastic; Humans; Retinoblastoma Protein; Staurosporine; Tumor Cells, Cultured | 1996 |
Potentiation of etoposide-induced apoptosis by staurosporine in human tumor cells is associated with events downstream of DNA-protein complex formation.
Topics: Apoptosis; Breast Neoplasms; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cell Line; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; DNA Replication; Dose-Response Relationship, Drug; Drug Synergism; Etoposide; Female; HeLa Cells; Humans; Kinetics; Neoplasm Proteins; Protein Serine-Threonine Kinases; Staurosporine; Tumor Cells, Cultured | 1997 |
Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis.
Topics: Animals; Apoptosis; Breast Neoplasms; Caspase 3; Caspases; Cysteine Endopeptidases; DNA Fragmentation; Exons; Female; Humans; Mice; Mice, Knockout; Neuroblastoma; Polymerase Chain Reaction; Protein Biosynthesis; Recombinant Proteins; RNA Precursors; RNA Splicing; RNA, Messenger; Sequence Deletion; Staurosporine; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1998 |
Staurosporine-induced versus spontaneous squamous metaplasia in pre- and postmenopausal breast tissue.
Topics: Adult; Aged; Anticarcinogenic Agents; Breast; Breast Neoplasms; Carcinogens; Carcinoma, Squamous Cell; Cell Differentiation; Cell Division; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; Immunophenotyping; Keratin-10; Keratinocytes; Keratins; Middle Aged; Naphthalenes; Postmenopause; Premenopause; Protein Kinase C; Staurosporine; Tamoxifen; Tetradecanoylphorbol Acetate; Thrombomodulin; Tumor Cells, Cultured; Up-Regulation | 1998 |
A 60 kd MDM2 isoform is produced by caspase cleavage in non-apoptotic tumor cells.
Topics: Amino Acid Sequence; Apoptosis; Breast Neoplasms; Caspase 3; Caspase Inhibitors; Caspases; Cytosol; Epitopes; Female; Humans; Molecular Sequence Data; Molecular Weight; Neoplasm Proteins; Nuclear Proteins; Oligonucleotides, Antisense; Protease Inhibitors; Protein Isoforms; Protein Precursors; Protein Processing, Post-Translational; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Staurosporine; Transfection; Tumor Cells, Cultured | 1998 |
High-throughput assay for G2 checkpoint inhibitors and identification of the structurally novel compound isogranulatimide.
Topics: Adenocarcinoma; Animals; Breast Neoplasms; DNA Repair; G2 Phase; Genes, p53; Humans; Imidazoles; Indoles; Lung Neoplasms; Radiation-Sensitizing Agents; Staurosporine; Succinimides; Tumor Cells, Cultured | 1998 |
Induction of 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase type 1 gene transcription in human breast cancer cell lines and in normal mammary epithelial cells by interleukin-4 and interleukin-13.
Topics: Androstenediol; Base Sequence; Binding Sites; Breast; Breast Neoplasms; Conserved Sequence; Enzyme Inhibitors; Epithelial Cells; Female; Gene Expression Regulation, Neoplastic; Humans; Interleukin-13; Interleukin-4; Multienzyme Complexes; Progesterone Reductase; Promoter Regions, Genetic; Receptors, Estrogen; STAT6 Transcription Factor; Staurosporine; Steroid Isomerases; Trans-Activators; Transcription, Genetic; Tumor Cells, Cultured; Up-Regulation | 1999 |
1Alpha,25-dihydroxyvitamin D3 up-regulates Bcl-2 expression and protects normal human thyrocytes from programmed cell death.
Topics: Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Breast Neoplasms; Calcitriol; Gene Expression Regulation; Genes, bcl-2; Humans; Kinetics; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; RNA, Messenger; Staurosporine; Thyroid Gland; Tumor Cells, Cultured; Ultraviolet Rays | 1999 |
Phosphorylation-induced rearrangement of the histone H3 NH2-terminal domain during mitotic chromosome condensation.
Topics: Anaphase; Antibodies, Monoclonal; Breast Neoplasms; Cell Cycle; Chromosomes, Human; Female; Histones; Humans; Interphase; Metaphase; Mitosis; Phosphorylation; Prophase; Protamine Kinase; Serine; Spermine; Staurosporine; Telophase; Tumor Cells, Cultured | 1999 |
Apoptotic response to camptothecin and 7-hydroxystaurosporine (UCN-01) in the 8 human breast cancer cell lines of the NCI Anticancer Drug Screen: multifactorial relationships with topoisomerase I, protein kinase C, Bcl-2, p53, MDM-2 and caspase pathways.
Topics: Alkaloids; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Breast Neoplasms; Camptothecin; Caspase Inhibitors; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Female; Humans; Neoplasm Proteins; Nuclear Proteins; Protein Kinase C; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-mdm2; Staurosporine; Topoisomerase I Inhibitors; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1999 |
Comparison of the efficacy of 7-hydroxystaurosporine (UCN-01) and other staurosporine analogs to abrogate cisplatin-induced cell cycle arrest in human breast cancer cell lines.
Topics: Alkaloids; Antineoplastic Agents; Breast Neoplasms; Cell Cycle; Cisplatin; Drug Interactions; Enzyme Inhibitors; Flow Cytometry; Humans; Staurosporine; Tumor Cells, Cultured | 1999 |
UCN-01-mediated G1 arrest in normal but not tumor breast cells is pRb-dependent and p53-independent.
Topics: Alkaloids; Antineoplastic Agents; Breast; Breast Neoplasms; CDC2-CDC28 Kinases; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Female; G1 Phase; Growth Inhibitors; Humans; Neoplasm Proteins; Phosphorylation; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Retinoblastoma Protein; Staurosporine; Tumor Suppressor Protein p53 | 1999 |
Enhancement of camptothecin-induced cytotoxicity with UCN-01 in breast cancer cells: abrogation of S/G(2) arrest.
Topics: Alkaloids; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Camptothecin; Cattle; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Endothelium, Vascular; G2 Phase; Humans; S Phase; Staurosporine; Tumor Cells, Cultured | 2000 |
UCN-01 selectively enhances mitomycin C cytotoxicity in p53 defective cells which is mediated through S and/or G(2) checkpoint abrogation.
Topics: Alkaloids; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Squamous Cell; Cell Cycle; Cell Survival; Cyclin B; Cyclin B1; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; DNA Damage; Drug Synergism; Female; G2 Phase; Genes, p53; Humans; In Situ Nick-End Labeling; Mitomycin; Protein Kinases; S Phase; Staurosporine; Tumor Cells, Cultured | 2000 |
Caspase-8 activation and bid cleavage contribute to MCF7 cellular execution in a caspase-3-dependent manner during staurosporine-mediated apoptosis.
Topics: Apoptosis; Breast Neoplasms; Caspase 3; Caspase 8; Caspase 9; Caspases; Cytochrome c Group; Enzyme Activation; Humans; Hydrolysis; Staurosporine; Tumor Cells, Cultured | 2000 |
Synergistic cytotoxicity between a protein kinase C inhibitor, UCN-01, and monoclonal antibody to the epidermal growth factor receptor on MDA-468 cells.
Topics: Alkaloids; Animals; Antibodies, Monoclonal; Antineoplastic Agents; Breast Neoplasms; Drug Synergism; Enzyme Inhibitors; ErbB Receptors; Female; Humans; Mice; Protein Kinase C; Staurosporine; Tumor Cells, Cultured | 1997 |
Caspase-3 mediated cleavage of HsRad51 at an unconventional site.
Topics: Adenocarcinoma; Amino Acid Sequence; Apoptosis; Breast Neoplasms; Caspase 3; Caspase Inhibitors; Caspases; DNA-Binding Proteins; Enzyme Inhibitors; Female; Humans; Jurkat Cells; Molecular Sequence Data; Mutagenesis, Site-Directed; Neoplasm Proteins; Peptide Fragments; Rad51 Recombinase; Recombinant Fusion Proteins; Staurosporine; Substrate Specificity; Tumor Cells, Cultured | 2000 |
UCN-01 and camptothecin induce DNA double-strand breaks in p53 mutant tumor cells, but not in normal or p53 negative epithelial cells.
Topics: Adenocarcinoma; Alkaloids; Antineoplastic Agents; Breast; Breast Neoplasms; Camptothecin; Cell Cycle; DNA Damage; DNA Repair; DNA Replication; DNA, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Inhibitors; Epithelial Cells; Female; Gene Expression Regulation, Neoplastic; Genes, p53; Humans; Neoplasm Proteins; Protein Kinase C; Staurosporine; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2000 |
Protection of normal proliferating cells against chemotherapy by staurosporine-mediated, selective, and reversible G(1) arrest.
Topics: Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Breast; Breast Neoplasms; Camptothecin; Cells, Cultured; Cyclin-Dependent Kinases; Cytoprotection; Doxorubicin; Enzyme Inhibitors; Epithelial Cells; Feasibility Studies; Female; Flow Cytometry; Humans; Interphase; Lymphocytes; Precipitin Tests; Staurosporine; Time Factors; Tumor Cells, Cultured | 2000 |
UCN-01 (7-hydoxystaurosporine) inhibits in vivo growth of human cancer cells through selective perturbation of G1 phase checkpoint machinery.
Topics: Alkaloids; Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Breast Neoplasms; CDC2-CDC28 Kinases; Cell Division; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; DNA, Neoplasm; Drug Resistance, Neoplasm; G1 Phase; Humans; Immunohistochemistry; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Pancreatic Neoplasms; Phosphorylation; Protein Serine-Threonine Kinases; Retinoblastoma Protein; Staurosporine; Transplantation, Heterologous | 2001 |
Electrophoretic characterization of ribosomal subunits and proteins in apoptosis: specific downregulation of S11 in staurosporine-treated human breast carcinoma cells.
Topics: Amino Acid Sequence; Animals; Apoptosis; Breast Neoplasms; Down-Regulation; Electrophoresis, Agar Gel; Electrophoresis, Polyacrylamide Gel; Female; Humans; Jurkat Cells; Male; Molecular Sequence Data; Rats; Rats, Sprague-Dawley; Ribosomal Proteins; Ribosomes; Staurosporine; Tumor Cells, Cultured; U937 Cells; Ubiquitin | 2001 |
Cytotoxicity induced by manipulation of signal transduction pathways is associated with down-regulation of Bcl-2 but not Mcl-1 in MCF-7 human breast cancer.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Breast Neoplasms; Butadienes; Chromones; Down-Regulation; Enzyme Inhibitors; Female; Flow Cytometry; Genistein; Humans; Mitogen-Activated Protein Kinases; Morpholines; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Nitriles; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Staurosporine; Tumor Cells, Cultured | 2001 |
Galectin-3 translocates to the perinuclear membranes and inhibits cytochrome c release from the mitochondria. A role for synexin in galectin-3 translocation.
Topics: Annexin A7; Antigens, Differentiation; Apoptosis; Breast Neoplasms; Caspases; Cytochrome c Group; Electron Transport Complex IV; Enzyme Activation; Epithelial Cells; Female; Galectin 3; Humans; Intracellular Membranes; Membrane Glycoproteins; Microscopy, Confocal; Mitochondria; Nuclear Envelope; Protein Transport; Recombinant Fusion Proteins; Staurosporine; Tumor Cells, Cultured | 2002 |
Human breast cancer MCF-7 cell line contains inherently drug-resistant subclones with distinct genotypic and phenotypic features.
Topics: Breast Neoplasms; Caspase 3; Caspases; Chromosome Banding; Chromosomes; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Inhibitors; Genotype; Humans; Immunohistochemistry; Karyotyping; Phenotype; Reverse Transcriptase Polymerase Chain Reaction; Staurosporine; Time Factors; Tumor Cells, Cultured | 2002 |
Staurosporine-induced G(1) arrest in cancer cells depends on an intact pRB but is independent of p16 status.
Topics: Adenocarcinoma; Breast Neoplasms; Cell Line; Cyclin-Dependent Kinase Inhibitor p16; DNA Replication; Enzyme Inhibitors; Female; G1 Phase; Humans; Kinetics; Lung Neoplasms; Retinoblastoma Protein; Staurosporine; Tumor Cells, Cultured | 2002 |
Interleukin-6 and 12-O-tetradecanoyl phorbol-13-acetate act synergistically in inducing cell-cell separation and migration of human breast carcinoma cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Alkaloids; Antibodies, Monoclonal; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Cell Line; Cell Movement; Cytokines; DNA Replication; Drug Synergism; Female; Floxuridine; Growth Substances; Humans; Interleukin-6; Methotrexate; Protein Kinase C; Recombinant Proteins; Second Messenger Systems; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Ribosomal protein S6 kinase and PKC in human mammary tumor cells.
Topics: Alkaloids; Breast Neoplasms; Cell Line; Dose-Response Relationship, Drug; Enzyme Activation; Estradiol; Growth Substances; Humans; Protein Kinase C; Protein Kinases; Ribosomal Protein S6 Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1989 |
Regulation of ribosomal protein S6 kinase in human mammary tumor cells: effect of estrogen, growth factors and phorbol ester.
Topics: Alkaloids; Breast Neoplasms; Enzyme Activation; Epidermal Growth Factor; Estradiol; Growth Substances; Humans; Insulin; Phorbol Esters; Phosphorylation; Protein Kinases; Ribosomal Protein S6 Kinases; Ribosomal Proteins; Staurosporine; Tumor Cells, Cultured | 1988 |