staurosporine has been researched along with Astrocytoma, Grade IV in 23 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (17.39) | 18.2507 |
| 2000's | 10 (43.48) | 29.6817 |
| 2010's | 8 (34.78) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Aittokallio, T; Denisova, OV; Jumppanen, M; Kaur, A; Merisaari, J; Ohlmeyer, M; Taipale, M; von Schantz-Fant, C; Wennerberg, K; Westermarck, J; Yetukuri, L | 1 |
| Brundage, K; Magro, A; Rankin, G; Shrestha, S | 1 |
| Biffoni, M; De Majo, M; De Maria, R; di Martino, S; Giannetti, S; Larocca, LM; Morgante, L; Pallini, R; Pelacchi, F; Petricoin, EF; Ricci-Vitiani, L; Runci, D; Signore, M; Stancato, L | 1 |
| Casanelles, E; Garcia-Belinchón, M; Gil-Guiñón, E; Iglesias-Guimarais, V; Sánchez-Osuna, M; Yuste, VJ | 1 |
| Alves, T; Anderluh, G; Borges, HL; Gabilan, NH; Moura-Neto, V; Soletti, RC; Terenzi, H; Vernal, J | 1 |
| Chen, WJ; Chou, AK; Chou, CH; Hong, YR; Howng, SL; Hsu, CM; Lin, CC; Loh, JK; Lung, FW; Wei, CC; Yang, MC | 1 |
| Dai, Y; Dent, P; Grant, S; Tang, Y | 1 |
| Chen, MS; Chiu, IM; Chung, YF; Hsu, YC; Kao, CY | 1 |
| Blaber, M; Blaber, SI; Decker, PA; Drucker, KL; Giannini, C; Jenkins, RB; O'Neill, BP; Paulsen, AR; Scarisbrick, IA; Uhm, JH | 1 |
| Bates, TE; Daley, E; Davies, D; Dewey, RA; Kos, J; Lah, TT; Levicar, N; Pilkington, GJ | 1 |
| Chandrasekar, N; Dinh, DH; Gujrati, M; Mohanam, S; Olivero, WC; Rao, JS | 1 |
| Chen, TC; Fry, D; Liebes, L; Su, S | 1 |
| Chen, GG; Leung, BC; Ng, HK; Poon, WS; Sin, FL | 2 |
| Cao, JP; Fan, SJ; Luo, JL; Meng, QH; Tong, J; Zhou, LX | 1 |
| Fassl, A; Gdynia, G; Lehmann-Koch, J; Matsuzawa, S; Reed, JC; Roth, W; Sieber, S; Tagscherer, KE; Zentgraf, H | 1 |
| Aragón, C; Giménez, C; Gomeza, J; Olivares, L; Zafra, F | 1 |
| Baltuch, GH; Couldwell, WT; Villemure, JG; Yong, VW | 1 |
| Begemann, M; Bruce, JN; Choi, YA; Christiansen, KM; Duigou, G; Fabbro, D; Ghosh, S; Heitjan, DF; Kashimawo, SA; Kim, S; Lampen, NM; Mueller, M; Schieren, I; Schiff, PB; Weinstein, IB | 1 |
| Abrams, K; Claffey, KP; Mukhopadhyay, D; Mullen, A; Shih, SC | 1 |
| Asai, A; Kirino, T; Kuchino, Y; Narita, Y | 1 |
| Berman, SA; Bursztajn, S; Feng, JJ; Nanda, A | 1 |
| Berger, MS; Hirose, Y; Pieper, RO | 1 |
23 other study(ies) available for staurosporine and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Development of actionable targets of multi-kinase inhibitors (AToMI) screening platform to dissect kinase targets of staurosporines in glioblastoma cells.
Topics: Antineoplastic Agents; Glioblastoma; Humans; Protein Kinase Inhibitors; Protein Phosphatase 2; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Staurosporine | 2022 |
Metalloproteinase dependent reduction of cell surface cluster determinants upon the induction of apoptosis.
Topics: Apoptosis; Cell Adhesion; Cell Line, Tumor; Cell Membrane; Enzyme Inhibitors; ErbB Receptors; Gene Expression Regulation, Neoplastic; Genes, MHC Class I; Glioblastoma; Humans; Indoles; Integrins; Models, Biological; PPAR alpha; Receptor, IGF Type 1; Staurosporine | 2014 |
Combined PDK1 and CHK1 inhibition is required to kill glioblastoma stem-like cells in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Death; Cell Line, Tumor; Checkpoint Kinase 1; Dacarbazine; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Glioblastoma; Humans; Mice; Mice, Inbred NOD; Mice, SCID; Molecular Targeted Therapy; Neoplastic Stem Cells; Protein Array Analysis; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Proteomics; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Signal Transduction; Small Molecule Libraries; Staurosporine; Temozolomide; Time Factors; Tumor Burden; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2014 |
Caspase-activated DNase is necessary and sufficient for oligonucleosomal DNA breakdown, but not for chromatin disassembly during caspase-dependent apoptosis of LN-18 glioblastoma cells.
Topics: Apoptosis; Caspases; Cell Line, Tumor; Chromatin Assembly and Disassembly; Deoxyribonucleases; DNA; DNA Fragmentation; Glioblastoma; Humans; Molecular Weight; Nucleosomes; Staurosporine | 2014 |
Inhibition of MAPK/ERK, PKC and CaMKII signaling blocks cytolysin-induced human glioma cell death.
Topics: Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Death; Cell Line, Tumor; Cnidarian Venoms; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glioblastoma; Humans; MAP Kinase Signaling System; Marine Toxins; Mitogen-Activated Protein Kinases; Perforin; Phosphatidylinositol 3-Kinases; Protein Kinase C; Staurosporine; Thymidine | 2010 |
GSK3β regulates Bcl2L12 and Bcl2L12A anti-apoptosis signaling in glioblastoma and is inhibited by LiCl.
Topics: Apoptosis; Brain Neoplasms; Cell Line, Tumor; Glioblastoma; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; HEK293 Cells; Humans; Lithium Chloride; Muscle Proteins; Phosphorylation; Protein Binding; Protein Isoforms; Protein Structure, Tertiary; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Staurosporine; tau Proteins; Two-Hybrid System Techniques | 2012 |
Enhancing CHK1 inhibitor lethality in glioblastoma.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; bcl-X Protein; Benzamides; Benzimidazoles; Checkpoint Kinase 1; Glioblastoma; Humans; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Kinase 4; Medulloblastoma; Phosphorylation; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Protein Kinase Inhibitors; Protein Kinases; Radiation-Sensitizing Agents; src-Family Kinases; Staurosporine; Tumor Cells, Cultured | 2012 |
Ciliogenic RFX transcription factors regulate FGF1 gene promoter.
Topics: Acetophenones; Benzopyrans; Cell Line, Tumor; Cell Nucleus; DNA-Binding Proteins; Fibroblast Growth Factor 1; Genes, Reporter; Glioblastoma; Green Fluorescent Proteins; Humans; Promoter Regions, Genetic; Protein Kinase C; Regulatory Factor X Transcription Factors; Regulatory Factor X1; RNA Interference; RNA, Small Interfering; Staurosporine; Transcription Factors; Transcription, Genetic | 2012 |
Clinical significance and novel mechanism of action of kallikrein 6 in glioblastoma.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Brain Neoplasms; Cell Proliferation; Cisplatin; Enzyme Inhibitors; Glioblastoma; Humans; Kallikreins; Neoplasm Grading; Prognosis; Real-Time Polymerase Chain Reaction; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Staurosporine; Survival Rate; Tumor Cells, Cultured | 2013 |
Selective suppression of cathepsin L by antisense cDNA impairs human brain tumor cell invasion in vitro and promotes apoptosis.
Topics: Apoptosis; Brain Neoplasms; Caspase 3; Caspases; Cathepsin L; Cathepsins; Cell Adhesion; Cell Division; Cell Movement; Cysteine Endopeptidases; DNA, Antisense; DNA, Complementary; Genetic Therapy; Glioblastoma; Humans; Neoplasm Invasiveness; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Tumor Cells, Cultured | 2003 |
Downregulation of uPA inhibits migration and PI3k/Akt signaling in glioblastoma cells.
Topics: Apoptosis; bcl-X Protein; cdc42 GTP-Binding Protein; Cell Movement; Central Nervous System Neoplasms; Down-Regulation; Enzyme Inhibitors; G2 Phase; Glioblastoma; Humans; Mitosis; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Transfection; Tumor Cells, Cultured; Urokinase-Type Plasminogen Activator | 2003 |
Combination therapy with irinotecan and protein kinase C inhibitors in malignant glioma.
Topics: Anthracenes; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-2-Associated X Protein; Brain Neoplasms; Camptothecin; Cell Line; Glioblastoma; Humans; Irinotecan; Naphthalenes; Perylene; Protein Kinase C; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Tamoxifen; Tumor Cells, Cultured | 2003 |
Glioblastoma cells deficient in DNA-dependent protein kinase are resistant to cell death.
Topics: Annexin A5; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Brain Neoplasms; Cell Line, Tumor; DNA-Activated Protein Kinase; DNA-Binding Proteins; Drug Resistance, Neoplasm; Enzyme Inhibitors; fas Receptor; Glioblastoma; Humans; In Situ Nick-End Labeling; Indicators and Reagents; Membrane Proteins; Nuclear Proteins; Propidium; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-bcl-2; Staurosporine | 2005 |
Differential role of hydrogen peroxide and staurosporine in induction of cell death in glioblastoma cells lacking DNA-dependent protein kinase.
Topics: Apoptosis; Brain Neoplasms; Cell Death; DNA-Activated Protein Kinase; DNA-Binding Proteins; Enzyme Inhibitors; Glioblastoma; Humans; Hydrogen Peroxide; Necrosis; Nuclear Proteins; Oxidants; Protein Serine-Threonine Kinases; Staurosporine | 2005 |
Effect of 7-hydroxystaurosporine on glioblastoma cell invasion and migration.
Topics: BRCA1 Protein; Cadherins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Glioblastoma; Humans; Protein Kinase C; RNA, Messenger; Staurosporine | 2005 |
BLOC1S2 interacts with the HIPPI protein and sensitizes NCH89 glioblastoma cells to apoptosis.
Topics: Adaptor Proteins, Signal Transducing; Adult; Amino Acid Sequence; Animals; Apoptosis; Caspase 3; Caspase 8; Cell Line, Tumor; Cytochromes c; Female; Glioblastoma; HeLa Cells; Humans; Immunohistochemistry; Male; Membrane Potential, Mitochondrial; Mitochondria; Molecular Sequence Data; Neoplasms; Protein Binding; Proteins; Sequence Alignment; Staurosporine; Tissue Distribution; TNF-Related Apoptosis-Inducing Ligand | 2008 |
Regulation by phorbol esters of the glycine transporter (GLYT1) in glioblastoma cells.
Topics: Alkaloids; Amino Acid Transport Systems, Neutral; Animals; Base Sequence; Biological Transport; Carrier Proteins; Cell Line; Glioblastoma; Glycine; Glycine Plasma Membrane Transport Proteins; Molecular Sequence Data; Neuroglia; Oligonucleotides, Antisense; Protein Kinase C; Rats; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Protein kinase C inhibitors suppress cell growth in established and low-passage glioma cell lines. A comparison between staurosporine and tamoxifen.
Topics: Alkaloids; Brain Neoplasms; Cell Count; Cell Division; Cell Line; Dose-Response Relationship, Drug; Glioblastoma; Glioma; Humans; Protein Kinase C; Staurosporine; Tamoxifen; Tumor Cells, Cultured | 1993 |
Inhibition of the growth of glioblastomas by CGP 41251, an inhibitor of protein kinase C, and by a phorbol ester tumor promoter.
Topics: Aged; Animals; Antineoplastic Agents; Astrocytes; Bromodeoxyuridine; Cell Cycle; Enzyme Inhibitors; Female; Glioblastoma; Humans; Isoenzymes; Male; Mice; Mice, Inbred BALB C; Middle Aged; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Role of protein kinase C isoforms in phorbol ester-induced vascular endothelial growth factor expression in human glioblastoma cells.
Topics: Endothelial Growth Factors; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Genes, Reporter; Glioblastoma; Humans; Isoenzymes; Lymphokines; Oligonucleotides, Antisense; Protein Kinase C; RNA Processing, Post-Transcriptional; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transcriptional Activation; Transfection; Tumor Cells, Cultured; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1999 |
Actinomycin D and staurosporine, potent apoptosis inducers in vitro, are potentially effective chemotherapeutic agents against glioblastoma multiforme.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cisplatin; Dactinomycin; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Glioblastoma; Humans; Nimustine; Staurosporine; Tumor Cells, Cultured | 2000 |
Differential responses of human neuroblastoma and glioblastoma to apoptosis.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Membrane; Cell Survival; Cytosol; DNA Fragmentation; Enzyme Inhibitors; Etoposide; Glioblastoma; Humans; L-Lactate Dehydrogenase; Neuroblastoma; Poly(ADP-ribose) Polymerases; Protein Kinase C; Staurosporine; Tumor Cells, Cultured | 2001 |
Abrogation of the Chk1-mediated G(2) checkpoint pathway potentiates temozolomide-induced toxicity in a p53-independent manner in human glioblastoma cells.
Topics: Alkaloids; Antineoplastic Agents, Alkylating; CDC2 Protein Kinase; cdc25 Phosphatases; Cell Cycle Proteins; Checkpoint Kinase 1; Dacarbazine; Drug Synergism; Enzyme Inhibitors; G2 Phase; Glioblastoma; Humans; Mitosis; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Temozolomide; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2001 |