staurosporine has been researched along with Alzheimer Disease in 47 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (19.15) | 18.2507 |
| 2000's | 20 (42.55) | 29.6817 |
| 2010's | 14 (29.79) | 24.3611 |
| 2020's | 4 (8.51) | 2.80 |
| Authors | Studies |
|---|---|
| Erenler, R; Hua, DH; Jin, LW; Li, J; Lu, J; Maezawa, I; Nguyen, J; Nguyen, TD; Ranjan, A; Srivastava, SK; Swisher, LZ; Weerasekara, S | 1 |
| Hoda, N; Maqbool, M; Mobashir, M | 1 |
| Elkamhawy, A; Hassan, AHE; Lee, J; Moon, B; Pae, AN; Park, BG; Park, HM; Park, JE; Ra, H; Roh, EJ | 1 |
| Liu, P; Liu, ZP; Shi, XL; Wu, JD | 1 |
| Chen, H; Ding, H; Gao, Y; Jiang, X; Liu, W; Liu, X; Tian, L; Xu, Z; Zhao, Q | 1 |
| Chen, H; Gao, Y; Huang, Y; Jiang, X; Li, D; Liu, W; Liu, X; Wang, N; Wu, L; Xu, Z; Zhao, Q; Zhou, L | 1 |
| Bravo, MJ; Brokate-Llanos, AM; Castilla-Ortega, E; Castro-Zavala, A; de Rojas, I; Esteban-Martos, A; García-González, P; González, I; Mañas-Padilla, MDC; Melgar-Locatelli, S; Muñoz, MJ; Pacheco-Sánchez, B; Polvillo, R; Real, LM; Reyes-Engel, A; Rivera, P; Rodriguez de Fonseca, F; Royo, JL; Ruiz, A; Ruiz-Galdon, M | 1 |
| Bowles, KR; Goate, AM; Gupta, I; Herbinet, M; Machlovi, SI; Marcora, E; Pimenova, AA | 1 |
| Agrawal, K; Annadurai, N; Das, V; Džubák, P; Hajdúch, M | 1 |
| Islam, MI; Park, IS; Ryu, EK; Sharoar, MG | 1 |
| Behbahani, H; Eriksdotter, M; Linderoth, B; Mitra, S; Navarro-Oviedo, M; Tjernberg, LO; Wahlberg, L | 1 |
| Islam, MI; Park, IS; Shahnawaz, M; Sharoar, MG; Shin, SY | 1 |
| Atwal, JK; Behrens, TW; Bhangale, TR; Cruchaga, C; Farrer, LA; Foreman, O; Goate, A; Graham, RR; Haines, J; Hansen, DV; Hunkapiller, J; Maloney, JA; Mayeux, R; Ortmann, W; Pericak-Vance, M; Rathore, N; Sa, SM; Schellenberg, GD; Srinivasan, K; Tessier-Lavigne, M; Watts, RJ; Wetzel-Smith, MK; Yaylaoglu, MB | 1 |
| Anderton, BH; Garwood, C; Hanger, DP; Kinsey, AM; Noble, W; Stephenson, J | 1 |
| Chen, CM; Chen, IC; Fung, HC; Huang, SY; Kao, SH; Lee, GC; Lee-Chen, GJ; Soong, BW; Wu, YR | 1 |
| Chauhan, A; Chauhan, V; Ji, L | 1 |
| Amadoro, G; Atlante, A; Bussani, R; Calissano, P; Capsoni, S; Corsetti, V; Florenzano, F; Mercanti, D | 1 |
| Bauer, C; Checler, F; Ferreira, ST; Guillot-Sestier, MV; Marzolo, MP; Sunyach, C; Thevenet, A | 1 |
| Albers, S; Cumming, RC; Newington, JT; Rappon, T; Rylett, RJ; Wong, DY | 1 |
| Agerman, K; Eckersley, S; Gu, GJ; Kamali-Moghaddam, M; Kvist, AJ; Landegren, U; Lund, H; Milner, R; Nilsson, LN; Sunnemark, D; Wu, D | 1 |
| Baclet, MC; Czech, C; Elyaman, W; Esclaire, F; Hugon, J; Pradier, L; Terro, F; Touchet, N; Tremp, G; Yardin, C | 1 |
| Brandt, R; Eidenmüller, J; Fath, T | 1 |
| Kitamura, Y; Miki, H; Perry, G; Shibagaki, K; Shimohama, S; Smith, MA; Takata, K; Takenawa, T; Taniguchi, T; Tsuchiya, D | 1 |
| Lovell, MA; Markesbery, WR; Xie, C; Xiong, S | 1 |
| Esclaire, F; Rametti, A; Terro, F; Yardin, C | 1 |
| Danion, JM; de Barry, J; Janoshazi, A; Marescaux, C; Sellal, F; Warter, JM | 1 |
| Eckert, A; Frölich, L; Kratzsch, T; Leutner, S; Maurer, K; Müller, WE; Schindowski, K | 1 |
| Dewitt, DA; Fox, N; Ghribi, O; Griffioen, KJ; Hurd, JA; Savory, J; Townsend, BE | 1 |
| Gottardi-Littell, NR; Perez, RG; Sodhi, CP | 1 |
| Delvaux, A; Demaerschalck, I; Octave, JN | 1 |
| D'Adamio, L; Lacanà, E; Vito, P | 1 |
| Cotman, CW; Deng, G; Pike, CJ | 1 |
| Jung, YK; Kim, TW; Kovacs, DM; Pettingell, WH; Tanzi, RE | 1 |
| Hashimoto, T; Hojo, K; Kawamata, T; Maeda, K; Nakai, M; Tanaka, C; Taniguchi, T; Terashima, A | 1 |
| Duchén, M; Etcheberrigaray, R; Ibarreta, D; Kozikowski, AP; Ma, D; Qiao, L | 1 |
| Alberici, A; Benussi, L; Binetti, G; Finazzi, D; Frisoni, GB; Gasparini, L; Gatta, LB; Ghidoni, R; Growdon, JH; Moratto, D; Nitsch, RM; Trabucchi, M | 1 |
| Henderson, J; Kim, TW; Kovacs, DM; Mancini, R; Na, SJ; Schmidt, SD; Tanzi, RE | 1 |
| Behrens, MI; Fagan, AM; Han, BH; Holtzman, DM; Lendon, CL; Muller, MC; Salimi, K | 1 |
| Bibb, JA; Biernat, J; Eisenbrand, G; Garnier, M; Greengard, P; Hoessel, R; Leclerc, S; Mandelkow, EM; Marko, D; Meijer, L; Snyder, GL; Wu, YZ | 1 |
| Goodyer, C; LeBlanc, A; Zhang, Y | 1 |
| Flood, DG; Lin, YG; Reaume, AG; Savage, MJ; Scott, RW; Siman, R; Trusko, S | 1 |
| Buxbaum, JD; Choi, EK; Crowley, AC; Lilliehook, C; Merriam, DE; Miller, JS; Wasco, W; Zaidi, NF | 1 |
| Akaike, A; Honda, K; Kihara, T; Nakamizo, T; Sawada, H; Shibasaki, H; Shimohama, S | 1 |
| Alberici, A; Barbiero, L; Benussi, L; Binetti, G; Frisoni, G; Gasparini, L; Ghidoni, R; Langer, U; Mayhaus, M; Mazzoli, F; Nicosia, F; Nitsch, RM; Zanetti, O | 1 |
| Araki, W; Shirotani, K; Tabira, T; Takahashi, K; Takeda, K; Takeda, S; Yuasa, K | 1 |
| Eckert, A; Haass, C; Leutz, S; Marques, CA; Müller, WE; Steiner, B | 1 |
| Growdon, JH; Nitsch, RM; Slack, BE; Wurtman, RJ | 1 |
2 review(s) available for staurosporine and Alzheimer Disease
| Article | Year |
|---|---|
Pivotal role of glycogen synthase kinase-3: A therapeutic target for Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Diabetes Mellitus; Glycogen Synthase Kinase 3; Hippocampus; Humans; Hypoglycemic Agents; Inflammation; Molecular Targeted Therapy; Neoplasms; Protein Kinase Inhibitors | 2016 |
Microtubule affinity-regulating kinases are potential druggable targets for Alzheimer's disease.
Topics: Alzheimer Disease; Antigens, Bacterial; Azepines; Bacterial Proteins; Humans; Methylene Blue; Neurons; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrazoles; Pyridines; Pyrroles; Staurosporine; tau Proteins | 2017 |
45 other study(ies) available for staurosporine and Alzheimer Disease
| Article | Year |
|---|---|
Syntheses, neural protective activities, and inhibition of glycogen synthase kinase-3β of substituted quinolines.
Topics: Alzheimer Disease; Animals; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Mice; Models, Animal; Molecular Structure; Protein Kinase C; Quinolines; Structure-Activity Relationship | 2014 |
Discovery of 1-(3-(benzyloxy)pyridin-2-yl)-3-(2-(piperazin-1-yl)ethyl)urea: A new modulator for amyloid beta-induced mitochondrial dysfunction.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Survival; Cells, Cultured; Cyclosporine; Drug Discovery; Hippocampus; Immunosuppressive Agents; Membrane Potential, Mitochondrial; Mice; Mitochondria; Mitochondrial Membrane Transport Proteins; Molecular Docking Simulation; Neurons; Piperazines; Protein Conformation; Urea | 2017 |
Synthesis and evaluation of novel GSK-3β inhibitors as multifunctional agents against Alzheimer's disease.
Topics: Alzheimer Disease; Amides; Amines; Animals; Antioxidants; Blood-Brain Barrier; Cell Line; Chelating Agents; Drug Design; Glycogen Synthase Kinase 3 beta; Humans; PC12 Cells; Protein Aggregation, Pathological; Protein Kinase Inhibitors; Rats; Structure-Activity Relationship; tau Proteins | 2019 |
Design, synthesis and biological evaluation of harmine derivatives as potent GSK-3β/DYRK1A dual inhibitors for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Dyrk Kinases; Glycogen Synthase Kinase 3 beta; Harmine; Humans; Models, Molecular; Molecular Structure; Neuroprotective Agents; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Structure-Activity Relationship | 2021 |
Discovery of novel β-carboline derivatives as selective AChE inhibitors with GSK-3β inhibitory property for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Antineoplastic Agents; Apoptosis; Carbolines; Cell Line, Tumor; Cell Proliferation; Cholinesterase Inhibitors; Drug Design; Glycogen Synthase Kinase 3 beta; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Binding; Protein Kinase Inhibitors; Signal Transduction; Structure-Activity Relationship | 2022 |
A Functional Pipeline of Genome-Wide Association Data Leads to Midostaurin as a Repurposed Drug for Alzheimer's Disease.
Topics: Alzheimer Disease; Animals; Caenorhabditis elegans; Drug Repositioning; Genome-Wide Association Study; Mice; Staurosporine | 2023 |
Alzheimer's-associated PU.1 expression levels regulate microglial inflammatory response.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Cell Line; Cytokines; Gene Expression Profiling; Gene Knockdown Techniques; Inflammation; Lipopolysaccharides; Mice; Microglia; Nitric Oxide; Peptide Fragments; Proto-Oncogene Proteins; Rotenone; Staurosporine; Trans-Activators; Uncoupling Agents | 2021 |
Limited activation of the intrinsic apoptotic pathway plays a main role in amyloid-β-induced apoptosis without eliciting the activation of the extrinsic apoptotic pathway.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Apoptosis; Apoptotic Protease-Activating Factor 1; Caspase 3; Caspase 9; Humans; Mitochondria; Signal Transduction; Staurosporine | 2017 |
Cerebrospinal fluid from Alzheimer patients affects cell-mediated nerve growth factor production and cell survival in vitro.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Cell Line, Transformed; Cell Survival; Cerebrospinal Fluid; Cognitive Dysfunction; Epithelial Cells; Gene Expression Regulation; Humans; Interleukin-1beta; Lewy Body Disease; Nerve Growth Factor; Peptide Fragments; Retinal Pigment Epithelium; Staurosporine | 2018 |
Amyloid β binds procaspase-9 to inhibit assembly of Apaf-1 apoptosome and intrinsic apoptosis pathway.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Apoptosis; Apoptosomes; Apoptotic Protease-Activating Factor 1; Caspase 3; Caspase 9; Cell-Free System; HeLa Cells; Humans; Protein Binding; Signal Transduction; Staurosporine | 2014 |
A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Animals; CA3 Region, Hippocampal; Cell Death; Female; Genetic Predisposition to Disease; Glutamic Acid; HEK293 Cells; Humans; Male; Mice; Netrin Receptors; Neurons; Rats; Receptors, Cell Surface; Receptors, Nerve Growth Factor; Staurosporine | 2014 |
Minocycline reduces the development of abnormal tau species in models of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Caspase 3; Cell Death; Cells, Cultured; Glutamic Acid; Humans; Mice; Mice, Transgenic; Minocycline; Neurons; Rats; Staurosporine; tau Proteins; Time Factors | 2009 |
SCA8 repeat expansion: large CTA/CTG repeat alleles in neurological disorders and functional implications.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Base Sequence; Case-Control Studies; Cell Line; Central Nervous System Diseases; DNA Primers; Female; Gene Expression; Humans; Leupeptins; Lymphocytes; Male; Microfilament Proteins; Middle Aged; Nerve Tissue Proteins; Parkinson Disease; Parkinsonian Disorders; Polymorphism, Single Nucleotide; Pyrimidines; RNA, Long Noncoding; RNA, Untranslated; Spinocerebellar Ataxias; Staurosporine; Sulfonamides; Trinucleotide Repeat Expansion | 2009 |
Upregulation of cytoplasmic gelsolin, an amyloid-beta-binding protein, under oxidative stress conditions: involvement of protein kinase C.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cytoplasm; Gelsolin; Hydrogen Peroxide; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Oxidative Stress; Phorbol Esters; Protein Kinase C; Protein Kinase Inhibitors; Staurosporine; Up-Regulation | 2010 |
Interaction between NH(2)-tau fragment and Aβ in Alzheimer's disease mitochondria contributes to the synaptic deterioration.
Topics: Adenine Nucleotide Translocator 1; Adenosine Diphosphate; Adenosine Triphosphate; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Animals; Animals, Newborn; Apoptosis; Brain; Cells, Cultured; Cerebellum; Cyclophilins; Disks Large Homolog 4 Protein; Enzyme Inhibitors; Female; Humans; Immunoprecipitation; Intracellular Signaling Peptides and Proteins; Lewy Body Disease; Male; Membrane Proteins; Middle Aged; Mitochondria; Neuroblastoma; Neurons; Parkinson Disease; Peptide Fragments; Rats; Rats, Wistar; Receptors, AMPA; Staurosporine; Subcellular Fractions; Synapses; Synaptosomes; tau Proteins | 2012 |
α-Secretase-derived fragment of cellular prion, N1, protects against monomeric and oligomeric amyloid β (Aβ)-associated cell death.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Caspase 3; Cell Death; CHO Cells; Cricetinae; Cricetulus; Enzyme Activation; Enzyme Inhibitors; HEK293 Cells; Humans; Mice; Neurons; Peptides; Protein Multimerization; PrPC Proteins; Staurosporine | 2012 |
Overexpression of pyruvate dehydrogenase kinase 1 and lactate dehydrogenase A in nerve cells confers resistance to amyloid β and other toxins by decreasing mitochondrial respiration and reactive oxygen species production.
Topics: Adenosine Triphosphate; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Animals; Case-Control Studies; Cell Line; Cell Respiration; Cerebral Cortex; Female; Gene Expression; Humans; Hydrogen Peroxide; Isoenzymes; L-Lactate Dehydrogenase; Lactate Dehydrogenase 5; Male; Membrane Potential, Mitochondrial; Mice; Mice, Transgenic; Mitochondria; Neurons; Oxygen Consumption; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Rats; Reactive Oxygen Species; Staurosporine | 2012 |
Elevated MARK2-dependent phosphorylation of Tau in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Brain; Cell Line, Transformed; Enzyme Inhibitors; Female; Green Fluorescent Proteins; Humans; Male; Mice; Middle Aged; Phosphorylation; Protein Serine-Threonine Kinases; Serine; Staurosporine; tau Proteins; Transfection | 2013 |
Neurons overexpressing mutant presenilin-1 are more sensitive to apoptosis induced by endoplasmic reticulum-Golgi stress.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Apoptosis; Brefeldin A; Caspases; Cells, Cultured; Cyclooxygenase Inhibitors; Endoplasmic Reticulum; Enzyme Inhibitors; Fetus; Golgi Apparatus; Masoprocol; Membrane Proteins; Mice; Mice, Transgenic; Mutation; Neurons; Oxidative Stress; Presenilin-1; Protein Folding; Protein Synthesis Inhibitors; Signal Transduction; Staurosporine | 2002 |
Tau-mediated cytotoxicity in a pseudohyperphosphorylation model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Apoptosis; Cell Differentiation; Cell Line; Colchicine; Enzyme Inhibitors; Humans; Immunoblotting; Immunohistochemistry; Microtubules; Models, Biological; Nerve Growth Factor; Neurons; PC12 Cells; Phosphorylation; Rats; Simplexvirus; Staurosporine; tau Proteins; Transfection | 2002 |
Possible involvement of Wiskott-Aldrich syndrome protein family in aberrant neuronal sprouting in Alzheimer's disease.
Topics: Adaptor Proteins, Signal Transducing; Aged; Aged, 80 and over; Alzheimer Disease; Brain; Carrier Proteins; Humans; Immunoblotting; Immunohistochemistry; Microfilament Proteins; Microscopy, Confocal; Muscle Proteins; Nerve Tissue Proteins; Neurons; Staurosporine; Tumor Cells, Cultured; Wiskott-Aldrich Syndrome; Wiskott-Aldrich Syndrome Protein Family; Wiskott-Aldrich Syndrome Protein, Neuronal | 2003 |
Wilms' tumor suppressor (WT1) is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antibody Specificity; Antisense Elements (Genetics); Apoptosis; Blotting, Western; Cell Survival; Codon, Nonsense; Female; Genes, Wilms Tumor; Hippocampus; Humans; Immunohistochemistry; Male; Nerve Degeneration; Neurofibrillary Tangles; Neurons; Rats; Staurosporine | 2003 |
Linking alterations in tau phosphorylation and cleavage during neuronal apoptosis.
Topics: Alzheimer Disease; Animals; Apoptosis; Caspase Inhibitors; Cells, Cultured; Cerebral Cortex; Colchicine; Embryo, Mammalian; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Lithium; Neurons; Okadaic Acid; Peptide Fragments; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2; Rats; Rats, Wistar; Staurosporine; tau Proteins | 2004 |
Alteration of protein kinase C conformation in red blood cells: a potential marker for Alzheimer's disease but not for Parkinson's disease.
Topics: Age Factors; Aged; Alzheimer Disease; Analysis of Variance; Biomarkers; Enzyme Inhibitors; Erythrocytes; Female; Fluoresceins; Humans; Indoles; Male; Parkinson Disease; Phorbol Esters; Protein Conformation; Protein Kinase C; Spectrum Analysis; Staurosporine | 2006 |
Enhanced ROS-generation in lymphocytes from Alzheimer's patients.
Topics: Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Antioxidants; Deoxyribose; Enzyme Inhibitors; Erythrocytes; Female; Flow Cytometry; Humans; In Vitro Techniques; Lipid Peroxidation; Lymphocytes; Male; Middle Aged; Oxidative Stress; Reactive Oxygen Species; Rhodamines; Staurosporine | 2005 |
Peri-nuclear clustering of mitochondria is triggered during aluminum maltolate induced apoptosis.
Topics: Alzheimer Disease; Amino Acid Chloromethyl Ketones; Animals; Antineoplastic Agents; Apoptosis; Cell Line; Cell Nucleus; Cytochromes c; Enzyme Inhibitors; Humans; Hydrogen Peroxide; Immunohistochemistry; In Situ Nick-End Labeling; Microtubules; Mitochondria; Neurites; Neuroprotective Agents; Nocodazole; Organelles; Organometallic Compounds; Pyrones; Rabbits; Staurosporine | 2006 |
Phosphorylation of beta-amyloid precursor protein (APP) cytoplasmic tail facilitates amyloidogenic processing during apoptosis.
Topics: Alzheimer Disease; Amino Acid Sequence; Amino Acids; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Apoptosis; Binding Sites; Brain; Down-Regulation; Endocytosis; Enzyme Inhibitors; Mitogen-Activated Protein Kinase 3; Nerve Degeneration; PC12 Cells; Peptide Fragments; Phosphorylation; Protein Structure, Tertiary; Rats; Staurosporine | 2008 |
Activation of protein kinase C increases the extracellular release of the transmembrane amyloid protein precursor of Alzheimer's disease.
Topics: Alkaloids; Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Endopeptidases; Enzyme Activation; Phorbol 12,13-Dibutyrate; Protein Kinase C; Staurosporine; Transfection | 1993 |
Interfering with apoptosis: Ca(2+)-binding protein ALG-2 and Alzheimer's disease gene ALG-3.
Topics: Alkaloids; Alzheimer Disease; Amino Acid Sequence; Animals; Apoptosis; Apoptosis Regulatory Proteins; Calcium; Calcium-Binding Proteins; Cell Line; Cloning, Molecular; Dactinomycin; Dexamethasone; DNA, Complementary; Fas Ligand Protein; fas Receptor; Hybridomas; Interleukin-2; Membrane Glycoproteins; Membrane Proteins; Mice; Molecular Sequence Data; Presenilin-2; Receptors, Antigen, T-Cell; Signal Transduction; Staurosporine; T-Lymphocytes; Transfection; Up-Regulation | 1996 |
Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cells.
Topics: Alzheimer Disease; Animals; Apoptosis; bcl-X Protein; Cell Survival; Gene Expression; Humans; Hydrogen Peroxide; Membrane Proteins; Mice; PC12 Cells; Presenilin-2; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Staurosporine; Transfection | 1996 |
Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease.
Topics: Alzheimer Disease; Amino Acid Chloromethyl Ketones; Amino Acid Substitution; Animals; Apoptosis; Caspase 3; Caspases; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Activation; Etoposide; Membrane Proteins; Mutation; Oligopeptides; Phosphorylation; Presenilin-1; Presenilin-2; Rats; Staurosporine; Tumor Cells, Cultured | 1997 |
PKC and tyrosine kinase involvement in amyloid beta (25-35)-induced chemotaxis of microglia.
Topics: Alkaloids; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzophenanthridines; Benzoquinones; Brain; Carcinogens; Cells, Cultured; Chemotaxis; Dose-Response Relationship, Drug; Enzyme Inhibitors; Lactams, Macrocyclic; Microglia; Naphthalenes; Peptide Fragments; Phenanthridines; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Rats; Rats, Wistar; Rifabutin; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1998 |
Benzolactam (BL) enhances sAPP secretion in fibroblasts and in PC12 cells.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Humans; Lactams; PC12 Cells; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Reference Values; Solubility; Staurosporine | 1999 |
Presenilin 1 protein directly interacts with Bcl-2.
Topics: Alzheimer Disease; Cell Line; Cloning, Molecular; HeLa Cells; Humans; In Situ Nick-End Labeling; Lymphocytes; Membrane Proteins; Presenilin-1; Protein Binding; Proto-Oncogene Proteins c-bcl-2; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Staurosporine; Tumor Cells, Cultured | 1999 |
Staurosporine-induced activation of caspase-3 is potentiated by presenilin 1 familial Alzheimer's disease mutations in human neuroglioma cells.
Topics: Alzheimer Disease; Amino Acid Substitution; Apoptosis; Brain Neoplasms; Caspase 3; Caspases; Enzyme Activation; Enzyme Precursors; Glioma; Humans; Membrane Proteins; Point Mutation; Poly(ADP-ribose) Polymerases; Presenilin-1; Recombinant Fusion Proteins; Staurosporine; Transfection | 1999 |
No effect of apolipoprotein E on neuronal cell death due to excitotoxic and apoptotic agents in vitro and neonatal hypoxic ischaemia in vivo.
Topics: Alzheimer Disease; Animals; Animals, Newborn; Antibodies; Apolipoprotein E3; Apolipoprotein E4; Apolipoproteins E; Apoptosis; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Gene Expression; Humans; Hypoxia-Ischemia, Brain; In Vitro Techniques; Mice; Mice, Inbred CBA; Mice, Knockout; N-Methylaspartate; Neurons; Neurotoxins; Staurosporine | 2000 |
Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?
Topics: Adenosine Triphosphate; Alkaloids; Alzheimer Disease; Animals; Antibiotics, Antineoplastic; Calcium-Calmodulin-Dependent Protein Kinases; CDC2 Protein Kinase; Cyclin B; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Dopamine and cAMP-Regulated Phosphoprotein 32; Drugs, Chinese Herbal; Enzyme Inhibitors; Flavonoids; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Indoles; Inhibitory Concentration 50; Mice; Molecular Structure; Neostriatum; Nerve Tissue Proteins; Phosphoproteins; Phosphorylation; Phosphothreonine; Piperidines; Staurosporine; tau Proteins | 2001 |
Selective and protracted apoptosis in human primary neurons microinjected with active caspase-3, -6, -7, and -8.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Apoptosis; Astrocytes; Caspase 3; Caspase 6; Caspase 7; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Microinjections; Neurons; Staurosporine; Time Factors | 2000 |
Presenilin-1 P264L knock-in mutation: differential effects on abeta production, amyloid deposition, and neuronal vulnerability.
Topics: Alzheimer Disease; Amino Acid Substitution; Amyloid; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Apoptosis; Calpain; Caspases; Cell Survival; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Gene Targeting; Glutamic Acid; Homozygote; Membrane Proteins; Mice; Mice, Mutant Strains; Mice, Transgenic; Neurons; Peptide Fragments; Presenilin-1; Staurosporine | 2000 |
Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2.
Topics: Alzheimer Disease; Animals; Apoptosis; Binding Sites; Blotting, Western; Calcium; Calcium-Binding Proteins; Caspase 3; Caspases; Cell Membrane; COS Cells; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Kv Channel-Interacting Proteins; Membrane Proteins; Microscopy, Confocal; Microscopy, Fluorescence; Models, Biological; Mutagenesis, Site-Directed; Mutation; Phosphorylation; Precipitin Tests; Presenilin-2; Protein Binding; Protein Structure, Tertiary; Repressor Proteins; Staurosporine; Subcellular Fractions; Transfection; Tumor Cells, Cultured | 2001 |
Nongenomic antiapoptotic signal transduction by estrogen in cultured cortical neurons.
Topics: Alzheimer Disease; Animals; Apoptosis; Cells, Cultured; Cerebral Cortex; Cyclic AMP Response Element-Binding Protein; Enzyme Inhibitors; Estradiol; Estrogen Replacement Therapy; Fetus; Glutamic Acid; Menopause; Nerve Degeneration; Neurons; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Serine; Signal Transduction; Staurosporine | 2001 |
Detection of the presenilin 1 COOH-terminal fragment in the extracellular compartment: a release enhanced by apoptosis.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Blotting, Western; Cell Line; Cells, Cultured; Cerebral Cortex; Enzyme Inhibitors; Extracellular Matrix; Hippocampus; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Membrane Proteins; Microscopy, Fluorescence; Neurons; Peptide Fragments; Peptides; Presenilin-1; Protein Binding; Protein Structure, Tertiary; Rats; Rats, Wistar; Staurosporine | 2001 |
Pro-apoptotic effect of presenilin 2 (PS2) overexpression is associated with down-regulation of Bcl-2 in cultured neurons.
Topics: Adenoviridae; Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Peptides; Animals; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Cells, Cultured; Cerebral Cortex; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Genes, bcl-2; Genetic Vectors; Humans; Membrane Proteins; Mutation, Missense; Nerve Tissue Proteins; Neurons; Presenilin-2; Protein Isoforms; Proto-Oncogene Proteins c-bcl-2; Rats; Recombinant Fusion Proteins; Staurosporine | 2001 |
Reduction of trophic support enhances apoptosis in PC12 cells expressing Alzheimer's APP mutation and sensitizes cells to staurosporine-induced cell death.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Apoptosis; Culture Media; DNA Fragmentation; Enzyme Inhibitors; Flow Cytometry; Humans; In Situ Nick-End Labeling; L-Lactate Dehydrogenase; Mutation; Neurons; Oxidative Stress; PC12 Cells; Rats; Staurosporine; Tetrazolium Salts; Thiazoles | 2002 |
Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors.
Topics: Alkaloids; Alzheimer Disease; Amyloid beta-Protein Precursor; Atropine; Blotting, Western; Brain Chemistry; Carbachol; Cell Line; Embryo, Mammalian; Humans; Kidney; Kinetics; Protein Kinase C; Receptors, Muscarinic; Staurosporine; Transfection | 1992 |