staurosporine has been researched along with Adenocarcinoma in 49 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 23 (46.94) | 18.2507 |
| 2000's | 15 (30.61) | 29.6817 |
| 2010's | 10 (20.41) | 24.3611 |
| 2020's | 1 (2.04) | 2.80 |
| Authors | Studies |
|---|---|
| Abdelhamid, D; Abourehab, MAS; Abuo-Rahma, GEA; Badr, M; Hassan, A; Hassan, HA | 1 |
| Balasse, L; Franceschini, E; Guillermin, R; Guillet, B; Muleki-Seya, P; Payan, C; Roffino, S | 1 |
| Bitzinger, D; Bundscherer, A; Graf, B; Malsy, M | 1 |
| Ashley, N; Bodmer, WF; Jones, M; Ouaret, D; Wilding, J | 1 |
| Bornancin, F; Fabbro, D; Huwiler, A; Japtok, L; Kleuser, B; Pastukhov, O; Pfeilschifter, J; Schwalm, S; Zangemeister-Wittke, U | 1 |
| Gayatri, S; Ghoshal-Gupta, S; Jiwani, S; Kutiyanawalla, A; Lee, BR; Nalluri, S; Rojiani, AM; Rojiani, MV | 1 |
| Bradford, CS; Dashwood, RH; Dashwood, WM; Fischer, KA; Ho, E; Johnson, G; Kang, Y; Löhr, CV; Wang, R; Williams, DE | 1 |
| Huang, J; Liu, H; Song, X; Wang, Y; Yang, H | 1 |
| Xing, D; Zhang, L; Zhang, Y | 1 |
| He, W; Hou, S; Hu, B; Li, H; Liu, J; Min, X; Wang, J | 1 |
| Shimizu, T | 1 |
| Hsu, CP; Hsu, PY; Lin, JJ; Wu, YL | 1 |
| Collecchi, P; Mariani, L; Piras, A; Poliseno, L; Rainaldi, G; Zaccaro, L | 1 |
| Ho, YS; Lee, WS; Liang, YC; Lin, SY; Pan, S; Tsai, SH | 1 |
| Gallick, GE; Kraker, AJ; McConkey, DJ; Parikh, NU; Siwak, DR; Summy, JM; Windham, TC | 1 |
| Ha, MW; Hou, KZ; Liu, YP; Yuan, Y | 1 |
| Hui, ZG; Li, YX; Yang, WZ; Yu, ZH | 1 |
| Furukawa, K; Kawado, T; Sato, T; Takahashi, M; Takayama, E | 1 |
| Cho, CH; Chu, KM; Koo, MW; Lam, EK; Shin, VY; Tai, EK; Wong, HP; Wu, WK | 1 |
| Chung, WH; Han, K; Han, KT; Kim, M; Kim, Y; Lim, J; Park, IY | 1 |
| Büchler, MW; Büchler, P; El Fitori, J; Friess, H; Giese, NA; Herr, I; Hines, OJ; Ludwig, R; Quentmeier, H; Su, Y | 1 |
| Gajkowska, B; Orzechowski, A; Pajak, B; Turowska, A | 1 |
| Bonney, RC; Franks, S; Watson, H | 1 |
| Connor, P; Gretz, HF; Lelle, RJ; Menon, KM; Pearl, M; Roberts, JA; Talavera, F | 1 |
| Easom, RA; Riehl, TE; Stenson, WF; Turk, J | 1 |
| Hayakawa, T; Inoue, T; Kishi, J; Koita, H; Komada, N; Koono, M; Nabeshima, K | 1 |
| Forstner, G; Forstner, J; McCool, D; Zhang, Y | 1 |
| Giaccia, AJ; Hahn, GM; Koong, AC; Saad, AH | 1 |
| Daly, C; Reich, NC | 1 |
| Hengels, KJ; Piontek, M; Porschen, R; Strohmeyer, G | 1 |
| Ikegami, Y; Nakao, K; Yano, S | 1 |
| Courage, C; Gescher, A; Snowden, R | 1 |
| Guzman, J; Koutsos, M; Kozoni, V; Qiao, L; Rigas, B; Shiff, SJ; Tsai, LL | 1 |
| Aguirre Ghiso, JA; Alonso, DF; Arregui, C; Bal de Kier Joffé, E; Farías, EF | 1 |
| Pommier, Y; Shao, RG; Shimizu, T | 1 |
| Albright, CD; Carter, CA; Kaufman, DG | 1 |
| Bradder, SM; Courage, C; Gescher, A; Jones, T; Schultze-Mosgau, MH | 1 |
| Carter, CA; Chambers, T; Parham, GP | 1 |
| Chiang, HS; Huang, TF; Lin, SW; Yang, RS | 1 |
| Andersen, RJ; Anderson, HJ; Berlinck, RG; Britton, R; Curman, D; Davies, P; Friend, SH; Haggarty, SJ; Kelly, MT; Lim, LY; Piers, E; Roberge, M; Stringer, CM; Vincent, I; Xu, L | 1 |
| Flygare, J; Hellgren, D; Wennborg, A | 1 |
| Clements, MK; Daoud, SS; Jones, CB; Redkar, A | 1 |
| Chrest, J; Gabrielson, E; Lin, Y; Wersto, R; Zhou, W | 1 |
| Butler, J; Franklin, WA; Makeyev, Y; Vikram, B; Xiao, HH | 1 |
| Alkhalaf, B; Ballejo, G; Gong, Y; Molnar, P; Murphy, LC; Murphy, LJ | 1 |
| Brown, JM; Giaccia, AJ; Kim, CY; Strulovici, B | 1 |
| Chadee, K; Keller, K; Olivier, M | 1 |
| Alkhalaf, B; Gong, Y; Murphy, LC; Murphy, LJ | 1 |
| Greten, H; Humburg, I; Kalthoff, H; Roeder, C; Schmiegel, W; Thiele, HG | 1 |
49 other study(ies) available for staurosporine and Adenocarcinoma
| Article | Year |
|---|---|
Design, synthesis, in vitro antiproliferative evaluation and in silico studies of new VEGFR-2 inhibitors based on 4-piperazinylquinolin-2(1H)-one scaffold.
Topics: Adenocarcinoma; Amines; Antineoplastic Agents; Breast Neoplasms; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Female; Humans; Molecular Docking Simulation; Molecular Structure; Protein Kinase Inhibitors; Sorafenib; Staurosporine; Structure-Activity Relationship; Vascular Endothelial Growth Factor Receptor-2 | 2022 |
Nonlinear ultrasound parameter to monitor cell death in cancer cell samples.
Topics: Adenocarcinoma; Algorithms; Apoptosis; Colonic Neoplasms; Enzyme Inhibitors; Flow Cytometry; HT29 Cells; Humans; Monitoring, Physiologic; Nonlinear Dynamics; Staurosporine; Ultrasonography | 2018 |
Staurosporine induces apoptosis in pancreatic carcinoma cells PaTu 8988t and Panc-1 via the intrinsic signaling pathway.
Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Enzyme Inhibitors; Humans; Pancreatic Neoplasms; Signal Transduction; Staurosporine | 2019 |
Rapidly derived colorectal cancer cultures recapitulate parental cancer characteristics and enable personalized therapeutic assays.
Topics: Adenocarcinoma; Cell Differentiation; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; Enzyme Inhibitors; Goblet Cells; Humans; Keratin-20; Spheroids, Cellular; Staurosporine; Time Factors; Tumor Cells, Cultured | 2014 |
The ceramide kinase inhibitor NVP-231 inhibits breast and lung cancer cell proliferation by inducing M phase arrest and subsequent cell death.
Topics: Adenocarcinoma; Apoptosis; Benzothiazoles; Blotting, Western; Breast Neoplasms; Bridged-Ring Compounds; Cell Proliferation; Cell Survival; DNA; Enzyme Inhibitors; Flow Cytometry; Humans; Lung Neoplasms; M Phase Cell Cycle Checkpoints; MCF-7 Cells; Phosphotransferases (Alcohol Group Acceptor); Staurosporine; Tumor Stem Cell Assay | 2014 |
TIMP-1 Inhibits Apoptosis in Lung Adenocarcinoma Cells via Interaction with Bcl-2.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Apoptosis; bcl-2-Associated X Protein; Biomarkers, Tumor; Cell Line, Tumor; Down-Regulation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Intracellular Membranes; Lung Neoplasms; Mitochondria; Permeability; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Tissue Inhibitor of Metalloproteinase-1 | 2015 |
Reciprocal regulation of BMF and BIRC5 (Survivin) linked to Eomes overexpression in colorectal cancer.
Topics: Adaptor Proteins, Signal Transducing; Adenocarcinoma; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; G2 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; Inhibitor of Apoptosis Proteins; Kaplan-Meier Estimate; Male; Microtubule-Associated Proteins; Neoplasm Staging; Rats, Inbred F344; RNA Interference; Signal Transduction; Staurosporine; Survival Analysis; Survivin; T-Box Domain Proteins; Time Factors; Transfection; Up-Regulation | 2016 |
Effect of staurosporine on the mobility and invasiveness of lung adenocarcinoma A549 cells: an in vitro study.
Topics: Adenocarcinoma; Apoptosis; Cadherins; Cell Adhesion; Cell Growth Processes; Cell Line, Tumor; Cell Movement; Humans; Integrin beta1; Lung Neoplasms; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Protein Kinase C-alpha; Staurosporine; Urokinase-Type Plasminogen Activator | 2009 |
LPLI inhibits apoptosis upstream of Bax translocation via a GSK-3beta-inactivation mechanism.
Topics: Adenocarcinoma; Androstadienes; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Line, Tumor; Dose-Response Relationship, Radiation; Enzyme Activation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Lasers, Gas; Low-Level Light Therapy; Lung Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Binding; Protein Kinase Inhibitors; Protein Transport; Proto-Oncogene Proteins c-akt; RNA Interference; Signal Transduction; Staurosporine; Time Factors; Transfection; Wortmannin | 2010 |
Activation of volume-sensitive Cl(-) channel is involved in carboplatin-induced apoptosis in human lung adenocarcinoma cells.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenocarcinoma; Angiogenesis Inhibitors; Antineoplastic Agents; Apoptosis; Carboplatin; Cell Line, Tumor; Chloride Channels; Humans; Hypotonic Solutions; Lung Neoplasms; Membrane Potentials; Nitrobenzoates; Patch-Clamp Techniques; Staurosporine | 2010 |
A new player in apoptosis triggered with anticancer drugs: the volume-sensitive outwardly-rectifying Cl(-) channel.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenocarcinoma; Antineoplastic Agents; Apoptosis; Carboplatin; Cell Line, Tumor; Chloride Channels; Humans; Lung Neoplasms; Membrane Potentials; Models, Biological; Staurosporine | 2010 |
Detecting the effect of targeted anti-cancer medicines on single cancer cells using a poly-silicon wire ion sensor integrated with a confined sensitive window.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Antineoplastic Agents; Apoptosis; Biosensing Techniques; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Delivery Systems; Gefitinib; Humans; Ions; Lung Neoplasms; Propylamines; Quinazolines; Silanes; Silicon; Single-Cell Analysis; Staurosporine | 2012 |
Bcl2-negative MCF7 cells overexpress p53: implications for the cell cycle and sensitivity to cytotoxic drugs.
Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Cycle; Cisplatin; DNA Damage; Drug Resistance, Neoplasm; Female; Gene Deletion; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, bcl-2; Genes, p53; Humans; Mitochondria; Staurosporine; Tumor Stem Cell Assay; Tumor Suppressor Protein p53 | 2002 |
Involvement of both extracellular signal-regulated kinase and c-jun N-terminal kinase pathways in the 12-O-tetradecanoylphorbol-13-acetate-induced upregulation of p21(Cip1) in colon cancer cells.
Topics: Adenocarcinoma; CDC2-CDC28 Kinases; Cell Cycle; Cell Division; Chromosome Mapping; Colonic Neoplasms; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Disease Progression; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Protein Kinase C; Protein Serine-Threonine Kinases; Protein Transport; Pyridines; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Up-Regulation | 2002 |
Src activation regulates anoikis in human colon tumor cell lines.
Topics: Adenocarcinoma; Amino Acid Substitution; Anoikis; Apoptosis; bcl-X Protein; Caspase 3; Caspases; Cell Adhesion; Cell Cycle; Chromones; Colonic Neoplasms; Disease Progression; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Genes, src; Humans; Morpholines; Mutation, Missense; Neoplasm Metastasis; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins pp60(c-src); Pyridones; Pyrimidines; Recombinant Fusion Proteins; Signal Transduction; Staurosporine; Transfection; Tumor Cells, Cultured | 2002 |
Effect of staurosporine on cycle of human gastric cancer cells.
Topics: Adenocarcinoma; Cell Division; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Dose-Response Relationship, Drug; Enzyme Inhibitors; G2 Phase; Humans; Mitosis; Protein Kinase C; Staurosporine; Stomach Neoplasms | 2004 |
[Abrogation effect of UCN-01 on radiation-induced G2 phase arrest of tumor cells and its mechanism].
Topics: Adenocarcinoma; Antineoplastic Agents; CDC2 Protein Kinase; Cell Line, Tumor; G2 Phase; Genes, p53; Humans; Lung Neoplasms; Mutation; Nasopharyngeal Neoplasms; Particle Accelerators; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Staurosporine | 2005 |
Effect of staurosporine on N-glycosylation and cell adhesion to fibronectin of SW480 human colorectal adenocarcinoma cells.
Topics: Adenocarcinoma; Cell Adhesion; Cell Line, Tumor; Colorectal Neoplasms; Fibronectins; Gene Expression; Glycosylation; Humans; N-Acetylglucosaminyltransferases; Neoplasm Metastasis; Phosphorylation; Protein Kinase C; Reverse Transcriptase Polymerase Chain Reaction; Staurosporine | 2005 |
Functional role of beta-adrenergic receptors in the mitogenic action of nicotine on gastric cancer cells.
Topics: Adenocarcinoma; Adrenergic beta-Antagonists; Atenolol; Butadienes; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 2; Dose-Response Relationship, Drug; Enzyme Induction; Extracellular Signal-Regulated MAP Kinases; Humans; Membrane Proteins; Mitogens; Nicotine; Nitriles; Phosphorylation; Propanolamines; Protein Kinase C; Protein Kinase C beta; Protein Kinase Inhibitors; Protein Transport; Receptors, Adrenergic, beta; Signal Transduction; Staurosporine; Stomach Neoplasms; Transcription Factor AP-1 | 2007 |
Antitumor and normal cell protective effect of PKC412 in the athymic mouse model of ovarian cancer.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Body Weight; Cell Line, Tumor; Cytokines; Drug Therapy, Combination; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Ovarian Neoplasms; Paclitaxel; Protein Kinase C; Spleen; Staurosporine; Xenograft Model Antitumor Assays | 2006 |
PKC 412 small-molecule tyrosine kinase inhibitor: single-compound therapy for pancreatic cancer.
Topics: Adenocarcinoma; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Flow Cytometry; fms-Like Tyrosine Kinase 3; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Male; Mice; Mice, Inbred BALB C; Microcirculation; Pancreatic Neoplasms; Point Mutation; Polymerase Chain Reaction; Protein Kinase C; Receptors, Vascular Endothelial Growth Factor; Sequence Analysis, DNA; Signal Transduction; Staurosporine; Tandem Repeat Sequences; Tumor Cells, Cultured | 2007 |
Bisindolylmaleimide IX facilitates extrinsic and initiates intrinsic apoptosis in TNF-alpha-resistant human colon adenocarcinoma COLO 205 cells.
Topics: Adenocarcinoma; Apoptosis; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspase 9; Cell Line, Tumor; Colonic Neoplasms; Drug Resistance, Neoplasm; Drug Synergism; Fas-Associated Death Domain Protein; Humans; Indoles; Maleimides; Protein Kinase C; Staurosporine; TNF Receptor-Associated Death Domain Protein; Tumor Necrosis Factor-alpha; Up-Regulation | 2008 |
The epidermal growth factor receptor in the human endometrial adenocarcinoma cell line HEC-1-B.
Topics: Adenocarcinoma; Alkaloids; Binding Sites; Endometrial Neoplasms; Epidermal Growth Factor; ErbB Receptors; Estradiol; Female; Humans; Kinetics; Progesterone; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Protein kinase C-dependent and -independent pathways mediate epidermal growth factor (EGF) effects in human endometrial adenocarcinoma cell line KLE.
Topics: Adenocarcinoma; Alkaloids; Animals; Cell Division; Dose-Response Relationship, Drug; Endometrial Neoplasms; Epidermal Growth Factor; Female; Humans; Mice; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Thymidine; Tumor Cells, Cultured | 1994 |
Regulation of paracellular permeability in Caco-2 cell monolayers by protein kinase C.
Topics: Adenocarcinoma; Alkaloids; Carbachol; Cell Line; Cell Membrane; Cell Membrane Permeability; Colonic Neoplasms; Enzyme Activation; Glycerides; Humans; Kinetics; Mannitol; Membrane Potentials; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1993 |
TPA-enhanced invasion of Matrigel associated with augmentation of cell motility but not metalloproteinase activity in a highly metastatic variant (L-10) of human rectal adenocarcinoma cell line RCM-1.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenocarcinoma; Alkaloids; Animals; Cell Membrane; Cell Movement; Collagen; Drug Combinations; Glycoproteins; Humans; Laminin; Metalloendopeptidases; Mice; Mice, Nude; Neoplasm Invasiveness; Protein Kinase C; Proteoglycans; Rectal Neoplasms; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinases; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1993 |
Mucin secretion by T84 cells: stimulation by PKC, Ca2+, and a protein kinase activated by Ca2+ ionophore.
Topics: Adenocarcinoma; Alkaloids; Calcimycin; Calcium; Colonic Neoplasms; Culture Media; Down-Regulation; Egtazic Acid; Humans; Mucins; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Activation of potassium channels by hypoxia and reoxygenation in the human lung adenocarcinoma cell line A549.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcysteine; Adenocarcinoma; Alkaloids; Free Radical Scavengers; Humans; Hypoxia; Isoquinolines; Lung Neoplasms; Oxidation-Reduction; Oxygen; Piperazines; Potassium Channels; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Tetraethylammonium; Tetraethylammonium Compounds; Time Factors; Tumor Cells, Cultured | 1993 |
Double-stranded RNA activates novel factors that bind to the interferon-stimulated response element.
Topics: Actins; Adenocarcinoma; Adenoviruses, Human; Alkaloids; Base Sequence; Binding Sites; Endometrial Neoplasms; Female; Genistein; HeLa Cells; Humans; Interferon Type I; Isoflavones; Kinetics; Molecular Sequence Data; Oligodeoxyribonucleotides; Oligonucleotide Probes; Protein-Tyrosine Kinases; Recombinant Proteins; RNA-Binding Proteins; RNA, Double-Stranded; RNA, Messenger; Simplexvirus; Staurosporine; Thymidine Kinase; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1993 |
Protein kinase C and adenylate cyclase as targets for growth inhibition of human gastric cancer cells.
Topics: Adenocarcinoma; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Alkaloids; Bucladesine; Cell Division; Colforsin; Enzyme Activation; Humans; Protein Kinase C; Staurosporine; Stomach Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Antitumor effect of CGP41251, a new selective protein kinase C inhibitor, on human non-small cell lung cancer cells.
Topics: Adenocarcinoma; Analysis of Variance; Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cell Cycle; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Lung Neoplasms; Male; Mice; Mice, Nude; Neoplasm Transplantation; Protein Kinase C; Staurosporine; Tumor Cells, Cultured | 1996 |
Differential effects of staurosporine analogues on cell cycle, growth and viability in A549 cells.
Topics: Adenocarcinoma; Antineoplastic Agents; Cell Cycle; Cell Division; Cell Survival; DNA, Neoplasm; Enzyme Inhibitors; Humans; Lung Neoplasms; Staurosporine; Time Factors; Tumor Cells, Cultured | 1996 |
Staurosporine inhibits the proliferation, alters the cell cycle distribution and induces apoptosis in HT-29 human colon adenocarcinoma cells.
Topics: Adenocarcinoma; Apoptosis; Cell Cycle; Cell Division; Colonic Neoplasms; Humans; Staurosporine; Tumor Cells, Cultured | 1996 |
A phospholipase D and protein kinase C inhibitor blocks the spreading of murine mammary adenocarcinoma cells altering f-actin and beta1-integrin point contact distribution.
Topics: 1-Butanol; Actins; Adenocarcinoma; Animals; Butanols; Cell Adhesion; Cell Division; Enzyme Inhibitors; Genistein; Integrin beta1; Isoflavones; Mammary Neoplasms, Experimental; Mice; Microscopy, Fluorescence; Phosphatidic Acids; Phospholipase D; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
7-Hydroxystaurosporine (UCN-01) induces apoptosis in human colon carcinoma and leukemia cells independently of p53.
Topics: Adenocarcinoma; Alkaloids; Apoptosis; Caspase 3; Caspases; CDC2 Protein Kinase; Colonic Neoplasms; Cyclin B; Cyclin B1; Cyclins; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA Fragmentation; Enzyme Inhibitors; HL-60 Cells; HT29 Cells; Humans; Lamin Type B; Lamins; Leukemia, Myeloid, Acute; Nuclear Proteins; Poly(ADP-ribose) Polymerases; Protein Kinase C; Protein Synthesis Inhibitors; Serine Proteinase Inhibitors; Staurosporine; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1997 |
Tamoxifen alters the localization of F-actin and alpha 5/beta 1-integrin fibronectin receptors in human endometrial stromal cells and carcinoma cells.
Topics: Actins; Adenocarcinoma; Cells, Cultured; Endometrial Neoplasms; Enzyme Inhibitors; Female; Fluorescent Antibody Technique, Indirect; Humans; Isoquinolines; Microscopy, Confocal; Protein Kinase Inhibitors; Receptors, Fibronectin; Staurosporine; Stromal Cells; Sulfonamides; Tamoxifen; Tumor Cells, Cultured | 1997 |
Characterisation of novel human lung carcinoma cell lines selected for resistance to anti-neoplastic analogues of staurosporine.
Topics: Adenocarcinoma; Alkaloids; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Cell Division; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Inhibitors; Humans; Indoles; Lung Neoplasms; Multidrug Resistance-Associated Proteins; Protein Kinase C; Staurosporine; Tumor Cells, Cultured | 1997 |
Cytoskeletal reorganization induced by retinoic acid treatment of human endometrial adenocarcinoma (RL95-2) cells is correlated with alterations in protein kinase C-alpha.
Topics: Adenocarcinoma; Antineoplastic Agents; Carbazoles; Cell Differentiation; Cytoskeleton; Enzyme Inhibitors; Female; Humans; Immunohistochemistry; Indoles; Isoenzymes; Maleimides; Phenotype; Protein Kinase C; Protein Kinase C-alpha; Staurosporine; Tretinoin; Tumor Cells, Cultured; Uterine Neoplasms | 1998 |
Tissue factor activity of SW-480 human colon adenocarcinoma cells is modulated by thrombin and protein kinase C activation.
Topics: Adenocarcinoma; Coagulants; Colonic Neoplasms; Enzyme Activation; Enzyme Inhibitors; Hemostatics; Humans; Neoplasm Proteins; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin; Thromboplastin; Tumor Cells, Cultured | 1998 |
High-throughput assay for G2 checkpoint inhibitors and identification of the structurally novel compound isogranulatimide.
Topics: Adenocarcinoma; Animals; Breast Neoplasms; DNA Repair; G2 Phase; Genes, p53; Humans; Imidazoles; Indoles; Lung Neoplasms; Radiation-Sensitizing Agents; Staurosporine; Succinimides; Tumor Cells, Cultured | 1998 |
Caspase-3 mediated cleavage of HsRad51 at an unconventional site.
Topics: Adenocarcinoma; Amino Acid Sequence; Apoptosis; Breast Neoplasms; Caspase 3; Caspase Inhibitors; Caspases; DNA-Binding Proteins; Enzyme Inhibitors; Female; Humans; Jurkat Cells; Molecular Sequence Data; Mutagenesis, Site-Directed; Neoplasm Proteins; Peptide Fragments; Rad51 Recombinase; Recombinant Fusion Proteins; Staurosporine; Substrate Specificity; Tumor Cells, Cultured | 2000 |
UCN-01 and camptothecin induce DNA double-strand breaks in p53 mutant tumor cells, but not in normal or p53 negative epithelial cells.
Topics: Adenocarcinoma; Alkaloids; Antineoplastic Agents; Breast; Breast Neoplasms; Camptothecin; Cell Cycle; DNA Damage; DNA Repair; DNA Replication; DNA, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Inhibitors; Epithelial Cells; Female; Gene Expression Regulation, Neoplastic; Genes, p53; Humans; Neoplasm Proteins; Protein Kinase C; Staurosporine; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2000 |
Staurosporine-induced G(1) arrest in cancer cells depends on an intact pRB but is independent of p16 status.
Topics: Adenocarcinoma; Breast Neoplasms; Cell Line; Cyclin-Dependent Kinase Inhibitor p16; DNA Replication; Enzyme Inhibitors; Female; G1 Phase; Humans; Kinetics; Lung Neoplasms; Retinoblastoma Protein; Staurosporine; Tumor Cells, Cultured | 2002 |
7-Hydroxystaurosporine (UCN-01) preferentially sensitizes cells with a disrupted TP53 to gamma radiation in lung cancer cell lines.
Topics: Adenocarcinoma; Alkaloids; Flow Cytometry; G2 Phase; Gamma Rays; Humans; Lung Neoplasms; Mutation; Radiation-Sensitizing Agents; Staurosporine; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2002 |
Phorbol esters differentially regulate the expression of insulin-like growth factor-binding proteins in endometrial carcinoma cells.
Topics: Adenocarcinoma; Alkaloids; Blotting, Northern; Calcimycin; Carrier Proteins; Cell Division; Cycloheximide; Endometrial Neoplasms; Enzyme Activation; Female; Gene Expression Regulation; Humans; Insulin-Like Growth Factor Binding Proteins; Kinetics; Protein Kinase C; RNA, Messenger; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Tumor Cells, Cultured | 1992 |
Differential expression of protein kinase C epsilon protein in lung cancer cell lines by ionising radiation.
Topics: Adenocarcinoma; Alkaloids; Animals; Carcinoma, Small Cell; Cell Survival; Cricetinae; DNA Damage; DNA Repair; DNA, Neoplasm; Enzyme Induction; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Isoenzymes; Kinetics; Lung Neoplasms; Mesocricetus; Neoplasm Proteins; Protein Biosynthesis; Protein Kinase C; RNA, Neoplasm; Staurosporine; Transcription, Genetic; Transcriptional Activation; Tumor Cells, Cultured | 1992 |
The fast release of mucin secretion from human colonic cells induced by Entamoeba histolytica is dependent on contact and protein kinase C activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenocarcinoma; Alkaloids; Animals; Calcium; Carbohydrate Sequence; Cell Adhesion; Colon; Colonic Neoplasms; Entamoeba histolytica; Enzyme Activation; Humans; Intestinal Mucosa; Isoquinolines; Lectins; Membrane Glycoproteins; Mice; Mice, Nude; Molecular Sequence Data; Mucins; Neoplasm Proteins; Piperazines; Protein Kinase C; Protozoan Proteins; Secretory Rate; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Differential effects of phorbol esters on proliferation and calcyclin expression in human endometrial carcinoma cells.
Topics: Adenocarcinoma; Alkaloids; Calcimycin; Calcium-Binding Proteins; Cell Cycle Proteins; Cell Division; Cycloheximide; Enzyme Activation; Female; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Proteins; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; RNA, Messenger; RNA, Neoplasm; S100 Calcium Binding Protein A6; S100 Proteins; Signal Transduction; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Uterine Neoplasms | 1992 |
Modulation of platelet-derived growth factor A- and B-chain/c-sis mRNA by tumor necrosis factor and other agents in adenocarcinoma cells.
Topics: Adenocarcinoma; Alkaloids; Blotting, Northern; Cell Line; Cycloheximide; Dose-Response Relationship, Drug; Humans; Interferon-gamma; Pancreatic Neoplasms; Platelet-Derived Growth Factor; Protein Kinase C; Protein Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-sis; RNA, Messenger; Signal Transduction; Staurosporine; Time Factors; Tumor Necrosis Factor-alpha | 1991 |