staurosporine has been researched along with Acute Disease in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (9.52) | 18.2507 |
| 2000's | 11 (52.38) | 29.6817 |
| 2010's | 6 (28.57) | 24.3611 |
| 2020's | 2 (9.52) | 2.80 |
| Authors | Studies |
|---|---|
| Cerchione, C; Martinelli, G | 1 |
| Bose, P; Cortes, JE; Dalle, IA; Daver, N; DiNardo, C; Garcia-Manero, G; Jabbour, EJ; Kadia, T; Kantarjian, HM; Loghavi, S; Naqvi, K; Patel, K; Pemmaraju, N; Pierce, S; Ravandi, F; Sasaki, K; Short, N; Yalniz, F; Yilmaz, M | 1 |
| Brunner, AM | 1 |
| Cotter, TG; Russell, EG; Stanicka, J; Woolley, JF | 1 |
| Burnett, A; Lo-Coco, F; Löwenberg, B; Sanz, M | 1 |
| Kiyoi, H | 1 |
| Hisakura, K; Ikeda, N; Ikeda, O; Kawasaki, T; Kohno, K; Matsuo, R; Murata, S; Myronovych, A; Nakano, Y; Ohkohchi, N; Pak, S; Takahashi, K; Watanabe, M | 1 |
| Agarwal, A; Agarwal, M; Agarwal, MK; Chakrabarti, A; Glick, A; Gupta, K; Sharma, JP; Wald, DN; Yang, J; Zhang, Y | 1 |
| Bornhäuser, M; Brenner, S; Brors, B; Ehninger, G; Heiderich, C; Hofmann, WK; Jacobi, A; Koch, S; Ortlepp, C; Ryser, M; Steudel, C; Thiede, C | 1 |
| Duyster, J; Grundler, R; Miething, C; Peschel, C; Steudel, C; Thiede, C | 1 |
| Bagrintseva, K; Eichenlaub, S; Ellwart, JW; Hiddemann, W; Kohl, TM; Schnittger, S; Schwab, R; Spiekermann, K | 1 |
| Clark, JJ; Cools, J; Fabbro, D; Furet, P; Gilliland, DG; Griffin, JD; Marynen, P; Mentens, N | 1 |
| Dai, Y; Dent, P; Grant, S; Han, SI; Khanna, P; Mitchell, C; Pei, XY; Rahmani, M | 1 |
| Berdel, WE; Brandts, C; Choudhary, C; Fischer, T; Kindler, T; Müller-Tidow, C; Sargin, B; Schwäble, J; Serve, H; Tickenbrock, L | 1 |
| Zhang, GS | 1 |
| Brandts, C; Breitenbuecher, F; Cohen, PS; Ehninger, G; Feldman, E; Fischer, T; Giles, F; Heidel, F; Huber, C; Kasper, S; Kindler, T; Lipka, DB; Nimer, S; Roesel, J; Schiller, GJ; Serve, H; Solem, FK; Stone, RM; Thiede, MH; Wang, Y | 1 |
| Austin, SJ; Burnett, AK; Gilkes, AF; Knapper, S; Mills, KI; Walsh, V | 1 |
| Chung, EJ; Kajiguchi, T; Kiyoi, H; Lee, S; Levis, MJ; Naoe, T; Neckers, L; Stine, A; Trepel, JB | 1 |
| Iversen, PO; Lopez, AF; To, LB | 1 |
| Fukushima, A; Hashida, M; Kodama, H; Ueno, H; Zhang, J | 1 |
| Budel, LM; Delwel, R; Elbaz, O; Hoogerbrugge, H; Löwenberg, B; Mahmoud, LA; Touw, IP | 1 |
2 review(s) available for staurosporine and Acute Disease
| Article | Year |
|---|---|
FLT3 inhibition as a targeted therapy for acute myeloid leukemia.
Topics: Acute Disease; Animals; Carbazoles; Drug Evaluation, Preclinical; fms-Like Tyrosine Kinase 3; Furans; Humans; Leukemia, Myeloid; Molecular Structure; Mutation; Staurosporine | 2009 |
[FLT3 kinase inhibitors for the treatment of acute leukemia].
Topics: Acute Disease; Clinical Trials as Topic; Drug Design; Enzyme Inhibitors; fms-Like Tyrosine Kinase 3; Humans; Indazoles; Leukemia; Mutation; Piperazines; Quinazolines; Signal Transduction; Staurosporine | 2010 |
19 other study(ies) available for staurosporine and Acute Disease
| Article | Year |
|---|---|
Acute leukemias in 2020: state of the art.
Topics: Acute Disease; Aminopyridines; Antineoplastic Agents; Antineoplastic Agents, Immunological; Congresses as Topic; Cytarabine; Daunorubicin; fms-Like Tyrosine Kinase 3; Gemtuzumab; Glycine; Humans; Leukemia; Pyridines; Recombinant Fusion Proteins; Staurosporine; Triazines | 2020 |
Sorafenib plus intensive chemotherapy improves survival in patients with newly diagnosed, FLT3-internal tandem duplication mutation-positive acute myeloid leukemia.
Topics: Acute Disease; Adult; Antineoplastic Combined Chemotherapy Protocols; Cohort Studies; Combined Modality Therapy; Female; fms-Like Tyrosine Kinase 3; Hematopoietic Stem Cell Transplantation; Humans; Induction Chemotherapy; Kaplan-Meier Estimate; Leukemia, Myeloid; Male; Middle Aged; Mutation; Remission Induction; Sorafenib; Staurosporine; Tandem Repeat Sequences; Transplantation, Homologous; Young Adult | 2019 |
Acute Myeloid Leukemia: A New Era of Therapies, a New Wave of Toxicities?
Topics: Acute Disease; Gastritis; Humans; Leukemia, Myeloid, Acute; Staurosporine | 2020 |
NADPH oxidase-generated hydrogen peroxide induces DNA damage in mutant FLT3-expressing leukemia cells.
Topics: Acute Disease; Animals; Blotting, Western; Cell Line; DNA Damage; fms-Like Tyrosine Kinase 3; Genomic Instability; HL-60 Cells; Humans; Hydrogen Peroxide; Leukemia, Myeloid; Mice; Microscopy, Confocal; Mutation; NADPH Oxidase 4; NADPH Oxidases; Protein Kinase Inhibitors; RNA Interference; Signal Transduction; Staurosporine; Tandem Repeat Sequences | 2015 |
Platelets prevent acute hepatitis induced by anti-fas antibody.
Topics: Acute Disease; Alanine Transaminase; Animals; Antibodies; Apoptosis; Apoptosis Regulatory Proteins; Cell Line; Disease Models, Animal; Endothelial Cells; fas Receptor; Hepatitis; Hepatocytes; In Situ Nick-End Labeling; Male; Mice; Mice, Inbred C57BL; Necrosis; Platelet Count; Polyethylene Glycols; Recombinant Proteins; Staurosporine; Thrombocytopenia; Thrombocytosis; Thrombopoiesis; Thrombopoietin; Time Factors | 2011 |
ATP depletion triggers acute myeloid leukemia differentiation through an ATR/Chk1 protein-dependent and p53 protein-independent pathway.
Topics: Acute Disease; Adenosine; Adenosine Triphosphate; Antibiotics, Antineoplastic; Ataxia Telangiectasia Mutated Proteins; Blotting, Western; Caffeine; Cell Cycle Proteins; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Checkpoint Kinase 1; Comet Assay; DNA Damage; Doxorubicin; HEK293 Cells; Humans; Leukemia, Myeloid; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Signal Transduction; Staurosporine; Thioinosine; Tumor Suppressor Protein p53 | 2012 |
Autotaxin is expressed in FLT3-ITD positive acute myeloid leukemia and hematopoietic stem cells and promotes cell migration and proliferation.
Topics: Acute Disease; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cells, Cultured; fms-Like Tyrosine Kinase 3; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Hematopoietic Stem Cells; Humans; Indoles; K562 Cells; Leukemia, Myeloid; Lysophosphatidylcholines; Lysophospholipids; Mutation; Oligonucleotide Array Sequence Analysis; Phosphoric Diester Hydrolases; Protein Kinase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; Staurosporine; Tandem Repeat Sequences | 2013 |
Sensitivity toward tyrosine kinase inhibitors varies between different activating mutations of the FLT3 receptor.
Topics: Acute Disease; Amino Acid Substitution; Animals; Cell Division; Cell Line; Codon; DNA-Binding Proteins; Drug Resistance; Enzyme Activation; Enzyme Inhibitors; fms-Like Tyrosine Kinase 3; Hematopoietic Stem Cells; Humans; Indoles; Leukemia, Myeloid; Membrane Proteins; Mice; Milk Proteins; Mutagenesis, Insertional; Mutation, Missense; Neoplasm Proteins; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Recombinant Proteins; Sequence Deletion; STAT5 Transcription Factor; Staurosporine; Structure-Activity Relationship; Trans-Activators; Transfection; Tyrphostins | 2003 |
Mutations in the tyrosine kinase domain of FLT3 define a new molecular mechanism of acquired drug resistance to PTK inhibitors in FLT3-ITD-transformed hematopoietic cells.
Topics: Acute Disease; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Cell Division; Cell Line, Transformed; Cytarabine; DNA-Binding Proteins; Drug Resistance, Neoplasm; Enzyme Inhibitors; fms-Like Tyrosine Kinase 3; Genistein; Humans; Indoles; Leukemia, Myeloid; MAP Kinase Signaling System; Milk Proteins; Mutagenesis; Phenotype; Phosphorylation; Protein Structure, Tertiary; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; STAT5 Transcription Factor; Staurosporine; Trans-Activators; Tyrphostins | 2004 |
Prediction of resistance to small molecule FLT3 inhibitors: implications for molecularly targeted therapy of acute leukemia.
Topics: Acute Disease; Amino Acid Sequence; Animals; Drug Resistance, Neoplasm; Enzyme Inhibitors; fms-Like Tyrosine Kinase 3; Leukemia, Myeloid; Mice; Models, Molecular; Molecular Sequence Data; Point Mutation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Structure, Tertiary; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Staurosporine; Structure-Activity Relationship | 2004 |
Farnesyltransferase inhibitors interact synergistically with the Chk1 inhibitor UCN-01 to induce apoptosis in human leukemia cells through interruption of both Akt and MEK/ERK pathways and activation of SEK1/JNK.
Topics: Acute Disease; Alkyl and Aryl Transferases; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Caspases; Cell Transformation, Neoplastic; Checkpoint Kinase 1; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Farnesyltranstransferase; HL-60 Cells; Humans; JNK Mitogen-Activated Protein Kinases; Jurkat Cells; Leukemia, Myeloid; MAP Kinase Kinase 4; MAP Kinase Signaling System; Membrane Potentials; Methionine; Mitochondria; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Staurosporine; U937 Cells | 2005 |
AML-associated Flt3 kinase domain mutations show signal transduction differences compared with Flt3 ITD mutations.
Topics: Acute Disease; Animals; Apoptosis; Cell Line; DNA-Binding Proteins; fms-Like Tyrosine Kinase 3; Humans; Intracellular Signaling Peptides and Proteins; Leukemia, Myeloid; Milk Proteins; Muridae; Mutagenesis, Site-Directed; Myeloid Cells; Phosphorylation; Point Mutation; Protein Structure, Tertiary; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Signal Transduction; STAT5 Transcription Factor; Staurosporine; Tandem Repeat Sequences; Trans-Activators; Transcription Factors | 2005 |
[New targets for molecular therapy of acute leukemia: a "single-hit" or "multiple-hit" strategy against signaling pathway].
Topics: Acute Disease; Antineoplastic Agents; Carbazoles; Furans; Humans; Indoles; Leukemia; Leukemia, Myeloid, Acute; Mutation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein-Tyrosine Kinases; Quinolones; ras Proteins; Staurosporine | 2005 |
Clinical resistance to the kinase inhibitor PKC412 in acute myeloid leukemia by mutation of Asn-676 in the FLT3 tyrosine kinase domain.
Topics: Acute Disease; Drug Resistance, Neoplasm; Enzyme Activation; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid; Mutation, Missense; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Recurrence; Staurosporine | 2006 |
The effects of lestaurtinib (CEP701) and PKC412 on primary AML blasts: the induction of cytotoxicity varies with dependence on FLT3 signaling in both FLT3-mutated and wild-type cases.
Topics: Acute Disease; Adolescent; Adult; Aged; Apoptosis; Blast Crisis; Carbazoles; Drug Screening Assays, Antitumor; Female; fms-Like Tyrosine Kinase 3; Furans; Humans; Indoles; Leukemia, Myeloid; Male; Middle Aged; Mutation; Protein Kinase C; Protein-Tyrosine Kinases; Signal Transduction; Staurosporine; Tumor Cells, Cultured | 2006 |
FLT3 regulates beta-catenin tyrosine phosphorylation, nuclear localization, and transcriptional activity in acute myeloid leukemia cells.
Topics: Active Transport, Cell Nucleus; Acute Disease; Animals; beta Catenin; Cell Line, Tumor; fms-Like Tyrosine Kinase 3; Gene Expression Regulation, Leukemic; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Interleukin-3; Leukemia, Myeloid; Membrane Proteins; Mice; Neoplasm Proteins; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Recombinant Proteins; RNA, Small Interfering; Staurosporine; Transcription, Genetic; Tyrphostins | 2007 |
Apoptosis of hemopoietic cells by the human granulocyte-macrophage colony-stimulating factor mutant E21R.
Topics: Acute Disease; Alkaloids; Apoptosis; Cell Division; Cell Survival; Cells, Cultured; Cycloheximide; Cytokines; Dactinomycin; Enzyme Inhibitors; Genistein; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Stem Cells; Humans; Interleukin-3; Isoflavones; Kinetics; Leukemia, Myeloid; Phosphorylation; Point Mutation; Protein Kinase C; Protein-Tyrosine Kinases; Reference Values; Staurosporine; Stem Cell Factor | 1996 |
Involvement of superoxide generated by polymorphonuclear leukocytes in endotoxin-induced uveitis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acute Disease; Animals; Blotting, Western; Dose-Response Relationship, Drug; Enzyme Inhibitors; Escherichia coli; Lipopolysaccharides; Male; Neutrophil Activation; Neutrophils; Protein Kinase C; Rats; Rats, Inbred Lew; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Time Factors; Uveitis, Anterior | 2000 |
Tumor necrosis factor downregulates granulocyte-colony-stimulating factor receptor expression on human acute myeloid leukemia cells and granulocytes.
Topics: Acute Disease; Alkaloids; Down-Regulation; Granulocyte Colony-Stimulating Factor; Granulocytes; Humans; In Vitro Techniques; Leukemia, Myeloid; Protease Inhibitors; Receptors, Granulocyte Colony-Stimulating Factor; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Tumor Necrosis Factor-alpha | 1991 |