staurosporine aglycone has been researched along with Neuroblastoma in 11 studies
staurosporine aglycone: metabolite from culture broth of Nocardiopsis sp.; a neurotrophin antag; inhibits BDNF TrkB receptor
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nicotine has been shown to produce some beneficial effects in neurodegenerative disorders, and several studies have suggested that these effects may be mediated in part through the action of the neurotrophic factor BDNF." | 5.33 | Nicotine regulates SH-SY5Y neuroblastoma cell proliferation through the release of brain-derived neurotrophic factor. ( Carney, SL; Serres, F, 2006) |
| "K-252a and the structurally similar compound staurosporine promote neurotrophic responses in several cell lines (PC12, SH-SY5Y human neuroblastoma) and in cultures of primary neurons." | 3.69 | Membranes of human neuroblastoma SH-SY5Y cells contain specific binding sites for [3H]K-252A. ( Connors, TJ; Hudkins, R; Knight, E; Maroney, AC; Neff, N, 1995) |
| "Nicotine has been shown to produce some beneficial effects in neurodegenerative disorders, and several studies have suggested that these effects may be mediated in part through the action of the neurotrophic factor BDNF." | 1.33 | Nicotine regulates SH-SY5Y neuroblastoma cell proliferation through the release of brain-derived neurotrophic factor. ( Carney, SL; Serres, F, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (36.36) | 18.2507 |
| 2000's | 7 (63.64) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Woo, CW | 1 |
| Lucarelli, E | 1 |
| Thiele, CJ | 1 |
| Tang, LL | 1 |
| Wang, R | 1 |
| Tang, XC | 1 |
| Serres, F | 1 |
| Carney, SL | 1 |
| Zhang, JH | 2 |
| Li, AM | 1 |
| Chen, S | 1 |
| Tong, HX | 1 |
| Zhang, KR | 1 |
| Hübinger, G | 1 |
| Geis, S | 1 |
| LeCorre, S | 1 |
| Mühlbacher, S | 1 |
| Gordon, S | 1 |
| Fracasso, RP | 1 |
| Hoffman, F | 1 |
| Ferrand, S | 1 |
| Klafki, HW | 1 |
| Roder, HM | 1 |
| Schwarzschild, MA | 1 |
| Dauer, WT | 1 |
| Lewis, SE | 1 |
| Hamill, LK | 1 |
| Fink, JS | 1 |
| Hyman, SE | 1 |
| Knight, E | 1 |
| Connors, TJ | 1 |
| Hudkins, R | 1 |
| Maroney, AC | 2 |
| Neff, N | 1 |
| Lipfert, L | 1 |
| Forbes, ME | 1 |
| Glicksman, MA | 1 |
| Neff, NT | 1 |
| Siman, R | 1 |
| Dionne, CA | 1 |
| Sugimoto, T | 1 |
| Kuroda, H | 1 |
| Horii, Y | 1 |
| Moritake, H | 1 |
| Tanaka, T | 1 |
| Hattori, S | 1 |
| McGinnis, KM | 1 |
| Wang, KK | 1 |
| Gnegy, ME | 1 |
| Tsuji, S | 1 |
| Yamashita, T | 1 |
| Matsuda, Y | 1 |
| Nagai, Y | 1 |
11 other studies available for staurosporine aglycone and Neuroblastoma
| Article | Year |
|---|---|
NGF activation of TrkA decreases N-myc expression via MAPK path leading to a decrease in neuroblastoma cell number.
Topics: Carbazoles; Cell Count; Cell Cycle Proteins; Cell Division; Cell Line, Tumor; Cyclin E; Cyclin-Depen | 2004 |
Huperzine A protects SHSY5Y neuroblastoma cells against oxidative stress damage via nerve growth factor production.
Topics: Alkaloids; Androstadienes; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Carbazol | 2005 |
Nicotine regulates SH-SY5Y neuroblastoma cell proliferation through the release of brain-derived neurotrophic factor.
Topics: Aconitine; Antibodies; Brain-Derived Neurotrophic Factor; Carbazoles; Carbon Isotopes; Cell Line, Tu | 2006 |
[Blocking TrkB-BDNF signal pathway decreases the livability of neuroblastoma cells].
Topics: Apoptosis; Brain-Derived Neurotrophic Factor; Carbazoles; Cell Line, Tumor; Cisplatin; Humans; Indol | 2008 |
Inhibition of PHF-like tau hyperphosphorylation in SH-SY5Y cells and rat brain slices by K252a.
Topics: Animals; Antibodies, Monoclonal; Blotting, Western; Carbazoles; Cell Culture Techniques; Cell Line; | 2008 |
Leukemia inhibitory factor and ciliary neurotrophic factor increase activated Ras in a neuroblastoma cell line and in sympathetic neuron cultures.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Animals, Newborn; Blotting, Weste | 1994 |
Membranes of human neuroblastoma SH-SY5Y cells contain specific binding sites for [3H]K-252A.
Topics: Alkaloids; Binding Sites; Carbazoles; Cell Line; Humans; Indole Alkaloids; Indoles; Kinetics; Maleim | 1995 |
K-252a induces tyrosine phosphorylation of the focal adhesion kinase and neurite outgrowth in human neuroblastoma SH-SY5Y cells.
Topics: Carbazoles; Cell Adhesion Molecules; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Prot | 1995 |
Signal transduction pathways through TRK-A and TRK-B receptors in human neuroblastoma cells.
Topics: Adrenal Gland Neoplasms; Animals; Carbazoles; Cell Differentiation; Cell Survival; Child, Preschool; | 2001 |
Calcium/calmodulin-dependent protein kinase inhibition potentiates thapsigargin-mediated cell death in SH-SY5Y human neuroblastoma cells.
Topics: Apoptosis; Aspartic Acid; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Ca | 2001 |
A novel glycosignaling system: GQ1b-dependent neuritogenesis of human neuroblastoma cell line, GOTO, is closely associated with GQ1b-dependent ecto-type protein phosphorylation.
Topics: Carbazoles; Cell Membrane Permeability; Gangliosides; Humans; Indole Alkaloids; Neurites; Neuroblast | 1992 |