staurosporine aglycone has been researched along with Epilepsy in 4 studies
staurosporine aglycone: metabolite from culture broth of Nocardiopsis sp.; a neurotrophin antag; inhibits BDNF TrkB receptor
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In adult mice, intrahippocampal administration of kainic acid induces a structural modification of the granule cell layer reminiscent of granule cell dispersion (GCD) seen in humans with temporal lobe epilepsy." | 3.73 | Patterns of dentate granule cell responses to perforant path stimulation in epileptic mice with granule cell dispersion. ( Arthaud, S; La Salle, Gle G; Rougier, A; Zombre, N, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, Y | 1 |
| Qi, JS | 1 |
| Kong, S | 1 |
| Sun, Y | 1 |
| Fan, J | 1 |
| Jiang, M | 1 |
| Chen, G | 1 |
| Ghiglieri, V | 1 |
| Sgobio, C | 1 |
| Patassini, S | 1 |
| Bagetta, V | 1 |
| Fejtova, A | 1 |
| Giampà, C | 1 |
| Marinucci, S | 1 |
| Heyden, A | 1 |
| Gundelfinger, ED | 1 |
| Fusco, FR | 1 |
| Calabresi, P | 1 |
| Picconi, B | 1 |
| Khirug, S | 1 |
| Ahmad, F | 1 |
| Puskarjov, M | 1 |
| Afzalov, R | 1 |
| Kaila, K | 1 |
| Blaesse, P | 1 |
| Rougier, A | 1 |
| Arthaud, S | 1 |
| Zombre, N | 1 |
| La Salle, Gle G | 1 |
4 other studies available for staurosporine aglycone and Epilepsy
| Article | Year |
|---|---|
BDNF-TrkB signaling pathway mediates the induction of epileptiform activity induced by a convulsant drug cyclothiazide.
Topics: Action Potentials; Analysis of Variance; Animals; Antibodies; Antihypertensive Agents; Benzothiadiaz | 2009 |
TrkB/BDNF-dependent striatal plasticity and behavior in a genetic model of epilepsy: modulation by valproic acid.
Topics: Analysis of Variance; Animals; Anticonvulsants; Avoidance Learning; Brain-Derived Neurotrophic Facto | 2010 |
A single seizure episode leads to rapid functional activation of KCC2 in the neonatal rat hippocampus.
Topics: Age Factors; Animals; Animals, Newborn; Biotinylation; Carbazoles; Enzyme Inhibitors; Epilepsy; Exci | 2010 |
Patterns of dentate granule cell responses to perforant path stimulation in epileptic mice with granule cell dispersion.
Topics: Action Potentials; Animals; Behavior, Animal; Carbazoles; Cell Count; Disease Models, Animal; Dose-R | 2005 |