staurosporine aglycone has been researched along with Disease Models, Animal in 42 studies
staurosporine aglycone: metabolite from culture broth of Nocardiopsis sp.; a neurotrophin antag; inhibits BDNF TrkB receptor
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In vivo, acute treatment of Mecp2-null and -heterozygous mutants with LM22A-4 completely eliminated spontaneous apneas in resting animals, without sedation." | 7.80 | A BDNF loop-domain mimetic acutely reverses spontaneous apneas and respiratory abnormalities during behavioral arousal in a mouse model of Rett syndrome. ( Adams, IT; Katz, DM; Kron, M; Lang, M; Longo, F; Sceniak, M, 2014) |
| "We conclude that substance P plays a role in the induction of AHR in our model for allergic asthma which is most likely mediated by NGF." | 7.73 | Airway hyper-responsiveness in allergic asthma in guinea-pigs is mediated by nerve growth factor via the induction of substance P: a potential role for trkA. ( Braun, A; de Vries, A; Dessing, MC; Engels, F; Fischer, A; Groneberg, DA; Henricks, PA; Leusink-Muis, T; McGregor, GP; Nijkamp, FP, 2006) |
| " In vivo, acute treatment of Mecp2-null and -heterozygous mutants with LM22A-4 completely eliminated spontaneous apneas in resting animals, without sedation." | 3.80 | A BDNF loop-domain mimetic acutely reverses spontaneous apneas and respiratory abnormalities during behavioral arousal in a mouse model of Rett syndrome. ( Adams, IT; Katz, DM; Kron, M; Lang, M; Longo, F; Sceniak, M, 2014) |
| " We investigated for the first time whether class I histone deacetylase inhibitor valproic acid (VPA) can reverse cognitive deficits in a mouse model of sepsis-associated encephalopathy (SAE)." | 3.79 | Class I histone deacetylase inhibitor valproic acid reverses cognitive deficits in a mouse model of septic encephalopathy. ( Dong, L; Ji, M; Jia, M; Qiu, L; Wu, J; Yang, J; Zhang, G; Zhang, M, 2013) |
| "In adult mice, intrahippocampal administration of kainic acid induces a structural modification of the granule cell layer reminiscent of granule cell dispersion (GCD) seen in humans with temporal lobe epilepsy." | 3.73 | Patterns of dentate granule cell responses to perforant path stimulation in epileptic mice with granule cell dispersion. ( Arthaud, S; La Salle, Gle G; Rougier, A; Zombre, N, 2005) |
| "We conclude that substance P plays a role in the induction of AHR in our model for allergic asthma which is most likely mediated by NGF." | 3.73 | Airway hyper-responsiveness in allergic asthma in guinea-pigs is mediated by nerve growth factor via the induction of substance P: a potential role for trkA. ( Braun, A; de Vries, A; Dessing, MC; Engels, F; Fischer, A; Groneberg, DA; Henricks, PA; Leusink-Muis, T; McGregor, GP; Nijkamp, FP, 2006) |
| "Considering that depression is involved in monoamine reduction, this study evaluated the antidepressant-like effects of gypenosides in mice exposed to chronic unpredictable mild stress (CUMS)." | 1.43 | Antidepressant-like effects of standardized gypenosides: involvement of brain-derived neurotrophic factor signaling in hippocampus. ( Chen, SM; Chen, XM; Fang, XY; Li, CF; Li, YC; Liu, Q; Mu, RH; Wang, SS; Yi, LT, 2016) |
| "Piperine treatment also significantly decreased immobility time in the forced swim test in naive mice." | 1.40 | Brain-derived neurotrophic factor signalling mediates the antidepressant-like effect of piperine in chronically stressed mice. ( Huang, Z; Ip, SP; Mao, QQ; Xian, YF; Zhong, XM, 2014) |
| "Mechanical hyperalgesia continued for 28 days at a lesion in the BLG, 21 days in PLG and 5 days in SLG after treatments, respectively." | 1.38 | Nerve growth factor and associated nerve sprouting contribute to local mechanical hyperalgesia in a rat model of bone injury. ( Hayashi, K; Hori, K; Ichiyanagi, M; Ozaki, N; Shiraishi, Y; Sugiura, Y; Yasui, M, 2012) |
| "Many drugs approved for neuropathic pain engage spinal noradrenergic and cholinergic systems for analgesia." | 1.37 | A tropomyosine receptor kinase inhibitor blocks spinal neuroplasticity essential for the anti-hypersensitivity effects of gabapentin and clonidine in rats with peripheral nerve injury. ( Eisenach, JC; Hayashida, K, 2011) |
| "Retinal neovascularization was measured by counting neovascular cell nuclei above the internal limiting membrane and by image quantification analysis in flat-mounted retinas perfused with fluorescein dextran." | 1.36 | Neuronal-driven angiogenesis: role of NGF in retinal neovascularization in an oxygen-induced retinopathy model. ( Liu, X; Liu, Y; Luo, Y; Ma, W; Wang, D; Xiao, W; Yu, Q, 2010) |
| "D-galactose-(D-gal)-treated mouse, with cognitive impairment, has been used for neurotoxicity investigation and anti-neurotoxicity pharmacology research." | 1.36 | NGF-Dependent activation of TrkA pathway: A mechanism for the neuroprotective effect of troxerutin in D-galactose-treated mice. ( Hu, B; Lu, J; Wang, YJ; Wu, DM; Zhang, ZF; Zheng, YL, 2010) |
| "These results indicated that cerebral ischemia induced the continuous activation of MLK3/MKK7/JNK3 cascade, which all had two active waves only in the CA1 region." | 1.33 | The neuroprotective effects of K252a through inhibiting MLK3/MKK7/JNK3 signaling pathway on ischemic brain injury in rat hippocampal CA1 region. ( Pan, J; Zhang, GY; Zhang, QG, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.38) | 18.2507 |
| 2000's | 11 (26.19) | 29.6817 |
| 2010's | 26 (61.90) | 24.3611 |
| 2020's | 4 (9.52) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Wang, N | 1 |
| Liu, X | 2 |
| Li, XT | 1 |
| Li, XX | 1 |
| Ma, W | 2 |
| Xu, YM | 1 |
| Liu, Y | 4 |
| Gao, Q | 1 |
| Yang, T | 1 |
| Wang, H | 1 |
| Peng, Y | 1 |
| Zhu, XF | 1 |
| Guan, YZ | 1 |
| Gudasheva, TA | 1 |
| Tallerova, AV | 1 |
| Mezhlumyan, AG | 1 |
| Antipova, TA | 1 |
| Logvinov, IO | 1 |
| Firsova, YN | 1 |
| Povarnina, PY | 1 |
| Seredenin, SB | 1 |
| Guan, W | 2 |
| Gu, JH | 1 |
| Ji, CH | 1 |
| Tang, WQ | 1 |
| Wang, Y | 5 |
| Jiang, B | 2 |
| Zhu, Y | 1 |
| Chao, C | 1 |
| Duan, X | 1 |
| Cheng, X | 1 |
| Liu, P | 1 |
| Su, S | 1 |
| Duan, J | 1 |
| Dong, TT | 1 |
| Tsim, KW | 1 |
| Xu, D | 1 |
| Lian, D | 1 |
| Wu, J | 2 |
| Zhu, M | 1 |
| Sun, J | 1 |
| He, D | 1 |
| Li, L | 1 |
| Zhang, M | 2 |
| Zhang, Y | 1 |
| Ding, J | 1 |
| Li, X | 1 |
| Zang, C | 1 |
| Yin, S | 1 |
| Ma, J | 1 |
| Cao, Y | 1 |
| Zhang, JJ | 1 |
| Gao, TT | 1 |
| Wang, JL | 1 |
| Wang, YJ | 2 |
| Wang, CN | 1 |
| Liu, JF | 1 |
| Dong, L | 1 |
| Jia, M | 1 |
| Zhang, G | 1 |
| Qiu, L | 1 |
| Ji, M | 1 |
| Yang, J | 2 |
| Takasaki, I | 1 |
| Oose, K | 1 |
| Otaki, Y | 1 |
| Ihara, D | 1 |
| Fukuchi, M | 1 |
| Tabuchi, A | 1 |
| Tsuneki, H | 1 |
| Tabuchi, Y | 1 |
| Kondo, T | 1 |
| Saitoh, A | 1 |
| Yamada, M | 1 |
| Tsuda, M | 1 |
| Yi, LT | 3 |
| Liu, BB | 2 |
| Li, J | 1 |
| Luo, L | 2 |
| Liu, Q | 3 |
| Geng, D | 2 |
| Tang, Y | 1 |
| Xia, Y | 1 |
| Wu, D | 1 |
| Mao, QQ | 1 |
| Huang, Z | 1 |
| Zhong, XM | 1 |
| Xian, YF | 1 |
| Ip, SP | 1 |
| Qi, D | 1 |
| Ouyang, C | 1 |
| Zhang, S | 1 |
| Ma, X | 1 |
| Song, Y | 1 |
| Yu, H | 1 |
| Tang, J | 1 |
| Fu, W | 1 |
| Sheng, L | 1 |
| Yang, L | 1 |
| Wang, M | 2 |
| Zhang, W | 1 |
| Miao, L | 1 |
| Li, T | 1 |
| Huang, X | 1 |
| Dong, H | 1 |
| Kron, M | 1 |
| Lang, M | 1 |
| Adams, IT | 1 |
| Sceniak, M | 1 |
| Longo, F | 1 |
| Katz, DM | 1 |
| Zhou, W | 1 |
| Zhou, X | 1 |
| Zhuang, F | 1 |
| Chen, Q | 1 |
| Li, M | 1 |
| Ma, T | 1 |
| Gu, S | 1 |
| Liu, XL | 1 |
| Mu, RH | 2 |
| Wu, YJ | 1 |
| Berdún, S | 1 |
| Rychter, J | 1 |
| Vergara, P | 1 |
| Shah, AP | 1 |
| Carreno, FR | 1 |
| Wu, H | 1 |
| Chung, YA | 1 |
| Frazer, A | 1 |
| Fang, XY | 1 |
| Wang, SS | 1 |
| Li, CF | 1 |
| Chen, SM | 1 |
| Chen, XM | 1 |
| Li, YC | 1 |
| Khodorova, A | 1 |
| Nicol, GD | 1 |
| Strichartz, G | 1 |
| Apostol, BL | 1 |
| Simmons, DA | 1 |
| Zuccato, C | 1 |
| Illes, K | 1 |
| Pallos, J | 1 |
| Casale, M | 1 |
| Conforti, P | 1 |
| Ramos, C | 1 |
| Roarke, M | 1 |
| Kathuria, S | 1 |
| Cattaneo, E | 1 |
| Marsh, JL | 1 |
| Thompson, LM | 1 |
| Qi, JS | 1 |
| Kong, S | 1 |
| Sun, Y | 1 |
| Fan, J | 1 |
| Jiang, M | 1 |
| Chen, G | 1 |
| Ghiglieri, V | 1 |
| Sgobio, C | 1 |
| Patassini, S | 1 |
| Bagetta, V | 1 |
| Fejtova, A | 1 |
| Giampà, C | 1 |
| Marinucci, S | 1 |
| Heyden, A | 1 |
| Gundelfinger, ED | 1 |
| Fusco, FR | 1 |
| Calabresi, P | 1 |
| Picconi, B | 1 |
| Wang, D | 1 |
| Luo, Y | 1 |
| Xiao, W | 1 |
| Yu, Q | 1 |
| Lu, J | 1 |
| Wu, DM | 1 |
| Hu, B | 1 |
| Zheng, YL | 1 |
| Zhang, ZF | 1 |
| Hayashida, K | 1 |
| Eisenach, JC | 1 |
| Lu, H | 1 |
| Cheng, PL | 1 |
| Lim, BK | 1 |
| Khoshnevisrad, N | 1 |
| Poo, MM | 1 |
| Skucas, VA | 1 |
| Mathews, IB | 1 |
| Cheng, Q | 1 |
| Treister, A | 1 |
| Duffy, AM | 1 |
| Verkman, AS | 1 |
| Hempstead, BL | 1 |
| Wood, MA | 1 |
| Binder, DK | 1 |
| Scharfman, HE | 1 |
| Hayashi, K | 2 |
| Ozaki, N | 2 |
| Kawakita, K | 1 |
| Itoh, K | 1 |
| Mizumura, K | 1 |
| Furukawa, K | 1 |
| Yasui, M | 2 |
| Hori, K | 2 |
| Yi, SQ | 1 |
| Yamaguchi, T | 1 |
| Sugiura, Y | 2 |
| Shiraishi, Y | 1 |
| Ichiyanagi, M | 1 |
| Iijima, M | 1 |
| Fukumoto, K | 1 |
| Chaki, S | 1 |
| Real, CC | 1 |
| Ferreira, AF | 1 |
| Chaves-Kirsten, GP | 1 |
| Torrão, AS | 1 |
| Pires, RS | 1 |
| Britto, LR | 1 |
| Raychaudhuri, SP | 1 |
| Sanyal, M | 1 |
| Weltman, H | 1 |
| Kundu-Raychaudhuri, S | 1 |
| Miletic, G | 1 |
| Hanson, EN | 1 |
| Miletic, V | 1 |
| Liu, N | 1 |
| Varma, S | 1 |
| Shooter, EM | 1 |
| Tolwani, RJ | 1 |
| Pan, J | 1 |
| Zhang, QG | 1 |
| Zhang, GY | 1 |
| Rougier, A | 1 |
| Arthaud, S | 1 |
| Zombre, N | 1 |
| La Salle, Gle G | 1 |
| de Vries, A | 1 |
| Engels, F | 1 |
| Henricks, PA | 1 |
| Leusink-Muis, T | 1 |
| McGregor, GP | 1 |
| Braun, A | 1 |
| Groneberg, DA | 1 |
| Dessing, MC | 1 |
| Nijkamp, FP | 1 |
| Fischer, A | 1 |
| Brackenbury, WJ | 1 |
| Djamgoz, MB | 1 |
| Takano, N | 1 |
| Sakurai, T | 1 |
| Ohashi, Y | 1 |
| Kurachi, M | 1 |
| Ruggeri, BA | 1 |
| Miknyoczki, SJ | 1 |
| Singh, J | 1 |
| Hudkins, RL | 1 |
| Wildering, WC | 1 |
| Hermann, PM | 1 |
| Bulloch, AG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Efficacy of Strategic Memory Training Coupled With Non-invasive Brain Stimulation Techniques in Healthy Aging Population and Subjective Cognitive Decline Patients: a Randomized-controlled Study[NCT05929872] | 56 participants (Anticipated) | Interventional | 2023-07-30 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for staurosporine aglycone and Disease Models, Animal
| Article | Year |
|---|---|
Role of neurotrophin-trk interactions in oncology: the anti-tumor efficacy of potent and selective trk tyrosine kinase inhibitors in pre-clinical tumor models.
Topics: Animals; Antineoplastic Agents; Carbazoles; Disease Models, Animal; Drug Design; Female; Furans; Hum | 1999 |
41 other studies available for staurosporine aglycone and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
7,8-Dihydroxyflavone Alleviates Anxiety-Like Behavior Induced by Chronic Alcohol Exposure in Mice Involving Tropomyosin-Related Kinase B in the Amygdala.
Topics: Amygdala; Animals; Anxiety; Behavior, Animal; Carbazoles; Disease Models, Animal; Ethanol; Excitator | 2021 |
Low-Molecular Weight BDNF Mimetic, Dimeric Dipeptide GSB-106, Reverses Depressive Symptoms in Mouse Chronic Social Defeat Stress.
Topics: Administration, Oral; Animals; Antidepressive Agents; Behavior, Animal; Biomimetic Materials; Brain- | 2021 |
Xanthoceraside administration produces significant antidepressant effects in mice through activation of the hippocampal BDNF signaling pathway.
Topics: Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Carbazoles; Depression; Disease Models | 2021 |
Kai-Xin-San series formulae alleviate depressive-like behaviors on chronic mild stressed mice via regulating neurotrophic factor system on hippocampus.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Carbazoles; Depression; Disease M | 2017 |
Brain-derived neurotrophic factor reduces inflammation and hippocampal apoptosis in experimental Streptococcus pneumoniae meningitis.
Topics: Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Carbazoles; Cytokines; Disease Models, Animal | 2017 |
The role of TrkA in the promoting wounding-healing effect of CD271 on epidermal stem cells.
Topics: Animals; Carbazoles; Cell Movement; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Epi | 2018 |
Andrographolide Exerts Significant Antidepressant-Like Effects Involving the Hippocampal BDNF System in Mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Carbazoles; Dis | 2019 |
Class I histone deacetylase inhibitor valproic acid reverses cognitive deficits in a mouse model of septic encephalopathy.
Topics: Animals; Brain Diseases; Brain-Derived Neurotrophic Factor; Carbazoles; Cecum; Cognition Disorders; | 2013 |
Type II pyrethroid deltamethrin produces antidepressant-like effects in mice.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Carbazoles; Depression; Disease M | 2013 |
BDNF signaling is necessary for the antidepressant-like effect of naringenin.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Carbazoles; Disease Models, Anima | 2014 |
Brain-derived neurotrophic factor signalling mediates the antidepressant-like effect of piperine in chronically stressed mice.
Topics: Alkaloids; Animals; Antidepressive Agents; Benzodioxoles; Brain-Derived Neurotrophic Factor; Carbazo | 2014 |
HO-1 attenuates hippocampal neurons injury via the activation of BDNF-TrkB-PI3K/Akt signaling pathway in stroke.
Topics: Animals; Apoptosis; Brain Ischemia; Brain-Derived Neurotrophic Factor; CA1 Region, Hippocampal; Carb | 2014 |
A BDNF loop-domain mimetic acutely reverses spontaneous apneas and respiratory abnormalities during behavioral arousal in a mouse model of Rett syndrome.
Topics: Animals; Apnea; Brain-Derived Neurotrophic Factor; Carbazoles; Disease Models, Animal; Humans; Indol | 2014 |
Antidepressant-like effects of alarin produced by activation of TrkB receptor signaling pathways in chronic stress mice.
Topics: Animals; Antidepressive Agents; Brain; Carbazoles; Cyclic AMP Response Element-Binding Protein; Depr | 2015 |
Hippocampal BDNF signaling restored with chronic asiaticoside treatment in depression-like mice.
Topics: Animals; Antidepressive Agents; Carbazoles; Central Nervous System Agents; Chronic Disease; Depressi | 2015 |
Effects of nerve growth factor antagonist K252a on peritoneal mast cell degranulation: implications for rat postoperative ileus.
Topics: Animals; Carbazoles; Cell Degranulation; Disease Models, Animal; Drug Monitoring; Gastric Emptying; | 2015 |
Role of TrkB in the anxiolytic-like and antidepressant-like effects of vagal nerve stimulation: Comparison with desipramine.
Topics: Adrenergic Uptake Inhibitors; Animals; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Anxiet | 2016 |
Antidepressant-like effects of standardized gypenosides: involvement of brain-derived neurotrophic factor signaling in hippocampus.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Carbazoles; Depression; Disease M | 2016 |
The TrkA receptor mediates experimental thermal hyperalgesia produced by nerve growth factor: Modulation by the p75 neurotrophin receptor.
Topics: Analgesics; Aniline Compounds; Animals; Antibodies; Benzylidene Compounds; Carbazoles; Disease Model | 2017 |
CEP-1347 reduces mutant huntingtin-associated neurotoxicity and restores BDNF levels in R6/2 mice.
Topics: Animals; Animals, Genetically Modified; Brain-Derived Neurotrophic Factor; Carbazoles; Cell Line; Di | 2008 |
BDNF-TrkB signaling pathway mediates the induction of epileptiform activity induced by a convulsant drug cyclothiazide.
Topics: Action Potentials; Analysis of Variance; Animals; Antibodies; Antihypertensive Agents; Benzothiadiaz | 2009 |
TrkB/BDNF-dependent striatal plasticity and behavior in a genetic model of epilepsy: modulation by valproic acid.
Topics: Analysis of Variance; Animals; Anticonvulsants; Avoidance Learning; Brain-Derived Neurotrophic Facto | 2010 |
Neuronal-driven angiogenesis: role of NGF in retinal neovascularization in an oxygen-induced retinopathy model.
Topics: Animals; Animals, Newborn; Carbazoles; Disease Models, Animal; Enzyme Inhibitors; Enzyme-Linked Immu | 2010 |
NGF-Dependent activation of TrkA pathway: A mechanism for the neuroprotective effect of troxerutin in D-galactose-treated mice.
Topics: Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; Brain; Calcium-Calmodulin-Depen | 2010 |
A tropomyosine receptor kinase inhibitor blocks spinal neuroplasticity essential for the anti-hypersensitivity effects of gabapentin and clonidine in rats with peripheral nerve injury.
Topics: Acetylcholine; Amines; Analgesics; Animals; Carbazoles; Choline O-Acetyltransferase; Clonidine; Cycl | 2011 |
Elevated BDNF after cocaine withdrawal facilitates LTP in medial prefrontal cortex by suppressing GABA inhibition.
Topics: Animals; Animals, Newborn; Biophysics; Brain-Derived Neurotrophic Factor; Carbazoles; Cocaine; Cocai | 2010 |
Impairment of select forms of spatial memory and neurotrophin-dependent synaptic plasticity by deletion of glial aquaporin-4.
Topics: Action Potentials; Animals; Aquaporin 4; Biophysics; Brain-Derived Neurotrophic Factor; Carbazoles; | 2011 |
Involvement of NGF in the rat model of persistent muscle pain associated with taut band.
Topics: Analysis of Variance; Animals; Carbazoles; Disease Models, Animal; Enzyme Inhibitors; Enzyme-Linked | 2011 |
Nerve growth factor and associated nerve sprouting contribute to local mechanical hyperalgesia in a rat model of bone injury.
Topics: Animals; Antibodies, Neutralizing; Behavior, Animal; Bone and Bones; Carbazoles; Disease Models, Ani | 2012 |
Acute and sustained effects of a metabotropic glutamate 5 receptor antagonist in the novelty-suppressed feeding test.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Carbazoles; Diazepam; Disease Models, A | 2012 |
BDNF receptor blockade hinders the beneficial effects of exercise in a rat model of Parkinson's disease.
Topics: Analysis of Variance; Animals; Apomorphine; Carbazoles; Corpus Striatum; Disease Models, Animal; Enz | 2013 |
K252a, a high-affinity nerve growth factor receptor blocker, improves psoriasis: an in vivo study using the severe combined immunodeficient mouse-human skin model.
Topics: Animals; Carbazoles; Cell Division; Disease Models, Animal; Humans; Indole Alkaloids; Keratinocytes; | 2004 |
Brain-derived neurotrophic factor-elicited or sciatic ligation-associated phosphorylation of cyclic AMP response element binding protein in the rat spinal dorsal horn is reduced by block of tyrosine kinase receptors.
Topics: Afferent Pathways; Animals; Brain-Derived Neurotrophic Factor; Carbazoles; Chronic Disease; Cyclic A | 2004 |
Enhancement of Schwann cell myelin formation by K252a in the Trembler-J mouse dorsal root ganglion explant culture.
Topics: Animals; Carbazoles; Cells, Cultured; Charcot-Marie-Tooth Disease; Disease Models, Animal; Enzyme In | 2005 |
The neuroprotective effects of K252a through inhibiting MLK3/MKK7/JNK3 signaling pathway on ischemic brain injury in rat hippocampal CA1 region.
Topics: Animals; Brain Ischemia; Carbazoles; Disease Models, Animal; Enzyme Inhibitors; Hippocampus; Indole | 2005 |
Patterns of dentate granule cell responses to perforant path stimulation in epileptic mice with granule cell dispersion.
Topics: Action Potentials; Animals; Behavior, Animal; Carbazoles; Cell Count; Disease Models, Animal; Dose-R | 2005 |
Airway hyper-responsiveness in allergic asthma in guinea-pigs is mediated by nerve growth factor via the induction of substance P: a potential role for trkA.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Carbazoles; Disease Models | 2006 |
Nerve growth factor enhances voltage-gated Na+ channel activity and Transwell migration in Mat-LyLu rat prostate cancer cell line.
Topics: Animals; Carbazoles; Cell Line, Tumor; Cell Movement; Cyclic AMP-Dependent Protein Kinases; Disease | 2007 |
Effects of high-affinity nerve growth factor receptor inhibitors on symptoms in the NC/Nga mouse atopic dermatitis model.
Topics: Animals; Carbazoles; Dermatitis, Atopic; Disease Models, Animal; Drug Evaluation, Preclinical; Enzym | 2007 |
Lymnaea epidermal growth factor promotes axonal regeneration in CNS organ culture.
Topics: Animals; Axons; Carbazoles; Central Nervous System; Disease Models, Animal; Enzyme Inhibitors; Epide | 2001 |