staurosporine aglycone and Bronchial Hyperreactivity studies

staurosporine aglycone: metabolite from culture broth of Nocardiopsis sp.; a neurotrophin antag; inhibits BDNF TrkB receptor

Bronchial Hyperreactivity: Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.

Research Excerpts

Excerpt	Relevance	Reference
"We conclude that substance P plays a role in the induction of AHR in our model for allergic asthma which is most likely mediated by NGF."	7.73	Airway hyper-responsiveness in allergic asthma in guinea-pigs is mediated by nerve growth factor via the induction of substance P: a potential role for trkA. ( Braun, A; de Vries, A; Dessing, MC; Engels, F; Fischer, A; Groneberg, DA; Henricks, PA; Leusink-Muis, T; McGregor, GP; Nijkamp, FP, 2006)
"We conclude that substance P plays a role in the induction of AHR in our model for allergic asthma which is most likely mediated by NGF."	3.73	Airway hyper-responsiveness in allergic asthma in guinea-pigs is mediated by nerve growth factor via the induction of substance P: a potential role for trkA. ( Braun, A; de Vries, A; Dessing, MC; Engels, F; Fischer, A; Groneberg, DA; Henricks, PA; Leusink-Muis, T; McGregor, GP; Nijkamp, FP, 2006)

Research

Studies (1)

Authors

Other Studies

1 other study available for staurosporine aglycone and Bronchial Hyperreactivity

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (100.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
de Vries, A	1
Engels, F	1
Henricks, PA	1
Leusink-Muis, T	1
McGregor, GP	1
Braun, A	1
Groneberg, DA	1
Dessing, MC	1
Nijkamp, FP	1
Fischer, A	1