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staurosporine aglycone and Brain Ischemia

staurosporine aglycone has been researched along with Brain Ischemia in 3 studies

staurosporine aglycone: metabolite from culture broth of Nocardiopsis sp.; a neurotrophin antag; inhibits BDNF TrkB receptor

Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.

Research Excerpts

ExcerptRelevanceReference
"These results indicated that cerebral ischemia induced the continuous activation of MLK3/MKK7/JNK3 cascade, which all had two active waves only in the CA1 region."1.33The neuroprotective effects of K252a through inhibiting MLK3/MKK7/JNK3 signaling pathway on ischemic brain injury in rat hippocampal CA1 region. ( Pan, J; Zhang, GY; Zhang, QG, 2005)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (33.33)29.6817
2010's2 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Qi, D1
Ouyang, C1
Wang, Y1
Zhang, S1
Ma, X1
Song, Y1
Yu, H1
Tang, J1
Fu, W1
Sheng, L1
Yang, L1
Wang, M1
Zhang, W1
Miao, L1
Li, T1
Huang, X1
Dong, H1
Wang, Q1
Yin, XH1
Liu, Y1
Zhang, GY2
Pan, J1
Zhang, QG1

Other Studies

3 other studies available for staurosporine aglycone and Brain Ischemia

ArticleYear
HO-1 attenuates hippocampal neurons injury via the activation of BDNF-TrkB-PI3K/Akt signaling pathway in stroke.
    Brain research, 2014, Aug-19, Volume: 1577

    Topics: Animals; Apoptosis; Brain Ischemia; Brain-Derived Neurotrophic Factor; CA1 Region, Hippocampal; Carb

2014
K252a suppresses neuronal cells apoptosis through inhibiting the translocation of Bax to mitochondria induced by the MLK3/JNK signaling after transient global brain ischemia in rat hippocampal CA1 subregion.
    Journal of receptor and signal transduction research, 2011, Volume: 31, Issue:4

    Topics: 14-3-3 Proteins; Animals; Apoptosis; bcl-2-Associated X Protein; Brain Ischemia; CA1 Region, Hippoca

2011
The neuroprotective effects of K252a through inhibiting MLK3/MKK7/JNK3 signaling pathway on ischemic brain injury in rat hippocampal CA1 region.
    Neuroscience, 2005, Volume: 131, Issue:1

    Topics: Animals; Brain Ischemia; Carbazoles; Disease Models, Animal; Enzyme Inhibitors; Hippocampus; Indole

2005