staurosporine aglycone has been researched along with Brain Ischemia in 3 studies
staurosporine aglycone: metabolite from culture broth of Nocardiopsis sp.; a neurotrophin antag; inhibits BDNF TrkB receptor
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "These results indicated that cerebral ischemia induced the continuous activation of MLK3/MKK7/JNK3 cascade, which all had two active waves only in the CA1 region." | 1.33 | The neuroprotective effects of K252a through inhibiting MLK3/MKK7/JNK3 signaling pathway on ischemic brain injury in rat hippocampal CA1 region. ( Pan, J; Zhang, GY; Zhang, QG, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Qi, D | 1 |
| Ouyang, C | 1 |
| Wang, Y | 1 |
| Zhang, S | 1 |
| Ma, X | 1 |
| Song, Y | 1 |
| Yu, H | 1 |
| Tang, J | 1 |
| Fu, W | 1 |
| Sheng, L | 1 |
| Yang, L | 1 |
| Wang, M | 1 |
| Zhang, W | 1 |
| Miao, L | 1 |
| Li, T | 1 |
| Huang, X | 1 |
| Dong, H | 1 |
| Wang, Q | 1 |
| Yin, XH | 1 |
| Liu, Y | 1 |
| Zhang, GY | 2 |
| Pan, J | 1 |
| Zhang, QG | 1 |
3 other studies available for staurosporine aglycone and Brain Ischemia
| Article | Year |
|---|---|
HO-1 attenuates hippocampal neurons injury via the activation of BDNF-TrkB-PI3K/Akt signaling pathway in stroke.
Topics: Animals; Apoptosis; Brain Ischemia; Brain-Derived Neurotrophic Factor; CA1 Region, Hippocampal; Carb | 2014 |
K252a suppresses neuronal cells apoptosis through inhibiting the translocation of Bax to mitochondria induced by the MLK3/JNK signaling after transient global brain ischemia in rat hippocampal CA1 subregion.
Topics: 14-3-3 Proteins; Animals; Apoptosis; bcl-2-Associated X Protein; Brain Ischemia; CA1 Region, Hippoca | 2011 |
The neuroprotective effects of K252a through inhibiting MLK3/MKK7/JNK3 signaling pathway on ischemic brain injury in rat hippocampal CA1 region.
Topics: Animals; Brain Ischemia; Carbazoles; Disease Models, Animal; Enzyme Inhibitors; Hippocampus; Indole | 2005 |