staphyloxanthin and Endocarditis

staphyloxanthin has been researched along with Endocarditis* in 1 studies

Other Studies

1 other study(ies) available for staphyloxanthin and Endocarditis

Article	Year
The role of Staphylococcal carotenogenesis in resistance to host defense peptides and in vivo virulence in experimental endocarditis model. Pathogens and disease, 2015, Volume: 73, Issue:7 The defining hallmark of the newly described species, Staphylococcus argenteus, in comparison to its sister species, S. aureus and S. schweitzeri, is the absence of production of the carotenoid pigment, staphyloxanthin. Staphylococcus argenteus lacks the responsible genetic locus crtOPQMN. We examined the impact of carotenoid synthesis in two non-pigmented S. argenteus strains, MSHR1132 and SCC1165. Following complementation with a plasmid containing the carotenoid operon (pTX-crtOPQMN), compared to wild type, both complemented strains showed substantial carotenoid production, with a resultant increase in cell membrane rigidity. Surprisingly, both crtOPQMN-complemented strains exhibited increased susceptibility to the host defense peptides, LL-37 and hNP-1 in vitro, and reduced virulence in an experimental rabbit endocarditis model. Topics: alpha-Defensins; Animals; Antimicrobial Cationic Peptides; Biosynthetic Pathways; Cathelicidins; Disease Models, Animal; Endocarditis; Genetic Complementation Test; Host-Pathogen Interactions; Operon; Plasmids; Rabbits; Staphylococcal Infections; Staphylococcus aureus; Virulence; Xanthophylls	2015

Article

Year

The role of Staphylococcal carotenogenesis in resistance to host defense peptides and in vivo virulence in experimental endocarditis model.

Pathogens and disease, 2015, Volume: 73, Issue:7

The defining hallmark of the newly described species, Staphylococcus argenteus, in comparison to its sister species, S. aureus and S. schweitzeri, is the absence of production of the carotenoid pigment, staphyloxanthin. Staphylococcus argenteus lacks the responsible genetic locus crtOPQMN. We examined the impact of carotenoid synthesis in two non-pigmented S. argenteus strains, MSHR1132 and SCC1165. Following complementation with a plasmid containing the carotenoid operon (pTX-crtOPQMN), compared to wild type, both complemented strains showed substantial carotenoid production, with a resultant increase in cell membrane rigidity. Surprisingly, both crtOPQMN-complemented strains exhibited increased susceptibility to the host defense peptides, LL-37 and hNP-1 in vitro, and reduced virulence in an experimental rabbit endocarditis model.

Topics: alpha-Defensins; Animals; Antimicrobial Cationic Peptides; Biosynthetic Pathways; Cathelicidins; Disease Models, Animal; Endocarditis; Genetic Complementation Test; Host-Pathogen Interactions; Operon; Plasmids; Rabbits; Staphylococcal Infections; Staphylococcus aureus; Virulence; Xanthophylls

2015