Proceedings of the National Academy of Sciences of the United States of America, 2019, 10-29, Volume: 116, Issue:44
Siderophores, iron-scavenging small molecules, are fundamental to bacterial nutrient metal acquisition and enable pathogens to overcome challenges imposed by nutritional immunity. Multimodal imaging mass spectrometry allows visualization of host-pathogen iron competition, by mapping siderophores within infected tissue. We have observed heterogeneous distributions of Topics: Abscess; Animals; Citrates; Host-Pathogen Interactions; Iron; Mice; Ornithine; Siderophores; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Staphylococcal Infections; Staphylococcus aureus | 2019 |