st-246 has been researched along with Animal-Diseases* in 1 studies
1 other study(ies) available for st-246 and Animal-Diseases
Article | Year |
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Efficacy of the antipoxvirus compound ST-246 for treatment of severe orthopoxvirus infection.
Efficacy of the new antipoxvirus compound ST-246 was evaluated as treatment of monkeypox (MPX) virus infection in a ground squirrel model of the disease. Ground squirrels were given a lethal dose of MPX virus and were then treated orally at various times post-inoculation (pi) with 100 mg/kg/day of ST-246. Morbidity and mortality, clinical laboratory results, viral load, and pathology of placebo and treatment groups were compared. All animals that started treatment with ST-246 on days 0, 1, 2, and 3 pi survived lethal challenge with MPX virus; 67% of animals treated on day 4 pi also survived. In contrast, 100% of the placebo group died. Most of the ST-246-treated animals showed no evidence of clinical disease or alteration of baseline clinical laboratory values and had minimal histopathologic changes. These results suggest that ST-246 is a promising candidate for early treatment of severe orthopoxvirus infection. Topics: Animal Diseases; Animals; Antiviral Agents; Benzamides; Drug Administration Schedule; Indoles; Isoindoles; Liver; Lung; Models, Animal; Mpox (monkeypox); Sciuridae; Spleen; Time Factors | 2007 |