srt2104 has been researched along with Muscular-Atrophy* in 1 studies
1 other study(ies) available for srt2104 and Muscular-Atrophy
| Article | Year |
|---|---|
The Impact of SRT2104 on Skeletal Muscle Mitochondrial Function, Redox Biology, and Loss of Muscle Mass in Hindlimb Unloaded Rats.
Mechanical unloading during microgravity causes skeletal muscle atrophy and impairs mitochondrial energetics. The elevated production of reactive oxygen species (ROS) by mitochondria and Nox2, coupled with impairment of stress protection (e.g., SIRT1, antioxidant enzymes), contribute to atrophy. We tested the hypothesis that the SIRT1 activator, SRT2104 would rescue unloading-induced mitochondrial dysfunction. Mitochondrial function in rat gastrocnemius and soleus muscles were evaluated under three conditions (10 days): ambulatory control (CON), hindlimb unloaded (HU), and hindlimb-unloaded-treated with SRT2104 (SIRT). Oxidative phosphorylation, electron transfer capacities, H Topics: Animals; Antioxidants; Biology; Hindlimb; Hydrogen Peroxide; Mitochondria; Muscle, Skeletal; Muscular Atrophy; Oxidation-Reduction; Oxidative Stress; Rats; Sirtuin 1 | 2023 |