Page last updated: 2024-08-26

sr141716 and Drug Withdrawal Symptoms

sr141716 has been researched along with Drug Withdrawal Symptoms in 61 studies

Research

Studies (61)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	11 (18.03)	18.2507
2000's	34 (55.74)	29.6817
2010's	13 (21.31)	24.3611
2020's	3 (4.92)	2.80

Authors

Authors	Studies
Adank, D; Butler, E; Johnson, K; Morgan, A; Patel, S	1
Bilbao, A; Ferrer, B; Granado, N; Moratalla, R; Pavon, FJ; Rodríguez de Fonseca, F; Serrano, A; Suárez, J; Vadas, E	1
Crowe, MS; Gross, JD; Jones, MS; Kinsey, SG; McKitrick, AW; Nass, SR; Siderovski, DP; Trexler, KR	1
Ahmad, U; Chen, X; Damaj, MI; Donvito, G; Jackson, KJ; Lichtman, AH; McIntosh, JM; Muldoon, PP; Zaveri, NT	1
McMahon, LR; Schulze, DR; Wilkerson, JL	1
Abdullah, R; Cravatt, BF; Kinsey, SG; Lichtman, AH; Ramesh, D; Selley, DE; Wise, LE	1
Järbe, TU; Makriyannis, A; Nikas, SP; Shukla, VG; Tai, S; Vemuri, K	1
Berrendero, F; Busquets-Garcia, A; de la Torre, R; Di Marzo, V; Flores, Á; Maldonado, R; Marsicano, G; Ozaita, A; Pastor, A; Plaza-Zabala, A; Saravia, R	1
Abdullah, RA; Carlson, BL; Cravatt, BF; Lichtman, AH; Long, JZ; Ramesh, D; Schlosburg, JE	1
Allen, CP; Lang, ST; Leri, F; Manwell, LA; Parker, LA; Satvat, E	1
Cowan, A; Huang, P; Liu-Chen, LY; Unterwald, EM	1
Huang, P; Kirby, LG; Liu-Chen, LY	1
McMahon, LR; Stewart, JL	1
Diana, M; Lintas, A; Migliore, M; Spiga, S	1
Lichtman, AH; Long, KA; Middleton, LS; Selley, DE; Sim-Selley, LJ; Varvel, SA; Wiebelhaus, JM; Wise, LE	1
Bonnet, D; Darwin, WD; Goodwin, RS; Gorelick, DA; Huestis, MA; Kelly, DL; Liu, F; McMahon, RP; Ortemann-Renon, C; Schwilke, E; Schwope, DM	1
Ali, C; Docagne, F; Fernandez-Ruiz, J; Ramos, JA; Roussel, BD; Rubio, M; Villain, H; Vivien, D	1
Ginsburg, BC; Hruba, L; McMahon, LR; Schulze, DR	1
Buggy, Y; Egberts, TC; Layton, D; Leufkens, HG; Mantel-Teeuwisse, AK; Straus, SM; Willemen, MJ	1
Anggadiredja, K; Shoyama, Y; Tanaka, H; Watanabe, S; Yamaguchi, T; Yamamoto, T	2
Deadwyler, SA; Hampson, RE; Kelly, EJ; Simeral, JD	1
Caberlotto, L; Eriksson, S; Hansson, A; Heilig, M; Rimondini, R	1
France, CP; McMahon, LR	1
Ambrosio, E; Arévalo, C; Cascio, MG; Di Marzo, V; Fernández-Ruiz, J; González, S; Hernández, M; Nicanor, C; Ramos, JA	1
Castañé, A; Maldonado, R; Valverde, O	1
Cohen, C; Griebel, G; Perrault, G; Soubrié, P	1
Amico, MC; Morrone, LA; Palmery, M; Romanelli, L; Tucci, P; Valeri, P	1
Lichtman, AH; Martin, BR	1
Cossu, G; Deiana, S; Fadda, P; Fattore, L; Fratta, W; Melis, V; Spano, MS	1
Harloe, JP; Lichtman, AH; Martin, BR; Varvel, SA; Wilson, DM	1
González-Cuevas, G; López-Moreno, JA; Navarro, M	1
Maldonado, R; Touriño, C; Valverde, O	1
Frishman, WH	1
Benyamina, A; Blecha, L; Lecacheux, M; Lukasiewcz, M; Reynaud, M	1
de Miguel, R; Fernández-Ruiz, J; Maestro, B; Michael Walker, J; Ramos, JA; Rubio, M	1
Damaj, MI; Lichtman, AH; Martin, BR; Merritt, LL; Walters, C	1
Buchhalter, AR; Fant, RV; Henningfield, JE	1
Aceto, MD; Lowe, JA; Martin, BR; Scates, SM	2
Patrick, SL; Tsou, K; Walker, JM	1
Carrera, MR; Koob, GF; Navarro, M; Rodríguez de Fonseca, F; Weiss, F	1
Fuzio, D; Giagnoni, G; Massi, P; Parolaro, D; Patrini, G; Rubino, T; Viganò, D	1
Cook, SA; Lowe, JA; Martin, BR	1
Arthur, DB; LaVecchia, KL; Lichtman, AH; Martin, BR; Neviaser, ST; Wiley, JL; Wilson, DM	1
Aceto, MD; Martin, BR; Razdan, RK; Scates, SM	1
Chowen, J; de Fonseca, FR; del Arco, I; Koob, GF; Martin, Y; Navarro, M; Roberts, AJ; Rocío A Carrera, M; Villanúa, MA	1
Hanoune, J; Hutcheson, DM; Maldonado, R; Roques, BP; Smadja, C; Tzavara, ET; Valjent, E	1
Di Chiara, G; Loddo, P; Tanda, G	1
Beardsley, PM; Martin, BR	1
Beslot, F; Defer, N; Firmo, C; Hanoune, J; Maldonado, R; Mas, M; Roques, BP; Tzavara, ET; Valjent, E	1
Colleoni, M; Costa, B; Giagnoni, G	1
Fuzio, D; Massi, P; Parolaro, D; Rubino, T; Viganò, D	1
Cheer, JF; Kendall, DA; Marsden, CA	1
Maldonado, R; Valjent, E; Valverde, O; Zimmer, A; Zimmer, AM	1
Aceto, MD; Martin, BB; Scates, SM	1
Caneparo, A; Da Nascimento, S; Le Fur, G; Mas-Nieto, M; Noble, F; Pommier, B; Roques, BP; Tzavara, ET	1
Lichtman, AH; Loh, HH; Martin, BR; Sheikh, SM	1
Filliol, D; Ghozland, S; Kieffer, BL; Maldonado, R; Matthes, HW; Simonin, F	1
Brunetti, G; Carai, MA; Colombo, G; Gessa, GL; Pani, M; Serra, S; Vacca, G	1
Dhawan, K; Kumar, S; Sharma, A	1

Reviews

5 review(s) available for sr141716 and Drug Withdrawal Symptoms

Article	Year
Cannabinoid tolerance and dependence. Handbook of experimental pharmacology, 2005, Issue:168 Topics: Animals; Cannabinoid Receptor Modulators; Cannabinoids; Drug Tolerance; Humans; Marijuana Abuse; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reinforcement, Psychology; Rimonabant; Substance Withdrawal Syndrome	2005
An endocannabinoid mechanism in relapse to drug seeking: a review of animal studies and clinical perspectives. Brain research reviews, 2007, Volume: 53, Issue:1 Topics: Animals; Brain; Cannabinoid Receptor Modulators; Disease Models, Animal; Endocannabinoids; Humans; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reward; Rimonabant; Secondary Prevention; Substance Withdrawal Syndrome; Substance-Related Disorders	2007
Smoking cessation pharmacotherapy--nicotine and non-nicotine preparations. Preventive cardiology, 2007,Spring, Volume: 10, Issue:2 Suppl 1 Topics: Administration, Cutaneous; Administration, Inhalation; Benzazepines; Bupropion; Chewing Gum; Clonidine; Coronary Artery Disease; Humans; Monoamine Oxidase Inhibitors; Nicotine; Nortriptyline; Piperidines; Pyrazoles; Quinoxalines; Receptors, Nicotinic; Rimonabant; Selective Serotonin Reuptake Inhibitors; Smoking; Smoking Cessation; Substance Withdrawal Syndrome; Tobacco Use Disorder; Tobacco, Smokeless; Varenicline	2007
Pharmacotherapy and psychotherapy in cannabis withdrawal and dependence. Expert review of neurotherapeutics, 2008, Volume: 8, Issue:3 Topics: Behavior Therapy; Buspirone; Cannabinoids; Cognitive Behavioral Therapy; Combined Modality Therapy; Dronabinol; Humans; Marijuana Abuse; Mianserin; Mirtazapine; Motivation; Piperidines; Psychotherapy; Psychotropic Drugs; Pyrazoles; Randomized Controlled Trials as Topic; Rimonabant; Substance Withdrawal Syndrome	2008
Novel pharmacological approaches for treating tobacco dependence and withdrawal: current status. Drugs, 2008, Volume: 68, Issue:8 Topics: Antidepressive Agents; Aryl Hydrocarbon Hydroxylases; Clonidine; Cytochrome P-450 CYP2A6; Drug Delivery Systems; GABA Modulators; Humans; Narcotic Antagonists; Nicotine; Piperidines; Pyrazoles; Receptors, Nicotinic; Rimonabant; Substance Withdrawal Syndrome; Tobacco Use Disorder; Vaccination	2008

Trials

1 trial(s) available for sr141716 and Drug Withdrawal Symptoms

Article	Year
Antagonist-elicited cannabis withdrawal in humans. Journal of clinical psychopharmacology, 2011, Volume: 31, Issue:5 Topics: Adult; Area Under Curve; Dose-Response Relationship, Drug; Double-Blind Method; Dronabinol; Humans; Male; Marijuana Abuse; Mass Spectrometry; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Substance Withdrawal Syndrome; Young Adult	2011

Other Studies

55 other study(ies) available for sr141716 and Drug Withdrawal Symptoms

Article	Year
2-Arachidonoylglycerol-mediated endocannabinoid signaling modulates mechanical hypersensitivity associated with alcohol withdrawal in mice. Alcoholism, clinical and experimental research, 2022, Volume: 46, Issue:11 Topics: Alcoholism; Animals; Endocannabinoids; Female; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Substance Withdrawal Syndrome	2022
Genetic deletion of dopamine D1 receptors increases the sensitivity to cannabinoid CB1 receptor antagonist-precipitated withdrawal when compared with wild-type littermates: studies in female mice repeatedly exposed to the Spice cannabinoid HU-210. Psychopharmacology, 2021, Volume: 238, Issue:2 Topics: Animals; Behavior, Animal; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Dronabinol; Female; Male; Mice; Mice, Knockout; Motor Activity; Receptor, Cannabinoid, CB1; Receptors, Dopamine D1; Receptors, Dopamine D2; Rimonabant; Substance Withdrawal Syndrome	2021
Novel behavioral assays of spontaneous and precipitated THC withdrawal in mice. Drug and alcohol dependence, 2018, Oct-01, Volume: 191 Topics: Animals; Behavior, Animal; Benzodioxoles; Cannabinoid Receptor Agonists; Dronabinol; Indoles; Male; Marijuana Abuse; Mice; Mice, Inbred C57BL; Naphthalenes; Piperidines; Pyrazoles; Rimonabant; Substance Withdrawal Syndrome	2018
Neuronal nicotinic acetylcholine receptors mediate ∆ Addiction biology, 2020, Volume: 25, Issue:1 Topics: Animals; Cannabinoid Receptor Antagonists; Disease Models, Animal; Dronabinol; Humans; Marijuana Abuse; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Nicotinic; Rimonabant; Substance Withdrawal Syndrome	2020
Tolerance and dependence to Δ9-tetrahydrocannabinol in rhesus monkeys: Activity assessments. PloS one, 2019, Volume: 14, Issue:3 Topics: Administration, Intravenous; Animals; Disease Models, Animal; Dronabinol; Drug Tolerance; Female; Hallucinogens; Humans; Macaca mulatta; Male; Motor Activity; Rimonabant; Substance Withdrawal Syndrome	2019
Repeated low-dose administration of the monoacylglycerol lipase inhibitor JZL184 retains cannabinoid receptor type 1-mediated antinociceptive and gastroprotective effects. The Journal of pharmacology and experimental therapeutics, 2013, Volume: 345, Issue:3 Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arachidonic Acids; Benzodioxoles; Brain Chemistry; Cyclohexanols; Diclofenac; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Endocannabinoids; Glycerides; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred C57BL; Monoacylglycerol Lipases; Pain Measurement; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Stomach Ulcer; Substance Withdrawal Syndrome; Substance-Related Disorders	2013
Cannabinoid withdrawal in mice: inverse agonist vs neutral antagonist. Psychopharmacology, 2015, Volume: 232, Issue:15 Topics: Animals; Body Temperature; Cannabinoid Receptor Antagonists; Cannabinoids; Disease Models, Animal; Dronabinol; Drug Tolerance; Male; Mice; Morpholines; Motor Activity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Substance Withdrawal Syndrome	2015
CB Biological psychiatry, 2017, 04-01, Volume: 81, Issue:7 Topics: Animals; Arachidonic Acids; Brain; Cannabinoid Receptor Antagonists; Endocannabinoids; GABAergic Neurons; Glycerides; Male; Memory; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuronal Plasticity; Nicotine; Piperidines; Polyunsaturated Alkamides; Pyramidal Cells; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, GABA; Recognition, Psychology; Rimonabant; Substance Withdrawal Syndrome	2017
Inhibitors of endocannabinoid-metabolizing enzymes reduce precipitated withdrawal responses in THC-dependent mice. The AAPS journal, 2009, Volume: 11, Issue:2 Topics: Amidohydrolases; Animals; Benzamides; Benzodioxoles; Cannabinoid Receptor Modulators; Carbamates; Dronabinol; Endocannabinoids; Enzyme Inhibitors; Hallucinogens; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Monoacylglycerol Lipases; Motor Activity; Piperidines; Postural Balance; Psychomotor Performance; Pyrazoles; Rimonabant; Substance Withdrawal Syndrome	2009
FAAH inhibitor, URB-597, promotes extinction and CB(1) antagonist, SR141716, inhibits extinction of conditioned aversion produced by naloxone-precipitated morphine withdrawal, but not extinction of conditioned preference produced by morphine in rats. Pharmacology, biochemistry, and behavior, 2009, Volume: 94, Issue:1 Topics: Amidohydrolases; Animals; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Choice Behavior; Conditioning, Psychological; Dietary Sucrose; Extinction, Psychological; Female; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Narcotics; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reinforcement Schedule; Rimonabant; Species Specificity; Substance Withdrawal Syndrome	2009
Hyperlocomotion and paw tremors are two highly quantifiable signs of SR141716-precipitated withdrawal from delta9-tetrahydrocannabinol in C57BL/6 mice. Neuroscience letters, 2009, Nov-06, Volume: 465, Issue:1 Topics: Analysis of Variance; Animals; Dronabinol; Dyskinesia, Drug-Induced; Forelimb; Locomotion; Male; Mice; Mice, Inbred C57BL; Motor Activity; Piperidines; Psychotropic Drugs; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Substance Withdrawal Syndrome; Tremor	2009
Anxiety-like effects of SR141716-precipitated delta9-tetrahydrocannabinol withdrawal in mice in the elevated plus-maze. Neuroscience letters, 2010, May-21, Volume: 475, Issue:3 Topics: Animals; Anxiety; Dronabinol; Emotions; Male; Maze Learning; Mice; Mice, Inbred ICR; Piperidines; Psychotropic Drugs; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Substance Withdrawal Syndrome	2010
Rimonabant-induced Delta9-tetrahydrocannabinol withdrawal in rhesus monkeys: discriminative stimulus effects and other withdrawal signs. The Journal of pharmacology and experimental therapeutics, 2010, Volume: 334, Issue:1 Topics: Adrenergic Agonists; Animals; Behavior, Animal; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Clonidine; Cyclohexanols; Discrimination, Psychological; Dronabinol; Female; Heart Rate; Macaca mulatta; Male; Morpholines; Motor Activity; Naphthalenes; Piperidines; Pyrazoles; Rimonabant; Substance Withdrawal Syndrome	2010
Altered architecture and functional consequences of the mesolimbic dopamine system in cannabis dependence. Addiction biology, 2010, Volume: 15, Issue:3 Topics: Animals; Axons; Cannabinoids; Dopamine; Limbic System; Male; Marijuana Abuse; Mesencephalon; Neural Pathways; Neurogenesis; Neuronal Plasticity; Neurons; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Substance Withdrawal Syndrome; Substantia Nigra; Synapses; Tyrosine 3-Monooxygenase; Ventral Tegmental Area	2010
delta(9)-Tetrahydrocannabinol-dependent mice undergoing withdrawal display impaired spatial memory. Psychopharmacology, 2011, Volume: 217, Issue:4 Topics: Animals; Dose-Response Relationship, Drug; Dronabinol; Male; Marijuana Abuse; Maze Learning; Memory Disorders; Memory, Short-Term; Mice; Mice, Inbred C57BL; Piperidines; Pyrazoles; Rimonabant; Spatial Behavior; Substance Withdrawal Syndrome	2011
Pharmacological activation/inhibition of the cannabinoid system affects alcohol withdrawal-induced neuronal hypersensitivity to excitotoxic insults. PloS one, 2011, Volume: 6, Issue:8 Topics: Animals; Cannabinoids; Cell Death; Cells, Cultured; Ethanol; Excitatory Amino Acid Agonists; Mice; N-Methylaspartate; Neurons; Neuroprotective Agents; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Substance Withdrawal Syndrome	2011
JWH-018 and JWH-073: Δ⁹-tetrahydrocannabinol-like discriminative stimulus effects in monkeys. The Journal of pharmacology and experimental therapeutics, 2012, Volume: 340, Issue:1 Topics: Animals; Behavior, Animal; Conditioning, Operant; Data Interpretation, Statistical; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Female; Hallucinogens; Illicit Drugs; Indoles; Macaca mulatta; Male; Marijuana Abuse; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Substance Withdrawal Syndrome	2012
Reasons for and time to discontinuation of rimonabant therapy: a modified prescription-event monitoring study. Drug safety, 2012, Dec-01, Volume: 35, Issue:12 Topics: Adult; Body Mass Index; Cannabinoid Receptor Antagonists; Cohort Studies; Drug Monitoring; Drug Prescriptions; Female; Humans; Male; Mental Disorders; Middle Aged; Obesity; Patient Compliance; Piperidines; Pyrazoles; Rimonabant; Risk Factors; Substance Withdrawal Syndrome; Time Factors	2012
Prostaglandin E2 attenuates SR141716A-precipitated withdrawal in tetrahydrocannabinol-dependent mice. Brain research, 2003, Mar-14, Volume: 966, Issue:1 Topics: Animals; Cannabinoids; Dinoprostone; Dose-Response Relationship, Drug; Dronabinol; Male; Mice; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Substance Withdrawal Syndrome	2003
Tolerance to the memory disruptive effects of cannabinoids involves adaptation by hippocampal neurons. Hippocampus, 2003, Volume: 13, Issue:5 Topics: Action Potentials; Adaptation, Physiological; Animals; Benzoxazines; Cannabinoids; Drug Administration Schedule; Drug Tolerance; Hippocampus; Male; Marijuana Abuse; Memory Disorders; Morpholines; Naphthalenes; Neurons; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Reaction Time; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Substance Withdrawal Syndrome; Synaptic Transmission	2003
Corticotropin-releasing hormone (CRH) mRNA expression in rat central amygdala in cannabinoid tolerance and withdrawal: evidence for an allostatic shift? Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2004, Volume: 29, Issue:1 Topics: Amygdala; Analysis of Variance; Animals; Behavior, Animal; Cannabinoids; Corticotropin-Releasing Hormone; Dose-Response Relationship, Drug; Dronabinol; Drug Administration Schedule; Drug Tolerance; Excitatory Amino Acid Antagonists; Gene Expression Regulation; In Situ Hybridization; Locomotion; Male; Maze Learning; Neostriatum; Neuropeptide Y; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Neuropeptide Y; Rimonabant; RNA, Messenger; Substance Withdrawal Syndrome; Time Factors	2004
Discriminative stimulus effects of the cannabinoid antagonist, SR 141716A, in delta -sup-9-tetrahydrocannabinol-treated rhesus monkeys. Experimental and clinical psychopharmacology, 2003, Volume: 11, Issue:4 Topics: Anesthetics; Animals; Behavior, Animal; Cannabinoids; Cocaine; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Female; Ketamine; Macaca mulatta; Male; Photic Stimulation; Piperidines; Psychotropic Drugs; Pyrazoles; Rimonabant; Substance Withdrawal Syndrome	2003
Behavioral and molecular changes elicited by acute administration of SR141716 to Delta9-tetrahydrocannabinol-tolerant rats: an experimental model of cannabinoid abstinence. Drug and alcohol dependence, 2004, May-10, Volume: 74, Issue:2 Topics: Animals; Arachidonic Acids; Behavior, Animal; Brain; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Corticosterone; Dronabinol; Drug Administration Schedule; Drug Tolerance; Endocannabinoids; Glycerides; Male; Paraventricular Hypothalamic Nucleus; Piperidines; Polyunsaturated Alkamides; Prolactin; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Corticotropin-Releasing Hormone; Rimonabant; RNA, Messenger; Substance Withdrawal Syndrome	2004
Role of different brain structures in the behavioural expression of WIN 55,212-2 withdrawal in mice. British journal of pharmacology, 2004, Volume: 142, Issue:8 Topics: Animals; Benzoxazines; Brain; Cannabinoids; Dose-Response Relationship, Drug; Male; Mice; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Substance Withdrawal Syndrome	2004
Nicotine-associated cues maintain nicotine-seeking behavior in rats several weeks after nicotine withdrawal: reversal by the cannabinoid (CB1) receptor antagonist, rimonabant (SR141716). Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2005, Volume: 30, Issue:1 Topics: Acoustic Stimulation; Animals; Cues; Dopamine; Environment; Extinction, Psychological; Light; Male; Motivation; Motor Activity; Nicotine; Nicotinic Agonists; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Self Administration; Substance Withdrawal Syndrome; Synaptic Transmission; Tobacco Use Disorder	2005
Involvement of the cannabinoid CB1 receptor in the opioid inhibition of the response to cholecystokinin and acute withdrawal response. Neurotoxicology, 2005, Volume: 26, Issue:5 Topics: Acute Disease; Adenosine A1 Receptor Antagonists; Analgesics, Opioid; Animals; Benzoxazines; Cholecystokinin; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morpholines; Muscle Contraction; Muscle, Smooth; Naloxone; Naphthalenes; Narcotic Antagonists; Neurons; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Opioid, kappa; Receptors, Opioid, mu; Rimonabant; Substance Withdrawal Syndrome; Theophylline	2005
Decrease in prostaglandin level is a prerequisite for the expression of cannabinoid withdrawal: a quasi abstinence approach. Brain research, 2005, Dec-20, Volume: 1066, Issue:1-2 Topics: Animals; Behavior, Animal; Cannabinoids; Cyclooxygenase Inhibitors; Diclofenac; Dronabinol; Male; Mice; Piperidines; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrazoles; Rimonabant; Substance Withdrawal Syndrome; Weight Loss	2005
SR 141716 (Rimonabant) precipitates withdrawal in marijuana-dependent mice. Pharmacology, biochemistry, and behavior, 2006, Volume: 85, Issue:1 Topics: Animals; Cannabis; Male; Mice; Mice, Inbred ICR; Piperidines; Pyrazoles; Rimonabant; Substance Withdrawal Syndrome; Substance-Related Disorders	2006
The CB1 cannabinoid receptor antagonist rimonabant chronically prevents the nicotine-induced relapse to alcohol. Neurobiology of disease, 2007, Volume: 25, Issue:2 Topics: Alcohol-Induced Disorders, Nervous System; Alcoholism; Animals; Anxiety Disorders; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Drug Synergism; Male; Maze Learning; Nicotine; Nicotinic Agonists; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Reinforcement, Psychology; Rimonabant; Secondary Prevention; Substance Withdrawal Syndrome; Sucrose	2007
MDMA attenuates THC withdrawal syndrome in mice. Psychopharmacology, 2007, Volume: 193, Issue:1 Topics: Animals; Brain; Cannabinoid Receptor Antagonists; Dopamine; Dose-Response Relationship, Drug; Dronabinol; Male; Mice; Mice, Inbred Strains; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Piperidines; Pyrazoles; Rimonabant; Serotonin; Substance Withdrawal Syndrome	2007
CB1 receptor blockade reduces the anxiogenic-like response and ameliorates the neurochemical imbalances associated with alcohol withdrawal in rats. Neuropharmacology, 2008, Volume: 54, Issue:6 Topics: Animals; Anxiety; Appetite; Arachidonic Acids; Autoradiography; Benzoxazines; Brain Chemistry; Cannabinoid Receptor Modulators; Central Nervous System Depressants; Chromatography, High Pressure Liquid; Emotions; Endocannabinoids; Enkephalins; Ethanol; Ethanolamines; Glycerides; In Situ Hybridization; Male; Morpholines; Motor Activity; Naphthalenes; Neuropeptide Y; Neurotransmitter Agents; Piperidines; Polyunsaturated Alkamides; Protein Precursors; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; RNA, Messenger; Stress, Psychological; Substance Withdrawal Syndrome	2008
The endogenous cannabinoid system modulates nicotine reward and dependence. The Journal of pharmacology and experimental therapeutics, 2008, Volume: 326, Issue:2 Topics: Animals; Cannabinoid Receptor Modulators; Conditioning, Psychological; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotine; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reward; Rimonabant; Signal Transduction; Substance Withdrawal Syndrome; Tobacco Use Disorder	2008
Cannabinoid precipitated withdrawal by the selective cannabinoid receptor antagonist, SR 141716A. European journal of pharmacology, 1995, Aug-25, Volume: 282, Issue:1-3 Topics: Animals; Dronabinol; Male; Piperidines; Psychotropic Drugs; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Substance Withdrawal Syndrome	1995
Physical withdrawal in rats tolerant to delta 9-tetrahydrocannabinol precipitated by a cannabinoid receptor antagonist. European journal of pharmacology, 1995, Jul-14, Volume: 280, Issue:3 Topics: Animals; Behavior, Animal; Dronabinol; Hallucinogens; Injections, Intraperitoneal; Motor Activity; Piperidines; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Substance Withdrawal Syndrome; Vocalization, Animal	1995
Dependence on delta 9-tetrahydrocannabinol: studies on precipitated and abrupt withdrawal. The Journal of pharmacology and experimental therapeutics, 1996, Volume: 278, Issue:3 Topics: Animals; Body Weight; Dronabinol; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Substance Withdrawal Syndrome	1996
Activation of corticotropin-releasing factor in the limbic system during cannabinoid withdrawal. Science (New York, N.Y.), 1997, Jun-27, Volume: 276, Issue:5321 Topics: Amygdala; Animals; Anxiety; Behavior, Animal; Brain; Corticosterone; Corticotropin-Releasing Hormone; Dronabinol; Male; Microdialysis; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Substance Withdrawal Syndrome	1997
Cannabinoid-precipitated withdrawal: a time-course study of the behavioral aspect and its correlation with cannabinoid receptors and G protein expression. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 285, Issue:2 Topics: Animals; Behavior, Animal; Cannabinoids; GTP-Binding Proteins; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; RNA, Messenger; Substance Withdrawal Syndrome	1998
CB1 receptor antagonist precipitates withdrawal in mice exposed to Delta9-tetrahydrocannabinol. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 285, Issue:3 Topics: Analysis of Variance; Animals; Antiemetics; Appetite Stimulants; Behavior, Animal; Dronabinol; Hallucinogens; Male; Mice; Mice, Inbred ICR; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Substance Withdrawal Syndrome	1998
Effects of SR 141716A after acute or chronic cannabinoid administration in dogs. European journal of pharmacology, 1998, Sep-18, Volume: 357, Issue:2-3 Topics: Animals; Arachidonic Acids; Behavior, Animal; Cannabinoids; Dogs; Dronabinol; Endocannabinoids; Female; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rimonabant; Substance Withdrawal Syndrome; Time Factors	1998
Anandamide, an endogenous cannabinoid, has a very low physical dependence potential. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 287, Issue:2 Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cannabinoids; Dose-Response Relationship, Drug; Endocannabinoids; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Substance Withdrawal Syndrome; Substance-Related Disorders	1998
CB1 cannabinoid receptor antagonist-induced opiate withdrawal in morphine-dependent rats. Neuroreport, 1998, Oct-26, Volume: 9, Issue:15 Topics: Animals; Brain Chemistry; Gene Expression; In Situ Hybridization; Male; Morphine Dependence; Naloxone; Narcotic Antagonists; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid, mu; Rimonabant; RNA, Messenger; Substance Withdrawal Syndrome	1998
Behavioural and biochemical evidence for signs of abstinence in mice chronically treated with delta-9-tetrahydrocannabinol. British journal of pharmacology, 1998, Volume: 125, Issue:7 Topics: Analysis of Variance; Animals; Body Temperature; Body Weight; Conditioning, Psychological; Cyclic AMP; Dronabinol; Drug Interactions; Hallucinogens; Hypothermia; In Vitro Techniques; Male; Mice; Motivation; Narcotics; Pain Measurement; Piperidines; Pyrazoles; Rimonabant; Substance Withdrawal Syndrome	1998
Dependence of mesolimbic dopamine transmission on delta9-tetrahydrocannabinol. European journal of pharmacology, 1999, Jul-02, Volume: 376, Issue:1-2 Topics: Animals; Behavior, Animal; Cannabinoids; Dopamine; Dronabinol; Hallucinogens; Male; Microdialysis; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Substance Withdrawal Syndrome; Substance-Related Disorders	1999
Effects of the cannabinoid CB(1) receptor antagonist, SR141716A, after Delta(9)-tetrahydrocannabinol withdrawal. European journal of pharmacology, 2000, Jan-03, Volume: 387, Issue:1 Topics: Animals; Dose-Response Relationship, Drug; Dronabinol; Male; Piperidines; Psychotropic Drugs; Pyrazoles; Rats; Rats, Long-Evans; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Substance Withdrawal Syndrome; Substance-Related Disorders	2000
Cannabinoid withdrawal is dependent upon PKA activation in the cerebellum. The European journal of neuroscience, 2000, Volume: 12, Issue:3 Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Behavior, Animal; Cerebellum; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dronabinol; Enzyme Activation; Hallucinogens; Injections; Injections, Intraventricular; Male; Mice; Piperidines; Pyrazoles; Receptors, Drug; Rimonabant; Stereotaxic Techniques; Substance Withdrawal Syndrome; Up-Regulation	2000
Precipitated and spontaneous withdrawal in rats tolerant to anandamide. Psychopharmacology, 2000, Volume: 149, Issue:2 Topics: Animals; Arachidonic Acids; Calcium Channel Blockers; Drug Tolerance; Endocannabinoids; Male; Piperidines; Polyunsaturated Alkamides; Psychomotor Performance; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Substance Withdrawal Syndrome	2000
Long-term treatment with SR141716A, the CB1 receptor antagonist, influences morphine withdrawal syndrome. Life sciences, 2000, Apr-21, Volume: 66, Issue:22 Topics: Analysis of Variance; Animals; Cannabinoids; Dogs; Drug Interactions; Drug Tolerance; Male; Morphine; Morphine Dependence; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Substance Withdrawal Syndrome	2000
Cannabinoid receptors and reward in the rat: a conditioned place preference study. Psychopharmacology, 2000, Volume: 151, Issue:1 Topics: Animals; Avoidance Learning; Cannabinoids; Conditioning, Psychological; Dronabinol; Male; Piperidines; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Reward; Rimonabant; Substance Withdrawal Syndrome	2000
Cannabinoid withdrawal syndrome is reduced in pre-proenkephalin knock-out mice. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Dec-15, Volume: 20, Issue:24 Topics: Acute Disease; Analysis of Variance; Animals; Autoradiography; Behavior, Animal; Body Temperature; Body Weight; Brain; Chronic Disease; Dronabinol; Drug Tolerance; Enkephalins; Hyperalgesia; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Protein Precursors; Psychotropic Drugs; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Substance Withdrawal Syndrome	2000
Spontaneous and precipitated withdrawal with a synthetic cannabinoid, WIN 55212-2. European journal of pharmacology, 2001, Mar-23, Volume: 416, Issue:1-2 Topics: Animals; Behavior, Animal; Benzoxazines; Body Weight; Cannabinoids; Dose-Response Relationship, Drug; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Substance Withdrawal Syndrome; Time Factors	2001
Reduction of opioid dependence by the CB(1) antagonist SR141716A in mice: evaluation of the interest in pharmacotherapy of opioid addiction. British journal of pharmacology, 2001, Volume: 132, Issue:8 Topics: Animals; Brain Chemistry; Cannabinoids; Conditioning, Operant; Dynorphins; Male; Mice; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Piperidines; Pyrazoles; Radioimmunoassay; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid, kappa; Rimonabant; Substance Withdrawal Syndrome; Synapses	2001
Opioid and cannabinoid modulation of precipitated withdrawal in delta(9)-tetrahydrocannabinol and morphine-dependent mice. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 298, Issue:3 Topics: Animals; Behavior, Animal; Cannabinoids; Diarrhea; Dronabinol; Drug Implants; Hallucinogens; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred ICR; Mice, Knockout; Morphine; Morphine Dependence; Narcotics; Opioid Peptides; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid, mu; Rimonabant; Substance Withdrawal Syndrome	2001
Motivational effects of cannabinoids are mediated by mu-opioid and kappa-opioid receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, Feb-01, Volume: 22, Issue:3 Topics: Analysis of Variance; Animals; Behavior, Animal; Cannabinoids; Crosses, Genetic; Dronabinol; Drug Tolerance; Hypothermia; Marijuana Abuse; Mice; Mice, Inbred Strains; Mice, Knockout; Motivation; Motor Activity; Piperidines; Psychotropic Drugs; Pyrazoles; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reward; Rimonabant; Spatial Behavior; Substance Withdrawal Syndrome	2002
Blockade by the cannabinoid CB(1) receptor antagonist, SR 141716, of alcohol deprivation effect in alcohol-preferring rats. European journal of pharmacology, 2002, May-17, Volume: 443, Issue:1-3 Topics: Alcohol Drinking; Analysis of Variance; Animals; Cannabinoids; Male; Piperidines; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Substance Withdrawal Syndrome	2002
Reversal of cannabinoids (delta9-THC) by the benzoflavone moiety from methanol extract of Passiflora incarnata Linneaus in mice: a possible therapy for cannabinoid addiction. The Journal of pharmacy and pharmacology, 2002, Volume: 54, Issue:6 Topics: Administration, Oral; Animals; Benzoflavones; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Hallucinogens; Methanol; Mice; Motor Activity; Passiflora; Piperidines; Plant Extracts; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Solvents; Substance Withdrawal Syndrome	2002