sr141716 has been researched along with Ache in 56 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (7.14) | 18.2507 |
| 2000's | 32 (57.14) | 29.6817 |
| 2010's | 19 (33.93) | 24.3611 |
| 2020's | 1 (1.79) | 2.80 |
| Authors | Studies |
|---|---|
| Botta, L; Corelli, F; Di Marzo, V; Ligresti, A; Maione, S; Mugnaini, C; Palazzo, E; Pasquini, S; Semeraro, T | 1 |
| Borea, PA; Brogi, S; Corelli, F; Di Marzo, V; Falciani, C; Guida, F; Ligresti, A; Luongo, L; Maione, S; Mugnaini, C; Pasquini, S; Pedani, V; Pesco, N; Tafi, A; Varani, K | 1 |
| Akgün, E; Kalyuzhny, AE; Le Naour, M; Lunzer, MM; Portoghese, PS; Powers, MD; Yekkirala, A | 1 |
| Andreu, D; Casadó, V; Castanho, MARB; Cavaco, M; Defaus, S; Gallo, M; Gonzalez, A; Maldonado, R; Moreno, E; Neves, V; Ortega-Alvaro, A; Pardo, L; Robledo, P | 1 |
| Craft, RM; Greene, NZ; Wakley, AA | 1 |
| Finn, DP; Ford, GK; Harhen, B; Olango, WM; Rea, K; Roche, M | 1 |
| Finn, DP; Ford, GK; Harhen, B; Moriarty, O; Mulcahy, A; Okine, BN; Tully, E | 1 |
| Arlt, H; Augé, F; Avenet, P; Beeské, S; Bergis, OE; Bert, L; Bertrand, T; Brittain, S; Didier, M; Escoubet, J; Even, L; Françon, D; George, P; Griebel, G; He, T; Houtmann, J; Jacquet, A; Leroy, T; Lopez-Grancha, M; Menet, V; Michot, N; Mikol, V; Pichat, P; Rak, A; Redon, N; Sun, F; Tolstykh, T; Vallée, F; Wiederschain, D; Yu, Q; Zhang, B | 1 |
| Pätz, M; Schneider, M; Schneider, P; Spanagel, R | 1 |
| Bjursell, M; Bohlooly-Y, M; Greasley, PJ; Hjorth, S; Ryberg, E; Wu, T | 1 |
| Hough, LB; Nalwalk, JW; Svokos, K | 1 |
| De Felice, M; Fioravanti, B; Gardell, LR; Ibrahim, M; King, T; Lai, J; Luo, MC; Malan, TP; Medler, KA; Ossipov, MH; Porreca, F; Stucky, CL; Vanderah, TW; Yamamura, HI | 1 |
| Burgos, E; Goicoechea, C; Martín, MI; Pascual, D | 1 |
| Filitz, J; Freund, TF; Ji, G; Kato, A; Katona, I; Koppert, W; Lutz, B; Marsicano, G; Neugebauer, V; Nyilas, R; Pernía-Andrade, AJ; Schüttler, J; Vanegas, H; Watanabe, M; Witschi, R; Zeilhofer, HU | 1 |
| Booker, L; Lichtman, AH; Mahadevan, A; Naidu, PS; Razdan, RK | 1 |
| Finn, DP; Johnston, P; Mackie, K; Mhuircheartaigh, ON; Olango, WM; Roche, M | 1 |
| Abdullah, RA; Dewey, WL; Hoot, MR; Poklis, JL; Scoggins, KL; Selley, DE; Sim-Selley, LJ | 1 |
| Bettoni, I; Colombo, A; Comelli, F; Costa, B; Fumagalli, P; Giagnoni, G | 1 |
| Dimitrov, EL; Petrus, E; Usdin, TB | 1 |
| Calignano, A; Clapper, JR; Duranti, A; Guijarro, A; Hohmann, AG; Mor, M; Moreno-Sanz, G; Piomelli, D; Russo, R; Sanchini, S; Sciolino, NR; Spradley, JM; Tarzia, G; Tontini, A; Vacondio, F | 1 |
| Conrad, DH; Lichtman, AH; O'Neal, ST; Schlosburg, JE | 1 |
| Dykstra, LA; Miller, LL; Picker, MJ; Schmidt, KT | 1 |
| Finn, DP; Ford, GK; Harhen, B; Olango, WM; Roche, M | 1 |
| Gregg, LC; Hohmann, AG; Jung, KM; Katona, I; Mackie, K; Nyilas, R; Piomelli, D; Spradley, JM; Suplita, RL; Watanabe, M; Zimmer, A | 1 |
| Arduino, C; Benedetti, F; Blanchard, C; Thoen, W; Vighetti, S | 1 |
| Dey, SK; Hough, LB; Leurs, R; Nalwalk, JW; Paria, BC; Stadel, R; Timmerman, H; Wang, X | 1 |
| Hohmann, AG; Nackley, AG; Suplita, RL | 1 |
| Croft, DL; Hamamoto, DT; Kehl, LJ; Norsted, BD; Simone, DA; Wacnik, PW; Wilcox, GL | 1 |
| Hohmann, AG; Makriyannis, A; Nackley, AG | 1 |
| Forman, LJ | 1 |
| Beckett, SR; Chapman, V; Finn, DP; Jhaveri, MD; Kendall, DA; Marsden, CA; Roe, CH | 1 |
| Angus, JA; Scott, DA; Wright, CE | 1 |
| Cox, ML; Welch, SP | 1 |
| Khodayar, MJ; Naderi, N; Shafaghi, B; Zarindast, MR | 1 |
| Colleoni, M; Costa, B; Croci, T; Giagnoni, G; Trovato, AE; Zarini, E | 1 |
| Bolton, N; Connell, K; Hohmann, AG; Olsen, D; Piomelli, D | 1 |
| Marx, J | 1 |
| Cichewicz, DL; Haller, VL; Welch, SP | 1 |
| Liu, C; Walker, JM | 1 |
| Bueno, L; Fioramonti, J; Sanson, M | 1 |
| Blackbeard, J; Hasnie, F; Lambert, DM; Pheby, T; Rice, AS; Segerdahl, AR; Vandevoorde, S; Wallace, VC | 1 |
| Cox, ML; Haller, VL; Welch, SP | 1 |
| Abood, ME; Gehani, NC; Hough, LB; Martin, BR; Nalwalk, JW; Razdan, RK; Sun, X; Wentland, M | 1 |
| Bettoni, I; Colleoni, M; Comelli, F; Costa, B; Giagnoni, G | 1 |
| Diskin, C; Finn, DP; O'Connor, E; Roche, M | 1 |
| Adler, MW; Benamar, K; Geller, EB | 1 |
| Bennett, GJ; Eliav, E; Herzberg, U; Kopin, IJ | 1 |
| Lowe, J; Mason, DJ; Welch, SP | 1 |
| Huang, SM; Sañudo-Peña, MC; Strangman, NM; Tsou, K; Walker, JM | 1 |
| Carta, G; Gessa, GL; Nava, F | 1 |
| Bridgen, DT; Byron, PR; Lichtman, AH; Martin, BR; Meng, Y; Peart, J; Poklis, A; Poklis, JL; Razdan, RK; Wilson, DM | 1 |
| Ahmad, K; Bridges, D; Rice, AS | 1 |
| Rice, AS | 1 |
| Chapman, V; Kelly, S | 1 |
| Baker, D; Bifulco, M; Bisogno, T; Bridges, D; Brooks, JW; Brown, P; Di Marzo, V; Hankey, DJ; Jaggar, SI; Ledent, C; Pryce, G; Rice, AS | 1 |
| Berrino, L; Cuomo, D; de Novellis, V; Maione, S; Marabese, I; Palazzo, E; Rossi, F | 1 |
1 review(s) available for sr141716 and Ache
| Article | Year |
|---|---|
Cannabinoids and pain.
Topics: Amides; Amidohydrolases; Analgesics; Animals; Arachidonic Acids; Benzoxazines; Brain; Camphanes; Cannabinoid Receptor Modulators; Cannabinoids; Cell Membrane; Clinical Trials as Topic; Disease Models, Animal; Drug Design; Drug Interactions; Endocannabinoids; Enzyme Inhibitors; Ethanolamines; Glycerides; Humans; Injections, Spinal; Molecular Structure; Morpholines; Naphthalenes; Pain; Palmitates; Palmitic Acids; Piperidines; Plant Extracts; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Spinal Cord | 2001 |
1 trial(s) available for sr141716 and Ache
| Article | Year |
|---|---|
Pain as a reward: changing the meaning of pain from negative to positive co-activates opioid and cannabinoid systems.
Topics: Adult; Arm; Attitude to Health; Cannabinoid Receptor Antagonists; Culture; Double-Blind Method; Female; Humans; Ischemia; Male; Naltrexone; Narcotic Antagonists; Opioid Peptides; Pain; Persuasive Communication; Physical Endurance; Piperidines; Pyrazoles; Receptors, Cannabinoid; Reward; Rimonabant; Suggestion; Time Factors; Young Adult | 2013 |
54 other study(ies) available for sr141716 and Ache
| Article | Year |
|---|---|
Investigations on the 4-quinolone-3-carboxylic acid motif. 2. Synthesis and structure-activity relationship of potent and selective cannabinoid-2 receptor agonists endowed with analgesic activity in vivo.
Topics: Adamantane; Analgesics; Animals; Carboxylic Acids; Humans; Mice; Pain; Quinolones; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Structure-Activity Relationship | 2008 |
Design, synthesis, and pharmacological characterization of indol-3-ylacetamides, indol-3-yloxoacetamides, and indol-3-ylcarboxamides: potent and selective CB2 cannabinoid receptor inverse agonists.
Topics: Amides; Animals; CHO Cells; Combinatorial Chemistry Techniques; Cricetinae; Cricetulus; Cyclic AMP; Drug Design; Drug Inverse Agonism; HEK293 Cells; Humans; Immunologic Factors; Indoles; Inflammation; Mice; Models, Molecular; Pain; Pain Measurement; Radioligand Assay; Receptor, Cannabinoid, CB2; Structure-Activity Relationship | 2012 |
Bivalent ligands that target μ opioid (MOP) and cannabinoid1 (CB1) receptors are potent analgesics devoid of tolerance.
Topics: Analgesics, Opioid; Animals; Cell Membrane; Drug Design; Drug Tolerance; Endocytosis; Fluorescent Antibody Technique; HEK293 Cells; Humans; Injections, Intraventricular; Injections, Spinal; Ligands; Male; Mice, Inbred ICR; Models, Chemical; Molecular Structure; Pain; Receptor, Cannabinoid, CB1; Receptors, Opioid, mu; Structure-Activity Relationship | 2013 |
Orally Active Peptide Vector Allows Using Cannabis to Fight Pain While Avoiding Side Effects.
Topics: Administration, Oral; Amino Acid Sequence; Analgesics; Animals; Behavior, Animal; Binding Sites; Blood-Brain Barrier; Cannabinoids; Cannabis; Dimerization; Mice; Mice, Inbred ICR; Molecular Dynamics Simulation; Pain; Peptides; Receptor, Cannabinoid, CB1; Receptor, Serotonin, 5-HT2A | 2021 |
Antinociceptive effects of JWH015 in female and male rats.
Topics: Analgesics; Animals; Camphanes; Cannabinoid Receptor Agonists; Dronabinol; Female; Freund's Adjuvant; Indoles; Male; Pain; Pain Measurement; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Sex Factors | 2018 |
Microinjection of 2-arachidonoyl glycerol into the rat ventral hippocampus differentially modulates contextually induced fear, depending on a persistent pain state.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Conditioning, Classical; Endocannabinoids; Fear; Freezing Reaction, Cataleptic; Glycerides; Hippocampus; Injections, Intraventricular; Mice; Nociception; Pain; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant | 2014 |
Involvement of the endocannabinoid system in attentional modulation of nociceptive behaviour in rats.
Topics: Animals; Arachidonic Acids; Attention; Behavior, Animal; Cannabinoid Receptor Antagonists; Endocannabinoids; Exploratory Behavior; Fear; Glycerides; Hippocampus; Male; Nociception; Pain; Pain Measurement; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant | 2015 |
Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents.
Topics: Acetylcholine; Administration, Oral; Analgesics; Animals; Arachidonic Acids; Binding Sites; Brain; Cannabinoid Receptor Antagonists; Carbamates; Chromatography, High Pressure Liquid; Crystallography, X-Ray; Disease Models, Animal; Electric Stimulation; Endocannabinoids; Enzyme Inhibitors; Glycerides; Hippocampus; Humans; Hydrolysis; In Vitro Techniques; Learning; Long-Term Potentiation; Mass Spectrometry; Memory, Short-Term; Mice; Mice, Inbred C57BL; Mice, SCID; Monoacylglycerol Lipases; Pain; Piperidines; Protein Structure, Tertiary; Pyrazoles; Rimonabant; Seizures; Sulfonamides | 2015 |
Adolescent social rejection alters pain processing in a CB1 receptor dependent manner.
Topics: Animals; Cannabinoid Receptor Antagonists; Cohort Studies; Female; Hot Temperature; Motor Activity; Pain; Pain Perception; Piperidines; Psychological Distance; Pyrazoles; Random Allocation; Rats, Inbred F344; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant | 2016 |
Deletion of Gpr55 Results in Subtle Effects on Energy Metabolism, Motor Activity and Thermal Pain Sensation.
Topics: Animals; Behavior, Animal; Body Temperature; Calorimetry; Cannabinoid Receptor Antagonists; Diet, High-Fat; Energy Metabolism; Gene Deletion; Longitudinal Studies; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Pain; Piperidines; Pyrazoles; Receptors, Cannabinoid; Rimonabant; Thermosensing | 2016 |
Non-opioid antinociception produced by brain stem injections of improgan: significance of local, but not cross-regional, cannabinoid mechanisms.
Topics: Analgesics; Animals; Benzoxazines; Brain Stem; Cannabinoid Receptor Modulators; Cimetidine; Male; Microinjections; Morpholines; Naphthalenes; Neural Pathways; Nociceptors; Pain; Pain Measurement; Pain Threshold; Periaqueductal Gray; Piperidines; Pyrazoles; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rhombencephalon; Rimonabant | 2009 |
Constitutive activity at the cannabinoid CB1 receptor is required for behavioral response to noxious chemical stimulation of TRPV1: antinociceptive actions of CB1 inverse agonists.
Topics: Analysis of Variance; Animals; Behavior, Animal; Bradykinin; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Cell Line, Tumor; Dose-Response Relationship, Drug; Galanin; Gene Expression Regulation; Male; Mice; Mice, Inbred ICR; Mice, Knockout; Morphine; Narcotics; Nerve Fibers, Unmyelinated; Neuroblastoma; Pain; Pain Measurement; Pain Threshold; Piperidines; Pyrazoles; Rats; Reaction Time; Receptor, Cannabinoid, CB1; Rimonabant; Stimulation, Chemical; Sulfonamides; TRPV Cation Channels | 2008 |
Antinociceptive effect of the cannabinoid agonist, WIN 55,212-2, in the orofacial and temporomandibular formalin tests.
Topics: Analgesics; Analgesics, Opioid; Anesthetics, Dissociative; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Benzoxazines; Camphanes; Facial Pain; Formaldehyde; Indomethacin; Inflammation; Ketamine; Male; Morphine; Morpholines; Motor Activity; Naphthalenes; Pain; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Temporomandibular Joint Disorders | 2010 |
Spinal endocannabinoids and CB1 receptors mediate C-fiber-induced heterosynaptic pain sensitization.
Topics: Adult; Animals; Cannabinoid Receptor Modulators; Electric Stimulation; Endocannabinoids; Excitatory Postsynaptic Potentials; Female; Humans; Hyperalgesia; Inhibitory Postsynaptic Potentials; Interneurons; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Fibers, Unmyelinated; Neural Inhibition; Pain; Piperidines; Posterior Horn Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Spinal Cord; Synaptic Transmission; Young Adult | 2009 |
Evaluation of prevalent phytocannabinoids in the acetic acid model of visceral nociception.
Topics: Acetic Acid; Analgesics; Animals; Anti-Obesity Agents; Camphanes; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Male; Mice; Mice, Inbred ICR; Motor Activity; Pain; Pain Measurement; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; RNA, Messenger | 2009 |
Effects of intra-basolateral amygdala administration of rimonabant on nociceptive behaviour and neuronal activity in the presence or absence of contextual fear.
Topics: Amygdala; Analysis of Variance; Animals; Behavior, Animal; Cannabinoid Receptor Antagonists; Catheters, Indwelling; Cell Count; Conditioning, Psychological; Fear; Formaldehyde; Hippocampus; Immunohistochemistry; Male; Medulla Oblongata; Neurons; Pain; Pain Measurement; Pain Threshold; Periaqueductal Gray; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Receptors, Cannabinoid; Rimonabant | 2010 |
Chronic constriction injury reduces cannabinoid receptor 1 activity in the rostral anterior cingulate cortex of mice.
Topics: Analgesics; Animals; Arachidonic Acids; Benzoxazines; Cannabinoid Receptor Modulators; Cell Membrane; Constriction; Disease Models, Animal; Endocannabinoids; Glycerides; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred Strains; Models, Neurological; Morpholines; Naphthalenes; Pain; Piperidines; Polyunsaturated Alkamides; Prefrontal Cortex; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Sulfur Radioisotopes; Tritium | 2010 |
Rimonabant, a cannabinoid CB1 receptor antagonist, attenuates mechanical allodynia and counteracts oxidative stress and nerve growth factor deficit in diabetic mice.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dose-Response Relationship, Drug; Hindlimb; Male; Mice; Mice, Inbred C57BL; Nerve Growth Factors; Oxidative Stress; Pain; Pain Measurement; Physical Stimulation; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Sciatic Nerve; Time Factors | 2010 |
Tuberoinfundibular peptide of 39 residues (TIP39) signaling modulates acute and tonic nociception.
Topics: Amidohydrolases; Animals; Cannabinoid Receptor Modulators; Formaldehyde; In Situ Hybridization; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Knockout; Naloxone; Narcotic Antagonists; Neuropeptides; Nociceptors; Pain; Pain Measurement; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Parathyroid Hormone, Type 2; Rimonabant; RNA, Messenger; Signal Transduction; Stress, Psychological; Synapses; Vesicular Glutamate Transport Protein 2 | 2010 |
Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Carrageenan; Chromatography, Liquid; Disease Models, Animal; Drug Administration Routes; Drug Administration Schedule; Endocannabinoids; Enzyme Inhibitors; Escape Reaction; Ethylene Glycols; Feeding Behavior; Formaldehyde; Gene Expression Regulation; Hyperalgesia; Indoles; Male; Mass Spectrometry; Mice; Mice, Inbred C57BL; Mice, Knockout; Monoacylglycerol Lipases; Motor Activity; Oncogene Proteins v-fos; Pain; Pain Measurement; Pain Threshold; Peripheral Nervous System Diseases; Piperidines; Polyunsaturated Alkamides; PPAR alpha; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Sciatica; Spinal Cord; Statistics, Nonparametric; Time Factors; Tissue Distribution; Tritium | 2010 |
CB1 receptors mediate rimonabant-induced pruritic responses in mice: investigation of locus of action.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Dronabinol; Female; Histamine H1 Antagonists; Hypersensitivity; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Loratadine; Male; Mast Cells; Mice; Mice, Inbred C57BL; Mice, Knockout; Pain; Piperidines; Pruritus; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2011 |
Effects of morphine on pain-elicited and pain-suppressed behavior in CB1 knockout and wildtype mice.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Pain; Pain Measurement; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2011 |
The endocannabinoid system in the rat dorsolateral periaqueductal grey mediates fear-conditioned analgesia and controls fear expression in the presence of nociceptive tone.
Topics: Analgesia; Animals; Cannabinoid Receptor Modulators; Conditioning, Psychological; Endocannabinoids; Fear; Formaldehyde; Male; Motor Activity; Pain; Periaqueductal Gray; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Ultrasonics | 2012 |
Activation of type 5 metabotropic glutamate receptors and diacylglycerol lipase-α initiates 2-arachidonoylglycerol formation and endocannabinoid-mediated analgesia.
Topics: Analgesia; Analysis of Variance; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cyclohexanones; Dose-Response Relationship, Drug; Electroconvulsive Therapy; Endocannabinoids; Excitatory Amino Acid Antagonists; Glycerides; Lipoprotein Lipase; Male; Methoxyhydroxyphenylglycol; Mice; Microscopy, Immunoelectron; Pain; Periaqueductal Gray; Piperidines; Protease Inhibitors; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Rimonabant; RNA, Messenger; RNA, Small Interfering; Synapses; Tandem Mass Spectrometry | 2012 |
Inhibition of improgan antinociception by the cannabinoid (CB)(1) antagonist N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A): lack of obligatory role for endocannabinoids acting at CB(1) receptor
Topics: Analgesics; Animals; Brain; Cannabinoid Receptor Modulators; Cannabinoids; Cerebral Ventricles; Cimetidine; Dronabinol; Endocannabinoids; Hot Temperature; Injections, Intraventricular; Male; Mice; Pain; Piperidines; Pyrazoles; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Time Factors | 2002 |
A peripheral cannabinoid mechanism suppresses spinal fos protein expression and pain behavior in a rat model of inflammation.
Topics: Analgesics; Animals; Behavior, Animal; Benzoxazines; Camphanes; Cannabinoids; Carrageenan; Disease Models, Animal; Drug Administration Routes; Drug Interactions; Edema; Functional Laterality; Gene Expression Regulation; Immunohistochemistry; Inflammation; Male; Mechanoreceptors; Morpholines; Naphthalenes; Pain; Pain Measurement; Physical Stimulation; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Spinal Cord; Time Factors | 2003 |
A cannabinoid agonist differentially attenuates deep tissue hyperalgesia in animal models of cancer and inflammatory muscle pain.
Topics: Animals; Benzoxazines; Calcium Channel Blockers; Camphanes; Cannabinoids; Carrageenan; Catalepsy; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Fibrosarcoma; Haloperidol; Hand Strength; Humerus; Hyperalgesia; Male; Mice; Mice, Inbred C3H; Morpholines; Myositis; Naphthalenes; Neoplasm Transplantation; Neoplasms; Pain; Piperidines; Psychomotor Performance; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2003 |
Selective activation of cannabinoid CB(2) receptors suppresses spinal fos protein expression and pain behavior in a rat model of inflammation.
Topics: Analgesics; Animals; Camphanes; Cannabinoids; Carrageenan; Disease Models, Animal; Drug Interactions; Hyperalgesia; Inflammation; Male; Nociceptors; Pain; Pain Threshold; Piperidines; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2003 |
The effect of cannabinoid receptor antagonism with SR141716A on antinociception induced by cocaine and the NMDA receptor antagonist, MK-801.
Topics: Anesthetics, Local; Animals; Cannabinoid Receptor Modulators; Cocaine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Male; Pain; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Cannabinoid; Receptors, Drug; Receptors, N-Methyl-D-Aspartate; Rimonabant | 2003 |
Effects of direct periaqueductal grey administration of a cannabinoid receptor agonist on nociceptive and aversive responses in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cannabinoid Receptor Agonists; Disinfectants; Dose-Response Relationship, Drug; Dronabinol; Drug Combinations; Escape Reaction; Excitatory Amino Acid Antagonists; Formaldehyde; Homocysteine; Immunohistochemistry; Male; Microinjections; Movement; Pain; Pain Measurement; Periaqueductal Gray; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Time Factors | 2003 |
Evidence that CB-1 and CB-2 cannabinoid receptors mediate antinociception in neuropathic pain in the rat.
Topics: Analgesics; Analysis of Variance; Animals; Behavior, Animal; Camphanes; Cyclohexanols; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Ligation; Male; Nociceptors; Pain; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Spinal Nerves; Time Factors | 2004 |
The antinociceptive effect of Delta9-tetrahydrocannabinol in the arthritic rat.
Topics: Animals; Arthritis, Experimental; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Dronabinol; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Freund's Adjuvant; Injections, Intradermal; Injections, Intraperitoneal; Male; Morphine; Mycobacterium; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Opioid; Rimonabant | 2004 |
Interaction between gamma-aminobutyric acid GABAB and cannabinoid CB1 receptors in spinal pain pathways in rat.
Topics: Analysis of Variance; Animals; Baclofen; Cyclohexanols; Dose-Response Relationship, Drug; Drug Interactions; Formaldehyde; GABA Agonists; GABA Antagonists; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; Injections, Spinal; Male; Pain; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, GABA-B; Rimonabant; Signal Transduction; Spinal Cord | 2005 |
Effect of the cannabinoid CB1 receptor antagonist, SR141716, on nociceptive response and nerve demyelination in rodents with chronic constriction injury of the sciatic nerve.
Topics: Analysis of Variance; Animals; Blotting, Western; Cannabinoid Receptor Antagonists; Constriction; Demyelinating Diseases; Dinoprostone; Enzyme-Linked Immunosorbent Assay; Lipid Peroxides; Male; Mice; Mice, Knockout; Nerve Tissue Proteins; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitrites; Pain; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Wistar; Reaction Time; Receptors, Cannabinoid; Rimonabant; Sciatic Nerve; Sciatic Neuropathy; Staining and Labeling; Tumor Necrosis Factor-alpha | 2005 |
Role of the basolateral nucleus of the amygdala in endocannabinoid-mediated stress-induced analgesia.
Topics: Amidohydrolases; Amygdala; Animals; Benzamides; Biphenyl Compounds; Cannabinoid Receptor Modulators; Carbamates; Endocannabinoids; Male; Microinjections; Monoacylglycerol Lipases; Pain; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Stress, Psychological | 2006 |
Drug development. Drugs inspired by a drug.
Topics: Animals; Anti-Obesity Agents; Anxiety; Arachidonic Acids; Blood Pressure; Brain; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Controlled Clinical Trials as Topic; Drug Evaluation, Preclinical; Endocannabinoids; Humans; Inflammation; Neurons; Obesity; Osteoporosis; Pain; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Rimonabant; Smoking Cessation | 2006 |
Non-cannabinoid CB1, non-cannabinoid CB2 antinociceptive effects of several novel compounds in the PPQ stretch test in mice.
Topics: Acetaminophen; Amides; Analgesics; Animals; Arachidonic Acids; Benzamides; Benzoquinones; Camphanes; Capsaicin; Carbamates; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Ethanolamines; Hyperalgesia; Male; Mesencephalon; Mice; Mice, Inbred ICR; Narcotic Antagonists; Pain; Palmitic Acids; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Opioid; Rimonabant; Spinal Cord; TRPV Cation Channels | 2006 |
Effects of a cannabinoid agonist on spinal nociceptive neurons in a rodent model of neuropathic pain.
Topics: Analgesics; Animals; Behavior, Animal; Benzoxazines; Camphanes; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Electrophysiology; Hot Temperature; Hyperalgesia; In Vitro Techniques; Morpholines; Naphthalenes; Neurons; Nociceptors; Pain; Peripheral Nervous System Diseases; Piperidines; Posterior Horn Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Spinal Cord | 2006 |
Involvement of cannabinoid receptors in inflammatory hypersensitivity to colonic distension in rats.
Topics: Animals; Benzoxazines; Calcium Channel Blockers; Camphanes; Colitis; Colon; Dose-Response Relationship, Drug; Indoles; Inflammation; Male; Manometry; Morpholines; Muscle Contraction; Muscle, Smooth; Naphthalenes; Nociceptors; Pain; Piperidines; Pressure; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Rimonabant; Trinitrobenzenesulfonic Acid | 2006 |
The effect of the palmitoylethanolamide analogue, palmitoylallylamide (L-29) on pain behaviour in rodent models of neuropathy.
Topics: Amides; Amines; Animals; Behavior, Animal; Camphanes; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Endocannabinoids; Ethanolamines; Gabapentin; gamma-Aminobutyric Acid; Hindlimb; Indoles; Injections, Intraperitoneal; Male; Pain; Pain Measurement; Pain Threshold; Palmitic Acids; Physical Stimulation; Piperidines; PPAR alpha; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Sciatic Neuropathy; Temperature; Zalcitabine | 2007 |
The antinociceptive effect of Delta9-tetrahydrocannabinol in the arthritic rat involves the CB(2) cannabinoid receptor.
Topics: Analgesics; Animals; Arthritis, Experimental; Camphanes; Dronabinol; Male; Mesencephalon; Pain; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Spinal Cord | 2007 |
Significance of cannabinoid CB1 receptors in improgan antinociception.
Topics: Analgesics; Analysis of Variance; Animals; Cimetidine; Disease Models, Animal; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Injections, Intraventricular; Male; Pain; Pain Measurement; Pain Threshold; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2007 |
The inhibition of monoacylglycerol lipase by URB602 showed an anti-inflammatory and anti-nociceptive effect in a murine model of acute inflammation.
Topics: Acute Disease; Animals; Biphenyl Compounds; Body Temperature; Camphanes; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Hindlimb; Hyperalgesia; Inflammation; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C57BL; Monoacylglycerol Lipases; Pain; Pain Measurement; Pain Threshold; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant | 2007 |
The effect of CB(1) receptor antagonism in the right basolateral amygdala on conditioned fear and associated analgesia in rats.
Topics: Amygdala; Analgesia; Analgesics; Animals; Cannabinoid Receptor Modulators; Cerebellum; Conditioning, Psychological; Dopamine; Electric Stimulation; Fear; Functional Laterality; Male; Pain; Pain Measurement; Periaqueductal Gray; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Serotonin; Synaptic Transmission; Vocalization, Animal | 2007 |
First in vivo evidence for a functional interaction between chemokine and cannabinoid systems in the brain.
Topics: Analgesics; Animals; Benzoxazines; Camphanes; Chemokine CXCL12; Male; Morpholines; Naphthalenes; Pain; Periaqueductal Gray; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, CXCR4; Rimonabant | 2008 |
The analgesic effects of R(+)-WIN 55,212-2 mesylate, a high affinity cannabinoid agonist, in a rat model of neuropathic pain.
Topics: Analgesics, Non-Narcotic; Animals; Benzoxazines; Cannabinoids; Hot Temperature; Hyperalgesia; Injections, Intraperitoneal; Male; Morpholines; Naphthalenes; Pain; Peripheral Nervous System Diseases; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1997 |
Cannabinoid modulation of dynorphin A: correlation to cannabinoid-induced antinociception.
Topics: Analgesics; Animals; Cannabinoids; Cyclohexanols; Dimethyl Sulfoxide; Dronabinol; Dynorphins; Injections, Spinal; Male; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant | 1999 |
Pain modulation by release of the endogenous cannabinoid anandamide.
Topics: Analgesia; Animals; Arachidonic Acids; Calcium Channel Blockers; Cannabinoids; Electrophysiology; Endocannabinoids; Formaldehyde; Gas Chromatography-Mass Spectrometry; Humans; Male; Microdialysis; Models, Biological; Pain; Periaqueductal Gray; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Time Factors | 1999 |
Dopamine D(2) receptor antagonists prevent delta(9)-tetrahydrocannabinol-induced antinociception in rats.
Topics: Analgesics, Non-Narcotic; Animals; Bromocriptine; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dronabinol; Male; Nociceptors; Pain; Piperidines; Pyrazoles; Quinpirole; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Rimonabant; Sulpiride | 1999 |
Pharmacological evaluation of aerosolized cannabinoids in mice.
Topics: Administration, Inhalation; Aerosols; Animals; Cannabinoids; Dose-Response Relationship, Drug; Dronabinol; Hallucinogens; Injections, Intravenous; Male; Mice; Mice, Inbred ICR; Pain; Piperidines; Pyrazoles; Rimonabant | 2000 |
The synthetic cannabinoid WIN55,212-2 attenuates hyperalgesia and allodynia in a rat model of neuropathic pain.
Topics: Analgesics; Animals; Benzoxazines; Cannabinoids; Disease Models, Animal; Drug Interactions; Hyperalgesia; Male; Morpholines; Naphthalenes; Pain; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2001 |
Selective cannabinoid CB1 receptor activation inhibits spinal nociceptive transmission in vivo.
Topics: Action Potentials; Animals; Arachidonic Acids; Male; Nerve Fibers; Nerve Fibers, Myelinated; Nociceptors; Pain; Piperidines; Posterior Horn Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Spinal Cord; Synaptic Transmission | 2001 |
Arvanil-induced inhibition of spasticity and persistent pain: evidence for therapeutic sites of action different from the vanilloid VR1 receptor and cannabinoid CB(1)/CB(2) receptors.
Topics: Animals; Arachidonic Acids; Benzoxazines; Camphanes; Cannabinoid Receptor Modulators; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Genotype; Mice; Mice, Inbred Strains; Mice, Knockout; Morpholines; Multiple Sclerosis; Muscle Spasticity; Naphthalenes; Pain; Pain Measurement; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2002 |
Interaction between vanilloid and glutamate receptors in the central modulation of nociception.
Topics: 2-Amino-5-phosphonovalerate; Animals; Capsaicin; Chromones; Excitatory Amino Acid Antagonists; Male; Pain; Periaqueductal Gray; Phosphoserine; Piperidines; Protein Binding; Pyrazoles; Pyridines; Rats; Rats, Wistar; Receptors, Drug; Receptors, Glutamate; Riluzole; Rimonabant; Time Factors | 2002 |