sr 95531 and Disease Models, Animal

Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection

Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzamides; Bridged Bicyclo Compounds; Cell Survival; Chronic Disease; Color Vision; Disease Models, Animal; Down-Regulation; GABA Antagonists; GABAergic Neurons; gamma-Aminobutyric Acid; Glaucoma; Glutamate Decarboxylase; Inhibitory Postsynaptic Potentials; Kinetics; Male; Models, Biological; Neuroprotective Agents; Ocular Hypertension; Presynaptic Terminals; Pyridazines; Rats, Wistar; Retinal Ganglion Cells

Topics: Action Potentials; Animals; Circadian Clocks; Disease Models, Animal; GABA-A Receptor Antagonists; Huntington Disease; Large-Conductance Calcium-Activated Potassium Channels; Male; Membrane Potentials; Mice; Mice, Transgenic; Neurons; Patch-Clamp Techniques; Pyridazines; Suprachiasmatic Nucleus

Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Adrenergic Agents; Anesthetics, Local; Animals; Animals, Newborn; Bicuculline; Biophysics; Calcium; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Antagonists; Feedback, Physiological; GABA Antagonists; gamma-Aminobutyric Acid; Green Fluorescent Proteins; In Vitro Techniques; Lidocaine; Lysine; Male; Mice; Mice, Transgenic; Monte Carlo Method; Neostriatum; Neural Inhibition; Neural Pathways; Neurons; Oxidopamine; Parkinsonian Disorders; Patch-Clamp Techniques; Pyridazines; Rats; Rats, Wistar; Reaction Time; Receptors, Dopamine D1; Receptors, Dopamine D2; Synaptic Transmission; Time Factors; Valine

Topics: Action Potentials; Affective Symptoms; Analysis of Variance; Aniline Compounds; Animals; Arginine; Corticotropin-Releasing Hormone; Cyclohexanes; Disease Models, Animal; Excitatory Amino Acid Antagonists; Formaldehyde; GABA Antagonists; Hormone Antagonists; Hormones; In Vitro Techniques; Kynurenic Acid; Male; Membrane Potentials; Microdialysis; Neurons; Neuropeptide Y; Pain; Pain Measurement; Peptide Fragments; Pyridazines; Pyrimidines; Rats; Rats, Sprague-Dawley; Septal Nuclei; Xanthenes

Topics: Action Potentials; Animals; Biotin; Corticosterone; Dextrans; Disease Models, Animal; GABA Antagonists; GABA-A Receptor Agonists; Male; Muscimol; Neural Pathways; Neurons; Paraventricular Hypothalamic Nucleus; Physical Stimulation; Piperidines; Pituitary Adenylate Cyclase-Activating Polypeptide; Pyridazines; Rats; Rats, Sprague-Dawley; Serotonin Receptor Agonists; Stilbamidines; Stress, Psychological; Trigeminal Nuclei; Tryptamines

Topics: Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Chromosome Deletion; Chromosome Disorders; Chromosomes, Human, Pair 15; Disease Models, Animal; Evoked Potentials, Auditory; Extinction, Psychological; GABA Antagonists; Gene Deletion; Humans; Intellectual Disability; Interneurons; Male; Mice; Mice, Inbred C57BL; Prefrontal Cortex; Pyramidal Cells; Pyridazines; Reaction Time; Receptors, GABA-A; Reversal Learning; Schizophrenia; Schizophrenic Psychology; Seizures

Topics: Action Potentials; Animals; Calcium; Dendrites; Dentate Gyrus; Disease Models, Animal; Epilepsy; Excitatory Postsynaptic Potentials; GABA Antagonists; Glutamic Acid; In Vitro Techniques; Male; Neurons; Patch-Clamp Techniques; Pyridazines; Rats; Rats, Wistar

Topics: Animals; Animals, Newborn; Biophysics; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Female; GABA Antagonists; gamma-Aminobutyric Acid; Gene Dosage; Hippocampus; Humans; In Vitro Techniques; Linear Models; Lysine; Male; Membrane Potentials; Mice; Mice, Knockout; Neurons; Patch-Clamp Techniques; Pyridazines; Seizures; Succinate-Semialdehyde Dehydrogenase

Topics: Animals; Baroreflex; Blood Pressure; Cardiovascular System; Disease Models, Animal; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Heart Rate; Hypertension; Microinjections; Neural Inhibition; Neurons; Perfusion; Phrenic Nerve; Pyridazines; Rats; Rats, Inbred SHR; Rats, Wistar; Respiratory Mechanics; Solitary Nucleus; Time Factors

Topics: Animals; Animals, Newborn; Biophysics; Brain-Derived Neurotrophic Factor; Carbazoles; Cocaine; Cocaine-Related Disorders; Diazepam; Disease Models, Animal; Dopamine Uptake Inhibitors; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Gene Expression Regulation; Green Fluorescent Proteins; Immunoprecipitation; In Vitro Techniques; Indole Alkaloids; Locomotion; Long-Term Potentiation; Neurotransmitter Agents; Patch-Clamp Techniques; Prefrontal Cortex; Pyramidal Cells; Pyridazines; Rats; Rats, Sprague-Dawley; Receptor, trkB; Receptors, GABA-A; Transfection

Topics: Animals; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Excitatory Amino Acid Antagonists; Freund's Adjuvant; GABA Agents; Hyperalgesia; In Vitro Techniques; Inflammation; Male; Medulla Oblongata; Membrane Potentials; Microinjections; Muscimol; Ondansetron; Oxazines; Pain Measurement; Pain Threshold; Posterior Horn Cells; Pyridazines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Neurokinin-1; Serotonin Antagonists; Spinal Cord; Substance P; Tryptophan; Up-Regulation

Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Age Factors; Animals; Carbenoxolone; Cyclooxygenase Inhibitors; Disease Models, Animal; Evoked Potentials, Visual; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Gap Junctions; Glutamic Acid; Glycine; In Vitro Techniques; Light; Male; Meclofenamic Acid; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Neurologic Mutants; Nerve Net; Neural Inhibition; Periodicity; Pyridazines; Quinoxalines; Retinal Degeneration; Retinal Rod Photoreceptor Cells; Sodium Channel Blockers; Statistics as Topic; Tetrodotoxin

Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; CA1 Region, Hippocampal; Disease Models, Animal; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Epilepsy; Excitatory Amino Acid Antagonists; GABA Antagonists; In Vitro Techniques; Isoquinolines; Male; Neural Inhibition; Neurons; Pyridazines; Rats; Rats, Wistar; Statistics, Nonparametric; Sulfonamides; Time Factors

Topics: Acoustic Stimulation; Aging; Animals; Auditory Cortex; Auditory Threshold; Cerebral Cortex; Chronic Disease; Disease Models, Animal; Evoked Potentials, Auditory, Brain Stem; Flavoproteins; GABA Antagonists; gamma-Aminobutyric Acid; Hearing Loss, Noise-Induced; Male; Mice; Mice, Inbred CBA; N-Methylaspartate; Neural Inhibition; Pyridazines; Receptors, GABA-A; Reflex, Startle; Tinnitus

Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Bicuculline; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Antagonists; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Isonicotinic Acids; Lipoproteins; Magnesium; Membrane Potentials; Neurons; Patch-Clamp Techniques; Potassium; Pyridazines; Rats; Seizures