sr-59230a and Hypertension

Beta3 adrenergic receptor (ADRB3) mediates vessel relaxation in the endothelium while it modulates lipolysis in the adipose tissue. However, the function and regulation mechanism of ADRB3 in the perivascular adipose tissue (PVAT), especially in hypertension, is still unclear. We show that ADRB3 protein is upregulated in the PVAT of deoxycorticosterone acetate-salt (DOCA-salt) hypertensive mice, with the characteristics of PVAT browning and increased uncoupling protein 1 (UCP1) expression. Inhibition of ADRB3 with selective antagonist SR59230A caused serious vascular injury in vivo, even though UCP1 expression was downregulated. ADRB3 protein was regulated by let-7b, which was decreased in the PVAT of the DOCA-salt group. These data reveal that ADRB3 in PVAT contributes to vascular function in the progression of hypertension.

Topics: 3' Untranslated Regions; 3T3-L1 Cells; Adipose Tissue; Adrenergic beta-3 Receptor Antagonists; Animals; Aorta, Thoracic; Base Sequence; Binding Sites; Cells, Cultured; Desoxycorticosterone Acetate; Humans; Hypertension; Ion Channels; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Mitochondrial Proteins; Molecular Sequence Data; Propanolamines; Receptors, Adrenergic, beta-3; Uncoupling Protein 1; Vascular System Injuries