Page last updated: 2024-08-26

sr 48968 and Bronchial Hyperreactivity

sr 48968 has been researched along with Bronchial Hyperreactivity in 15 studies

Research

Studies (15)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	10 (66.67)	18.2507
2000's	5 (33.33)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Abe, S; Kaneko, S; Tanaka, H; Teramoto, S	2
Advenier, C; Boichot, E; Germain, N; Lagente, V	1
Advenier, C; Emonds-Alt, X; Girard, V; Yavo, JC	1
Advenier, C; Biyah, K; Boichot, E; Emonds-Alt, X; Germain, N; Lagente, V	1
Ikeda, H; Kaneko, T; Nishikawa, M; Nishiyama, H; Okubo, T; Yamakawa, H	1
Advenier, C; Cognon, C; Daoui, S; Emonds-Alt, X; Naline, E	1
Brouard, RJ; Chasson, BL; Joos, GF; Pauwels, RA; Van Schoor, J	1
Hsu, TH; Kou, YR; Lai, YL	1
Meurs, H; Schuiling, M; Zaagsma, J; Zuidhof, AB	2
Lee, LY; Wu, ZX	1
Chen, G; Lee, LY; Wu, ZX; Zhou, D	1
Kraan, J; Postma, DS; Vink-Klooster, H	1
Kashon, ML; Krajnak, KM; Kwong, K; Lee, LY; Wise, PM; Wu, ZX	1

Trials

2 trial(s) available for sr 48968 and Bronchial Hyperreactivity

Article	Year
The effect of the NK2 tachykinin receptor antagonist SR 48968 (saredutant) on neurokinin A-induced bronchoconstriction in asthmatics. The European respiratory journal, 1998, Volume: 12, Issue:1 Topics: Adult; Asthma; Benzamides; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Forced Expiratory Volume; Humans; Male; Neurokinin A; Piperidines; Receptors, Neurokinin-2; Treatment Outcome	1998
The NK-2 receptor antagonist SR 48968C does not improve adenosine hyperresponsiveness and airway obstruction in allergic asthma. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2001, Volume: 31, Issue:2 Topics: Adenosine Monophosphate; Adult; Airway Obstruction; Asthma; Benzamides; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cross-Over Studies; Forced Expiratory Volume; Humans; Male; Middle Aged; Peak Expiratory Flow Rate; Piperidines; Receptors, Neurokinin-2	2001

Article

Year

The effect of the NK2 tachykinin receptor antagonist SR 48968 (saredutant) on neurokinin A-induced bronchoconstriction in asthmatics.

The European respiratory journal, 1998, Volume: 12, Issue:1

Topics: Adult; Asthma; Benzamides; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Forced Expiratory Volume; Humans; Male; Neurokinin A; Piperidines; Receptors, Neurokinin-2; Treatment Outcome

1998

The NK-2 receptor antagonist SR 48968C does not improve adenosine hyperresponsiveness and airway obstruction in allergic asthma.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2001, Volume: 31, Issue:2

Topics: Adenosine Monophosphate; Adult; Airway Obstruction; Asthma; Benzamides; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cross-Over Studies; Forced Expiratory Volume; Humans; Male; Middle Aged; Peak Expiratory Flow Rate; Piperidines; Receptors, Neurokinin-2

2001

Other Studies

13 other study(ies) available for sr 48968 and Bronchial Hyperreactivity

Article	Year
Neurokinin-1 and neurokinin-2 antagonism inhibits long-term acid fog-induced airway hyperresponsiveness. Chest, 2003, Volume: 123, Issue:2 Topics: Airway Resistance; Animals; Benzamides; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Dipeptides; Eosinophilia; Guinea Pigs; Indoles; Leukocyte Count; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Sulfuric Acids; Weather	2003
Prevention by the tachykinin NK2 receptor antagonist, SR 48968, of antigen-induced airway hyperresponsiveness in sensitized guinea-pigs. British journal of pharmacology, 1995, Volume: 114, Issue:2 Topics: Acetylcholine; Animals; Benzamides; Bronchial Hyperreactivity; Dose-Response Relationship, Drug; Guinea Pigs; Male; Neurokinin-1 Receptor Antagonists; Ovalbumin; Piperidines; Quinuclidines; Receptors, Neurokinin-2	1995
The tachykinin NK2 receptor antagonist SR 48968 inhibits citric acid-induced airway hyperresponsiveness in guinea pigs. American journal of respiratory and critical care medicine, 1996, Volume: 153, Issue:5 Topics: Acetylcholine; Aerosols; Animals; Benzamides; Bronchial Hyperreactivity; Bronchoconstriction; Capsaicin; Citrates; Citric Acid; Codeine; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Guinea Pigs; Injections, Intraperitoneal; Injections, Intravenous; Male; Narcotics; Piperidines; Protease Inhibitors; Quinuclidines; Receptors, Neurokinin-2; Receptors, Tachykinin; Stereoisomerism; Tachykinins; Thiorphan	1996
Involvement of tachykinin NK1 and NK2 receptors in substance P-induced microvascular leakage hypersensitivity and airway hyperresponsiveness in guinea-pigs. The European respiratory journal, 1996, Volume: 9, Issue:7 Topics: Animals; Benzamides; Bronchial Hyperreactivity; Capillary Leak Syndrome; Female; Glycopeptides; Guinea Pigs; Male; Metalloendopeptidases; Neurokinin-1 Receptor Antagonists; Piperidines; Premedication; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Stereoisomerism; Substance P	1996
[Airway hyperresponsiveness and airway mucosal permeability]. Nihon Kyobu Shikkan Gakkai zasshi, 1996, Volume: 34 Suppl Topics: Animals; Benzamides; Biphenyl Compounds; Bronchi; Bronchial Hyperreactivity; Capillary Permeability; Guinea Pigs; Male; Piperidines; Receptors, Neurokinin-2; Superoxide Dismutase; Tachykinins	1996
Involvement of tachykinin NK3 receptors in citric acid-induced cough and bronchial responses in guinea pigs. American journal of respiratory and critical care medicine, 1998, Volume: 158, Issue:1 Topics: Animals; Benzamides; Bronchi; Bronchial Hyperreactivity; Bronchoconstriction; Citric Acid; Cough; Female; Guinea Pigs; Male; Piperidines; Receptors, Neurokinin-2; Receptors, Neurokinin-3	1998
Smoke-induced airway hyperresponsiveness to inhaled wood smoke in guinea pigs: tachykininergic and cholinergic mechanisms. Life sciences, 1998, Volume: 63, Issue:17 Topics: Airway Resistance; Animals; Atropine; Benzamides; Biphenyl Compounds; Bronchi; Bronchial Hyperreactivity; Cholinergic Antagonists; Drug Combinations; Glycopeptides; Guinea Pigs; Male; Neprilysin; Piperidines; Protease Inhibitors; Receptors, Cholinergic; Receptors, Tachykinin; Smoke; Wood	1998
Role of tachykinin NK1 and NK2 receptors in allergen-induced early and late asthmatic reactions, airway hyperresponsiveness, and airway inflammation in conscious, unrestrained guinea pigs. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1999, Volume: 29 Suppl 2 Topics: Allergens; Animals; Asthma; Benzamides; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchitis; Chemotaxis, Leukocyte; Eosinophils; Guinea Pigs; Lymphocytes; Neurokinin-1 Receptor Antagonists; Neutrophils; Ovalbumin; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2	1999
Role of tachykinin NK2-receptor activation in the allergen-induced late asthmatic reaction, airway hyperreactivity and airway inflammatory cell influx in conscious, unrestrained guinea-pigs. British journal of pharmacology, 1999, Volume: 127, Issue:4 Topics: Allergens; Animals; Asthma; Benzamides; Bronchial Hyperreactivity; Bronchoconstriction; Female; Guinea Pigs; Histamine; Inflammation; Lymphocytes; Male; Neutrophils; Piperidines; Receptors, Neurokinin-2	1999
Airway hyperresponsiveness induced by chronic exposure to cigarette smoke in guinea pigs: role of tachykinins. Journal of applied physiology (Bethesda, Md. : 1985), 1999, Volume: 87, Issue:5 Topics: Acetylcholine; Air Pressure; Animals; Benzamides; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Capsaicin; Cell Count; Dose-Response Relationship, Drug; Guinea Pigs; Male; Neurokinin A; Neuropeptides; Nicotiana; Piperidines; Plants, Toxic; Receptors, Neurokinin-2; Smoke; Tachykinins; Vagotomy	1999
Airway hyperresponsiveness to cigarette smoke in ovalbumin-sensitized guinea pigs. American journal of respiratory and critical care medicine, 2000, Volume: 161, Issue:1 Topics: Acetylcholine; Airway Resistance; Animals; Benzamides; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Calcitonin Gene-Related Peptide; Disease Models, Animal; Eosinophils; Guinea Pigs; Leukocyte Count; Lung; Lung Compliance; Male; Neutrophils; Nicotiana; Ovalbumin; Piperidines; Plants, Toxic; Receptors, Neurokinin-2; Smoke	2000
Neurokinin-1 receptor antagonist inhibits short-term sulfuric-acid-induced airway hyperresponsiveness in sensitized guinea pigs. International archives of allergy and immunology, 2000, Volume: 121, Issue:1 Topics: Aerosols; Airway Resistance; Animals; Benzamides; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Dipeptides; Guinea Pigs; Indoles; Male; Methacholine Chloride; Nebulizers and Vaporizers; Neurokinin-1 Receptor Antagonists; Ovalbumin; Piperidines; Receptors, Neurokinin-2; Sulfuric Acids	2000
Chronic smoking enhances tachykinin synthesis and airway responsiveness in guinea pigs. American journal of respiratory cell and molecular biology, 2001, Volume: 25, Issue:3 Topics: Analysis of Variance; Animals; Benzamides; Bronchi; Bronchial Hyperreactivity; Calcitonin Gene-Related Peptide; Capsaicin; Guinea Pigs; In Situ Hybridization; Male; Neurons, Afferent; Piperidines; Protein Precursors; Radioimmunoassay; Random Allocation; Receptors, Neurokinin-2; Smoking; Tachykinins	2001