sr-48527 has been researched along with Brain-Diseases* in 1 studies
1 other study(ies) available for sr-48527 and Brain-Diseases
| Article | Year |
|---|---|
Turning behavior induced by intrastriatal injection of neurotensin in mice: sensitivity to non-peptide neurotensin antagonists.
The intrastriatal injection of neurotensin (10 pg/mouse) elicited vigorous contralateral rotations which were not affected by disruption of dopaminergic transmission using 6-OHDA lesion of the striatum or systemic administration of spiroperidol (0.03 mg/kg). SR 48692, a selective non-peptide antagonist of neurotensin receptor, produced the following pattern of changes: a significant antagonism of rotations was observed at 0.04 and 0.08 mg/kg i.p. followed by a reinstatement of rotations at 0.16-0.64 mg/kg (at higher doses, a second antagonism occurred that lacked stereoselectivity). The reinstatement of rotations observed at 0.16 and 0.32 mg/kg of SR 48692 was abolished by spiroperidol and 6-OHDA lesions, suggesting the role of dopamine regulatory mechanisms. Topics: Animals; Behavior, Animal; Brain Diseases; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Female; Injections, Intraperitoneal; Mice; Neurotensin; Oxidopamine; Pyrazoles; Quinolines; Sensitivity and Specificity; Spiperone | 1994 |