sr-146131 and Obesity

sr-146131 has been researched along with Obesity* in 1 studies

Other Studies

1 other study(ies) available for sr-146131 and Obesity

Article	Year
2-Substituted piperazine-derived imidazole carboxamides as potent and selective CCK1R agonists for the treatment of obesity. Bioorganic & medicinal chemistry letters, 2008, Sep-01, Volume: 18, Issue:17 The discovery and structure-activity relationship of 1,2-diarylimidazole piperazine carboxamides bearing polar side chains as potent and selective cholecystokinin 1 receptor (CCK1R) agonists are described. Optimization of this series resulted in the discovery of isopropyl carboxamide 40, a CCK1R agonist with sub-nanomolar functional and binding activity as well as excellent potency in a mouse overnight food intake reduction assay. Topics: Animals; Anti-Obesity Agents; Benzodiazepines; Chemokines, CC; Humans; Indoles; Methylamines; Mice; Obesity; Piperazine; Piperazines; Receptor, Cholecystokinin A; Receptors, Cholecystokinin; Thiazoles	2008

Article

Year

2-Substituted piperazine-derived imidazole carboxamides as potent and selective CCK1R agonists for the treatment of obesity.

Bioorganic & medicinal chemistry letters, 2008, Sep-01, Volume: 18, Issue:17

The discovery and structure-activity relationship of 1,2-diarylimidazole piperazine carboxamides bearing polar side chains as potent and selective cholecystokinin 1 receptor (CCK1R) agonists are described. Optimization of this series resulted in the discovery of isopropyl carboxamide 40, a CCK1R agonist with sub-nanomolar functional and binding activity as well as excellent potency in a mouse overnight food intake reduction assay.

Topics: Animals; Anti-Obesity Agents; Benzodiazepines; Chemokines, CC; Humans; Indoles; Methylamines; Mice; Obesity; Piperazine; Piperazines; Receptor, Cholecystokinin A; Receptors, Cholecystokinin; Thiazoles

2008