sr-144528 and Seizures

sr-144528 has been researched along with Seizures* in 1 studies

Other Studies

1 other study(ies) available for sr-144528 and Seizures

Article	Year
Reduced cannabinoid 2 receptor activity increases susceptibility to induced seizures in mice. Epilepsia, 2019, Volume: 60, Issue:12 The endocannabinoid system (ECS) is comprised of cannabinoid receptors 1 and 2 (CB1R and CB2R), endogenous ligands, and regulatory enzymes, and serves to regulate several important physiological functions throughout the brain and body. Recent evidence suggests that the ECS may be a promising target for the treatment of epilepsy, including epilepsy subtypes that arise from mutations in the voltage-gated sodium channel SCN1A. The objective of this study was to explore the effects of modulating CB2R activity on seizure susceptibility.. We examined susceptibility to induced seizures using a number of paradigms in CB2R knockout mice (Cnr2. Our results demonstrate that reduced CB2R activity is associated with increased seizure susceptibility. CB2Rs might therefore provide a therapeutic target for the treatment of some forms of epilepsy. Topics: Animals; Camphanes; Cannabinoids; Female; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pyrazoles; Receptor, Cannabinoid, CB2; Seizures	2019

Article

Year

Reduced cannabinoid 2 receptor activity increases susceptibility to induced seizures in mice.

Epilepsia, 2019, Volume: 60, Issue:12

The endocannabinoid system (ECS) is comprised of cannabinoid receptors 1 and 2 (CB1R and CB2R), endogenous ligands, and regulatory enzymes, and serves to regulate several important physiological functions throughout the brain and body. Recent evidence suggests that the ECS may be a promising target for the treatment of epilepsy, including epilepsy subtypes that arise from mutations in the voltage-gated sodium channel SCN1A. The objective of this study was to explore the effects of modulating CB2R activity on seizure susceptibility.. We examined susceptibility to induced seizures using a number of paradigms in CB2R knockout mice (Cnr2. Our results demonstrate that reduced CB2R activity is associated with increased seizure susceptibility. CB2Rs might therefore provide a therapeutic target for the treatment of some forms of epilepsy.

Topics: Animals; Camphanes; Cannabinoids; Female; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pyrazoles; Receptor, Cannabinoid, CB2; Seizures

2019