sr-142948 has been researched along with Central-Nervous-System-Diseases* in 1 studies
1 other study(ies) available for sr-142948 and Central-Nervous-System-Diseases
| Article | Year |
|---|---|
Discovery of β-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators.
Neurotensin receptor 1 (NTR1) is a G protein coupled receptor that is widely expressed throughout the central nervous system where it acts as a neuromodulator. Neurotensin receptors have been implicated in a wide variety of CNS disorders, but despite extensive efforts to develop small molecule ligands there are few reports of such compounds. Herein we describe the optimization of a quinazoline based lead to give Topics: Administration, Oral; Allosteric Regulation; Animals; beta-Arrestins; Biological Availability; Central Nervous System Diseases; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Drug Discovery; Female; Locomotion; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Structure; Quinazolines; Rats; Receptors, Neurotensin; Structure-Activity Relationship | 2019 |