sr-142948 and Cell-Transformation--Neoplastic

sr-142948 has been researched along with Cell-Transformation--Neoplastic* in 1 studies

Other Studies

1 other study(ies) available for sr-142948 and Cell-Transformation--Neoplastic

Article	Year
Synthesis and evaluation of a (18)F-labeled diarylpyrazole glycoconjugate for the imaging of NTS1-positive tumors. Journal of medicinal chemistry, 2013, Nov-27, Volume: 56, Issue:22 Aiming to image NTS1 overexpressing tumors, the diarylpyrazole glycoconjugate 8, derived from the potent NTS1 antagonist SR142948A, was synthesized taking advantage of the palladium-catalyzed aminocarbonylation reaction. The glycoconjugate 8 displayed excellent affinity and selectivity toward NTS1. Radiosynthesis proceeded straightforwardly, obtaining [(18)F]8 with excellent stability and highly beneficial biodistribution in vivo as demonstrated by PET imaging in HT29 tumor-bearing nude mice. Thus, the tracer [(18)F]8 represents a highly promising candidate for PET imaging of NTS1-positive tumors. Topics: Alkynes; Animals; Azides; Brain; Catalysis; Cell Transformation, Neoplastic; Chemistry Techniques, Synthetic; Click Chemistry; Fluorine Radioisotopes; Glycoconjugates; HT29 Cells; Humans; Isotope Labeling; Mice; Microwaves; Palladium; Positron-Emission Tomography; Pyrazoles; Rats; Receptors, Neurotensin	2013

Article

Year

Synthesis and evaluation of a (18)F-labeled diarylpyrazole glycoconjugate for the imaging of NTS1-positive tumors.

Journal of medicinal chemistry, 2013, Nov-27, Volume: 56, Issue:22

Aiming to image NTS1 overexpressing tumors, the diarylpyrazole glycoconjugate 8, derived from the potent NTS1 antagonist SR142948A, was synthesized taking advantage of the palladium-catalyzed aminocarbonylation reaction. The glycoconjugate 8 displayed excellent affinity and selectivity toward NTS1. Radiosynthesis proceeded straightforwardly, obtaining [(18)F]8 with excellent stability and highly beneficial biodistribution in vivo as demonstrated by PET imaging in HT29 tumor-bearing nude mice. Thus, the tracer [(18)F]8 represents a highly promising candidate for PET imaging of NTS1-positive tumors.

Topics: Alkynes; Animals; Azides; Brain; Catalysis; Cell Transformation, Neoplastic; Chemistry Techniques, Synthetic; Click Chemistry; Fluorine Radioisotopes; Glycoconjugates; HT29 Cells; Humans; Isotope Labeling; Mice; Microwaves; Palladium; Positron-Emission Tomography; Pyrazoles; Rats; Receptors, Neurotensin

2013