sr-1078 and Asthma

Allergic asthma is a chronic inflammatory disease of the lung and the airway, which is characterized by aberrant type 2 immune responses to otherwise unharmful aeroallergens. While the central role of Th2 cells and type 2 cytokines in the pathogenesis of allergic asthma is well documented, the regulation and plasticity of Th2 cells remain incompletely understood. By using an animal model of allergic asthma in IL-4-reporter mice, we found that Th2 cells in the lung expressed higher levels of Rora than those in the lymph nodes, and that treatment with an RORα agonist SR1078 resulted in diminished Th2 cell responses in vivo. To determine the T cell-intrinsic role of RORα in allergic asthma in vivo, we established T cell-specific RORα-deficient (Cd4creRora

Topics: Administration, Intranasal; Animals; Aspergillus oryzae; Asthma; Benzamides; CD8-Positive T-Lymphocytes; Cell Differentiation; Disease Models, Animal; Interleukin-4; Lung; Mice; Nuclear Receptor Subfamily 1, Group F, Member 1; Ovalbumin; Th2 Cells