squamocin and Adenocarcinoma

squamocin has been researched along with Adenocarcinoma* in 1 studies

Other Studies

1 other study(ies) available for squamocin and Adenocarcinoma

Article	Year
Antitumoral effects of squamocin on parental and multidrug resistant MCF7 (human breast adenocarcinoma) cell lines. Life sciences, 1999, Volume: 65, Issue:5 The antiproliferative effects of squamocin, one of the easiest annonaceous acetogenins to obtain, were studied in the parental (MCF7-S) and the multidrug resistant (MCF7-R) human breast adenocarcinoma cell lines. Squamocin inhibited proliferation of both cell lines identically, by blocking the cell cycle in the G1-phase. This inhibition was reversible in the long term. Squamocin decreased the ATP pool in both MCF7 cell lines, but did not seem to induce apoptosis. Cytotoxic activity of adriamycin was not restored in MCF7-R Pgp expressing cells by squamocin addition. Topics: Adenocarcinoma; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Cell Division; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Female; Furans; G1 Phase; Humans; Lactones; Tumor Cells, Cultured	1999

Article

Year

Antitumoral effects of squamocin on parental and multidrug resistant MCF7 (human breast adenocarcinoma) cell lines.

Life sciences, 1999, Volume: 65, Issue:5

The antiproliferative effects of squamocin, one of the easiest annonaceous acetogenins to obtain, were studied in the parental (MCF7-S) and the multidrug resistant (MCF7-R) human breast adenocarcinoma cell lines. Squamocin inhibited proliferation of both cell lines identically, by blocking the cell cycle in the G1-phase. This inhibition was reversible in the long term. Squamocin decreased the ATP pool in both MCF7 cell lines, but did not seem to induce apoptosis. Cytotoxic activity of adriamycin was not restored in MCF7-R Pgp expressing cells by squamocin addition.

Topics: Adenocarcinoma; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Cell Division; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Female; Furans; G1 Phase; Humans; Lactones; Tumor Cells, Cultured

1999