sq-23377 and Lichen-Planus--Oral

Oral lichen planus (OLP) is a T cell-mediated inflammatory condition in the oral cavity. Mucosal-associated invariant T (MAIT) cells are gaining more relevance in immune diseases because they can be activated by cytokines without T cell receptor stimulation. Herein, we tested the effect of interleukin-23 (IL-23) on the activation status of OLP MAIT cells.. Peripheral blood mononuclear cells (PBMCs) isolated from OLP patients were stimulated by IL-23 in the absence or presence of phorbol myristate acetate (PMA) and ionomycin. The activation status of MAIT cells was analyzed by flow cytometry after staining for CD3, CD4, CD8, CD161, TCR Vα7.2, and CD69.. The fraction of MAIT cells in OLP peripheral blood was approximately 0.38% to 3.97%, and CD8. IL-23 showed different effects on the activation status of OLP MAIT cells and CD8

Topics: Humans; Interleukin-23; Ionomycin; Leukocytes, Mononuclear; Lichen Planus, Oral; Mucosal-Associated Invariant T Cells