sq-109 and Malaria--Falciparum

sq-109 has been researched along with Malaria--Falciparum* in 1 studies

Other Studies

1 other study(ies) available for sq-109 and Malaria--Falciparum

ArticleYear
Multitarget drug discovery for tuberculosis and other infectious diseases.
    Journal of medicinal chemistry, 2014, Apr-10, Volume: 57, Issue:7

    We report the discovery of a series of new drug leads that have potent activity against Mycobacterium tuberculosis as well as against other bacteria, fungi, and a malaria parasite. The compounds are analogues of the new tuberculosis (TB) drug SQ109 (1), which has been reported to act by inhibiting a transporter called MmpL3, involved in cell wall biosynthesis. We show that 1 and the new compounds also target enzymes involved in menaquinone biosynthesis and electron transport, inhibiting respiration and ATP biosynthesis, and are uncouplers, collapsing the pH gradient and membrane potential used to power transporters. The result of such multitarget inhibition is potent inhibition of TB cell growth, as well as very low rates of spontaneous drug resistance. Several targets are absent in humans but are present in other bacteria, as well as in malaria parasites, whose growth is also inhibited.

    Topics: Anti-Infective Agents; Antineoplastic Agents; Antitubercular Agents; Bacteria; Breast Neoplasms; Cell Proliferation; Drug Design; Drug Discovery; Female; Fungi; Humans; Malaria, Falciparum; MCF-7 Cells; Membrane Transport Proteins; Models, Molecular; Molecular Structure; Mycobacterium tuberculosis; Plasmodium falciparum; Structure-Activity Relationship; Tuberculosis; Tumor Cells, Cultured

2014