spironolactone has been researched along with Water-Electrolyte Imbalance in 18 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Water-Electrolyte Imbalance: Disturbances in the body's WATER-ELECTROLYTE BALANCE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Aldosterone has a variety of detrimental effects on the heart and vasculature and is increasingly recognized as an important target in chronic heart failure, as illustrated by the Randomized Aldactone Evaluation Study." | 6.42 | The role of aldosterone in heart failure and the clinical benefits of aldosterone blockade. ( Davies, JI; Dawson, A; Struthers, AD, 2004) |
| "In 3 patients with severe cardiac failure high dose therapy with the ACE inhibitor enalapril was instituted during a state of extracellular volume depletion." | 3.67 | [Severe complications during enalapril therapy for heart insufficiency]. ( Stäubli, M; Wieland, T, 1988) |
| "Tolvaptan is an orally administered selective vasopressin 2 receptor antagonist that promotes aquaresis." | 2.82 | Efficacy and Safety Evaluation of Tolvaptan on Management of Fluid Balance after Cardiovascular Surgery Using Cardiopulmonary Bypass. ( Hirai, H; Hosono, M; Kaku, D; Kubota, Y; Nakahira, A; Sasaki, Y; Shibata, T; Suehiro, S; Suehiro, Y, 2016) |
| "Since hyperprolactinemia is frequently observed in liver disease, this prospective study of 19 patients evaluated the influence of prolactin on urinary electrolytes excretion in cirrhosis." | 2.67 | Indirect evidence to suggest that prolactin induces salt retention in cirrhosis. ( Buisson, L; Decaux, G; Prospert, F; Soupart, A, 1994) |
| "Aldosterone also promotes collagen synthesis, which leads to increased arterial stiffness and elevation of blood pressure." | 2.53 | Resistant Hypertension and the Pivotal Role for Mineralocorticoid Receptor Antagonists: A Clinical Update 2016. ( Duprez, DA; Epstein, M, 2016) |
| "Aldosterone has a variety of detrimental effects on the heart and vasculature and is increasingly recognized as an important target in chronic heart failure, as illustrated by the Randomized Aldactone Evaluation Study." | 2.42 | The role of aldosterone in heart failure and the clinical benefits of aldosterone blockade. ( Davies, JI; Dawson, A; Struthers, AD, 2004) |
| "In conclusion, hypokalemia is extremely common in patients presenting with VT/VF, much more so than in patients with CHF alone." | 1.56 | Electrolyte Abnormalities in Patients Presenting With Ventricular Arrhythmia (from the LYTE-VT Study). ( Basil, A; Cooper, JM; Gangireddy, C; Greenberg, RM; Laslett, DB; Whitman, IR; Yesenosky, GA, 2020) |
| "The magnesium deficiency is especially dangerous since it prevents the cells from keeping their high intracellular potassium concentration unchanged." | 1.27 | Potassium-sparing diuretics. ( Dyckner, T; Wester, PO, 1986) |
| "Total starvation is effective for acute weight reduction in obesity." | 1.26 | [Complications in null-diet]. ( Mordasini, R; Oster, P; Raetzer, H; Schellenberg, B; Schlierf, G, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (61.11) | 18.7374 |
| 1990's | 1 (5.56) | 18.2507 |
| 2000's | 2 (11.11) | 29.6817 |
| 2010's | 3 (16.67) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Laslett, DB | 1 |
| Cooper, JM | 1 |
| Greenberg, RM | 1 |
| Yesenosky, GA | 1 |
| Basil, A | 1 |
| Gangireddy, C | 1 |
| Whitman, IR | 1 |
| Suehiro, Y | 1 |
| Hosono, M | 1 |
| Shibata, T | 1 |
| Sasaki, Y | 1 |
| Hirai, H | 1 |
| Nakahira, A | 1 |
| Kubota, Y | 1 |
| Kaku, D | 1 |
| Suehiro, S | 1 |
| Tannenbaum, S | 1 |
| Sayer, GT | 1 |
| Epstein, M | 2 |
| Duprez, DA | 1 |
| Dawson, A | 1 |
| Davies, JI | 1 |
| Struthers, AD | 1 |
| Fujii, M | 1 |
| Suto, H | 1 |
| Goto, M | 1 |
| Miki, Y | 1 |
| Asai, N | 1 |
| Kuntz, E | 1 |
| Weishar, C | 1 |
| Soupart, A | 1 |
| Buisson, L | 1 |
| Prospert, F | 1 |
| Decaux, G | 1 |
| Taylor, JW | 1 |
| Andler, W | 1 |
| Roosen, K | 1 |
| Reinhardt, V | 1 |
| Oster, P | 1 |
| Mordasini, R | 1 |
| Raetzer, H | 1 |
| Schellenberg, B | 1 |
| Schlierf, G | 1 |
| Pins, DS | 1 |
| Schneider, N | 1 |
| Levinson, R | 1 |
| Wieland, T | 1 |
| Stäubli, M | 1 |
| Dyckner, T | 1 |
| Wester, PO | 1 |
| Lant, A | 1 |
| Merrem, B | 1 |
| Rost, W | 1 |
4 reviews available for spironolactone and Water-Electrolyte Imbalance
| Article | Year |
|---|---|
Advances in the pathophysiology and treatment of heart failure with preserved ejection fraction.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Benzazepines; Car | 2015 |
Resistant Hypertension and the Pivotal Role for Mineralocorticoid Receptor Antagonists: A Clinical Update 2016.
Topics: Age Factors; Aldosterone; Blood Pressure Monitoring, Ambulatory; Comorbidity; Diabetes Mellitus; Hum | 2016 |
The role of aldosterone in heart failure and the clinical benefits of aldosterone blockade.
Topics: Aldosterone; Autonomic Nervous System Diseases; Endomyocardial Fibrosis; Eplerenone; Heart Failure; | 2004 |
Diuretics. Clinical pharmacology and therapeutic use (Part II).
Topics: Amiloride; Canrenoic Acid; Diuretics; Diuretics, Osmotic; Drug Interactions; Hearing Disorders; Hear | 1985 |
2 trials available for spironolactone and Water-Electrolyte Imbalance
| Article | Year |
|---|---|
Efficacy and Safety Evaluation of Tolvaptan on Management of Fluid Balance after Cardiovascular Surgery Using Cardiopulmonary Bypass.
Topics: Aged; Antidiuretic Hormone Receptor Antagonists; Cardiopulmonary Bypass; Cardiovascular Surgical Pro | 2016 |
Indirect evidence to suggest that prolactin induces salt retention in cirrhosis.
Topics: Adult; Aged; Creatinine; Female; Humans; Hyperprolactinemia; Incidence; Kidney; Liver; Liver Cirrhos | 1994 |
12 other studies available for spironolactone and Water-Electrolyte Imbalance
| Article | Year |
|---|---|
Electrolyte Abnormalities in Patients Presenting With Ventricular Arrhythmia (from the LYTE-VT Study).
Topics: Aged; Cardiomyopathies; Case-Control Studies; Diarrhea; Diuretics; Female; Heart Failure; Humans; Hy | 2020 |
[Water-electrolyte imbalance: Reality in diagnosis and therapy (discussion)].
Topics: Acid-Base Equilibrium; Acidosis; Diagnosis, Differential; Extracellular Fluid; Humans; Hypercalcemia | 2006 |
[Disorders of water and electrolyte equilibrium in liver diseases. Part 3: therapy (author's transl)].
Topics: Ascites; Benzothiadiazines; Canrenoic Acid; Diuretics; Humans; Hyperaldosteronism; Liver Diseases; S | 1982 |
Case study: drug-induced electrolyte changes.
Topics: Antihypertensive Agents; Drug Combinations; Female; Humans; Hydrochlorothiazide; Methyldopa; Middle | 1982 |
Mental symptoms and electrolyte imbalance.
Topics: Aged; Chlorine; Cognition Disorders; Confusion; Depression; Diuretics; Female; Humans; Hyponatremia; | 1979 |
[Hypothalamic hyperosmolarity in childhood (author's transl)].
Topics: Astrocytoma; Brain Diseases; Brain Neoplasms; Child; Craniopharyngioma; Female; Histiocytosis, Lange | 1979 |
Drugs for hypertension.
Topics: Antihypertensive Agents; Benzothiadiazines; Clonidine; Depression; Diuretics; Drug Combinations; Dru | 1977 |
[Complications in null-diet].
Topics: Acetone; Adult; Allopurinol; Arrhythmias, Cardiac; Diet, Reducing; Edema; Female; Humans; Ischemic A | 1977 |
Determinants of deranged sodium and water homeostasis in decompensated cirrhosis.
Topics: Adult; Aldosterone; Body Weight; Creatinine; Desoxycorticosterone; Diet; Homeostasis; Humans; Immers | 1976 |
[Severe complications during enalapril therapy for heart insufficiency].
Topics: Acute Kidney Injury; Drug Interactions; Enalapril; Heart Failure; Humans; Hypotension; Male; Middle | 1988 |
Potassium-sparing diuretics.
Topics: Amiloride; Diuretics; Heart Failure; Humans; Hypokalemia; Magnesium Deficiency; Potassium; Spironola | 1986 |
[Influencing postoperative water-electrolyte imbalance with spironolactone (verospirone)].
Topics: Brain Edema; Dose-Response Relationship, Drug; Humans; Neurosurgery; Postoperative Complications; Po | 1974 |