spironolactone has been researched along with Vasculitis in 10 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Vasculitis: Inflammation of any one of the blood vessels, including the ARTERIES; VEINS; and rest of the vasculature system in the body.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thus aldosterone and salt treatment in uninephrectomized rats led to severe hypertension and the development of a vascular inflammatory phenotype in the heart, which may represent one mechanism by which aldosterone contributes to myocardial disease." | 1.31 | Aldosterone induces a vascular inflammatory phenotype in the rat heart. ( Blomme, EA; Delyani, JA; Frierdich, GE; Kekec, BK; McMahon, EG; Nachowiak, DA; Rocha, R; Rudolph, AE, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (80.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mortensen, LA | 1 |
| Bistrup, C | 1 |
| Stubbe, J | 1 |
| Carlström, M | 1 |
| Checa, A | 1 |
| Wheelock, CE | 1 |
| Palarasah, Y | 1 |
| Bladbjerg, EM | 1 |
| Thiesson, HC | 1 |
| Jensen, BL | 1 |
| Kurobe, H | 1 |
| Hirata, Y | 1 |
| Matsuoka, Y | 1 |
| Sugasawa, N | 1 |
| Higashida, M | 1 |
| Nakayama, T | 1 |
| Maxfield, MW | 1 |
| Yoshida, Y | 1 |
| Shimabukuro, M | 1 |
| Kitagawa, T | 1 |
| Sata, M | 1 |
| Rocha, R | 2 |
| Rudolph, AE | 1 |
| Frierdich, GE | 1 |
| Nachowiak, DA | 1 |
| Kekec, BK | 1 |
| Blomme, EA | 1 |
| McMahon, EG | 1 |
| Delyani, JA | 1 |
| Martin-Berger, CL | 1 |
| Yang, P | 1 |
| Scherrer, R | 1 |
| Delyani, J | 1 |
| McMahon, E | 1 |
| Young, MJ | 2 |
| Moussa, L | 1 |
| Dilley, R | 1 |
| Funder, JW | 3 |
| Young, M | 1 |
| Sanz-Rosa, D | 1 |
| Cediel, E | 1 |
| de las Heras, N | 1 |
| Miana, M | 1 |
| Balfagón, G | 1 |
| Lahera, V | 1 |
| Cachofeiro, V | 1 |
| Nagata, K | 1 |
| Obata, K | 1 |
| Xu, J | 1 |
| Ichihara, S | 1 |
| Noda, A | 1 |
| Kimata, H | 1 |
| Kato, T | 1 |
| Izawa, H | 1 |
| Murohara, T | 1 |
| Yokota, M | 1 |
| Rickard, AJ | 1 |
| Morgan, J | 1 |
| Fuller, PJ | 1 |
| Deliyska, B | 1 |
| Lazarov, V | 1 |
| Minkova, V | 1 |
| Nikolov, D | 1 |
| Tishkov, I | 1 |
1 trial available for spironolactone and Vasculitis
| Article | Year |
|---|---|
Effect of spironolactone for 1 yr on endothelial function and vascular inflammation biomarkers in renal transplant recipients.
Topics: Adult; Aged; Anti-Inflammatory Agents; Biomarkers; Double-Blind Method; Endothelium, Vascular; Femal | 2019 |
9 other studies available for spironolactone and Vasculitis
| Article | Year |
|---|---|
Protective effects of selective mineralocorticoid receptor antagonist against aortic aneurysm progression in a novel murine model.
Topics: Animals; Aortic Aneurysm; Blood Pressure; Chemokine CCL2; Disease Models, Animal; Disease Progressio | 2013 |
Aldosterone induces a vascular inflammatory phenotype in the rat heart.
Topics: Aldosterone; Animals; Blood Pressure; Chemokine CCL2; Coronary Vessels; Cyclooxygenase 2; Endomyocar | 2002 |
Selective aldosterone blockade prevents angiotensin II/salt-induced vascular inflammation in the rat heart.
Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Body Weight; Coronary Disease; Coronary Vessels | 2002 |
Early inflammatory responses in experimental cardiac hypertrophy and fibrosis: effects of 11 beta-hydroxysteroid dehydrogenase inactivation.
Topics: 11-beta-Hydroxysteroid Dehydrogenases; Animals; Blood Pressure; Carbenoxolone; Cardiomegaly; Coronar | 2003 |
Eplerenone, but not steroid withdrawal, reverses cardiac fibrosis in deoxycorticosterone/salt-treated rats.
Topics: Animals; Biomarkers; Coronary Vessels; Desoxycorticosterone; Eplerenone; Fibrosis; Male; Mineralocor | 2004 |
Participation of aldosterone in the vascular inflammatory response of spontaneously hypertensive rats: role of the NFkappaB/IkappaB system.
Topics: Aldosterone; Animals; Antihypertensive Agents; Drug Therapy, Combination; Eplerenone; Hypertension; | 2005 |
Mineralocorticoid receptor antagonism attenuates cardiac hypertrophy and failure in low-aldosterone hypertensive rats.
Topics: Aldosterone; Animals; Cardiac Output, Low; Cardiomegaly; Cardiotonic Agents; Coronary Vessels; Corti | 2006 |
Does glucocorticoid receptor blockade exacerbate tissue damage after mineralocorticoid/salt administration?
Topics: Animals; Biomarkers; Blood Pressure; Cardiomegaly; Cardiomyopathies; Coronary Vessels; Desoxycortico | 2007 |
Association of Bartter's syndrome with vasculitis.
Topics: Adult; Bartter Syndrome; Cyclophosphamide; Female; Humans; Methylprednisolone; Mineralocorticoid Rec | 2000 |