spironolactone has been researched along with Varicocele in 2 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Varicocele: A condition characterized by the dilated tortuous veins of the SPERMATIC CORD with a marked left-sided predominance. Adverse effect on male fertility occurs when varicocele leads to an increased scrotal (and testicular) temperature and reduced testicular volume.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the effect of spironolactone, as an angiogenesis inhibitor, on the isometric contractile responses in isolated vas deferens strips from left varicocele-induced rats." | 7.78 | Effects of angiogenesis inhibition by spironolactone on isolated vas deferens contractility in an experimental varicocele model in rats. ( Çaylak, B; Erdem, ŞR; Köse, MG; Peșkircioğlu, ÇL, 2012) |
| "Microvessel density increased in varicocele group and spironolactone inhibited angiogenesis neither by antimineralocorticoid, nor by antiandrogenic effect." | 3.80 | Angiogenesis inhibition impairs testicular morphology in experimental left varicocele rat model. ( Çaylak, B; Erdem, ŞR; Gökhan-Köse, M; Peşkircioğlu, ÇL, 2014) |
| "To investigate the effect of spironolactone, as an angiogenesis inhibitor, on the isometric contractile responses in isolated vas deferens strips from left varicocele-induced rats." | 3.78 | Effects of angiogenesis inhibition by spironolactone on isolated vas deferens contractility in an experimental varicocele model in rats. ( Çaylak, B; Erdem, ŞR; Köse, MG; Peșkircioğlu, ÇL, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gökhan-Köse, M | 1 |
| Erdem, ŞR | 2 |
| Peşkircioğlu, ÇL | 2 |
| Çaylak, B | 2 |
| Köse, MG | 1 |
2 other studies available for spironolactone and Varicocele
| Article | Year |
|---|---|
Angiogenesis inhibition impairs testicular morphology in experimental left varicocele rat model.
Topics: Angiogenesis Inhibitors; Animals; Disease Models, Animal; Male; Random Allocation; Rats; Rats, Wista | 2014 |
Effects of angiogenesis inhibition by spironolactone on isolated vas deferens contractility in an experimental varicocele model in rats.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Angiogenesis Inhibito | 2012 |