spironolactone has been researched along with Stomach Ulcer in 6 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Stomach Ulcer: Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The risk of gastroduodenal ulcers or upper gastrointestinal bleeding is significantly increased in patients using spironolactone." | 3.73 | Spironolactone and risk of upper gastrointestinal events: population based case-control study. ( Dieleman, J; Mosis, G; Stricker, B; Sturkenboom, M; Verhamme, K, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gulmez, SE | 1 |
| Lassen, AT | 1 |
| Aalykke, C | 1 |
| Dall, M | 1 |
| Andries, A | 1 |
| Andersen, BS | 1 |
| Hansen, JM | 1 |
| Andersen, M | 1 |
| Hallas, J | 1 |
| Verhamme, K | 1 |
| Mosis, G | 1 |
| Dieleman, J | 1 |
| Stricker, B | 1 |
| Sturkenboom, M | 1 |
| Mackay, A | 1 |
| Stevenson, RD | 1 |
| Goodman, MJ | 1 |
| Doll, R | 1 |
| Langman, MJ | 1 |
| Shawdon, HH | 1 |
2 trials available for spironolactone and Stomach Ulcer
| Article | Year |
|---|---|
Carbenoxolone sodium for gastric ulcer.
Topics: Benzothiadiazines; Body Weight; Carbenoxolone; Clinical Trials as Topic; Diuretics; Duodenal Ulcer; | 1975 |
Treatment of gastric ulcer with carbenoxolone: antagonistic effect of spironolactone.
Topics: Adult; Aged; Body Weight; Female; Glycyrrhiza; Humans; Hydrochlorothiazide; Hypertension; Male; Midd | 1968 |
4 other studies available for spironolactone and Stomach Ulcer
| Article | Year |
|---|---|
Spironolactone use and the risk of upper gastrointestinal bleeding: a population-based case-control study.
Topics: Aged; Case-Control Studies; Denmark; Diuretics; Dose-Response Relationship, Drug; Duodenal Ulcer; Ep | 2008 |
Spironolactone and risk of upper gastrointestinal events: population based case-control study.
Topics: Adolescent; Adult; Aged; Case-Control Studies; Diuretics; Duodenal Ulcer; Female; Humans; Male; Midd | 2006 |
Gastric ulceration induced by spironolactone.
Topics: Ascites; Female; Hematemesis; Humans; Middle Aged; Peptic Ulcer Hemorrhage; Spironolactone; Stomach | 1977 |
Gastric ulceration induced by spironolactone.
Topics: Humans; Spironolactone; Stomach Ulcer | 1977 |