spironolactone has been researched along with Sensitivity and Specificity in 17 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Primary hyperaldosteronism was confirmed if plasma renin activity was <1." | 2.70 | Hyperaldosteronism among black and white subjects with resistant hypertension. ( Calhoun, DA; Nishizaka, MK; Thakkar, RB; Weissmann, P; Zaman, MA, 2002) |
| " The method was successfully applied to the pharmacokinetic study after an intravenous administration of isoforskolin in beagle dogs." | 1.37 | A sensitive and specific HPLC-MS/MS analysis and preliminary pharmacokinetic characterization of isoforskolin in beagle dogs. ( Chen, J; Huang, J; Ling, Y; Tian, L; Wang, Y; Yin, J, 2011) |
| "Male Wistar rats fed with an unrestricted sodium diet received CsA 15 mg/kg/day or CsA at the same dosage plus 20 mg/kg/day of spironolactone." | 1.35 | The effect of aldosterone antagonist in experimental nephropathy induced by cyclosporine A. ( Miorin, LA; Sens, YA; Silva, FM, 2008) |
| "Metabolic syndrome is a highly predisposing condition for cardiovascular disease and could be a cause of excess salt-induced organ damage." | 1.35 | Salt excess causes left ventricular diastolic dysfunction in rats with metabolic disorder. ( Ando, K; Fujita, M; Fujita, T; Kawarazaki, H; Matsui, H; Nagae, A; Nagase, M; Shimosawa, T, 2008) |
| "Primary aldosteronism is a common cause of non-renal secondary hypertension." | 1.31 | Normokalemic hyperaldosteronism in patients with resistant hypertension. ( Benchetrit, S; Bernheim, J; Podjarny, E, 2002) |
| "Although autoimmune sensorineural hearing loss can be effectively treated with corticosteroids, little is known about how these drugs affect cochlear function." | 1.31 | Spironolactone blocks glucocorticoid-mediated hearing preservation in autoimmune mice. ( Gross, ND; Kempton, JB; Trune, DR, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.88) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 11 (64.71) | 29.6817 |
| 2010's | 4 (23.53) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Diamandis, P | 1 |
| Wildenhain, J | 1 |
| Clarke, ID | 1 |
| Sacher, AG | 1 |
| Graham, J | 1 |
| Bellows, DS | 1 |
| Ling, EK | 1 |
| Ward, RJ | 1 |
| Jamieson, LG | 1 |
| Tyers, M | 1 |
| Dirks, PB | 1 |
| Silva, FM | 1 |
| Miorin, LA | 1 |
| Sens, YA | 1 |
| Matsui, H | 1 |
| Ando, K | 1 |
| Kawarazaki, H | 1 |
| Nagae, A | 1 |
| Fujita, M | 1 |
| Shimosawa, T | 1 |
| Nagase, M | 1 |
| Fujita, T | 1 |
| Hegazy, MA | 1 |
| Metwaly, FH | 1 |
| Abdelkawy, M | 1 |
| Abdelwahab, NS | 1 |
| Vergaro, G | 1 |
| Emdin, M | 1 |
| Iervasi, A | 1 |
| Zyw, L | 1 |
| Gabutti, A | 1 |
| Poletti, R | 1 |
| Mammini, C | 1 |
| Giannoni, A | 1 |
| Fontana, M | 1 |
| Passino, C | 1 |
| Tian, L | 1 |
| Wang, Y | 1 |
| Ling, Y | 1 |
| Yin, J | 1 |
| Chen, J | 1 |
| Huang, J | 1 |
| Wang, T | 1 |
| Zhao, QJ | 1 |
| Hu, HG | 1 |
| Yu, SC | 1 |
| Liu, X | 1 |
| Liu, L | 1 |
| Wu, QY | 1 |
| Calhoun, DA | 1 |
| Nishizaka, MK | 1 |
| Zaman, MA | 1 |
| Thakkar, RB | 1 |
| Weissmann, P | 1 |
| Alonso, JC | 1 |
| Ortega, FJ | 1 |
| Gonzalo, MJ | 1 |
| Palla, PS | 1 |
| Reincke, M | 1 |
| Gore, M | 1 |
| Lester, E | 1 |
| Dong, H | 1 |
| Xu, F | 1 |
| Zhang, Z | 1 |
| Tian, Y | 1 |
| Chen, Y | 1 |
| Dasgupta, A | 1 |
| Kang, E | 1 |
| Datta, P | 1 |
| Mihas, AA | 1 |
| Saccomani, G | 1 |
| Spenney, JG | 1 |
| McMurray, J | 1 |
| Cohen-Solal, A | 1 |
| Dietz, R | 1 |
| Eichhorn, E | 1 |
| Erhardt, L | 1 |
| Hobbs, R | 1 |
| Maggioni, A | 1 |
| Pina, I | 1 |
| Soler-Soler, J | 1 |
| Swedberg, K | 1 |
| Benchetrit, S | 1 |
| Bernheim, J | 1 |
| Podjarny, E | 1 |
| Gross, ND | 1 |
| Kempton, JB | 1 |
| Trune, DR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prospective Cross-sectional Study on Prevalence of Primary Aldosteronism in Resistant Hypertension and Association With Cardiometabolic Complications[NCT04213963] | 100 participants (Anticipated) | Observational | 2011-09-01 | Recruiting | |||
| The Prevalence and the Prognosis of Resistant Hypertension Ascertained With Systemic Investigation and Optimal Treatment With Antihypertensive Drugs[NCT01703780] | 9,638 participants (Actual) | Observational | 2012-07-31 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for spironolactone and Sensitivity and Specificity
| Article | Year |
|---|---|
Hyperaldosteronism among black and white subjects with resistant hypertension.
Topics: Adult; Aged; Aged, 80 and over; Alabama; Aldosterone; Black People; Blood Pressure; Diuretics; Drug | 2002 |
Hyperaldosteronism among black and white subjects with resistant hypertension.
Topics: Adult; Aged; Aged, 80 and over; Alabama; Aldosterone; Black People; Blood Pressure; Diuretics; Drug | 2002 |
Hyperaldosteronism among black and white subjects with resistant hypertension.
Topics: Adult; Aged; Aged, 80 and over; Alabama; Aldosterone; Black People; Blood Pressure; Diuretics; Drug | 2002 |
Hyperaldosteronism among black and white subjects with resistant hypertension.
Topics: Adult; Aged; Aged, 80 and over; Alabama; Aldosterone; Black People; Blood Pressure; Diuretics; Drug | 2002 |
16 other studies available for spironolactone and Sensitivity and Specificity
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic | 2007 |
The effect of aldosterone antagonist in experimental nephropathy induced by cyclosporine A.
Topics: Animals; Creatinine; Cyclosporine; Disease Models, Animal; Disease Progression; Glomerular Filtratio | 2008 |
Salt excess causes left ventricular diastolic dysfunction in rats with metabolic disorder.
Topics: Aldosterone; Animals; Blood Pressure Determination; Disease Models, Animal; Echocardiography, Dopple | 2008 |
Validated chromatographic methods for determination of hydrochlorothiazide and spironolactone in pharmaceutical formulation in presence of impurities and degradants.
Topics: Chemistry, Pharmaceutical; Chromatography, Liquid; Drug Contamination; Drug Stability; Hydrochloroth | 2011 |
Prognostic value of plasma renin activity in heart failure.
Topics: Aged; Aldosterone; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Bioma | 2011 |
A sensitive and specific HPLC-MS/MS analysis and preliminary pharmacokinetic characterization of isoforskolin in beagle dogs.
Topics: Animals; Chromatography, High Pressure Liquid; Colforsin; Dogs; Drug Stability; Eplerenone; Female; | 2011 |
Spirolactonized Si-rhodamine: a novel NIR fluorophore utilized as a platform to construct Si-rhodamine-based probes.
Topics: Color; Copper; Fluorescent Dyes; Hydrogen-Ion Concentration; Mercury; Molecular Imaging; Rhodamines; | 2012 |
Cutaneous reaction to oral spironolactone with positive patch test.
Topics: Administration, Oral; Allergens; Dose-Response Relationship, Drug; Drug Eruptions; Female; Follow-Up | 2002 |
[Conn syndrome as cause of stubborn hypertension. Which hypertensives should you screen?].
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Adrenergic beta-Antagonists; Aldosterone; Angiotens | 2003 |
Comparison of a fluorimetric method and a competitive protein binding assay kit for the determination of plasma hydroxycorticosteroids.
Topics: Adult; Binding, Competitive; Diuretics; Female; Fluorometry; Humans; Hydroxycorticosteroids; Male; M | 1975 |
Simultaneous determination of spironolactone and its active metabolite canrenone in human plasma by HPLC-APCI-MS.
Topics: Blood Chemical Analysis; Canrenone; Chromatography, High Pressure Liquid; Complex Mixtures; Humans; | 2006 |
A new enzyme-linked chemiluminescent immunosorbent digoxin assay is virtually free from interference of spironolactone, potassium canrenoate, and their common metabolite canrenone.
Topics: Artifacts; Canrenone; Cross Reactions; Digoxin; Enzyme-Linked Immunosorbent Assay; Fluorescence Pola | 2006 |
LSA--a new liver-specific antigen in the rat. II: Immunological and biological properties.
Topics: Animals; Bile Acids and Salts; Carbon Tetrachloride; Chromatography; Counterimmunoelectrophoresis; E | 1994 |
Practical recommendations for the use of ACE inhibitors, beta-blockers and spironolactone in heart failure: putting guidelines into practice.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Clinical Trials as Topic; Hea | 2001 |
Normokalemic hyperaldosteronism in patients with resistant hypertension.
Topics: Adult; Aged; Aldosterone; Analysis of Variance; Antihypertensive Agents; Creatinine; Female; Humans; | 2002 |
Spironolactone blocks glucocorticoid-mediated hearing preservation in autoimmune mice.
Topics: Aldosterone; Animals; Audiometry, Pure-Tone; Auditory Threshold; Disease Models, Animal; Drug Intera | 2002 |