spironolactone has been researched along with Sclerosis in 3 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Sclerosis: A pathological process consisting of hardening or fibrosis of an anatomical structure, often a vessel or a nerve.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with eplerenone in Dahl salt-sensitive rats was associated with significant improvements in kidney to body weight ratio, urinary protein excretion and renal injury scores and decreased renal (pro)renin receptor protein expression and angiotensinogen and AT1R mRNA levels and kidney Ang II content." | 1.35 | Effect of mineralocorticoid receptor blockade on the renal renin-angiotensin system in Dahl salt-sensitive hypertensive rats. ( Demura, M; Karashima, S; Takeda, Y; Usukura, M; Yamagishi, M; Yoneda, T; Zhu, A, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gromadziński, L | 1 |
| Januszko-Giergielewicz, B | 1 |
| Kubiak, M | 1 |
| Pruszczyk, P | 1 |
| Zhu, A | 1 |
| Yoneda, T | 1 |
| Demura, M | 1 |
| Karashima, S | 1 |
| Usukura, M | 1 |
| Yamagishi, M | 1 |
| Takeda, Y | 1 |
| Pabst, K | 1 |
3 other studies available for spironolactone and Sclerosis
| Article | Year |
|---|---|
Patient with purulent pericarditis: a case doomed to fail?
Topics: Amoxicillin-Potassium Clavulanate Combination; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; | 2013 |
Effect of mineralocorticoid receptor blockade on the renal renin-angiotensin system in Dahl salt-sensitive hypertensive rats.
Topics: Animals; Eplerenone; Hypertension; Kidney; Kidney Glomerulus; Male; Mineralocorticoid Receptor Antag | 2009 |
[Clinical picture and treatment of cor pulmonale (author's transl)].
Topics: Anticoagulants; Asthma; Bronchiectasis; Bronchitis; Digitalis; Diuretics; Electrocardiography; Human | 1973 |