spironolactone has been researched along with Schizophrenia in 1 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Schizophrenia: A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Spironolactone treatment reverted hyperphosphorylation of activated Erbb4 in these mice." | 5.46 | Spironolactone is an antagonist of NRG1-ERBB4 signaling and schizophrenia-relevant endophenotypes in mice. ( Brzózka, MM; Falkai, P; Herholt, A; Hinrichs, W; Kravchenko, M; Nave, KA; Papiol, S; Rossner, MJ; Schwab, MH; Soto-Bernardini, MC; Unterbarnscheidt, T; Wehr, MC; Wichert, SP; Wintgens, JP; Zhang, M; Zhang, W, 2017) |
| "Spironolactone treatment reverted hyperphosphorylation of activated Erbb4 in these mice." | 1.46 | Spironolactone is an antagonist of NRG1-ERBB4 signaling and schizophrenia-relevant endophenotypes in mice. ( Brzózka, MM; Falkai, P; Herholt, A; Hinrichs, W; Kravchenko, M; Nave, KA; Papiol, S; Rossner, MJ; Schwab, MH; Soto-Bernardini, MC; Unterbarnscheidt, T; Wehr, MC; Wichert, SP; Wintgens, JP; Zhang, M; Zhang, W, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wehr, MC | 1 |
| Hinrichs, W | 1 |
| Brzózka, MM | 1 |
| Unterbarnscheidt, T | 1 |
| Herholt, A | 1 |
| Wintgens, JP | 1 |
| Papiol, S | 1 |
| Soto-Bernardini, MC | 1 |
| Kravchenko, M | 1 |
| Zhang, M | 1 |
| Nave, KA | 1 |
| Wichert, SP | 1 |
| Falkai, P | 1 |
| Zhang, W | 1 |
| Schwab, MH | 1 |
| Rossner, MJ | 1 |
1 other study available for spironolactone and Schizophrenia
| Article | Year |
|---|---|
Spironolactone is an antagonist of NRG1-ERBB4 signaling and schizophrenia-relevant endophenotypes in mice.
Topics: Animals; Behavior Rating Scale; Cell Line, Tumor; Coculture Techniques; Disease Models, Animal; Huma | 2017 |