spironolactone has been researched along with Retinal Diseases in 3 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Retinal Diseases: Diseases involving the RETINA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pretreatment with candesartan, spironolactone, or candesartan and spironolactone significantly inhibited retinal ischemic injury." | 5.38 | Activation of the aldosterone/mineralocorticoid receptor system and protective effects of mineralocorticoid receptor antagonism in retinal ischemia-reperfusion injury. ( Fujita, T; Hirooka, K; Itano, T; Lei, B; Liu, Y; Nakamura, T; Nishiyama, A; Shiraga, F; Zhang, J, 2012) |
| "Pretreatment with candesartan, spironolactone, or candesartan and spironolactone significantly inhibited retinal ischemic injury." | 1.38 | Activation of the aldosterone/mineralocorticoid receptor system and protective effects of mineralocorticoid receptor antagonism in retinal ischemia-reperfusion injury. ( Fujita, T; Hirooka, K; Itano, T; Lei, B; Liu, Y; Nakamura, T; Nishiyama, A; Shiraga, F; Zhang, J, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kouassi, AC | 1 |
| Masse, H | 1 |
| Lebreton, O | 1 |
| Weber, M | 1 |
| Liu, Y | 1 |
| Hirooka, K | 1 |
| Nishiyama, A | 1 |
| Lei, B | 1 |
| Nakamura, T | 1 |
| Itano, T | 1 |
| Fujita, T | 1 |
| Zhang, J | 1 |
| Shiraga, F | 1 |
| Simopoulos, AP | 1 |
| Delea, CS | 1 |
| Bartter, FC | 1 |
3 other studies available for spironolactone and Retinal Diseases
| Article | Year |
|---|---|
[Treatment of diffuse retinal pigment epitheliopathies by antialdosterones or by photodynamic therapy].
Topics: Central Serous Chorioretinopathy; Eplerenone; Follow-Up Studies; Humans; Mineralocorticoid Receptor | 2015 |
Activation of the aldosterone/mineralocorticoid receptor system and protective effects of mineralocorticoid receptor antagonism in retinal ischemia-reperfusion injury.
Topics: Aldosterone; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; C | 2012 |
Neurodegenerative disorders and hyperaldosteronism.
Topics: Adolescent; Aldosterone; Angiotensin II; Birth Weight; Blood Pressure; Body Weight; Bundle-Branch Bl | 1971 |