spironolactone and Respiratory Insufficiency studies

spironolactone and Respiratory Insufficiency

Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.

Respiratory Insufficiency: Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)

Research Excerpts

Excerpt	Relevance	Reference
"Hypokalemic periodic paralysis (HOKPP) is a rare disorder characterized by episodic muscle weakness with hypokalemia."	1.36	Severe respiratory phenotype caused by a de novo Arg528Gly mutation in the CACNA1S gene in a patient with hypokalemic periodic paralysis. ( Kil, TH; Kim, JB, 2010)

Research

Studies (19)

Timeframe	Studies, this research(%)	All Research%
pre-1990	18 (94.74)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (5.26)	24.3611
2020's	0 (0.00)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

18 (94.74)

18.7374

1990's

0 (0.00)

18.2507

2000's

0 (0.00)

29.6817

2010's

1 (5.26)

24.3611

2020's

0 (0.00)

2.80

Authors

Authors	Studies
Kil, TH	1
Kim, JB	1
BALMES, A	1
VEDEL, A	1
DAUVERCHAIN, J	1
DUMAS, A	1
HAENEL, J	1
BELLISARIO, G	1
CORDOVA, C	1
LOCOCO, G	1
NATOLI, A	1
SANTUCCI, A	1
FARDEAU, M	1
LAPRESLE, J	1
BOUDIN, G	1
GOULON, M	2
HAMBURGER, J	1
LHERMITTE, F	1
PEQUIGNOT, H	1
Fukushima, Y	1
Daum, S	1
Goerg, R	1
Schlehe, H	1
Wang, D	1
Protivinsky, R	1
Storm, W	1
Noble, MI	1
Trenchard, D	1
Guz, A	1
Henriquet, F	1
Balestra, L	1
Barois, A	1
Gajdos, P	1
Grosbuis, S	1
Joron, MH	1
Bennaiche, M	1
Cochrane, GM	1
Clark, TJ	1
Nolte, D	2
Lüder-Lühr, I	1
Selchau, M	1
Hutás, I	1
Ferlinz, R	1
Schroers, E	1
Stadeler, HJ	1

Studies

Kil, TH

Kim, JB

BALMES, A

VEDEL, A

DAUVERCHAIN, J

DUMAS, A

HAENEL, J

BELLISARIO, G

CORDOVA, C

LOCOCO, G

NATOLI, A

SANTUCCI, A

FARDEAU, M

LAPRESLE, J

BOUDIN, G

GOULON, M

HAMBURGER, J

LHERMITTE, F

PEQUIGNOT, H

Fukushima, Y

Daum, S

Goerg, R

Schlehe, H

Wang, D

Protivinsky, R

Storm, W

Noble, MI

Trenchard, D

Guz, A

Henriquet, F

Balestra, L

Barois, A

Gajdos, P

Grosbuis, S

Joron, MH

Bennaiche, M

Cochrane, GM

Clark, TJ

Nolte, D

Lüder-Lühr, I

Selchau, M

Hutás, I

Ferlinz, R

Schroers, E

Stadeler, HJ

Reviews

1 review available for spironolactone and Respiratory Insufficiency

Article	Year
[Diuretics. 47]. Pharmazeutische Praxis, 1970, Volume: 9 Topics: Antihypertensive Agents; Bendroflumethiazide; Chlorothiazide; Chlorthalidone; Clopamide; Dichlorphen	1970

Article

Year

[Diuretics. 47].

Pharmazeutische Praxis, 1970, Volume: 9

Topics: Antihypertensive Agents; Bendroflumethiazide; Chlorothiazide; Chlorthalidone; Clopamide; Dichlorphen

1970

Trials

1 trial available for spironolactone and Respiratory Insufficiency

Article	Year
Ventilatory response to spironolactone in respiratory failure. British journal of diseases of the chest, 1972, Volume: 66, Issue:1 Topics: Airway Obstruction; Body Weight; Carbon Dioxide; Clinical Trials as Topic; Humans; Hydrogen-Ion Conc	1972

Article

Year

Ventilatory response to spironolactone in respiratory failure.

British journal of diseases of the chest, 1972, Volume: 66, Issue:1

Topics: Airway Obstruction; Body Weight; Carbon Dioxide; Clinical Trials as Topic; Humans; Hydrogen-Ion Conc

1972

Other Studies

17 other studies available for spironolactone and Respiratory Insufficiency

Article	Year
Severe respiratory phenotype caused by a de novo Arg528Gly mutation in the CACNA1S gene in a patient with hypokalemic periodic paralysis. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2010, Volume: 14, Issue:3 Topics: Adolescent; Amiloride; Amino Acid Substitution; Arginine; Calcium Channels; Calcium Channels, L-Type	2010
[The hyperaldosteronism syndrome in edema caused by decompensated respiratory insufficiency and its treatment by spirolactones]. Le Poumon et le coeur, 1962, Volume: 18 Topics: Diuretics; Edema; Humans; Hyperaldosteronism; Mineralocorticoid Receptor Antagonists; Pulmonary Emph	1962
[THE EFFECT OF ALDACTONE ON ADVANCED RESPIRATORY INSUFFICIENCY (RESPIRATORY ACIDOSIS) IN CHRONIC COR PULMONALE]. Munchener medizinische Wochenschrift (1950), 1963, Nov-01, Volume: 105 Topics: Acidosis, Respiratory; Bicarbonates; Blood Gas Analysis; Body Fluids; Carbon Dioxide; Humans; Hydrog	1963
[PRELIMINARY RESULTS OF THE USE OF SPIROLACTONE IN PATIENTS WITH CIRCULATORY INSUFFICIENCY]. Bollettino della Societa italiana di cardiologia, 1963, Volume: 8 Topics: Body Weight; Diuresis; Electrolytes; Heart Failure; Humans; Pericarditis; Pericarditis, Constrictive	1963
[MYASTHENIA]. La Revue du praticien, 1964, Feb-11, Volume: 14 Topics: Ammonium Compounds; Blood; Cardiovascular Agents; Child; Diagnosis; Endocrinology; Ephedrine; Guanid	1964
[HOW TO TREAT MYASTHENIA]. La Presse medicale, 1964, Oct-10, Volume: 72 Topics: Ambenonium Chloride; Ephedrine; Humans; Muscle Weakness; Myasthenia Gravis; Neostigmine; Physostigmi	1964
[Respiratory failure: therapeutic trial on its acute exacerbation]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1983, Volume: 72, Issue:12 Topics: Acute Disease; Doxapram; Drug Therapy, Combination; Humans; Respiratory Insufficiency; Spironolacton	1983
[Long-term domiciliary oxygen therapy of cardiac failure and cardiac arrhythmia accompanying respiratory insufficiency (author's transl)]. Praxis und Klinik der Pneumologie, 1981, Volume: 35, Issue:11 Topics: Adult; Aged; Arrhythmias, Cardiac; Digitalis; Heart Failure; Humans; Long-Term Care; Male; Middle Ag	1981
[Spironolactone in respiratory insufficiency. Partial report, 12th Reichenhall Colloquium, 15-17 June 1979 in Bad Reichenhall]. Fortschritte der Medizin, 1979, Oct-04, Volume: 97, Issue:37 Topics: Digitalis Glycosides; Drug Synergism; Gynecomastia; Heart; Humans; Male; Pulmonary Circulation; Resp	1979
[Respiratory insufficiency in mucoviscidosis. Pathophysiologic aspects of conservative drug therapy]. Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde, 1989, Volume: 137, Issue:1 Topics: Acid-Base Equilibrium; Child; Combined Modality Therapy; Cystic Fibrosis; Drug Therapy, Combination;	1989
The value of diuretics in respiratory failure. Lancet (London, England), 1966, Jul-30, Volume: 2, Issue:7457 Topics: Aged; Blood Gas Analysis; Bronchitis; Diuretics; Female; Furosemide; Heart Failure; Humans; Male; Mi	1966
[On the therapy of myasthenia gravis. (Presentation of a case)]. Minerva anestesiologica, 1970, Volume: 36, Issue:4 Topics: Adrenocorticotropic Hormone; Adult; Autoantibodies; Autoimmune Diseases; Female; Humans; Myasthenia	1970
[Treatment of myasthenia with corticotropic hormones]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1972, Dec-14, Volume: 48, Issue:51 Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Delayed-Action Preparations; Female; Hu	1972
[Studies on the respiration-stimulating effect of spirolactone in healthy subjects]. Klinische Wochenschrift, 1973, Feb-15, Volume: 51, Issue:4 Topics: Adult; Airway Resistance; Carbon Dioxide; Humans; Male; Middle Aged; Respiration; Respiratory Insuff	1973
[Spironolactone effect and the lung]. Deutsche medizinische Wochenschrift (1946), 1973, Dec-14, Volume: 98, Issue:50 Topics: Blood Gas Analysis; Chronic Disease; Humans; Respiratory Insufficiency; Spironolactone; Ventilation-	1973
Treatment of cor pulmonale decompensatum with diuretics. Therapia Hungarica (English edition), 1971, Volume: 19, Issue:4 Topics: Acidosis, Respiratory; Blood Gas Analysis; Body Weight; Diuresis; Diuretics; Drug Resistance; Drug S	1971
[Results of treatment of the chronic general alveolar hypoventilation with aldadiene potassium]. Die Medizinische Welt, 1969, Aug-09, Volume: 32 Topics: Adult; Aged; Bicarbonates; Carbon Dioxide; Humans; Hydrogen-Ion Concentration; Hypoventilation; Inje	1969

Article

Year

Severe respiratory phenotype caused by a de novo Arg528Gly mutation in the CACNA1S gene in a patient with hypokalemic periodic paralysis.

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2010, Volume: 14, Issue:3

Topics: Adolescent; Amiloride; Amino Acid Substitution; Arginine; Calcium Channels; Calcium Channels, L-Type

2010

[The hyperaldosteronism syndrome in edema caused by decompensated respiratory insufficiency and its treatment by spirolactones].

Le Poumon et le coeur, 1962, Volume: 18

Topics: Diuretics; Edema; Humans; Hyperaldosteronism; Mineralocorticoid Receptor Antagonists; Pulmonary Emph

1962

[THE EFFECT OF ALDACTONE ON ADVANCED RESPIRATORY INSUFFICIENCY (RESPIRATORY ACIDOSIS) IN CHRONIC COR PULMONALE].

Munchener medizinische Wochenschrift (1950), 1963, Nov-01, Volume: 105

Topics: Acidosis, Respiratory; Bicarbonates; Blood Gas Analysis; Body Fluids; Carbon Dioxide; Humans; Hydrog

1963

[PRELIMINARY RESULTS OF THE USE OF SPIROLACTONE IN PATIENTS WITH CIRCULATORY INSUFFICIENCY].

Bollettino della Societa italiana di cardiologia, 1963, Volume: 8

Topics: Body Weight; Diuresis; Electrolytes; Heart Failure; Humans; Pericarditis; Pericarditis, Constrictive

1963

[MYASTHENIA].

La Revue du praticien, 1964, Feb-11, Volume: 14

Topics: Ammonium Compounds; Blood; Cardiovascular Agents; Child; Diagnosis; Endocrinology; Ephedrine; Guanid

1964

[HOW TO TREAT MYASTHENIA].

La Presse medicale, 1964, Oct-10, Volume: 72

Topics: Ambenonium Chloride; Ephedrine; Humans; Muscle Weakness; Myasthenia Gravis; Neostigmine; Physostigmi

1964

[Respiratory failure: therapeutic trial on its acute exacerbation].

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1983, Volume: 72, Issue:12

Topics: Acute Disease; Doxapram; Drug Therapy, Combination; Humans; Respiratory Insufficiency; Spironolacton

1983

[Long-term domiciliary oxygen therapy of cardiac failure and cardiac arrhythmia accompanying respiratory insufficiency (author's transl)].

Praxis und Klinik der Pneumologie, 1981, Volume: 35, Issue:11

Topics: Adult; Aged; Arrhythmias, Cardiac; Digitalis; Heart Failure; Humans; Long-Term Care; Male; Middle Ag

1981

[Spironolactone in respiratory insufficiency. Partial report, 12th Reichenhall Colloquium, 15-17 June 1979 in Bad Reichenhall].

Fortschritte der Medizin, 1979, Oct-04, Volume: 97, Issue:37

Topics: Digitalis Glycosides; Drug Synergism; Gynecomastia; Heart; Humans; Male; Pulmonary Circulation; Resp

1979

[Respiratory insufficiency in mucoviscidosis. Pathophysiologic aspects of conservative drug therapy].

Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde, 1989, Volume: 137, Issue:1

Topics: Acid-Base Equilibrium; Child; Combined Modality Therapy; Cystic Fibrosis; Drug Therapy, Combination;

1989

The value of diuretics in respiratory failure.

Lancet (London, England), 1966, Jul-30, Volume: 2, Issue:7457

Topics: Aged; Blood Gas Analysis; Bronchitis; Diuretics; Female; Furosemide; Heart Failure; Humans; Male; Mi

1966

[On the therapy of myasthenia gravis. (Presentation of a case)].

Minerva anestesiologica, 1970, Volume: 36, Issue:4

Topics: Adrenocorticotropic Hormone; Adult; Autoantibodies; Autoimmune Diseases; Female; Humans; Myasthenia

1970

[Treatment of myasthenia with corticotropic hormones].

La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1972, Dec-14, Volume: 48, Issue:51

Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Delayed-Action Preparations; Female; Hu

1972

[Studies on the respiration-stimulating effect of spirolactone in healthy subjects].

Klinische Wochenschrift, 1973, Feb-15, Volume: 51, Issue:4

Topics: Adult; Airway Resistance; Carbon Dioxide; Humans; Male; Middle Aged; Respiration; Respiratory Insuff

1973

[Spironolactone effect and the lung].

Deutsche medizinische Wochenschrift (1946), 1973, Dec-14, Volume: 98, Issue:50

Topics: Blood Gas Analysis; Chronic Disease; Humans; Respiratory Insufficiency; Spironolactone; Ventilation-

1973

Treatment of cor pulmonale decompensatum with diuretics.

Therapia Hungarica (English edition), 1971, Volume: 19, Issue:4

Topics: Acidosis, Respiratory; Blood Gas Analysis; Body Weight; Diuresis; Diuretics; Drug Resistance; Drug S

1971

[Results of treatment of the chronic general alveolar hypoventilation with aldadiene potassium].

Die Medizinische Welt, 1969, Aug-09, Volume: 32

Topics: Adult; Aged; Bicarbonates; Carbon Dioxide; Humans; Hydrogen-Ion Concentration; Hypoventilation; Inje

1969