spironolactone has been researched along with Radiculopathy in 2 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Radiculopathy: Disease involving a spinal nerve root (see SPINAL NERVE ROOTS) which may result from compression related to INTERVERTEBRAL DISK DISPLACEMENT; SPINAL CORD INJURIES; SPINAL DISEASES; and other conditions. Clinical manifestations include radicular pain, weakness, and sensory loss referable to structures innervated by the involved nerve root.
| Excerpt | Relevance | Reference |
|---|---|---|
| "These results suggest that intrathecal delivery spironolactone has therapeutic effects on radicular pain in rats." | 7.78 | Intrathecal injection of spironolactone attenuates radicular pain by inhibition of spinal microglia activation in a rat model. ( Bo, J; Gu, X; Liu, C; Ma, Z; Peng, L; Sun, X; Sun, YE; Yang, D; Zheng, Y; Zhu, B, 2012) |
| "These results suggest that intrathecal delivery spironolactone has therapeutic effects on radicular pain in rats." | 3.78 | Intrathecal injection of spironolactone attenuates radicular pain by inhibition of spinal microglia activation in a rat model. ( Bo, J; Gu, X; Liu, C; Ma, Z; Peng, L; Sun, X; Sun, YE; Yang, D; Zheng, Y; Zhu, B, 2012) |
| "Spironolactone can enhance the analgesic effects of dexamethasone via complex mechanisms." | 1.37 | The respective and interaction effects of spinal GRs and MRs on radicular pain induced by chronic compression of the dorsal root ganglion in the rat. ( Gu, X; Liu, C; Ma, Q; Ma, Z; Peng, L; Song, L; Sun, X; Yang, D; Zheng, Y; Zhu, B, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gu, X | 2 |
| Peng, L | 2 |
| Yang, D | 2 |
| Ma, Q | 1 |
| Zheng, Y | 2 |
| Liu, C | 2 |
| Zhu, B | 2 |
| Song, L | 1 |
| Sun, X | 2 |
| Ma, Z | 2 |
| Sun, YE | 1 |
| Bo, J | 1 |
2 other studies available for spironolactone and Radiculopathy
| Article | Year |
|---|---|
The respective and interaction effects of spinal GRs and MRs on radicular pain induced by chronic compression of the dorsal root ganglion in the rat.
Topics: Animals; Dexamethasone; Disease Models, Animal; Drug Synergism; Ganglia, Spinal; Hormone Antagonists | 2011 |
Intrathecal injection of spironolactone attenuates radicular pain by inhibition of spinal microglia activation in a rat model.
Topics: Animals; Blotting, Western; Cytokines; Disease Models, Animal; Ganglia, Spinal; Immunohistochemistry | 2012 |