spironolactone has been researched along with Pulmonary Fibrosis in 6 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Pulmonary Fibrosis: A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To examine the therapeutic/preventive potential of liposome-encapsulated spironolactone (SP; Lipo-SP) for acute lung injury (ALI) and fibrosis." | 7.83 | Inflammatory monocyte/macrophage modulation by liposome-entrapped spironolactone ameliorates acute lung injury in mice. ( Ji, WJ; Li, YM; Lin, ZC; Ma, YQ; Su, CC; Wang, PP; Wei, LQ; Xiang, GA; Zhang, L; Zhang, MP; Zhang, X; Zhang, YD; Zhang, Z; Zhou, X, 2016) |
| "Rats were divided into control, fibrosis and treatment groups; rat pulmonary fibrosis was induced by endotracheal injection of bleomycin A5 and spironolactone was given 100 mg/kg daily in drinking water to treatment group." | 7.70 | [Spironolactone ameliorates rat pulmonary fibrosis induced by bleomycin A5]. ( Fang, Q; Zhao, L; Zhao, M, 1998) |
| "To examine the therapeutic/preventive potential of liposome-encapsulated spironolactone (SP; Lipo-SP) for acute lung injury (ALI) and fibrosis." | 3.83 | Inflammatory monocyte/macrophage modulation by liposome-entrapped spironolactone ameliorates acute lung injury in mice. ( Ji, WJ; Li, YM; Lin, ZC; Ma, YQ; Su, CC; Wang, PP; Wei, LQ; Xiang, GA; Zhang, L; Zhang, MP; Zhang, X; Zhang, YD; Zhang, Z; Zhou, X, 2016) |
| "Rats were divided into control, fibrosis and treatment groups; rat pulmonary fibrosis was induced by endotracheal injection of bleomycin A5 and spironolactone was given 100 mg/kg daily in drinking water to treatment group." | 3.70 | [Spironolactone ameliorates rat pulmonary fibrosis induced by bleomycin A5]. ( Fang, Q; Zhao, L; Zhao, M, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ji, WJ | 2 |
| Ma, YQ | 2 |
| Zhou, X | 2 |
| Zhang, YD | 2 |
| Lu, RY | 1 |
| Guo, ZZ | 1 |
| Sun, HY | 1 |
| Hu, DC | 1 |
| Yang, GH | 1 |
| Li, YM | 2 |
| Wei, LQ | 2 |
| Zhang, X | 1 |
| Zhang, L | 1 |
| Su, CC | 1 |
| Xiang, GA | 1 |
| Zhang, MP | 1 |
| Lin, ZC | 1 |
| Wang, PP | 1 |
| Zhang, Z | 1 |
| Dundalek, E | 1 |
| Vetter, N | 1 |
| Morawetz, F | 1 |
| Witek, F | 1 |
| Zhao, L | 1 |
| Zhao, M | 1 |
| Fang, Q | 1 |
| Pabst, K | 1 |
6 other studies available for spironolactone and Pulmonary Fibrosis
| Article | Year |
|---|---|
Spironolactone attenuates bleomycin-induced pulmonary injury partially via modulating mononuclear phagocyte phenotype switching in circulating and alveolar compartments.
Topics: Acute Lung Injury; Animals; Antigens, CD; Antigens, Ly; Bleomycin; Bronchoalveolar Lavage Fluid; Che | 2013 |
Inflammatory monocyte/macrophage modulation by liposome-entrapped spironolactone ameliorates acute lung injury in mice.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Bleomycin; Cell Polarity; Humans; Liposomes; M | 2016 |
[Drug therapy of lung fibrosis].
Topics: Azathioprine; Cortisone; Humans; Penicillamine; Pulmonary Fibrosis; Spironolactone | 1981 |
[Therapy of chronic fibrosing alveolitis (author's transl)].
Topics: Drug Therapy, Combination; Humans; Immunosuppressive Agents; Penicillamine; Pulmonary Fibrosis; Spir | 1980 |
[Spironolactone ameliorates rat pulmonary fibrosis induced by bleomycin A5].
Topics: Aldosterone; Animals; Bleomycin; Bronchoalveolar Lavage Fluid; Collagen; Lung; Male; Mineralocortico | 1998 |
[Clinical picture and treatment of cor pulmonale (author's transl)].
Topics: Anticoagulants; Asthma; Bronchiectasis; Bronchitis; Digitalis; Diuretics; Electrocardiography; Human | 1973 |