spironolactone has been researched along with Prostatic Hyperplasia in 11 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Prostatic Hyperplasia: Increase in constituent cells in the PROSTATE, leading to enlargement of the organ (hypertrophy) and adverse impact on the lower urinary tract function. This can be caused by increased rate of cell proliferation, reduced rate of cell death, or both.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Spironolactone was prescribed at a dose of 100 mg per day for three months." | 1.26 | [The influence of spironolactone on the concentration of gonadotrophins and gonadal hormones in prostatic hypertrophy (author's transl)]. ( Baranowska, B; Szymanowski, J; Zgliczynski, S, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zgliczynski, S | 1 |
| Baranowska, B | 1 |
| Szymanowski, J | 1 |
| Schoenenberger, A | 1 |
| Hauri, D | 1 |
| Scott, WW | 1 |
| Coffey, DS | 1 |
| Rifka, SM | 1 |
| Pita, JC | 1 |
| Vigersky, RA | 1 |
| Wilson, YA | 1 |
| Loriaux, DL | 1 |
| Caine, M | 1 |
| Namer, M | 1 |
| Castro, JE | 4 |
| Griffiths, HJ | 2 |
| Edwards, DE | 2 |
| Schoonees, R | 1 |
| de Klerk, JN | 1 |
| Sellwood, RA | 1 |
| Shackman, R | 1 |
4 reviews available for spironolactone and Prostatic Hyperplasia
| Article | Year |
|---|---|
[Conservative treatment of benign prostatic hyperplasia (author's transl)].
Topics: Adrenergic alpha-Antagonists; Bromocriptine; Cyproterone; Gestonorone Caproate; Humans; Male; Medrog | 1982 |
Nonsurgical treatment of human benign prostatic hyperplasia.
Topics: Androgen Antagonists; Androgens; Animals; Castration; Cyproterone; Dogs; Drug Synergism; Estrogens; | 1975 |
Clinical applications of antiandrogens.
Topics: Androgen Antagonists; Breast Neoplasms; Cyproterone; Cyproterone Acetate; Female; Flutamide; Humans; | 1988 |
[Hormonal treatment benign prostatic hyperplasia. A review].
Topics: Adult; Aldosterone; Androgens; Castration; Diethylstilbestrol; Estrogens; Hormones; Humans; Male; Mi | 1972 |
3 trials available for spironolactone and Prostatic Hyperplasia
| Article | Year |
|---|---|
A double-blind, controlled, clinical trial of spironolactone for benign prostatic hypertrophy.
Topics: Clinical Trials as Topic; Cystoscopy; Factor Analysis, Statistical; Humans; Male; Placebos; Prostati | 1971 |
Pills for the benign prostate. Trial designs.
Topics: Clinical Trials as Topic; Humans; Male; Methods; Placebos; Prostatectomy; Prostatic Hyperplasia; Spi | 1972 |
A controlled clinical trial of aldactone-A in the treatment of benign prostatic hyperplasia.
Topics: Clinical Trials as Topic; Humans; Male; Placebos; Prostatic Hyperplasia; Spironolactone; Urination D | 1969 |
4 other studies available for spironolactone and Prostatic Hyperplasia
| Article | Year |
|---|---|
[The influence of spironolactone on the concentration of gonadotrophins and gonadal hormones in prostatic hypertrophy (author's transl)].
Topics: Aged; Dihydrotestosterone; Estradiol; Follicle Stimulating Hormone; Gonadal Steroid Hormones; Gonado | 1981 |
Interaction of digitalis and spironolactone with human sex steroid receptors.
Topics: Binding, Competitive; Digitoxin; Estradiol; Female; Humans; Infant, Newborn; Male; Menopause; Penis; | 1978 |
Medical management of prostatic hyperplasia.
Topics: Adrenergic alpha-Antagonists; Aged; Aging; Bromocriptine; Cyproterone; Humans; Male; Phenoxybenzamin | 1986 |
Effects of aldosterone antagonists on organ cultures of human prostatic tissue.
Topics: Culture Media; Humans; Ketosteroids; Lactones; Male; Mineralocorticoid Receptor Antagonists; Organ C | 1974 |