spironolactone has been researched along with Pregnancy in 115 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The anti-hypertensive effect of spironolactone and thiabutazide was tested on 47 unselected patients with primary hypertension." | 7.65 | [Spironolactone and thiabutazide in the treatment of essential hypertension (author's transl)]. ( Braun, B; Klaus, D; Klump, F; Lemke, R; Zehner, J; Zöfel, P, 1975) |
| " The recent introduction of a novel, long-acting testosterone formulation (testosterone undecanoate) which only requires one intramuscular injection every 3 months, together with the already available hydroalcoholic testosterone gels, appear to be promising alternatives to the previous standard substitution therapy for male hypogonadism." | 4.83 | [The latest developments in endocrinology 2004/2005]. ( Fottner, C; Weber, MM, 2006) |
| " Blood pressure was normal during treatment with spironolactone and during pregnancy, when the action of aldosterone and other similar steroids was presumably blocked by an increased production of progesterone; this suggests that the hypertension is dependent upon sodium-retaining steroids such as aldosterone." | 3.66 | Overproduction of sodium-retaining steroids by the zona glomerulosa is adrenocorticotropin-dependent and mediates hypertension in dexamethasone-suppressible aldosteronism. ( Bartter, FC; Gill, JR, 1981) |
| "The anti-hypertensive effect of spironolactone and thiabutazide was tested on 47 unselected patients with primary hypertension." | 3.65 | [Spironolactone and thiabutazide in the treatment of essential hypertension (author's transl)]. ( Braun, B; Klaus, D; Klump, F; Lemke, R; Zehner, J; Zöfel, P, 1975) |
| "Spironolactone, which has been shown to have antiandrogen action in mature male rats, was given to pregnant rats from day 14 of pregnancy until delivery in a dose equivalent to the 400-mg adult human regimen." | 3.65 | Lack of effect of spironolactone on male genital development. ( Reckler, JM; Regestein, Q; Rose, LI, 1975) |
| "Primary aldosteronism (PA) is the most common form of secondary hypertension." | 3.01 | Primary aldosteronism in pregnancy. ( Forestiero, V; Monticone, S; Mulatero, P; Sconfienza, E, 2023) |
| "Primary aldosteronism (PA) is the most common cause of secondary hypertension." | 2.52 | Progress in primary aldosteronism: mineralocorticoid receptor antagonists and management of primary aldosteronism in pregnancy. ( Reincke, M; Riester, A, 2015) |
| "Hypertension is one of the most common cardiovascular diseases during pregnancy." | 2.52 | [Hypertension in the course of primary aldosteronism during pregnancy]. ( Chudek, J; Maruniak-Chudek, I; Olszanecka-Glinianowicz, M; Sikora, J; Wyskida, K; Wyskida, M, 2015) |
| "Acne vulgaris is a common reason why adult women present to dermatologists and can be a clinical challenge to treat." | 2.48 | Acne in the adult female patient: a practical approach. ( Kamangar, F; Shinkai, K, 2012) |
| "Pregnancy is rare in women with decompensated chronic liver disease." | 2.47 | Successful pregnancy outcome in decompensated chronic liver disease with portal vein thrombosis: case report and review of literature. ( Hussain, R; Kamani, L; Kumar, M; Siddique, S, 2011) |
| "Considerations for treating acne in adult women include childbearing potential, pregnancy, lactation, and concomitant skin conditions." | 1.48 | Treating Acne in Adult Women. ( Alexis, AF; Harper, JC; Stein Gold, LF; Tan, JKL, 2018) |
| "Spironolactone treatment resulted in decreased blood pressure and rise in serum potassium levels." | 1.46 | Apparent mineralocorticoid excess and the long term treatment of genetic hypertension. ( Khattab, A; New, MI; Razzaghy-Azar, M; Yau, M, 2017) |
| "Echocardiography showed 73% dilated cardiomyopathy; 83% showed moderate to severe LV systolic dysfunction (mean EF 36." | 1.43 | Clinical and echocardiographic characteristics and outcomes in congestive heart failure at the Hospital of The State University of Haiti. ( Malebranche, R; Morisset, PH; Raphael, NA; Tabou Moyo, C; Wilentz, JR, 2016) |
| "Enalapril was continued for 42 days." | 1.38 | Therapeutic challenges and management of heart failure during pregnancy (part I). ( Bilińska, ZT; Czajkowski, K; Dangel, J; Demkow, M; Dzielińska, Z; Konka, M; Kryczka, K; Przybylski, A; Różański, J; Szczudlik, J, 2012) |
| "Our study confirms pregnancy is more difficult to manage at the beginning of MG." | 1.33 | [Myasthenia gravis and pregnancy: clinical course and management of delivery and the postpartum phase]. ( de Seze, J; Defebvre, L; Delalande, S; Delrieu, O; Destée, A; Fourrier, F; Leys, D; Ramirez, C; Stojkovic, T; Vermersch, P, 2006) |
| "The diagnosis of myasthenia gravis is often difficult and calls for a broader use of pharmacological and electrodiagnostic tests." | 1.24 | MYASTHENIA GRAVIS: MEDICAL ASPECTS. ( BUCKLER, WS; ZELDOWICZ, LR, 1965) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 69 (60.00) | 18.7374 |
| 1990's | 11 (9.57) | 18.2507 |
| 2000's | 6 (5.22) | 29.6817 |
| 2010's | 26 (22.61) | 24.3611 |
| 2020's | 3 (2.61) | 2.80 |
| Authors | Studies |
|---|---|
| Nickisch, K | 2 |
| Bittler, D | 2 |
| Laurent, H | 2 |
| Losert, W | 2 |
| Nishino, Y | 2 |
| Schillinger, E | 2 |
| Wiechert, R | 2 |
| Forestiero, V | 1 |
| Sconfienza, E | 1 |
| Mulatero, P | 1 |
| Monticone, S | 1 |
| Cao, N | 1 |
| Lan, C | 1 |
| Chen, C | 1 |
| Xu, Z | 1 |
| Luo, H | 1 |
| Zheng, S | 1 |
| Gong, X | 1 |
| Ren, H | 1 |
| Li, Z | 1 |
| Qu, S | 1 |
| Yu, C | 1 |
| Yang, J | 1 |
| Jose, PA | 1 |
| Chen, Y | 1 |
| Wu, G | 1 |
| Hu, C | 1 |
| Yu, J | 1 |
| Zeng, C | 1 |
| Amar, J | 1 |
| Angoulvant, T | 1 |
| Boivin, JM | 1 |
| Amar, L | 1 |
| Lantelme, P | 1 |
| Blacher, J | 1 |
| Plu-Bureau, G | 1 |
| Vehier, CM | 1 |
| Vaksmann, G | 1 |
| Lucidarme, S | 1 |
| Henriet, E | 1 |
| Olatunji, LA | 3 |
| Usman, TO | 2 |
| Akinade, AI | 1 |
| Adeyanju, OA | 1 |
| Kim, I | 2 |
| Soladoye, AO | 1 |
| Harper, JC | 1 |
| Stein Gold, LF | 1 |
| Alexis, AF | 1 |
| Tan, JKL | 1 |
| Liszewski, W | 1 |
| Boull, C | 1 |
| Badmus, OO | 2 |
| West, CA | 1 |
| Shaw, S | 1 |
| Sasser, JM | 1 |
| Fekete, A | 1 |
| Alexander, T | 1 |
| Cunningham, MW | 1 |
| Masilamani, SM | 2 |
| Baylis, C | 1 |
| Lewey, J | 1 |
| Haythe, J | 1 |
| Riester, A | 1 |
| Reincke, M | 1 |
| Seres, A | 1 |
| Ducza, E | 1 |
| Gáspár, R | 1 |
| Wyskida, M | 1 |
| Wyskida, K | 1 |
| Olszanecka-Glinianowicz, M | 1 |
| Maruniak-Chudek, I | 1 |
| Sikora, J | 1 |
| Chudek, J | 1 |
| Moreno, LE | 1 |
| Bonnell, A | 1 |
| Neher, JO | 1 |
| Safranek, S | 1 |
| Pieper, PG | 1 |
| Razzaghy-Azar, M | 1 |
| Yau, M | 1 |
| Khattab, A | 1 |
| New, MI | 1 |
| Malebranche, R | 1 |
| Tabou Moyo, C | 1 |
| Morisset, PH | 1 |
| Raphael, NA | 1 |
| Wilentz, JR | 1 |
| Morton, A | 2 |
| Laurie, J | 1 |
| de Arriba, G | 1 |
| Sánchez-Heras, M | 1 |
| Basterrechea, MA | 1 |
| Speake, PF | 1 |
| Glazier, JD | 1 |
| Greenwood, SL | 1 |
| Sibley, CP | 1 |
| Yim, HE | 1 |
| Kim, JH | 1 |
| Yoo, KH | 1 |
| Bae, IS | 1 |
| Jang, GY | 1 |
| Hong, YS | 1 |
| Lee, JW | 1 |
| West, C | 1 |
| Zhang, Z | 1 |
| Ecker, G | 1 |
| Panitz, B | 1 |
| Bush, A | 1 |
| Fikri Benbrahim, O | 1 |
| García Agudo, R | 1 |
| Cazalla Cadenas, F | 1 |
| Martínez Calero, A | 1 |
| González-Spínola, J | 1 |
| Kumar, M | 1 |
| Kamani, L | 1 |
| Hussain, R | 1 |
| Siddique, S | 1 |
| Cabassi, A | 1 |
| Rocco, R | 1 |
| Berretta, R | 1 |
| Regolisti, G | 1 |
| Bacchi-Modena, A | 1 |
| Crovetto, F | 1 |
| Moroni, G | 1 |
| Zaina, B | 1 |
| Acaia, B | 1 |
| Ossola, MW | 1 |
| Fedele, L | 1 |
| Kryczka, K | 1 |
| Dzielińska, Z | 1 |
| Przybylski, A | 1 |
| Szczudlik, J | 1 |
| Dangel, J | 1 |
| Konka, M | 1 |
| Czajkowski, K | 1 |
| Różański, J | 1 |
| Bilińska, ZT | 1 |
| Demkow, M | 1 |
| Kamangar, F | 1 |
| Shinkai, K | 1 |
| STARK, G | 1 |
| CATTANEO, G | 2 |
| DE LUCA, S | 2 |
| DEMARTINIS, C | 1 |
| FONZO, D | 1 |
| PATRINI, G | 1 |
| BROWN, JJ | 2 |
| DAVIES, DL | 2 |
| LEVER, AF | 2 |
| ROBERTSON, JI | 2 |
| CRANE, MG | 1 |
| ANDES, JP | 1 |
| HARRIS, JJ | 1 |
| SLATE, WG | 1 |
| FREZZA, M | 1 |
| MAROUDIS, D | 1 |
| HALKINDAKIS, J | 1 |
| PSILAKIS, D | 1 |
| SAKLARIDES, J | 1 |
| HIRSCH, MR | 1 |
| MARK, MS | 1 |
| CHAPIS, NJ | 1 |
| DELVAGLIO, B | 1 |
| MAGNIN, P | 1 |
| PELISSIER, B | 1 |
| ZELDOWICZ, LR | 1 |
| BUCKLER, WS | 1 |
| BOUCHER, BJ | 1 |
| MASON, AS | 1 |
| LONGO, LD | 1 |
| ASSALI, NS | 1 |
| RICHTER, RH | 1 |
| ARNOLD, M | 1 |
| Fottner, C | 1 |
| Weber, MM | 1 |
| Ramirez, C | 1 |
| de Seze, J | 1 |
| Delrieu, O | 1 |
| Stojkovic, T | 1 |
| Delalande, S | 1 |
| Fourrier, F | 1 |
| Leys, D | 1 |
| Defebvre, L | 1 |
| Destée, A | 1 |
| Vermersch, P | 1 |
| Glavas, MM | 1 |
| Yu, WK | 1 |
| Weinberg, J | 1 |
| Koizumi, M | 1 |
| Yada, T | 1 |
| Gill, JR | 1 |
| Bartter, FC | 1 |
| Nagi, S | 1 |
| Virgo, BB | 1 |
| Scoggins, BA | 1 |
| Coghlan, JP | 1 |
| Kallen, RJ | 1 |
| Aronson, DJ | 1 |
| Churchill, S | 1 |
| Bengele, HH | 1 |
| Melby, JC | 2 |
| Alexander, EA | 1 |
| Molinatti, GM | 2 |
| Hecker, A | 1 |
| Hasan, SH | 1 |
| Neumann, F | 1 |
| Groves, TD | 1 |
| Corenblum, B | 1 |
| Vĕtr, M | 1 |
| Sobek, A | 1 |
| Rigó, J | 1 |
| Gláz, E | 1 |
| Papp, Z | 1 |
| de Macedo, IL | 1 |
| Calderón, RB | 1 |
| Müller-Berghaus, J | 1 |
| Homoki, J | 1 |
| Michalk, DV | 1 |
| Querfeld, U | 1 |
| Koloszár, S | 1 |
| Szöllösi, J | 1 |
| Bártfai, G | 1 |
| Kubisch, HM | 1 |
| Mathialagan, S | 1 |
| Gómez-Sánchez, EP | 1 |
| Huang, Y | 1 |
| Wang, DH | 1 |
| Brooks, JR | 1 |
| Steelman, SL | 1 |
| Patanelli, DJ | 1 |
| Lammintausta, R | 1 |
| Erkkola, R | 1 |
| Choe, J | 1 |
| Stern, P | 1 |
| Feldman, D | 1 |
| Horký, K | 1 |
| Hájek, Z | 1 |
| Gregorová, I | 1 |
| Vancura, J | 1 |
| Silinková-Málková, E | 1 |
| Pokorný, A | 1 |
| Hall, WD | 1 |
| Reisert, VP | 1 |
| Kistner, M | 1 |
| Boink, AB | 2 |
| Kruyswijk, HH | 2 |
| Willebrands, AF | 2 |
| Maas, AH | 2 |
| Külpmann, WR | 1 |
| Spiegelhalder, B | 1 |
| Wilk, C | 1 |
| Breuer, H | 3 |
| MacGillivray, I | 1 |
| Campbell, DM | 1 |
| Wilson, GM | 1 |
| Klump, F | 1 |
| Braun, B | 1 |
| Klaus, D | 1 |
| Lemke, R | 1 |
| Zehner, J | 1 |
| Zöfel, P | 1 |
| Loggie, JM | 1 |
| Kleinman, LI | 1 |
| Van Maanen, EF | 1 |
| Rose, LI | 1 |
| Regestein, Q | 1 |
| Reckler, JM | 1 |
| Gayral, MN | 1 |
| Millet, D | 1 |
| Netter, A | 1 |
| Mitchell, JB | 1 |
| Betito, K | 1 |
| Rowe, W | 1 |
| Boksa, P | 1 |
| Meaney, MJ | 1 |
| Beier, S | 1 |
| Elger, W | 1 |
| Kairaitis, K | 1 |
| Lumbers, ER | 1 |
| Cooke, RG | 1 |
| Benhaj, KM | 1 |
| Quirk, SJ | 1 |
| Gannell, JE | 1 |
| Funder, JW | 1 |
| Jaussan, V | 1 |
| Lemarchand-Béraud, T | 1 |
| Gómez, F | 1 |
| Kincaid-Smith, P | 2 |
| Zander, J | 1 |
| Goebel, R | 1 |
| Kuhn, W | 1 |
| Selye, H | 2 |
| Taché, Y | 1 |
| Szabo, S | 1 |
| Hussey, HH | 1 |
| Lagrue, G | 1 |
| Fournier, A | 1 |
| Beevers, DG | 1 |
| Ferriss, JB | 1 |
| Fraser, R | 1 |
| Crocker, AD | 1 |
| Hinsull, SM | 1 |
| Felder, KD | 1 |
| Wernze, H | 1 |
| Brunswig, D | 1 |
| Jambroes, G | 1 |
| Yagil, R | 1 |
| Etzion, Z | 1 |
| Berlyne, GM | 1 |
| Mackay, EV | 1 |
| Khoo, SK | 1 |
| Adsett, G | 1 |
| Zymanska, S | 1 |
| Anderton, JL | 1 |
| Slawov, I | 1 |
| Inoue, K | 1 |
| Yamashita, F | 1 |
| Nagayama, T | 1 |
| Ivanov, IP | 1 |
| Shekhtman, MM | 1 |
| Zhav, B | 1 |
| Bolch, OH | 1 |
| Warren, JC | 1 |
| Spark, RF | 1 |
| Klink, R | 2 |
| Lichton, IR | 2 |
| Nocke, L | 1 |
| Nocke, W | 1 |
| Seassaro, E | 1 |
| Pellegrini, R | 1 |
| Huchzermeyer, H | 1 |
| Kavunets, GP | 1 |
| Lichton, IJ | 2 |
| Rasa, AP | 1 |
| Hugh, JE | 2 |
| Sassi, D | 1 |
| D'Avossa, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Topical Silymarin Cream Versus Salicylic Acid Peeling in Treatment of Acne Vulgaris: Split Face Study[NCT04490967] | Phase 4 | 30 participants (Anticipated) | Interventional | 2021-04-30 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
18 reviews available for spironolactone and Pregnancy
| Article | Year |
|---|---|
Primary aldosteronism in pregnancy.
Topics: Eplerenone; Female; Humans; Hyperaldosteronism; Hypertension; Mineralocorticoid Receptor Antagonists | 2023 |
Topics: Age Factors; Antihypertensive Agents; Blood Pressure; Breast Neoplasms; Female; Humans; Hypertension | 2019 |
Lack of evidence for feminization of males exposed to spironolactone in utero: A systematic review.
Topics: Animals; Diuretics; Edema; Female; Feminization; Humans; Male; Pregnancy; Pregnancy Complications; P | 2019 |
Cardiomyopathy in pregnancy.
Topics: Adrenergic beta-Antagonists; Adult; Anesthesia, Obstetrical; Angiotensin-Converting Enzyme Inhibitor | 2014 |
Progress in primary aldosteronism: mineralocorticoid receptor antagonists and management of primary aldosteronism in pregnancy.
Topics: Animals; Disease Management; Eplerenone; Female; Humans; Hyperaldosteronism; Mineralocorticoid Recep | 2015 |
[Hypertension in the course of primary aldosteronism during pregnancy].
Topics: Acid Sensing Ion Channel Blockers; Aldosterone; Amiloride; Antihypertensive Agents; Eplerenone; Fema | 2015 |
Clinical Inquiry: What therapies alleviate symptoms of polycystic ovary syndrome?
Topics: Body Mass Index; Contraceptives, Oral; Diuretics; Female; Humans; Hydroxymethylglutaryl-CoA Reductas | 2015 |
Use of medication for cardiovascular disease during pregnancy.
Topics: Amiodarone; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Cardiovascul | 2015 |
Successful pregnancy outcome in decompensated chronic liver disease with portal vein thrombosis: case report and review of literature.
Topics: Adult; Antiviral Agents; Ascites; Blood Transfusion; Esophageal and Gastric Varices; Female; Hepatit | 2011 |
Pregnancy in women with Alport syndrome.
Topics: Adolescent; Angiotensin-Converting Enzyme Inhibitors; Cesarean Section; Female; Follow-Up Studies; G | 2013 |
Acne in the adult female patient: a practical approach.
Topics: Acne Vulgaris; Adolescent; Adult; Androgen Antagonists; Contraceptives, Oral, Hormonal; Dermatologic | 2012 |
[SECONDARY HYPERALDOSTERONISM. PHYSIOPATHOLOGIC, CLINICAL AND THERAPEUTIC CONSIDERATIONS].
Topics: Adrenal Cortex Hormones; Angiotensins; Blood Transfusion; Capillary Permeability; Diet; Diet Therapy | 1963 |
[The latest developments in endocrinology 2004/2005].
Topics: Adrenal Gland Neoplasms; Adult; Bone Density Conservation Agents; Chronic Kidney Disease-Mineral and | 2006 |
Primary hyperaldosteronism.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Aldosterone; Amiloride; Diagnosis, Differential; F | 1980 |
Diuretics: mechanism of action and clinical application.
Topics: Acute Kidney Injury; Amiloride; Animals; Benzothiadiazines; Diabetes Insipidus; Diuretics; Diuretics | 1975 |
Protection by catatoxic steroids against cyclophosphamide-induced organ lesions.
Topics: Adrenal Glands; Animals; Body Weight; Bone Marrow; Cyclophosphamide; Desoxycorticosterone; Enzyme In | 1970 |
The use of spironolactone in the diagnosis and the treatment of hypertension associated with mineralocorticoid excess.
Topics: Adenoma; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Aldosterone; Antihypertensive Agents; Carc | 1973 |
Diuretics. II. Clinical considerations.
Topics: Administration, Oral; Aminophylline; Ascites; Calcium; Carbohydrate Metabolism; Carbonic Anhydrase I | 1971 |
3 trials available for spironolactone and Pregnancy
| Article | Year |
|---|---|
Low dose spironolactone in the treatment of female hyperandrogenemia and hirsutism.
Topics: Adolescent; Adult; Female; Hirsutism; Humans; Hyperandrogenism; Infant, Newborn; Luteinizing Hormone | 1993 |
[Ovulation induction with adjuvant antiandrogen treatment in Stein-Leventhal syndrome].
Topics: Adult; Androgen Antagonists; Anovulation; Cyproterone Acetate; Dexamethasone; Female; Humans; Hypera | 1996 |
A clinical study of the effects of an aldosterone antagonist (Aldactone-A) and a thiazide diuretic (Enduron) in pregnancy.
Topics: Chlorine; Clinical Trials as Topic; Diuresis; Female; Humans; Hypertension; Methyclothiazide; Minera | 1969 |
94 other studies available for spironolactone and Pregnancy
| Article | Year |
|---|---|
Aldosterone antagonists. 3. Synthesis and activities of steroidal 7 alpha-(alkoxycarbonyl)-15,16-methylene spirolactones.
Topics: Animals; Biological Assay; Chemical Phenomena; Chemistry; Female; Male; Mineralocorticoid Receptor A | 1990 |
Prenatal Lipopolysaccharides Exposure Induces Transgenerational Inheritance of Hypertension.
Topics: Animals; Cyclic N-Oxides; Female; Histone Demethylases; Histones; Hypertension; Jumonji Domain-Conta | 2022 |
Fetal ventricular tachycardia: betablockers should be the first line treatment.
Topics: Adrenergic beta-Antagonists; Adult; Diuretics; Female; Fetal Diseases; Fetal Monitoring; Humans; Inf | 2021 |
Low-dose spironolactone ameliorates insulin resistance and suppresses elevated plasminogen activator inhibitor-1 during gestational testosterone exposure.
Topics: Animals; Biomarkers; Blood Glucose; Body Weight; Dose-Response Relationship, Drug; Drinking; Dyslipi | 2017 |
Treating Acne in Adult Women.
Topics: Acne Vulgaris; Adult; Contraceptives, Oral, Combined; Contraindications, Drug; Dermatologic Agents; | 2018 |
Mineralocorticoid receptor blockade attenuates disrupted glutathione-dependent antioxidant defense and elevated endoglin in the hearts of pregnant rats exposed to testosterone.
Topics: Animals; Antioxidants; Endoglin; Eplerenone; Female; Gestational Age; Glutathione; Mineralocorticoid | 2019 |
Involvement of glucocorticoid and mineralocorticoid receptors in lipid accumulation and depressed G6PD activity in the livers of rats treated with postpartum oral estrogen-progestin.
Topics: Animals; Contraceptives, Oral, Hormonal; Estrogens; Ethinyl Estradiol; Female; Glucose; Glucosephosp | 2019 |
Chronic vasodilation increases renal medullary PDE5A and α-ENaC through independent renin-angiotensin-aldosterone system pathways.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pr | 2013 |
[Investigation of gestagenic effect of raw drone milk in rats].
Topics: Androgens; Animals; Bees; Blotting, Western; Calcitonin Receptor-Like Protein; Drug Therapy, Combina | 2014 |
Apparent mineralocorticoid excess and the long term treatment of genetic hypertension.
Topics: 11-beta-Hydroxysteroid Dehydrogenases; Adolescent; Adult; Blood Pressure; Child; Child, Preschool; D | 2017 |
Clinical and echocardiographic characteristics and outcomes in congestive heart failure at the Hospital of The State University of Haiti.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Age Distribution; Aged; Aged, 80 and over; Angiotens | 2016 |
Eplerenone in the management of resistant hypertension with obstructive sleep apnoea in pregnancy.
Topics: Adult; Eplerenone; Female; Humans; Mineralocorticoid Receptor Antagonists; Obesity, Morbid; Pre-Ecla | 2017 |
Gitelman syndrome during pregnancy: a therapeutic challenge.
Topics: Adult; Diuretics; Female; Gitelman Syndrome; Humans; Infant, Newborn; Magnesium; Male; Potassium; Pr | 2009 |
Aldosterone and cortisol acutely stimulate Na+/H+ exchanger activity in the syncytiotrophoblast of the human placenta: effect of fetal sex.
Topics: Aldosterone; Female; Humans; Hydrocortisone; Infant, Newborn; Male; Mifepristone; Placenta; Pregnanc | 2010 |
Spironolactone, but not enalapril, potentiates hypoxia-inducible factor-1 alpha and Ets-1 expression in newborn rat kidney.
Topics: Animals; Animals, Newborn; Enalapril; Female; Gene Expression Regulation, Developmental; Hypoxia-Ind | 2010 |
Increased renal alpha-epithelial sodium channel (ENAC) protein and increased ENAC activity in normal pregnancy.
Topics: Amiloride; Animals; Epithelial Sodium Channel Blockers; Epithelial Sodium Channels; Eplerenone; Fema | 2010 |
Eplerenone for gitelman syndrome in pregnancy.
Topics: Eplerenone; Female; Gitelman Syndrome; Humans; Live Birth; Mineralocorticoid Receptor Antagonists; M | 2011 |
[Diagnosis of secondary hypertension causing miscarriage during the first trimester of pregnancy].
Topics: Abortion, Spontaneous; Adrenal Cortex Neoplasms; Adrenocortical Adenoma; Adult; Antihypertensive Age | 2011 |
Eplerenone use in primary aldosteronism during pregnancy.
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Adenoma; Adult; Eplerenone; Female; Follow-U | 2012 |
Therapeutic challenges and management of heart failure during pregnancy (part I).
Topics: Adult; Digitalis; Drug Therapy, Combination; Enalapril; Female; Furosemide; Heart Failure; Humans; M | 2012 |
[Our experiences with the aldosterone blocking agent, aldactone in obstetrics].
Topics: Aldosterone; Body Fluids; Diuretics; Female; Humans; Mineralocorticoid Receptor Antagonists; Obstetr | 1962 |
[On the use of spironolactone in water and salt retention in pregnancy toxemia].
Topics: Female; Humans; Hypernatremia; Natriuresis; Pre-Eclampsia; Pregnancy; Spironolactone; Toxemia; Water | 1962 |
[Spirolactone and lipoprotein metabolism in nephropathy in pregnancy].
Topics: Blood Proteins; Edema; Female; Hypertension; Hypertension, Renal; Kidney; Kidney Diseases; Lipoprote | 1962 |
[APROPOS OF BACTEREMIC SHOCK IN OBSTETRICS].
Topics: Abortion, Induced; Anti-Bacterial Agents; Central Nervous System Stimulants; Communicable Diseases; | 1963 |
VARIATIONS IN PLASMA RENIN CONCENTRATION IN SEVERAL PHYSIOLOGICAL AND PATHOLOGICAL STATES.
Topics: Addison Disease; Aldosterone; Angiotensins; Blood Chemical Analysis; Hypertension; Hypokalemia; Live | 1964 |
PRIMARY ALDOSTERONISM IN PREGNANCY.
Topics: Adolescent; Black People; Clinical Laboratory Techniques; Diagnosis, Differential; Epistaxis; Female | 1964 |
[OBSERVATIONS ON RENAL ACTIVITY OF THE SPIROLACTONES].
Topics: Diet, Sodium-Restricted; Edema; Female; Humans; Kidney; Mineralocorticoid Receptor Antagonists; Phar | 1963 |
THE EFFECT OF 17-SPIRONOLACTONES IN TOXEMIA.
Topics: Albuminuria; Blood Chemical Analysis; Blood Pressure; Blood Pressure Determination; Drug Therapy; Ed | 1964 |
PSEUDOTOXEMIA AND ERYTHROBLASTOSIS. REPORT OF A CASE.
Topics: Adrenocorticotropic Hormone; Anemia; Chlorothiazide; Diet; Diet Therapy; Edema; Erythroblastosis, Fe | 1964 |
PORTACAVAL SHUNT PERFORMED DURING PREGNANCY.
Topics: Chlorothiazide; Diet, Sodium-Restricted; Esophageal and Gastric Varices; Female; Gastrointestinal He | 1964 |
[EDEMAS AND SPIRONOLACTONES].
Topics: Edema; Female; Glomerulonephritis; Humans; Nephritis; Pregnancy; Pregnancy Complications; Premenstru | 1964 |
[THERAPEUTIC IMPORTANCE OF THE COMBINATION OF A SALIDIURETIC AND SPIRONOLACTONE IN OBSTETRICS. APROPOS OF 15 CASES].
Topics: Adolescent; Diuretics; Drug Synergism; Drug Therapy; Edema; Female; Humans; Obstetrics; Pregnancy; S | 1965 |
MYASTHENIA GRAVIS: MEDICAL ASPECTS.
Topics: Acetylcholine; Botulism; Bromides; Cholinesterase Inhibitors; Decamethonium Compounds; Diagnosis; Di | 1965 |
CONN'S SYNDROME WITH ASSOCIATED PREGNANCY.
Topics: Adenoma; Adrenal Gland Neoplasms; Blood; Dexamethasone; Diagnosis; Female; Humans; Hyperaldosteronis | 1965 |
Effects of antialdosterone compounds (spirolactones) on the antinatruresis of the upright position in pregnancy.
Topics: Aldosterone; Body Fluids; Female; Humans; Mineralocorticoid Receptor Antagonists; Pregnancy; Sodium; | 1960 |
[Observations on the effect of the aldosterone antagonist spironolactone (aldactone) in normal and toxemic pregnancy (preliminary report)].
Topics: Aldosterone; Antihypertensive Agents; Diuretics; Female; Hormone Antagonists; Humans; Mineralocortic | 1961 |
[Myasthenia gravis and pregnancy: clinical course and management of delivery and the postpartum phase].
Topics: Abortion, Therapeutic; Adult; Autoantibodies; Autoantigens; Cholinesterase Inhibitors; Delivery, Obs | 2006 |
Effects of mineralocorticoid and glucocorticoid receptor blockade on hypothalamic-pituitary-adrenal function in female rats prenatally exposed to ethanol.
Topics: Adrenocorticotropic Hormone; Animals; Body Weight; Central Nervous System Depressants; Ethanol; Feed | 2006 |
Sub-chronic stimulation of glucocorticoid receptor impairs and mineralocorticoid receptor protects cytosolic Ca2+ responses to glucose in pancreatic beta-cells.
Topics: Aldosterone; Animals; Calcium; Corticosterone; Cytosol; Dose-Response Relationship, Drug; Female; Gl | 2008 |
Overproduction of sodium-retaining steroids by the zona glomerulosa is adrenocorticotropin-dependent and mediates hypertension in dexamethasone-suppressible aldosteronism.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Adult; Aldosterone; Aminoglutethimide; Child, Preschool | 1981 |
The effects of spironolactone on reproductive functions in female rats and mice.
Topics: Animals; Estradiol; Estrus; Female; Gonadal Steroid Hormones; Gonadotropin-Releasing Hormone; Litter | 1982 |
Metabolic alkalosis in identical twins receiving a low-chloride formula (pseudo-Bartter's syndrome).
Topics: Alkalosis; Chlorides; Diseases in Twins; Female; Hematuria; Humans; Hypokalemia; Infant Food; Potass | 1980 |
Role of aldosterone in sodium retention of pregnancy in the rat.
Topics: Adrenal Glands; Aldosterone; Animals; Female; Kidney; Pregnancy; Pregnancy, Animal; Rats; Sodium; Sp | 1981 |
[Can the anti-androgenic effect of spironolactone contraindicate its use in pregnancy?].
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Animals; Female; Fetus; Genitalia, Male; Hirsutism; | 1980 |
[Can the anti-androgenic effect of spironolactone contraindicate its use in pregnancy?].
Topics: Abnormalities, Drug-Induced; Androgen Antagonists; Androgens; Animals; Female; Fetus; Genitalia, Mal | 1980 |
Disturbances in sexual differentiation of rat foetuses following spironolactone treatment.
Topics: Animals; Female; Feminization; Fetus; Male; Penis; Pregnancy; Prostate; Rats; Sex Differentiation; S | 1980 |
Spironolactone therapy during human pregnancy.
Topics: Adolescent; Adult; Bartter Syndrome; Child; Female; Humans; Male; Pregnancy; Pregnancy Complications | 1995 |
Low or high doses of spironolactone for treatment of maternal Bartter's syndrome.
Topics: Bartter Syndrome; Female; Humans; Pregnancy; Pregnancy Complications; Spironolactone | 1996 |
[Nonimmune fetal edema].
Topics: Adult; Anemia, Macrocytic; Apgar Score; Cardiotonic Agents; Digoxin; Diuretics; Female; Humans; Hydr | 1995 |
Diagnosis and treatment of a child with the syndrome of apparent mineralocorticoid excess type 1.
Topics: 11-beta-Hydroxysteroid Dehydrogenases; Failure to Thrive; Female; Fetal Growth Retardation; Humans; | 1996 |
Modulation of blood pressure in the Dahl SS/jr rat by embryo transfer.
Topics: Adult; Aging; Animals; Blood Pressure; Cerebral Ventricles; Embryo Transfer; Female; Genotype; Human | 1998 |
Role of renin-angiotensin-aldosterone system in salt-sensitive hypertension induced by sensory denervation.
Topics: Aldosterone; Animals; Blood Pressure; Body Weight; Capsaicin; Denervation; Female; Hypertension; Min | 2001 |
Biological spectrum of two spirolactone derivatives with some observations on anti-fertility activity.
Topics: Androgens; Animals; Castration; Contraceptives, Oral, Synthetic; Dose-Response Relationship, Drug; E | 1977 |
Effect of spironolactone treatment on the renin-aldosterone system during pregnancy.
Topics: Aldosterone; Canrenone; Female; Humans; Potassium; Pregnancy; Renin; Sodium; Spironolactone; Time Fa | 1979 |
Receptor mediated glucocorticoid inhibition of protein synthesis in isolated bone cells.
Topics: Animals; Bone and Bones; Cortodoxone; Dexamethasone; Estradiol; Female; Parathyroid Hormone; Pregnan | 1978 |
[Effect of pregnancy and long-term treatment with spirolactone on the clinical and laboratory picture of primary hyperaldosteronism].
Topics: Adult; Female; Humans; Hyperaldosteronism; Pregnancy; Pregnancy Complications; Spironolactone | 1978 |
Clinical use of diuretics in congestive heart failure.
Topics: Amiloride; Benzothiadiazines; Diuretics; Ethacrynic Acid; Female; Furosemide; Heart Failure; Humans; | 1979 |
[Clinically significant cross reactions in radioimmunological determination of digoxin].
Topics: Adult; Antigen-Antibody Reactions; Cross Reactions; Digoxin; False Positive Reactions; Female; Human | 1977 |
Some factors affecting a commercial kit for radioimmunoassay of digoxin using tritiated digoxin.
Topics: Amniotic Fluid; Chemical Phenomena; Chemistry; Cross Reactions; Digitoxin; Digoxin; Ethanol; Female; | 1977 |
[Effect of spirolactones on the urinary excretion of individual 17-oxosteroids and of pregnanediol in man (author's transl)].
Topics: 17-Ketosteroids; Adult; Canrenoic Acid; Female; Humans; Male; Pregnadienes; Pregnancy; Pregnanediol; | 1977 |
A prospective study of factors affecting intrauterine growth (with an emphasis on blood pressure and diuretics).
Topics: Benzothiadiazines; Birth Weight; Blood Pressure; Blood Volume; Body Water; Diet; Diuretics; Female; | 1976 |
[Spironolactone and thiabutazide in the treatment of essential hypertension (author's transl)].
Topics: Aldosterone; Antihypertensive Agents; Blood Pressure; Body Weight; Butanes; Female; Furosemide; Huma | 1975 |
Renal function and diuretic therapy in infants and children. Part II.
Topics: Acetazolamide; Aldosterone; Benzothiadiazines; Carbonic Anhydrase Inhibitors; Child; Diuretics; Diur | 1975 |
Lack of effect of spironolactone on male genital development.
Topics: Abnormalities, Drug-Induced; Animals; Female; Fetus; Genitalia, Male; Hypospadias; Male; Pregnancy; | 1975 |
[Ovarian hyperstimulation syndrome. Notes on the physiopathology and treatment apropos of 3 cases].
Topics: Adult; Ascites; Capillary Permeability; Chorionic Gonadotropin; Female; Gonadotropins, Pituitary; Hu | 1975 |
Serotonergic regulation of type II corticosteroid receptor binding in hippocampal cell cultures: evidence for the importance of serotonin-induced changes in cAMP levels.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Amphetamines; Animals; Cells, Cultured; Cyclic AMP; Female; | 1992 |
Aldosterone antagonists. 4. Synthesis and activities of steroidal 6,6-ethylene-15,16-methylene 17-spirolactones.
Topics: Adrenalectomy; Aldosterone; Animals; Chemical Phenomena; Chemistry; Endometrium; Female; Male; Miner | 1991 |
The influence of endogenous mineralocorticoids on the composition of fetal urine.
Topics: Aldosterone; Amiloride; Animals; Chlorides; Female; Fetus; Glomerular Filtration Rate; Mineralocorti | 1990 |
A possible role for testosterone during luteolysis in the ewe.
Topics: Animals; Arachis; Estrus; Female; Luteolysis; Plant Oils; Pregnancy; Progesterone; Sheep; Spironolac | 1988 |
Adrenocorticoid-dependent alpha-lactalbumin synthesis in rat mammary gland explants: antagonist studies.
Topics: Aldosterone; Androstanols; Animals; Culture Techniques; Dexamethasone; Female; Glucocorticoids; Lact | 1986 |
Modifications of the gonadal function in the adult rat after fetal exposure to spironolactone.
Topics: Animals; Cell Nucleus; Cytosol; Female; Fetus; Follicle Stimulating Hormone; Genitalia; Gonadal Ster | 1985 |
Management of severe hypertension.
Topics: Benzothiadiazines; Blood Pressure; Clonidine; Diazoxide; Diet, Sodium-Restricted; Disseminated Intra | 1973 |
[Hypertension in pregnancy (author's transl)].
Topics: Alkaline Phosphatase; Estriol; Female; Fetal Diseases; Fetal Heart; Fetoscopy; Guanethidine; Humans; | 1974 |
Interruption of pregnancy by various steroids.
Topics: Abortion, Induced; Anabolic Agents; Animals; Cholesterol; Dehydroepiandrosterone; Dexamethasone; Dig | 1971 |
Editorial: Gynecomastia.
Topics: Age Factors; Antidepressive Agents; Busulfan; Child; Child, Preschool; Digitalis Glycosides; Estroge | 1974 |
[Nephrology in 1972].
Topics: Bone Resorption; Calcium; Dextrans; Female; Fluorescent Antibody Technique; Gentamicins; Glomerulone | 1972 |
Renal electrolyte excretion during the oestrous cycle in the rat.
Topics: Animals; Castration; Estrus; Female; Glomerular Filtration Rate; Kidney; Natriuresis; Potassium; Pre | 1972 |
[Pregnancy in liver cirrhosis. Internal medicine and gynecological aspects].
Topics: Adult; Ascites; Colon; Diet, Sodium-Restricted; Diuretics; Esophageal and Gastric Varices; Esophagea | 1973 |
[Clinical experiences with the determination of the plasma digoxin level].
Topics: Amniotic Fluid; Blood; Digoxin; False Positive Reactions; Female; Humans; Maternal-Fetal Exchange; P | 1973 |
The effect of D-aldosterone and spironolactone on the concentration of sodium and potassium in the milk of rats.
Topics: Aldosterone; Animals; Female; Humans; Lactation; Milk; Potassium; Pregnancy; Rats; Sodium; Spironola | 1973 |
[Therapeutic effect of spirolactones in late pregnancy toxicosis].
Topics: Female; Humans; Pre-Eclampsia; Pregnancy; Spironolactone | 1965 |
The clinical pattern & the causative factors of late edema observed in low birth weight infants.
Topics: Birth Weight; Blood Proteins; Dexamethasone; Edema; Female; Gestational Age; Humans; Hypoproteinemia | 1968 |
[Comparative assessment of the therapeutic effect of modern nonmercuric diuretics in the edematous syndrome of pregnancy].
Topics: Diuretics; Edema; Female; Furosemide; Humans; Mannitol; Pre-Eclampsia; Pregnancy; Spironolactone | 1971 |
Induction of premature menstruation with catatoxic steroids.
Topics: Abortion, Therapeutic; Adult; Biotransformation; Body Temperature; Contraceptives, Oral; Endometrium | 1971 |
Hypertension and low plasma renin activity: presumptive evidence for mineralocorticoid excess.
Topics: Adrenal Glands; Aldosterone; Blood Pressure; Body Weight; Carbon Dioxide; Chlorides; Female; Humans; | 1971 |
[Aldosterone and sodium excretion in pregnancy].
Topics: Aldosterone; Aminohippuric Acids; Female; Glomerular Filtration Rate; Humans; Inulin; Kidney Tubules | 1971 |
[Influence of spironolactone on the excretion of C21-, C19-, and C18 steroids in pregnant and nonpregnant women].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Aldosterone; Estradiol; Estriol; Estrogens; Estrone; Fem | 1971 |
[Experimental study on teratology of spironolactone].
Topics: Abnormalities, Drug-Induced; Animals; Female; Fetus; Lung Diseases; Male; Mice; Pregnancy; Pregnancy | 1969 |
[Ascites in pregnancy in liver cirrhosis].
Topics: Ascites; Diet, Sodium-Restricted; Female; Fetal Death; Humans; Hypertension, Portal; Infant, Newborn | 1970 |
[Treatment of late pregnancy toxemias with aldactone].
Topics: Adolescent; Adult; Aldosterone; Colorimetry; Female; Humans; Potassium; Pre-Eclampsia; Pregnancy; So | 1971 |
Effects of vasopressin and spironolactone on excretion of water and solutes by the pregnant rat.
Topics: Animals; Body Weight; Extracellular Space; Female; Inulin; Potassium; Pregnancy; Pregnancy, Animal; | 1968 |
Renal clearance of water and solutes by pregnant rats treated with spironolactone.
Topics: Animals; Female; Glomerular Filtration Rate; Injections, Intramuscular; Injections, Intravenous; Inu | 1968 |
[Use of spirolactone in treatment of myasthenia in pregnancy].
Topics: Female; Humans; Myasthenia Gravis; Pregnancy; Pregnancy Complications; Spironolactone | 1965 |
[Spirolactones and the hypertensive edemo-nephrosic syndrome].
Topics: Edema; Female; Humans; Pre-Eclampsia; Pregnancy; Spironolactone | 1965 |