spironolactone has been researched along with Potassium Deficiency in 29 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Potassium Deficiency: A condition due to decreased dietary intake of potassium, as in starvation or failure to administer in intravenous solutions, or to gastrointestinal loss in diarrhea, chronic laxative abuse, vomiting, gastric suction, or bowel diversion. Severe potassium deficiency may produce muscular weakness and lead to paralysis and respiratory failure. Muscular malfunction may result in hypoventilation, paralytic ileus, hypotension, muscle twitches, tetany, and rhabomyolysis. Nephropathy from potassium deficit impairs the concentrating mechanism, producing POLYURIA and decreased maximal urinary concentrating ability with secondary POLYDIPSIA. (Merck Manual, 16th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Extra potassium supplements, spironolactone or amiloride were given for 5 months to forty-nine patients with heart failure who were taking furosemide and were in a steady state." | 9.04 | The effects of potassium supplements, spironolactone of amiloride on the potassium status of patients with heart failure. ( Burkinshaw, L; Davidson, C; Morgan, DB, 1978) |
| "Extra potassium supplements, spironolactone or amiloride were given for 5 months to forty-nine patients with heart failure who were taking furosemide and were in a steady state." | 5.04 | The effects of potassium supplements, spironolactone of amiloride on the potassium status of patients with heart failure. ( Burkinshaw, L; Davidson, C; Morgan, DB, 1978) |
| " Triamterene seemed ineffective in the dosage used (50 mg twice daily)." | 2.64 | Potassium-sparing agents during diuretic therapy in hypertension. ( Brien, TG; Canning, BS; Donohoe, JF; Healy, JJ; McKenna, TJ; Muldowney, FP, 1971) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (86.21) | 18.7374 |
| 1990's | 2 (6.90) | 18.2507 |
| 2000's | 1 (3.45) | 29.6817 |
| 2010's | 1 (3.45) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bhatt, DL | 1 |
| KUECHEL, O | 1 |
| HORKY, K | 1 |
| JIRANKOVA, J | 1 |
| KAPITOLA, J | 1 |
| GHOSE, RR | 1 |
| RAAB, W | 1 |
| LUETSCHER, JA | 1 |
| BOUCHER, BJ | 1 |
| MASON, AS | 1 |
| McKay, AJ | 1 |
| Peterson, LN | 1 |
| Haris, A | 1 |
| Radó, J | 1 |
| Laragh, J | 1 |
| Davidson, C | 1 |
| Burkinshaw, L | 1 |
| Morgan, DB | 1 |
| Edmonds, CJ | 1 |
| Jasani, B | 1 |
| Vesin, P | 1 |
| Senewiratne, B | 1 |
| Sherlock, S | 1 |
| Sitt, R | 1 |
| Senft, G | 1 |
| Losert, W | 1 |
| Kaess, H | 1 |
| Berg, KJ | 1 |
| Gisholt, K | 1 |
| Wideroe, TE | 1 |
| Fleming, JS | 1 |
| Bernik, V | 1 |
| France, R | 1 |
| Stone, WJ | 1 |
| Michelakis, AM | 1 |
| Island, DP | 1 |
| Merrill, JM | 1 |
| Tolleson, WJ | 1 |
| Kalbian, VV | 1 |
| Salvador, M | 1 |
| Thomas, C | 1 |
| Mazenq, M | 1 |
| Conté, J | 1 |
| Mériel, P | 1 |
| Lesbre, P | 1 |
| McKenna, TJ | 1 |
| Donohoe, JF | 1 |
| Brien, TG | 1 |
| Healy, JJ | 1 |
| Canning, BS | 1 |
| Muldowney, FP | 1 |
| Larcan, A | 1 |
| Calamai, M | 1 |
| Jacob, F | 1 |
| Savoie, LL | 1 |
| Gitelman, HJ | 1 |
| Graham, JB | 1 |
| Welt, LG | 1 |
| Vinogradov, AV | 1 |
| Matveev, LN | 1 |
| Stefan, H | 1 |
| Helge, H | 1 |
| Merker, HJ | 1 |
| Bachmann, D | 1 |
| Isch, F | 1 |
| Isch-Treussard, C | 1 |
| Jésel, M | 1 |
| Warter, JM | 1 |
| Frank, J | 1 |
4 reviews available for spironolactone and Potassium Deficiency
| Article | Year |
|---|---|
NEUROGENIC MULTIFOCAL DESTRUCTION OF MYOCARDIAL TISSUE (PATHOGENIC MECHANISM AND ITS PREVENTION).
Topics: Adrenal Cortex Hormones; Catecholamines; Epinephrine; Heart Diseases; Hypoxia; Myocardial Infarction | 1963 |
[Potassium-sparing diuretics (spironolactone, triamterene, amylorid)].
Topics: Amiloride; Diuretics; Humans; Hypertension; Hypokalemia; Potassium Deficiency; Spironolactone; Triam | 1996 |
Laragh's lessons in pathophysiology and clinical pearls for treating hypertension.
Topics: Diuretics; Humans; Hypertension; Mineralocorticoid Receptor Antagonists; Potassium Deficiency; Spiro | 2001 |
[The problem of potassium and diuretics].
Topics: Administration, Oral; Amiloride; Benzothiadiazines; Clopamide; Digitalis Glycosides; Diuretics; Drug | 1972 |
2 trials available for spironolactone and Potassium Deficiency
| Article | Year |
|---|---|
The effects of potassium supplements, spironolactone of amiloride on the potassium status of patients with heart failure.
Topics: Adult; Aged; Amiloride; Female; Furosemide; Heart Failure; Humans; Male; Middle Aged; Potassium; Pot | 1978 |
Potassium-sparing agents during diuretic therapy in hypertension.
Topics: Adult; Aged; Chlorthalidone; Diuretics; Humans; Hypertension; Middle Aged; Potassium; Potassium Defi | 1971 |
23 other studies available for spironolactone and Potassium Deficiency
| Article | Year |
|---|---|
Ask the doctor. The June 2013 issue states on page 3 that "it's important to increase potassium intake, particularly if you take a diuretic." But on page 5, it says that if you take spironolactone (which I do), you should avoid high-potassium foods. I'm c
Topics: Diuretics; Food, Organic; Health Behavior; Health Education; Humans; Potassium Deficiency; Potassium | 2014 |
[ENDOCRINOLOGICAL ASPECTS OF THE POTASSIUM DEPLETION SYNDROME].
Topics: Diuretics; Endocrine Glands; Heparin; Hyperaldosteronism; Hypokalemia; Liver Cirrhosis; Mineralocort | 1963 |
ALKALOSIS WITH PLASMA-BICARBONATE VARIATIONS IN COR PULMONALE WITH HYPERCAPNIA.
Topics: Alkalosis; Bicarbonates; Blood Chemical Analysis; Blood Gas Analysis; Carbon Dioxide; Chlorides; Diu | 1964 |
PRIMARY ALDOSTERONISM: OBSERVATIONS IN SIX CASES AND REVIEW OF DIAGNOSTIC PROCEDURES.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Aldosterone; Diabetes Mellitus; Diagnosis, Differen | 1964 |
CONN'S SYNDROME WITH ASSOCIATED PREGNANCY.
Topics: Adenoma; Adrenal Gland Neoplasms; Blood; Dexamethasone; Diagnosis; Female; Humans; Hyperaldosteronis | 1965 |
Lasix.
Topics: Diuresis; Edema; Furosemide; Heart Failure; Humans; Kidney Diseases; Liver Cirrhosis; Potassium Defi | 1967 |
K infusion corrects thick ascending limb Cl reabsorption in K-depleted rats by an aldosterone-independent mechanism.
Topics: Absorption; Aldosterone; Animals; Chlorides; Infusions, Intravenous; Loop of Henle; Male; Potassium; | 1993 |
Total-body potassium in hypertension patients during prolonged diuretic therapy.
Topics: Adult; Aged; Body Weight; Diuretics; Female; Humans; Hypertension; Long-Term Care; Male; Middle Aged | 1972 |
Potassium supplements and diuretics.
Topics: Diuretics; Humans; Liver Cirrhosis; Potassium; Potassium Chloride; Potassium Deficiency; Spironolact | 1972 |
Amiloride ('MK 870') in patients with ascites due to cirrhosis of the liver.
Topics: Adult; Ascites; Bicarbonates; Creatinine; Diuretics; Ethacrynic Acid; Furosemide; Guanidines; Humans | 1968 |
[The effect of hydrochlorthiazide on the blood sugar-increasing action of diazoxide].
Topics: Animals; Antihypertensive Agents; Carbohydrate Metabolism; Diazoxide; Hydrochlorothiazide; Hyperglyc | 1966 |
Potassium deficiency in hypertensives treated with diuretics. Analysis of three alternative treatments by an oral test for potassium deficiency.
Topics: Adult; Aged; Chlorthalidone; Diuretics; Female; Humans; Hypertension; Male; Potassium; Potassium Def | 1974 |
Heart failure and cardiac arrhythmias.
Topics: Arrhythmia, Sinus; Arrhythmias, Cardiac; Coronary Disease; Digoxin; Diuretics; Electroconvulsive The | 1974 |
Renal potassium-wasting of unknown cause in a clinical setting of chronic potassium depletion: report of a case.
Topics: Aldosterone; Biopsy; Humans; Kidney; Kidney Tubules, Proximal; Magnesium; Male; Middle Aged; Muscula | 1973 |
Iatrogenic hyperkalemic paralysis with electrocardiographic changes.
Topics: Bicarbonates; Calcium; Electrocardiography; Furosemide; Gluconates; Glucose; Heart; Humans; Hyperkal | 1974 |
[Rhythm disorders induced directly or by potassium depletion. General review apropos of 20 cases].
Topics: Aged; Alcoholic Intoxication; Arrhythmias, Cardiac; Cathartics; Cell Membrane; Cell Membrane Permeab | 1970 |
[Severe kaliopenia and electrolytic gradient disturbances in medico-surgical resuscitation. Value of a spironolactone with antialdosterone and catatoxic effect].
Topics: Brain Edema; Cardiac Surgical Procedures; Cardiovascular Diseases; Extracorporeal Circulation; Human | 1971 |
[Effect of antikaliuretics on the development of cardiac lesions in potassium or magnesium deficiencies in the rat].
Topics: Amiloride; Animals; Chlorides; Diet; Diuretics; Female; Heart; Heart Diseases; Magnesium; Magnesium | 1971 |
A familial disorder characterized by hypokalemia and hypomagnesemia.
Topics: Calcium; Diuretics; Female; Humans; Kidney; Magnesium; Magnesium Deficiency; Pedigree; Potassium; Po | 1969 |
[Prevention of potassium metabolism disorders arising during the treatment of cardiac insufficiency with diuretics].
Topics: Adult; Digitalis Glycosides; Diuretics; Drug Synergism; Female; Furosemide; Heart Failure; Humans; H | 1967 |
[Kidney artery stenosis, renal hypertension and secondary hyperaldosteronism in an 8-year-old boy. (Stunted growth through potassium deficiency)].
Topics: Adrenal Glands; Aldosterone; Child; Dwarfism; Humans; Hyperaldosteronism; Hypertension, Renal; Hypok | 1968 |
[Electromyographic study of 2 cases of von Eulenburg's paramyotonia congenita].
Topics: Adult; Body Temperature; Calcium; Child; Electric Stimulation; Electromyography; Female; Humans; Mus | 1968 |
[On the management of postoperative motility of the intestines by aldosterone antagonists].
Topics: Aldosterone; Gastrointestinal Motility; Humans; Postoperative Complications; Potassium Deficiency; P | 1966 |